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Evidence against trigger point injection technique for the treatment of cervicothoracic myofascial pain with botulinum toxin type A.

Abstract：

BACKGROUND:Traditional strategies for myofascial pain relief provide transient, incomplete, variable, or unpredictable outcomes. Botulinum toxin is itself an analgesic but can also cause sustained muscular relaxation, thereby possibly affording even greater relief than traditional therapies. METHODS:The study goal was to determine whether direct injection of botulinum toxin type A (BoNT-A) into trigger points was efficacious for cervicothoracic myofascial pain, and if so, to determine the presence or absence of a dose-response relation. One hundred thirty-two patients with cervical or shoulder myofascial pain or both and active trigger points were enrolled in a 12-week, randomized, double-blind, placebo-controlled trial. After a 2-week washout period for all medications, patients were injected with either saline or 10, 25, or 50 U BoNT-A into up to five active trigger points. The maximum doses in each experimental group were 0, 50, 125, and 250 U per patient, respectively. Patients subsequently received myofascial release physical therapy and amitriptyline, ibuprofen, and propoxyphene-acetaminophen napsylate. Follow-up visits occurred at 1, 2, 4, 6, 8, and 12 weeks. Outcome measures included visual analog pain scores, pain threshold as measured by pressure algometry, and rescue dose use of propoxyphene-acetaminophen napsylate. RESULTS:No significant differences occurred between placebo and BoNT-A groups with respect to visual analog pain scores, pressure algometry, and rescue medication. CONCLUSIONS:Injection of BoNT-A directly into trigger points did not improve cervicothoracic myofascial pain. The role of direct injection of trigger points with BoNT-A is discussed in comparison to other injection methodologies in the potential genesis of pain relief.

journal_name

Anesthesiology

journal_title

Anesthesiology

authors

Ferrante FM,Bearn L,Rothrock R,King L

doi

10.1097/00000542-200508000-00021

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

377-83

issue

eissn

0003-3022

issn

1528-1175

pii

00000542-200508000-00021

journal_volume

103

pub_type

临床试验,杂志文章,随机对照试验

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Evidence against trigger point injection technique for the treatment of cervicothoracic myofascial pain with botulinum toxin type A.