Abstract:
PURPOSE OF REVIEW:This review examines progress being made in the treatment of cocaine abuse and dependence, with a particular focus on pharmacotherapies. Medications with apparently very different mechanisms of action have been reported to reduce cocaine use in controlled clinical trials in outpatient settings. This review will summarize the latest findings in this area. RECENT FINDINGS:Of all the medications tested to date, disulfiram has demonstrated the most consistent effect to reduce cocaine use. Several medications have been reported to reduce cocaine use in double-blind, placebo-controlled clinical trials, namely baclofen, modafinil, tiagabine, and topiramate. All pharmacotherapy trials in cocaine-dependent patients include a behavioral therapy that is common to all participants. Consequently, these pharmacotherapy trials can be considered to evaluate whether the medication is adding to the effect of the behavioral therapy. SUMMARY:Confirmatory clinical studies are necessary to replicate the initial efficacy findings for baclofen, modafinil, tiagabine, and topiramate. More research is needed in both cocaine and cocaine-alcohol dependent populations. Once confirmatory studies have been carried out, testing of rational medication combinations with different behavioral therapies is an obvious next step to increase the ability to manage cocaine dependence.
journal_name
Curr Opin Psychiatryjournal_title
Current opinion in psychiatryauthors
Vocci FJ,Elkashef Adoi
10.1097/01.yco.0000165596.98552.02subject
Has Abstractpub_date
2005-05-01 00:00:00pages
265-70issue
3eissn
0951-7367issn
1473-6578pii
00001504-200505000-00008journal_volume
18pub_type
杂志文章abstract:PURPOSE OF REVIEW:The present article reviews the increasing literature on comorbidity, treatment and use of health service resources for children and adolescents with autism spectrum disorders and intellectual disability from January 2006 to January 2007. RECENT FINDINGS:Children and adolescents with autism spectrum ...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e32821f6095
更新日期:2007-09-01 00:00:00
abstract:PURPOSE OF REVIEW:This review outlines the positive and negative aspects of DNA testing and provides an account of the issues particularly relevant to schizophrenia. RECENT FINDINGS:Modern technology has changed the field of medicine so rapidly that patients and their families have become much more independent in thei...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000060
更新日期:2014-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The present review focuses on atypical antipsychotics and tardive dyskinesia. RECENT FINDINGS:We have known for many years that clozapine has a diminished risk of tardive dyskinesia compared with typical antipsychotics. The last decade has seen the introduction of a number of other atypical antipsych...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e328017f6b1
更新日期:2007-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Failing adult neurogenesis is increasingly considered a factor in the pathogenesis and course of psychiatric disorders. The level of evidence in favor of such hypotheses varies, but disturbed cellular plasticity in the hippocampus may be a common aspect of several neuropsychiatric diseases. RECENT FI...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e3282fad375
更新日期:2008-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Depression is a common and disabling disorder that affects people of all ages and 10% of those older than 65 years. Current strategies to decrease the personal and societal burden of depression in older age rely on the management of people with depression or of those at risk, but benefits have been li...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e328356bd57
更新日期:2012-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent epidemiology, biological and clinical findings correlate high cigarette consumption in patients with schizophrenia, impeding both treatment strategies and the effectiveness of antipsychotics. RECENT FINDINGS:New data suggests that despite world-wide efforts to curb cigarette consumption, smoki...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000529
更新日期:2019-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this article is to review the most relevant conceptual models of borderline personality disorder (BPD), with a focus on recent developments in this area. RECENT FINDINGS:Several conceptual models have been proposed with the aim of better understanding BPD: the borderline personality or...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000374
更新日期:2018-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent advances in neuroimaging methods have provided new ways of unravelling the complex interplay between genetic and environmental factors that influence functional brain development in the critical first years of life. This has allowed new insights into the effects that early adverse experience ca...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e3283387a8c
更新日期:2010-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The comorbidity between psychiatric and substance use disorders remains an important phenomenon to understand, and an active area of investigation. The purpose of this review is to highlight key 2011 issues and novel findings on psychiatric and substance disorders comorbidity from the National Epidemi...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e3283523dcc
更新日期:2012-05-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the literature on decriminalization of drug use from 2016 to 2017 and suggest the way forward. RECENT FINDINGS:The systematic review of the literature on decriminalization resulted in seven articles that discuss decriminalization as compared with 57 published articles on legalization. Decri...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章
doi:10.1097/YCO.0000000000000429
更新日期:2018-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To examine the influence of personality disorder comorbidity on the general treatment of mood disorders. RECENT FINDINGS:Personality disorders generally have a negative influence on outcome of mood disorders, both unipolar and bipolar. When the personality features are addressed, however, the outcome...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The present review examines the recent advances in psychological interventions for two major lifestyle disorders in adults namely, type 2 diabetes mellitus and cardiovascular disorders. The review summarizes findings from studies carried out between the years 2015 and 2017. RECENT FINDINGS:The effect...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000348
更新日期:2017-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Considerable progress has been made in the neurobiological understanding of expectations in physiological and pathological processes. This article is aimed at presenting an overview of the role of expectations in producing health-related effects. We selected recent laboratory and clinical studies in t...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e328343803b
更新日期:2011-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Over 70 million people worldwide, including those with neurodegenerative disease (NDD), have been diagnosed with coronavirus disease 2019 (COVID-19) to date. We review outcomes in patients with NDD and COVID-19 and discuss the hypothesis that due to putative commonalities of neuropathogenesis, COVID-1...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章
doi:10.1097/YCO.0000000000000688
更新日期:2021-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this review is to describe the considerable advances in consolidating the empirical evidence on several key topics in the genetics of attention deficit hyperactivity disorder, namely the quantitative genetic studies of the nature of attention deficit hyperactivity disorder and its comorbidi...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e328303ba54
更新日期:2008-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Schizophrenia occurs in ∼25% of individuals with 22q11.2 deletion syndrome (22q11.2DS), the strongest known molecular genetic risk factor for schizophrenia. This review highlights recent literature in 22q11.2DS as it pertains to psychosis and schizophrenia. RECENT FINDINGS:Advances in noninvasive pre...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000324
更新日期:2017-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The development of acute and posttraumatic stress symptoms after a traumatic event is common and often leads to personal distress, functional impairment, and economic consequences in trauma victims and their loved ones. Hence, the prevention of acute and chronic posttraumatic stress is an important pu...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e32834cdde2
更新日期:2011-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide an update of the recent studies on the olfactory function in Alzheimer's disease, with a focus on the olfactory identification function. RECENT FINDINGS:The studies reviewed here confirm previous reports on the poor olfactory function in Alzheimer's disease compared to health normal contro...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000146
更新日期:2015-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Including the psychopathic specifier within the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition alternative model of personality disorder (AMPD) trait conceptualization of antisocial personality disorder (ASPD) represents a significant development in the history of the conceptualiz...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章
doi:10.1097/YCO.0000000000000648
更新日期:2021-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Poor psychosocial functioning in schizophrenia can be conceptualized as an early indicator of chronic neurodevelopmental illness. Alternatively, impaired psychosocial functioning could be the result of social and environmental factors associated with the onset of psychotic illness. We review recent ev...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e32835d82aa
更新日期:2013-03-01 00:00:00
abstract:PURPOSE OF REVIEW:This article reviews recent literature published over the period March 2012-August 2013 on antidepressant pharmacogenetics, with a focus on clinical translation and methodological challenges. RECENT FINDINGS:Recently, various polymorphisms associated with differential antidepressant efficacy, tolerab...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000023
更新日期:2014-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Compelling evidence suggests that a small group of men who develop schizophrenia display a stable pattern of antisocial behaviour from childhood onwards, causing considerable suffering to victims and to themselves and imposing a significant financial burden on society. We reviewed the literature on th...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/01.yco.0000238484.12023.aa
更新日期:2006-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Multiple lines of evidence support the conceptualization of bipolar disorder as a disorder of circadian rhythms. Considering bipolar disorder in the framework of circadian disturbances also helps understand the clinical phenomenology pointing toward a multisystemic involvement. RECENT FINDINGS:Patien...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000108
更新日期:2014-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Clinical practice guidelines (CPGs) do not usually offer a sex-specific approach for the management of schizophrenia. With this narrative review, we aim to give an integrated and synthesized overview of the current state of knowledge regarding sex-specific aspects in schizophrenia and how this topic m...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章
doi:10.1097/YCO.0000000000000597
更新日期:2020-05-01 00:00:00
abstract:PURPOSE OF REVIEW:This article reviews recent evidence and other earlier relevant articles regarding early intervention studies for children with autism spectrum disorder (ASD). RECENT FINDINGS:There is a well-established body of empirical evidence for the effectiveness of Early Intensive Behavioural Intervention (EIB...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000043
更新日期:2014-03-01 00:00:00
abstract:PURPOSE OF REVIEW:In this paper, we analyze the concept of objectivity as it is accepted in the 'standard position' on ethical practice in forensic psychiatry and confront it with the current trends of psychiatric nosology, specially the debate that we have now regarding the theoretical orientation of DSM-5, which is i...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e32833cd1e6
更新日期:2010-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To understand pathways into healthcare people of minority ethnic groups use and if these differ from those of the majority. RECENT FINDINGS:The current literature shows that some forms of treatment are seen as less stigmatizing and more acceptable. The treatment expectations also dictate choice of he...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e3283477ae8
更新日期:2011-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Clinical registries, routinely collected administrative data and electronic medical records (EMRs) provide new opportunities to investigate medication safety and effectiveness. This review outlines the strengths and limitations of these data, and highlights recent research related to safe and effectiv...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000579
更新日期:2020-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To examine recent philosophical work which impacts on fitting mental content into a satisfactory picture of nature. RECENT FINDINGS:Both reductionist and nonreductionist forms of naturalism about mental content have sustained criticism. SUMMARY:The connection between having a mind and fitting a rati...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e32834b7b24
更新日期:2011-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the rationale behind and the use of cerebrospinal fluid (CSF) biomarkers in Alzheimer's disease (AD). Established as well as new candidate biomarkers will be covered. RECENT FINDINGS:AD is a complex disorder and the AD brain is characterized by multiple pathological processes, in addition t...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e32835f6747
更新日期:2013-05-01 00:00:00