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A comparison of tocolysis with nifedipine or ritodrine: analysis of efficacy and maternal, fetal, and neonatal outcome.

Abstract：

:Nifedipine, a dihydropyridone calcium entry blocker, has been used with increasing frequency in the treatment of preterm labor. We studied 66 patients in this prospective, randomized trial to evaluate the efficacy and maternal, fetal, and neonatal outcome associated with tocolysis with nifedipine or ritodrine. Delivery was delayed for 48 hours, 7 days, and until the thirty-sixth week of gestation in 84%, 70%, and 41%, respectively, of patients in the nifedipine group, compared with 72%, 63%, and 52% of patients in the ritodrine group (difference not significant). Maternal side effects were more common and more serious in the group of patients who received ritodrine compared with those who received nifedipine (18 of 38 versus 5 of 38, p less than 0.01); however, fetal and neonatal outcome appeared to be similar when the groups were compared. On the basis of this study, it appears that tocolysis with either nifedipine or ritodrine is equally efficacious; however, maternal side effects are less common with nifedipine treatment. We conclude that nifedipine may have a role in the treatment of preterm labor but suggest further careful evaluation of this agent before it is considered for routine clinical use.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Ferguson JE 2nd,Dyson DC,Schutz T,Stevenson DK

doi

10.1016/s0002-9378(11)90679-6

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

105-11

issue

1 Pt 1

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(11)90679-6

journal_volume

163

pub_type

临床试验,杂志文章,随机对照试验

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