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Uterine venous, peripheral venous, and radial arterial levels of prostaglandins E and F in women with pregnancy-induced hypertension.

Abstract：

:Patients with pregnancy-induced hypertension have higher prostaglandin (PG) F concentrations in radial arterial blood (0.39 +/- 0.03 ng/ml) than control subjects (0.24 +/- 0.03 ng/ml) and higher (PGE plus PGF) concentrations in uterine venous blood obtained at the time of cesarean section (1.62 +/- 0.18 versus 1.03 +/- 0.12 ng/ml in the control group). The present results suggest that both PGE and PGF production by the uterus in patients with pregnancy-induced hypertension is increased but that catabolism of PGF by the lung is compromised; this permits larger quantities of the vasoconstrictor PG to pass into the systemic circulation, where it may cause hypertension directly or indirectly, by association with other vasoactive substances.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Valenzuela G,Harper MJ,Hayashi RH

doi

10.1016/0002-9378(83)90333-2

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

11-4

issue

1

eissn

0002-9378

issn

1097-6868

pii

0002-9378(83)90333-2

journal_volume

145

pub_type

杂志文章

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