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Magnesium and neoplasia: from carcinogenesis to tumor growth and progression or treatment.

Abstract：

:Magnesium is involved in a wide range of biochemical reactions that are crucial to cell proliferation, differentiation, angiogenesis, and apoptosis. Changes in magnesium availability have been shown to influence biological responses of immuno-inflammatory cells. Equally plausible seems to be an involvement of magnesium in the multistep and interconnected processes that lead to tumor formation and development; however, the "how" and "when" of such an involvement remain to be defined. Here, we reviewed in vitro and in vivo data that indicated a role for magnesium in many biological and clinical aspects of cancer (from neoplastic transformation to tumor growth and progression or pharmacologic treatment). In adopting this approach we went through a full circle from molecular aspects to observational or epidemiological studies that could reconcile in a unifying picture the otherwise fragmentary or puzzling data currently available on the role of magnesium in cancer.

journal_name

Arch Biochem Biophys

journal_title

Archives of biochemistry and biophysics

authors

Wolf FI,Maier JA,Nasulewicz A,Feillet-Coudray C,Simonacci M,Mazur A,Cittadini A

doi

10.1016/j.abb.2006.02.016

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

24-32

issue

1

eissn

0003-9861

issn

1096-0384

pii

S0003-9861(06)00069-5

journal_volume

458

pub_type

杂志文章,评审

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