当前位置： SCI文献检索 > AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY期刊下所有文献 > Fetal membranes act as a barrier for adenoviruses: gene transfer into exocoelomic cavity of rat fetuses does not affect cells in the fetus.

Fetal membranes act as a barrier for adenoviruses: gene transfer into exocoelomic cavity of rat fetuses does not affect cells in the fetus.

Abstract：

OBJECTIVES:In utero gene therapy has a potential to correct genetic disorders before the first clinical symptoms appear. Our aim was to examine whether the exocoelomic cavity between amniotic and chorionic membranes offers a minimally invasive route for gene transfer to the fetus during early pregnancy. STUDY DESIGN:We injected lacZ-adenovirus (4 x 10(9) pfu) during open surgery into the exocoelomic cavity of rat fetuses (n=50) and analyzed the fetuses and rat dams for transgene expression with X-gal staining and polymerase chain reaction. RESULTS:Giant cells around Reichert's membrane, the outermost extraembryonic membrane in rodents, were transduced; but no transduction was observed in the cells of the fetuses or rat dams. CONCLUSION:In rodents, the exocoelomic cavity does not offer a route for gene transfer into the fetus. It was concluded that fetal membranes act as a barrier that prevents adenoviral particles from passing between embryonic cavities.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Laurema A,Vanamo K,Heikkilä A,Riekkinen M,Heinonen S,Ylä-Herttuala S

doi

10.1016/j.ajog.2003.07.010

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

264-7

issue

1

eissn

0002-9378

issn

1097-6868

pii

S0002937803009840

journal_volume

190

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY文献大全
  • Effect of excisional therapy and highly active antiretroviral therapy on cervical intraepithelial neoplasia in women infected with human immunodeficiency virus.

    abstract：OBJECTIVE:Our purpose was to determine the rates of recurrence, persistence, and progression of cervical intraepithelial neoplasia in women who were seropositive for human immunodeficiency virus after excisional therapy with and without highly active antiretroviral therapy. STUDY DESIGN:The records of 118 women with c...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2001.111103

    authors： Robinson WR,Hamilton CA,Michaels SH,Kissinger P

    更新日期：2001-03-01 00:00:00

  • A comparison of tocolysis with nifedipine or ritodrine: analysis of efficacy and maternal, fetal, and neonatal outcome.

    abstract：:Nifedipine, a dihydropyridone calcium entry blocker, has been used with increasing frequency in the treatment of preterm labor. We studied 66 patients in this prospective, randomized trial to evaluate the efficacy and maternal, fetal, and neonatal outcome associated with tocolysis with nifedipine or ritodrine. Deliver...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0002-9378(11)90679-6

    authors： Ferguson JE 2nd,Dyson DC,Schutz T,Stevenson DK

    更新日期：1990-07-01 00:00:00

  • The relationship of maternal position to the results of brief nonstress tests: a randomized clinical trial.

    abstract：OBJECTIVE:This study was undertaken to determine whether maternal posture (left lateral recumbent vs semi-Fowler position) had any effect on nonstress test results when the test was performed for a shortened period (10 minutes). STUDY DESIGN:In this randomized clinical trial of 108 patients with singleton pregnancies ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1067/mob.2000.105443

    authors： Nathan EB,Haberman S,Burgess T,Minkoff H

    更新日期：2000-05-01 00:00:00

  • Ultrasonographic prediction of neonatal survival in extremely low-birth-weight infants.

    abstract：OBJECTIVE:Our purpose was to improve the accuracy of prenatal prognostication by directly correlating obstetric ultrasonographic measurements with neonatal survival. STUDY DESIGN:We studied 130 singleton live-born infants with birth weights between 500 and 1000 gm and who underwent complete ultrasonographic examinatio...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(93)90606-j

    authors： Smith RS,Bottoms SF

    更新日期：1993-09-01 00:00:00

  • Nutrient intake and congenital heart defects in maternal phenylketonuria.

    abstract：OBJECTIVE:The purpose of this study was to determine whether nutritional components other than high maternal blood phenylalanine levels (> or = 10 mg/dL) are associated with congenital heart defects in the offspring of women with hyperphenylalaninemia. STUDY DESIGN:Of the 414 subjects who had live births, 249 women (6...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2002.124276

    authors： Michals-Matalon K,Platt LD,Acosta P P,Azen C,Walla CA

    更新日期：2002-08-01 00:00:00

  • Secondary müllerian system and endometriosis.

    abstract：:The pathogenesis of endometriosis is controversial. The two principal histogenetic theories are (1) metastases of endometrial tissues to an ectopic location (metastatic theory) and (2) metaplastic development of endometrial tissue at the ectopic site (metaplastic theory). Studies on the development of the coelomic cav...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,评审

    doi：10.1016/0002-9378(91)90255-p

    authors： Fujii S

    更新日期：1991-07-01 00:00:00

  • Is maternal posturing during labor efficient in preventing persistent occiput posterior position? A randomized controlled trial.

    abstract：OBJECTIVE:We sought to evaluate the efficacy of maternal posturing during labor on the prevention of persistent occiput posterior (OP) position. STUDY DESIGN:We conducted a randomized trial including 220 patients in labor with a single fetus in documented OP position. Main outcome was the proportion of anterior rotati...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ajog.2012.10.882

    authors： Desbriere R,Blanc J,Le Dû R,Renner JP,Carcopino X,Loundou A,d'Ercole C

    更新日期：2013-01-01 00:00:00

  • Neuroprotective peptides influence cytokine and chemokine alterations in a model of fetal alcohol syndrome.

    abstract：OBJECTIVE:Fetal alcohol syndrome (FAS) is associated with intellectual disability and neurodevelopmental abnormalities. Neuroprotective peptides NAPVSIPQ (NAP) and SALLRSIPA (SAL) can prevent some of the alcohol-induced teratogenesis including fetal death, growth abnormalities, and learning impairment in part by preven...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2012.10.005

    authors： Roberson R,Kuddo T,Benassou I,Abebe D,Spong CY

    更新日期：2012-12-01 00:00:00

  • The role of midtrimester targeted fetal organ screening combined with the "triple test" and maternal age in the diagnosis of trisomy 21: a retrospective study.

    abstract：OBJECTIVE:Our purpose was to evaluate the role of fetal ultrasonography in prenatal detection of trisomy 21. STUDY DESIGN:A retrospective study was performed on all cases of trisomy 21 diagnosed prenatally or postnatally between January 1990 and December 1993 in the Jerusalem metropolitan area. Our program of prenatal...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(98)70623-4

    authors： Yagel S,Anteby EY,Hochner-Celnikier D,Ariel I,Chaap T,Ben Neriah Z

    更新日期：1998-01-01 00:00:00

  • Reduction of cardiovascular disease-related mortality among postmenopausal women who use hormones: evidence from a national cohort.

    abstract：:A national sample of 1944 white menopausal women greater than or equal to 55 years old from the epidemiologic follow-up of participants in the National Health and Nutrition Examination Survey was reviewed to investigate the role of hormone therapy in altering the risk of death from cardiovascular disease. Women in the...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(11)80006-2

    authors： Wolf PH,Madans JH,Finucane FF,Higgins M,Kleinman JC

    更新日期：1991-02-01 00:00:00

  • Ovarian vein thrombosis after debulking surgery for ovarian cancer: epidemiology and clinical significance.

    abstract：OBJECTIVE:Ovarian vein thrombosis is associated with pregnancy and pelvic surgery. Postpartum ovarian vein thrombosis is associated with infection and a high morbidity rate and is treated with anticoagulant and intravenous antibiotic therapy. The natural history of such thrombotic events after debulking surgery for ova...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2015.02.028

    authors： Mantha S,Sarasohn D,Ma W,Devlin SM,Chi DS,Roche KL,Suidan RS,Woo K,Soff GA

    更新日期：2015-08-01 00:00:00

  • The relationship between pregnancy weight gain and glucose tolerance status among black and white women in central North Carolina.

    abstract：OBJECTIVE:The objective of the study was to examine weight and its relationship to glucose intolerance during pregnancy. STUDY DESIGN:Women were classified into mutually exclusive glucose tolerance groups; impaired glucose tolerance of pregnancy defined as 1 high value on the oral glucose tolerance test, gestational d...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2006.05.017

    authors： Saldana TM,Siega-Riz AM,Adair LS,Suchindran C

    更新日期：2006-12-01 00:00:00

  • Uterine venous, peripheral venous, and radial arterial levels of prostaglandins E and F in women with pregnancy-induced hypertension.

    abstract：:Patients with pregnancy-induced hypertension have higher prostaglandin (PG) F concentrations in radial arterial blood (0.39 +/- 0.03 ng/ml) than control subjects (0.24 +/- 0.03 ng/ml) and higher (PGE plus PGF) concentrations in uterine venous blood obtained at the time of cesarean section (1.62 +/- 0.18 versus 1.03 +/...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(83)90333-2

    authors： Valenzuela G,Harper MJ,Hayashi RH

    更新日期：1983-01-01 00:00:00

  • Symptomatic and anatomic 1-year outcomes after robotic and abdominal sacrocolpopexy.

    abstract：OBJECTIVE:The purpose of this study was to compare symptomatic and anatomic outcomes 1 year after robotic vs abdominal sacrocolpopexy. STUDY DESIGN:Our retrospective cohort study compared women who underwent robotic sacrocolpopexy (RSC) with 1 surgeon to those who underwent abdominal sacrocolpopexy (ASC) as part of th...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ajog.2012.01.035

    authors： Siddiqui NY,Geller EJ,Visco AG

    更新日期：2012-05-01 00:00:00

  • Cefotetan-induced anaphylaxis.

    abstract：:Three cases of anaphylactic reactions associated with the use of intravenous cefotetan as surgical prophylaxis for cesarean section (two cases) and transabdominal hysterectomy (one case) are presented. Comprehensive review of these cases revealed no evidence of lot-specific association, drug-drug interaction, or metho...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(88)90506-6

    authors： Bloomberg RJ

    更新日期：1988-07-01 00:00:00

  • Fetal plasma interferon gamma concentration in normal pregnancy.

    abstract：OBJECTIVE:Our purpose was to investigate changes with gestation in fetal plasma interferon gamma concentration. STUDY DESIGN:A cross-sectional study at the Harris Birthright Research Centre for Fetal Medicine, London, was performed. Enzyme-linked immunoassay was used to measure plasma concentration in 54 fetal blood s...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(11)90774-1

    authors： Abbas A,Thilaganathan B,Buggins AG,Layton DM,Nicolaides KH

    更新日期：1993-05-01 00:00:00

  • Comparing variation in hospital rates of cesarean delivery among low-risk women using 3 different measures.

    abstract：:This report describes the development of a measure of low-risk cesarean delivery by the Society for Maternal-Fetal Medicine (SMFM). Safely lowering the cesarean delivery rate is a priority for maternity care clinicians and health care delivery systems. Therefore, hospital quality assurance programs are increasingly tr...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2015.10.935

    authors： Armstrong JC,Kozhimannil KB,McDermott P,Saade GR,Srinivas SK,Society for Maternal-Fetal Medicine Health Policy Committee.

    更新日期：2016-02-01 00:00:00

  • Pulsed Doppler flow-velocity waveforms in the prediction of fetal hematocrit of the severely isoimmunized pregnancy.

    abstract：:We previously reported a significant relationship between the hematocrit levels of anemic fetuses and information derived from ultrasonographic and Doppler flow-velocity waveforms. In this study we prospectively tested two formulas for the prediction of hematocrit values, by use of gestational age, presence or absence...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(89)90516-4

    authors： Copel JA,Grannum PA,Green JJ,Belanger K,Hobbins JC

    更新日期：1989-08-01 00:00:00

  • Congenital absence of the umbilical cord resulting from maldevelopment of embryonic body folding.

    abstract：:We report a case of extreme maldevelopment of embryonic body folding that resulted in incomplete fusion of the amnion to the chorion and failure to form an umbilical cord. Massive intra-abdominal and intrathoracic herniation led to rapid neonatal death. The accurate ultrasonic characterization of the defect enabled pr...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(86)90345-5

    authors： Lockwood CJ,Scioscia AL,Hobbins JC

    更新日期：1986-11-01 00:00:00

  • Accuracy of salivary estriol testing compared to traditional risk factor assessment in predicting preterm birth.

    abstract：OBJECTIVE:The objective was to compare the predictive accuracy (percentage of correct vs incorrect predictions) of salivary estriol levels (SalEst; Biex, Inc, Dublin, Calif) with that of the modified Creasy score for predicting preterm labor followed by preterm delivery. STUDY DESIGN:A triple-blinded prospective trial...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/s0002-9378(99)70703-9

    authors： Heine RP,McGregor JA,Dullien VK

    更新日期：1999-01-01 00:00:00

  • Very-low-birth-weight outcomes of the National Institute of Child Health and Human Development Neonatal Network, November 1989 to October 1990.

    abstract：OBJECTIVE:Our purpose was to describe the neonatal outcomes of 1804 very-low-birth-weight (< or = 1500 gm) infants delivered between November 1989 and October 1990 in the participating centers of the National Institute of Child Health and Human Development Neonatal Research Network. STUDY DESIGN:In an observational st...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/0002-9378(95)90557-x

    authors： Hack M,Wright LL,Shankaran S,Tyson JE,Horbar JD,Bauer CR,Younes N

    更新日期：1995-02-01 00:00:00

  • Vaginal administration of the nitric oxide donor isosorbide mononitrate for cervical ripening at term: a randomized controlled study.

    abstract：OBJECTIVE:Our aim was to examine the effect of the nitric oxide donor isosorbide mononitrate on the uterine cervix at term and to evaluate possible adverse effects of this treatment. STUDY DESIGN:Term pregnant women were randomly selected to receive either 40 mg vaginally administered isosorbide mononitrate or placebo...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0002-9378(03)00865-2

    authors： Ekerhovd E,Bullarbo M,Andersch B,Norström A

    更新日期：2003-12-01 00:00:00

  • Implementation and evaluation of a training program to improve resident teaching skills.

    abstract：OBJECTIVE:This study was undertaken to develop, implement, and evaluate a program designed to improve residents' teaching skills. STUDY DESIGN:A training program to improve the teaching skills of obstetrics and gynecology residents was developed and implemented. All residents completed a survey of their teaching skill...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/s0002-9378(03)00879-2

    authors： Frattarelli LC,Kasuya R

    更新日期：2003-09-01 00:00:00

  • Contemporary labor patterns: the impact of maternal body mass index.

    abstract：OBJECTIVE:We sought to compare labor patterns by body mass index (BMI). STUDY DESIGN:A total of 118,978 gravidas with a singleton term cephalic gestation were studied. Repeated-measures analysis constructed mean labor curves by parity and BMI categories for those who reached 10 cm. Interval-censored regression analysi...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ajog.2011.06.014

    authors： Kominiarek MA,Zhang J,Vanveldhuisen P,Troendle J,Beaver J,Hibbard JU

    更新日期：2011-09-01 00:00:00

  • Increased vascular endothelial cell production of interleukin-6 in severe preeclampsia.

    abstract：OBJECTIVE:The purpose of this study was to determine whether plasma from women with severe preeclampsia stimulates the production of endothelial cell interleukin-6 production and whether vitamin E could inhibit this process. STUDY DESIGN:Human umbilical vein endothelial cells were cultured in the presence of 5% plasma...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2003.134

    authors： Takacs P,Green KL,Nikaeo A,Kauma SW

    更新日期：2003-03-01 00:00:00

  • Effect of a cholesterol-lowering diet during pregnancy on maternal and fetal Doppler velocimetry: the CARRDIP study.

    abstract：OBJECTIVE:The purpose of this study was to evaluate the effect of a low-cholesterol low-saturated fat diet on Doppler indices in the fetus and mother. STUDY DESIGN:Two hundred ninety nonsmoking white women, aged 21-38 years, without previous pregnancy complications and carrying a single fetus were assigned randomly to...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ajog.2007.01.017

    authors： Khoury J,Haugen G,Tonstad S,Frøslie KF,Henriksen T

    更新日期：2007-06-01 00:00:00

  • Twin Birth Study: 2-year neurodevelopmental follow-up of the randomized trial of planned cesarean or planned vaginal delivery for twin pregnancy.

    abstract：BACKGROUND:The Twin Birth Study randomized women with uncomplicated pregnancies, between 32(0/7)-38(6/7) weeks' gestation where the first twin was in cephalic presentation, to a policy of either a planned cesarean or planned vaginal delivery. The primary analysis showed that planned cesarean delivery did not increase o...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ajog.2015.12.051

    authors： Asztalos EV,Hannah ME,Hutton EK,Willan AR,Allen AC,Armson BA,Gafni A,Joseph KS,Ohlsson A,Ross S,Sanchez JJ,Mangoff K,Barrett JF

    更新日期：2016-03-01 00:00:00

  • Peritoneal serous papillary carcinoma, a phenotypic variant of familial ovarian cancer: implications for ovarian cancer screening.

    abstract：OBJECTIVE:Our purpose was to report the cancers arising during a familial ovarian cancer screening program and investigate the tumor's clonality and association with BRCA1 and BRCA2 mutations. STUDY DESIGN:Program participants with a diagnosis of ovarian cancer or peritoneal serous papillary carcinoma were identified ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(99)70663-0

    authors： Karlan BY,Baldwin RL,Lopez-Luevanos E,Raffel LJ,Barbuto D,Narod S,Platt LD

    更新日期：1999-04-01 00:00:00

  • The effect of maternal glucose administration on the specificity of the nonstress test.

    abstract：:To determine whether maternal glucose administration can decrease the incidence of false positive nonstress tests, 296 nonstress tests were performed on 235 high-risk obstetric patients in a prospective controlled study. Patients were alternately given a 50 gm oral glucose drink or an equal volume of water 30 minutes ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(83)90480-5

    authors： Richardson B,Briggs ML,Toomey C,Burry KJ,O'Grady JP

    更新日期：1983-01-15 00:00:00

  • Transvaginal placement of cervicoisthmic cerclage: report on pregnancy outcome.

    abstract：OBJECTIVE:This study was undertaken to review pregnancy course and outcome in 56 pregnancies after the placement of a cervicoisthmic cerclage transvaginally. STUDY DESIGN:Fifty-three pregnant patients with unique indications such as previous failure of conventional cerclages or compromised cervical anatomy, underwent ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2005.02.127

    authors： Katz M,Abrahams C

    更新日期：2005-06-01 00:00:00