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Myelomeningocele: characterization of a surgically induced sheep model and its central nervous system similarities and differences to the human disease.

Abstract：

OBJECTIVE:The purpose of this study was to determine how closely the surgically induced sheep myelomeningocele (MMC) model resembles the central nervous system derangements seen in human disease, and identify which aspects of MMC are the result of the early neuronal developmental defect, and which are secondary to the cerebrospinal fluid (CSF) drainage. STUDY DESIGN:An MMC-like lesion was created surgically in 16 fetal sheep at 75 days' gestation: 5 died in utero, 7 underwent no fetal repair, 4 were repaired (2-layer closure or biological glue) at 100 days' gestation. MMC sheep were delivered at term and allowed to survive up to 17 days for analysis of behavioral status and feeding behavior. Animals not repaired in utero were repaired at birth. All lambs were sacrificed and analyzed for hindbrain herniation, hydrocephalus, and other CNS derangements. RESULTS:Hindbrain herniation was observed in 43% of animals not repaired in utero, and in 1 lamb repaired with Bioglue. No animal developed hydrocephalus or other CNS derangements. CONCLUSION:Although this sheep MMC-like model reproduces the CSF leak, but not the developmental defect seen in humans, it suggests CSF leak contributes to hindbrain herniation seen in humans. This model may be useful to develop new minimally invasive techniques to halt CSF leak in utero.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

von Koch CS,Compagnone N,Hirose S,Yoder S,Harrison MR,Farmer DL

doi

10.1016/j.ajog.2005.02.110

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

1456-62

issue

4

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(05)00356-X

journal_volume

193

pub_type

杂志文章

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