当前位置： SCI文献检索 > AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY期刊下所有文献 > Temporal alterations in vascular angiotensin receptors and vasomotor responses in offspring of protein-restricted rat dams.

Temporal alterations in vascular angiotensin receptors and vasomotor responses in offspring of protein-restricted rat dams.

Abstract：

OBJECTIVE:Examine temporal alterations in vascular angiotensin II receptors (AT(1)R and AT(2)R) and determine vascular response to angiotensin II in growth-restricted offspring. STUDY DESIGN:Offspring of pregnant rats fed low-protein (6%) and control (20%) diet were compared. RESULTS:Prenatal protein restriction reprogrammed AT(1a)R messenger RNA expression in male rats' mesenteric arteries to cause 1.7- and 2.3-fold increases at 3 and 6 months of age associated with arterial pressure increases of 10 and 33 mm Hg, respectively; however, in female rats, increased AT(1a)R expression (2-fold) and arterial pressure (15 mm Hg) occurred only at 6 months. Prenatal protein restriction did not affect AT(2)R expression. Losartan abolished hypertension, suggesting that AT(1a)R plays a primary role in arterial pressure elevation. Vasoconstriction to angiotensin II was exaggerated in all protein-restricted offspring, with greater potency and efficacy in male rats. CONCLUSION:Prenatal protein restriction increased vascular AT(1)R expression and vasoconstriction to angiotensin II, possibly contributing to programmed hypertension.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Sathishkumar K,Balakrishnan M,Chinnathambi V,Gao H,Yallampalli C

doi

10.1016/j.ajog.2012.04.010

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

507.e1-10

issue

6

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(12)00388-2

journal_volume

206

pub_type

杂志文章

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