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Prospective validation of a laparoscopic predictive model for optimal cytoreduction in advanced ovarian carcinoma.

Abstract：

OBJECTIVE:The purpose of this study was to validate the performance of a laparoscopy-based model to predict optimal cytoreduction in advanced ovarian cancer patients. STUDY DESIGN:In a consecutive prospective series of 113 advanced ovarian cancer patients, the presence of omental cake, peritoneal and diaphragmatic extensive carcinosis, mesenteric retraction, bowel and stomach infiltration, spleen and/or liver superficial metastasis were investigated by laparoscopy. By summing the scores relative to all parameters, a laparoscopic assessment for each patient (total predictive index value = PIV) has been calculated. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy have been calculated for each PIV. RESULTS:The overall accuracy rate of the laparoscopic procedure ranged between 77.3 and 100%. At a PIV >/= 8 the probability of optimally resecting the disease at laparotomy is equal to 0, and the rate of unnecessary exploratory laparotomy is 40.5%. CONCLUSION:The proposed laparoscopic model appears a reliable and flexible tool to predict optimal cytoreduction in advanced ovarian cancer.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Fagotti A,Ferrandina G,Fanfani F,Garganese G,Vizzielli G,Carone V,Salerno MG,Scambia G

doi

10.1016/j.ajog.2008.06.052

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

642.e1-6

issue

6

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(08)00683-2

journal_volume

199

pub_type

杂志文章

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