Do we need sex-oriented clinical practice guidelines for the treatment of schizophrenia?

Abstract:

PURPOSE OF REVIEW:Clinical practice guidelines (CPGs) do not usually offer a sex-specific approach for the management of schizophrenia. With this narrative review, we aim to give an integrated and synthesized overview of the current state of knowledge regarding sex-specific aspects in schizophrenia and how this topic may be adapted in the development of CPGs. RECENT FINDINGS:Recent studies further suggest sex-specific differences in epidemiologic features, the course of illness, underlying pathomechanisms, response likelihood to antipsychotic medication and differences in tolerability. Beyond this, selective estrogen receptor modulators like raloxifene have shown beneficial effects on symptom severity and cognition in women with schizophrenia. SUMMARY:Sex-specific aspects can already be integrated in clinical guideline recommendations, especially with regard to efficacy and tolerability of antipsychotic treatment. Moreover, these aspects may be used for an individual risk-stratification. Recent studies provide evidence supporting the hypothesis of sex-specific modulation in schizophrenia and build the groundwork for sex-specific novel treatment options. However, there remains a clear need for additional studies focusing on women with schizophrenia to substantiate current findings.

journal_name

Curr Opin Psychiatry

authors

Fernando P,Sommer IEC,Hasan A

doi

10.1097/YCO.0000000000000597

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

192-199

issue

3

eissn

0951-7367

issn

1473-6578

journal_volume

33

pub_type

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