Abstract:
PURPOSE OF REVIEW:This article reviews recent literature published over the period March 2012-August 2013 on antidepressant pharmacogenetics, with a focus on clinical translation and methodological challenges. RECENT FINDINGS:Recently, various polymorphisms associated with differential antidepressant efficacy, tolerability, and safety have emerged in association studies, but mixed findings, limited effect sizes, and poor control of confounders have prevented findings translating to practice. Although promising steps have been made, empirically robust clinically translatable pharmacogenetic tests are not yet established. The complex neurobiology of major depressive disorder (MDD) together with the evolving understanding of genetic processes present research challenges for clinical translation. SUMMARY:Early reports of clinical utility are published. The current evidence base for antidepressant pharmacogenetics is, however, not yet empirically robust enough to inform routine prescribing guidelines. Over the coming years, genetically guided versus unguided trials will help determine if antidepressant pharmacogenetics merits more widespread application.
journal_name
Curr Opin Psychiatryjournal_title
Current opinion in psychiatryauthors
Singh AB,Bousman CA,Ng C,Berk Mdoi
10.1097/YCO.0000000000000023subject
Has Abstractpub_date
2014-01-01 00:00:00pages
43-51issue
1eissn
0951-7367issn
1473-6578journal_volume
27pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:This review highlights what current research says about how local beliefs and norms can facilitate expansion of mental healthcare to meet the large unmet need for services in Africa. RECENT FINDINGS:In contemporary Africa, religious beliefs exert important influences on mental health as well as the w...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章
doi:10.1097/YCO.0000000000000590
更新日期:2020-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Bariatric surgery is the most effective treatment for morbid obesity. However, 20-30% of patients undergoing bariatric surgery experience premature weight stabilization or weight regain postoperatively. We report on the recent literature of predictors of weight loss and the efficacy of cognitive behav...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000359
更新日期:2017-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent advances in neuroimaging methods have provided new ways of unravelling the complex interplay between genetic and environmental factors that influence functional brain development in the critical first years of life. This has allowed new insights into the effects that early adverse experience ca...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e3283387a8c
更新日期:2010-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Failing adult neurogenesis is increasingly considered a factor in the pathogenesis and course of psychiatric disorders. The level of evidence in favor of such hypotheses varies, but disturbed cellular plasticity in the hippocampus may be a common aspect of several neuropsychiatric diseases. RECENT FI...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e3282fad375
更新日期:2008-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Social cognition refers broadly to the way in which we process social information, and is a critical predictor of social competency. This article provides an overview of some of the assessment approaches that have been developed to assess this construct. RECENT FINDINGS:A variety of well validated as...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000139
更新日期:2015-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To collect and update published information on the stigma associated with substance abuse in nonclinical samples, which has not been recently reviewed. RECENT FINDINGS:Searching large databases, a total of only 17 articles were published since 1999, with the majority of studies conducted outside the ...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000351
更新日期:2017-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To review recent neuro-imaging findings with respect to conduct disorder and callous-unemotional traits in childhood and comparable psychopathy in adult-hood that deepen the literature in important ways. RECENT FINDINGS:Recent structural findings particularly bring clarity to the literature. First, t...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章
doi:10.1097/YCO.0000000000000559
更新日期:2020-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Chronological age is a crude measure and may not be the best indicator of the ageing process. Establishing valid and reliable biomarkers to understand the true effect of ageing is of great interest. We provide an overview of biological and psychological characteristics that change with age and can pot...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000473
更新日期:2019-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The importance of ensuring robust arrangements for young people's transitions from specialist child and adolescent mental health services to specialist mental health services for adults is well documented in the international literature. Nonetheless, according to young people, there remains great vari...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e32833a51e2
更新日期:2010-07-01 00:00:00
abstract::A shift in accepted practice regarding sharing research led one editor to discuss adopting a legal rather than a moral stance to enforce ethical standards. Familiar ethical concerns regarding consent and balancing individual rights against those of others are considered, alongside lacunae in the field, by drawing on v...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章
doi:10.1097/00001504-199909000-00002
更新日期:1999-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Progress in neurosciences, increasing computational power, and ongoing miniaturization of micro-technological components enable both a better understanding of human brain functions and development of new diagnostic and therapeutic tools. Research and development as well as clinical application of devi...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e32834bb8ca
更新日期:2011-11-01 00:00:00
abstract:PURPOSE OF REVIEW:This article summarizes major results in the field of epidemiology and characteristics of stalking, as published in literature between 2003 and October 2005. RECENT FINDINGS:Although stalking had been only recently conceptualized, it soon became evident that it represents a significant social and med...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/01.yco.0000228760.95237.f5
更新日期:2006-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Since the first description of the foetal damage of alcohol in 1967, numerous studies have outlined different aspects of neurodevelopmental dysfunction, adversely affecting the lives of children worldwide. Although the cause of the syndrome is sorted out, the pathogenesis of brain damage is far from b...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000038
更新日期:2014-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To understand pathways into healthcare people of minority ethnic groups use and if these differ from those of the majority. RECENT FINDINGS:The current literature shows that some forms of treatment are seen as less stigmatizing and more acceptable. The treatment expectations also dictate choice of he...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e3283477ae8
更新日期:2011-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Cognitive dysfunction in major depressive disorder (MDD) is common, pervasive across multiple subdomains of cognitive function, and is a principle determinant of health outcomes from patient, provider, and societal perspectives. The overarching aim herein is to provide rationale for the evaluation, me...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000221
更新日期:2016-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The issue of workplace bullying has become an area of research interest in the last 3 decades. Much of the extant literature is published in the business management journals. This is problematic as the targets of workplace bullying may need psychiatric treatment; as a discipline, therefore psychiatris...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000084
更新日期:2014-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Mentally ill homeless persons are among the most neglected or marginalized patient groups. Their needs for mental healthcare are widely unmet. The current economic crisis probably accelerates the social decline and deterioration of physical and mental health in high-risk groups worldwide and increases...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e328361e596
更新日期:2013-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Schizophrenia occurs in ∼25% of individuals with 22q11.2 deletion syndrome (22q11.2DS), the strongest known molecular genetic risk factor for schizophrenia. This review highlights recent literature in 22q11.2DS as it pertains to psychosis and schizophrenia. RECENT FINDINGS:Advances in noninvasive pre...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000324
更新日期:2017-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Attempts to remediate the cognitive difficulties of people with a diagnosis of schizophrenia have shown efficacy; however, existing treatment studies display huge variation, frustrating efforts to determine how best to apply this treatment tool. This review summarizes findings of induced cognitive cha...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e328322fbf4
更新日期:2009-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Females experience eating disorders at substantially higher rates than males. Although sociocultural factors have traditionally been thought to underlie this sex disparity, accumulating evidence implicates differential exposure to gonadal hormones early in life. Gonadal hormones also impact within-sex...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000543
更新日期:2019-11-01 00:00:00
abstract:PURPOSE OF REVIEW:We review the recent literature on the comparative efficacy/effectiveness of antipsychotic long-acting injections (LAIs) vs. oral antipsychotics. Randomized controlled trials (RCTs), mirror-image studies and cohort studies are reviewed, and the strength and weaknesses of each design discussed. RECENT...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000160
更新日期:2015-05-01 00:00:00
abstract:PURPOSE OF REVIEW:To consider comorbidity across multiple classes of disorders in data derived from recent large-scale community surveys. RECENT FINDINGS:There has been substantial recent progress in our understanding of patterns and implications of comorbidity of mental disorders. There is now converging evidence on ...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e3281c61dc5
更新日期:2007-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize research into public policy affecting people with intellectual and developmental disabilities, published in 2009 and early 2010. RECENT FINDINGS:There is a growing body of international policy relating to intellectual disability, usually expressed as general moral objectives. However, th...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e32833be998
更新日期:2010-09-01 00:00:00
abstract:PURPOSE OF REVIEW:India has experienced rapid urbanization in the last few decades. This review focuses on recent research related to the effects of urbanization on mental health with a specific focus on various population groups in urban India. RECENT FINDINGS:With a specific focus on recent research undertaken among...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000408
更新日期:2018-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Multiple lines of evidence support the conceptualization of bipolar disorder as a disorder of circadian rhythms. Considering bipolar disorder in the framework of circadian disturbances also helps understand the clinical phenomenology pointing toward a multisystemic involvement. RECENT FINDINGS:Patien...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000108
更新日期:2014-11-01 00:00:00
abstract:PURPOSE OF REVIEW:The overview focuses on publications relating to the history of social psychiatry and the mental health movement, respectively. RECENT FINDINGS:The selected works show fundamental developments within psychiatry, which can be conceived in the broadest sense as sociomedical in nature. Main emphases are...
journal_title:Current opinion in psychiatry
pub_type: 历史文章,杂志文章,评审
doi:10.1097/YCO.0b013e3283590509
更新日期:2012-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Screening measures for bipolar disorder are positioned as playing an important role in improving diagnostic accuracy. This review considers the principal screening measures developed over the past decade. RECENT FINDINGS:Although the development and evaluation of bipolar screening measures were disti...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000125
更新日期:2015-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent epidemiology, biological and clinical findings correlate high cigarette consumption in patients with schizophrenia, impeding both treatment strategies and the effectiveness of antipsychotics. RECENT FINDINGS:New data suggests that despite world-wide efforts to curb cigarette consumption, smoki...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000529
更新日期:2019-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Overview on integrated care trials focusing on effectiveness and efficiency published from 2011 to 2013. RECENT FINDINGS:Eight randomized controlled trials (RCTs) and 21 non-RCT studies were published from 2011 to 2013. Studies differed in several methodological aspects such as study population, psyc...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e328361ec3b
更新日期:2013-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Schizophrenia (SCZ) and bipolar disorder are severe mental disorders, both placing a significant burden on individuals' wellbeing and global health generally. The complex interaction of multiple mechanisms, underlying these disorders, still needs further elucidation. Increased activation of components...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000499
更新日期:2019-05-01 00:00:00