Circadian rhythms and sleep in bipolar disorder: implications for pathophysiology and treatment.

Abstract:

PURPOSE OF REVIEW:Multiple lines of evidence support the conceptualization of bipolar disorder as a disorder of circadian rhythms. Considering bipolar disorder in the framework of circadian disturbances also helps understand the clinical phenomenology pointing toward a multisystemic involvement. RECENT FINDINGS:Patients with bipolar disorder show altered rhythmicity in body temperature and melatonin rhythms, high day-to-day variability in activity and sleep timing, persistent disturbances of sleep or wake cycles, including disturbances of sleep continuity. The internal clocks are, indeed, responsible for regulating a variety of physiologic functions, including appetitive behaviors, cognitive functions and metabolism. SUMMARY:An underlying circadian pathology in bipolar disorder is a unifying explicatory model for the high psychiatric and medical comorbidity observed during the long-term course of the disorder. This model also provides a rationale for therapeutic interventions aimed at re-entraining the internal clock.

journal_name

Curr Opin Psychiatry

authors

Soreca I

doi

10.1097/YCO.0000000000000108

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

467-71

issue

6

eissn

0951-7367

issn

1473-6578

journal_volume

27

pub_type

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