当前位置： SCI文献检索 > AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY期刊下所有文献 > Gynecologic conditions in participants in the NSABP breast cancer prevention study of tamoxifen and raloxifene (STAR).

Gynecologic conditions in participants in the NSABP breast cancer prevention study of tamoxifen and raloxifene (STAR).

Abstract：

OBJECTIVE:This study reports the gynecologic conditions in postmenopausal women (intact uterus on enrollment) in the National Surgical Adjuvant Breast and Bowel Project (NSABP) study of tamoxifen and raloxifene (STAR)/P-2 trial. STUDY DESIGN:This study, with a median follow-up period of 81 months, evaluated the incidence rates/risks of gynecologic conditions among women who were treated with tamoxifen and raloxifene. RESULTS:Compared with women who received tamoxifen therapy, women who received raloxifene therapy had a lower incidence of uterine cancer (relative risk, 0.55)/endometrial hyperplasia (relative risk, 0.19), leiomyomas (relative risk, 0.55), ovarian cysts (relative risk, 0.60), and endometrial polyps (relative risk, 0.30) and had fewer procedures performed. Women receiving tamoxifen therapy had more hot flashes (P < .0001), vaginal discharge (P < .0001), and vaginal bleeding (P < .0001). CONCLUSION:Our results suggest that tamoxifen has more of an estrogenic effect on the gynecologic reproductive organs. These effects should be considered in counseling women on options for breast cancer prevention.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Runowicz CD,Costantino JP,Wickerham DL,Cecchini RS,Cronin WM,Ford LG,Vogel VG,Wolmark N

doi

10.1016/j.ajog.2011.06.067

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

535.e1-5

issue

6

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(11)00812-X

journal_volume

205

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY文献大全
  • Fetal renal volume assessment by three-dimensional ultrasonography.

    abstract：OBJECTIVE:This study was undertaken to measure fetal renal volume by means of three-dimensional ultrasonography and to use those data to establish the accurate constant and formula for fetal renal volume assessment with two-dimensional ultrasonography. STUDY DESIGN:Singleton fetuses between 15 and 40 weeks' gestation ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(00)70227-4

    authors： Hsieh YY,Chang CC,Lee CC,Tsai HD

    更新日期：2000-02-01 00:00:00

  • Fetal and neonatal cardiovascular complications from beta-sympathomimetic therapy for tocolysis.

    abstract：:beta-Sympathomimetic drugs cross the placenta freely. Just as these agents cause serious cardiovascular changes in the mother, they may cause severe cardiovascular complications in the fetus. beta-Sympathomimetic agents for tocolysis have been associated with fetal heart rate and rhythm disturbances, hydrops, stillbir...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(89)90219-6

    authors： Katz VL,Seeds JW

    更新日期：1989-07-01 00:00:00

  • The effect of peritoneal fluid from patients with endometriosis on human sperm function in vitro.

    abstract：OBJECTIVE:Our purpose was to evaluate the effect of peritoneal fluid from women with endometriosis on sperm motility and function in an in vitro model. STUDY DESIGN:Peritoneal fluid was collected at laparoscopy from patients with and without endometriosis. Human donor sperm was diluted with this fluid, and its effect ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(96)70210-7

    authors： Aeby TC,Huang T,Nakayama RT

    更新日期：1996-06-01 00:00:00

  • Relationship of race and severity of neonatal illness.

    abstract：OBJECTIVE:Our goal was to determine whether there are racial differences in the severity of illness on admission for premature newborn infants independent of gestational age. STUDY DESIGN:The study population consisted of all African American and Caucasian singleton infants with gestational ages <34 weeks who were adm...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2001.109941

    authors： Berman S,Richardson DK,Cohen AP,Pursley DM,Lieberman E

    更新日期：2001-03-01 00:00:00

  • Characteristics of sexual assault in women with a major psychiatric diagnosis.

    abstract：OBJECTIVE:In a previous study of women who had been sexually assaulted, we reported a 26% prevalence of a major psychiatric diagnosis. The purpose of this study was to better characterize sexual assaults in women with a major psychiatric diagnosis. STUDY DESIGN:All female patients >or=15 years old with a complaint of ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2002.123731

    authors： Eckert LO,Sugar N,Fine D

    更新日期：2002-06-01 00:00:00

  • Reactivities of the nongravid uterine vasculatures: effects of norepinephrine.

    abstract：:Responses of the component tissues of the nonpregnant ovine uterus to intravenous administration of norepinephrine were determined with radioactively labeled microspheres under flowmeter guidance. During a mean decrease in uterine conductance to 42 per cent of control, no significant differences in the distribution of...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：

    authors： Griss FC Jr

    更新日期：1978-08-01 00:00:00

  • Insulin sensitivity and B-cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes.

    abstract：:We used the minimal model technique to obtain concurrent measurements of whole-body insulin sensitivity and pancreatic B-cell responsiveness to glucose during the third trimester of pregnancy. Insulin sensitivity in normal pregnant women (n = 8) was reduced to only one third that of a group of nonpregnant women (n = 7...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(90)91306-w

    authors： Buchanan TA,Metzger BE,Freinkel N,Bergman RN

    更新日期：1990-04-01 00:00:00

  • The effect of tetracycline on levels of oral contraceptives.

    abstract：:Despite the widespread use of tetracycline for treatment of dermatologic disorders and sexually transmitted diseases, the pharmacodynamics of oral contraceptive use in the presence of tetracycline has not been studied. Seven normal women ingested an oral contraceptive containing ethinyl estradiol 35 micrograms and nor...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(91)90617-z

    authors： Murphy AA,Zacur HA,Charache P,Burkman RT

    更新日期：1991-01-01 00:00:00

  • Gentamicin dosing in postpartum women with endometritis.

    abstract：:Postpartum women receiving gentamicin for endometritis were studied to determine if selective determination of gentamicin serum levels was cost-effective in terms of safety and efficacy. The women were randomized into two groups of 30 patients each. In the control group gentamicin serum levels were determined after th...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0002-9378(89)90431-6

    authors： Briggs GG,Ambrose P,Nageotte MP

    更新日期：1989-02-01 00:00:00

  • Intraobserver and interobserver variability of the amniotic fluid index.

    abstract：OBJECTIVE:We assessed intraobserver and interobserver variations in the performance of the amniotic fluid index. STUDY DESIGN:A total of 34 women in the third trimester with intact membranes were examined twice by each of three examiners. The amniotic fluid index was measured once by each of the three examiners in ord...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(93)90386-w

    authors： Bruner JP,Reed GW,Sarno AP Jr,Harrington RA,Goodman MA

    更新日期：1993-04-01 00:00:00

  • Type and screen: a safe and effective preoperative blood ordering policy with emphasis on its use in obstetrics and gynecology.

    abstract：:In September, 1979, the Transfusion Committee at the University of Texas Medical Branch in Galveston implemented a preoperative blood ordering policy of type and screen (TS) for selected surgical procedures. During the first year in which this policy was in force, 2,301 TS requests were received, most of them for pati...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(82)90762-1

    authors： Patten E,Alperin JB

    更新日期：1982-03-01 00:00:00

  • Defining the role of fluorescence in situ hybridization on uncultured amniocytes for prenatal diagnosis of aneuploidies.

    abstract：OBJECTIVE:This study examines the role of fluorescence in situ hybridization on uncultured amniocytes for prenatal diagnosis in a population at high risk for aneuploidies. STUDY DESIGN:All patients undergoing amniocentesis for fetal structural abnormality on ultrasonographic examination (performed from 13 to 39 weeks)...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(97)70600-8

    authors： D'Alton ME,Malone FD,Chelmow D,Ward BE,Bianchi DW

    更新日期：1997-04-01 00:00:00

  • Botulinum toxin: from life-threatening disease to novel medical therapy.

    abstract：:Botulinum toxin A is the newest therapy for the treatment of a variety of medical disorders caused by abnormalities of muscle activity. After successful use in other medical subspecialties, the newest applications of this potent neurotoxin are within the lower urinary tract. The toxin has evolved from a cause of fatal...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ajog.2006.03.108

    authors： Mahajan ST,Brubaker L

    更新日期：2007-01-01 00:00:00

  • Prenatal diagnosis of 46,XX male fetuses.

    abstract：:Ultrasonography can accurately determine phenotypic sex differences from those of the genetic sex. Two cases were identified; they were the result of a translocation of the SRY gene from the Y chromosome to the X chromosome during meiosis. An ultrasonographic difference may represent an otherwise unsuspected genetic a...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(99)70673-3

    authors： Ginsberg NA,Cadkin A,Strom C,Bauer-Marsh E,Verlinsky Y

    更新日期：1999-04-01 00:00:00

  • 13, 14-dihydro-15-keto-prostaglandin F2alpha concentrations in human plasma and amniotic fluid.

    abstract：:An antiserum to 13,14-dihydro-15-keto-prostaglandin F2alpha (PGF2alphaM) was prepared and a radioimmunoassay evaluated in various reproductive states. PGF2alphaM plasma concentration was 63.6 +/- 10.3 pg/ml (mean +/- SEM) in cycling women. The concentration fluctuated throughout the menstrual cycle and pregnancy, but ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(16)33031-9

    authors： Ghodgaonkar RB,Dubin NH,Blake DA,King TM

    更新日期：1979-06-01 00:00:00

  • The role of Swan-Ganz catheterization in severe pregnancy-induced hypertension.

    abstract：:Swan-Ganz catheterization was performed in 15 postpartum women who presented with severe pregnancy-induced hypertension at a mean gestational age of 31.5 weeks. The mean arterial pressure on presentation was 137.6 torr (range, 116 to 167 torr), and it remained at approximately 115 torr for the next 72 hours. Serial pu...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(84)90750-6

    authors： Henderson DW,Vilos GA,Milne KJ,Nichol PM

    更新日期：1984-03-01 00:00:00

  • Levator ani denervation and reinnervation 6 months after childbirth.

    abstract：OBJECTIVE:The objective of the study was to assess the prevalence of levator ani denervation and reinnervation 6 months after the first delivery. STUDY DESIGN:Ninety-six primigravida women underwent quantitative electromyography of the levator ani during the third trimester and twice postpartum. A 95% confidence inter...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2008.12.044

    authors： South MM,Stinnett SS,Sanders DB,Weidner AC

    更新日期：2009-05-01 00:00:00

  • Serum progesterone and serum human chorionic gonadotropin in gestational and nongestational choriocarcinoma.

    abstract：:Serum progesterone was assayed by the competitive protein-binding technique in 20 cases of gestational choriocarcinoma and one case of nongestational choriocarcinoma. Serum human chorionic gonadotropin (HCG) was simultaneously measured from the same blood samples by the hemagglutination-inhibition technique. Serum pro...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(75)90503-7

    authors： Dawood MY

    更新日期：1975-12-01 00:00:00

  • Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: a randomized placebo-controlled double-blind study.

    abstract：OBJECTIVE:The purpose of this study was to evaluate the effect of prophylactic vaginal progesterone in decreasing preterm birth rate in a high-risk population. STUDY DESIGN:A randomized, double-blind, placebo-controlled study included 142 high-risk singleton pregnancies. Progesterone (100 mg) or placebo was administer...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1067/mob.2003.41

    authors： da Fonseca EB,Bittar RE,Carvalho MH,Zugaib M

    更新日期：2003-02-01 00:00:00

  • Neuromodulatory regulation of gonadotropin-releasing hormone pulsatile discharge in women.

    abstract：:The pulsatile release of gonadotropin-releasing hormone and the consequent secretion of gonadotropins are regulated by a complex interplay of steroids, neuropeptides, catecholamines, and environmental factors. Estrogen and progesterone influence the amplitude and frequency of luteinizing hormone pulsatile secretion. T...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,评审

    doi：10.1016/0002-9378(90)91436-g

    authors： Jaffe RB,Plosker S,Marshall L,Martin MC

    更新日期：1990-11-01 00:00:00

  • Onapristone and prostaglandin E2 induction of delivery in the rat in late pregnancy: a model for the analysis of cervical softening.

    abstract：OBJECTIVES:Our purpose was to develop a method to induce premature delivery in rats and to use this method to identify biochemical changes that are critical to cervical dilatation by comparison to changes that occur during term delivery. STUDY DESIGN:Rats were treated with antiprogestational agents onapristone or lilo...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1053/ob.1996.v175.a74254

    authors： Rechberger T,Abramson SR,Woessner JF Jr

    更新日期：1996-09-01 00:00:00

  • The Green Bay cesarean section study. III. Falling cesarean birth rates without a formal curtailment program.

    abstract：OBJECTIVES:We observed decreases in cesarean birth rates at two Green Bay hospitals after the 1990 publication of our first cesarean section study. The purpose of this study was to determine the causes of those decreases and to see whether any outcome changes occurred with lower rates. An additional objective was to de...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(94)70355-8

    authors： Sandmire HF,DeMott RK

    更新日期：1994-06-01 00:00:00

  • The nonstress test: an evaluation of 1,000 patients.

    abstract：:In November, 1978, the fetal heart rate nonstress test (NST) was instituted as the primary screening procedure for the evaluation of fetal well-being at Vanderbilt University Hospital. The results of the first 1,000 patients tested are presented. The stillborn rate within 8 days of a reactive NST was 6.4 per 1,000, wi...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(16)32583-2

    authors： Barrett JM,Salyer SL,Boehm FH

    更新日期：1981-09-15 00:00:00

  • Mode of delivery for the morbidly obese with prior cesarean delivery: vaginal versus repeat cesarean section.

    abstract：OBJECTIVE:We sought to describe the peripartum outcome of women weighing >300 pounds (135 kg) who were candidates for trial of labor after a prior cesarean delivery. STUDY DESIGN:All pregnant women who weighed in excess of 300 pounds and had a prior cesarean delivery were included in this prospective investigation. St...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2001.116729

    authors： Chauhan SP,Magann EF,Carroll CS,Barrilleaux PS,Scardo JA,Martin JN Jr

    更新日期：2001-08-01 00:00:00

  • Placental energy metabolism in health and disease-significance of development and implications for preeclampsia.

    abstract：:The placenta is a highly metabolically active organ fulfilling the bioenergetic and biosynthetic needs to support its own rapid growth and that of the fetus. Placental metabolic dysfunction is a common occurrence in preeclampsia although its causal relationship to the pathophysiology is unclear. At the outset, this ma...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ajog.2020.11.005

    authors： Aye ILMH,Aiken CE,Charnock-Jones DS,Smith GCS

    更新日期：2020-11-13 00:00:00

  • INTERGROWTH-21st vs customized birthweight standards for identification of perinatal mortality and morbidity.

    abstract：BACKGROUND:The recently published INTERGROWTH-21st Project international population standard for newborn size is intended for global use, but its ability to identify small infants at risk of adverse outcomes in a general obstetric population has not been reported. OBJECTIVE:The objective of the study was to compare ad...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2015.10.931

    authors： Anderson NH,Sadler LC,McKinlay CJD,McCowan LME

    更新日期：2016-04-01 00:00:00

  • The perils of the imperfect expectation of the perfect baby.

    abstract：:Advances in modern medicine invite the assumption that medicine can control human biology. There is a perilous logic that leads from expectations of medicine's control over reproductive biology to the expectation of having a perfect baby. This article proposes that obstetricians should take a preventive ethics approac...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ajog.2010.01.058

    authors： Chervenak FA,McCullough LB,Brent RL

    更新日期：2010-08-01 00:00:00

  • The paradoxical effect of smoking in preeclamptic pregnancies: smoking reduces the incidence but increases the rates of perinatal mortality, abruptio placentae, and intrauterine growth restriction.

    abstract：OBJECTIVES:Smoking is associated with a reduced risk of preeclampsia, but what is the outcome of pregnancy when preeclampsia develops in women who smoke? STUDY DESIGN:Single births in Sweden from 1987 through 1993 to nulliparous women aged 15 to 34 years (N = 317,652) were included. Poisson regression analyses were us...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(97)70455-1

    authors： Cnattingius S,Mills JL,Yuen J,Eriksson O,Salonen H

    更新日期：1997-07-01 00:00:00

  • Impaired vascular reactivity in pregnant women with insulin-dependent diabetes mellitus.

    abstract：OBJECTIVE:The purpose of this study was to investigate the vascular function of pregnant women with insulin-dependent diabetes mellitus, using a noninvasive method. STUDY DESIGN:This was a cross-sectional study that examined vascular function, which was assessed by flow-mediated dilatation of the brachial artery, in 3...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2002.119111

    authors： Savvidou MD,Geerts L,Nicolaides KH

    更新日期：2002-01-01 00:00:00

  • Inhibition of amniotic prostaglandin E release by ampicillin.

    abstract：OBJECTIVE:The effect of antibiotics in the prevention of preterm labor needs to be further investigated. The aim of this study was to determine the effect of ampicillin on prostaglandin E release from amnion as a possible explanation for its ability to retard preterm labor. STUDY DESIGN:The effect of the beta-lactam a...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(98)70488-0

    authors： Vesce F,Buzzi M,Ferretti ME,Pavan B,Bianciotto A,Jorizzo G,Biondi C

    更新日期：1998-04-01 00:00:00