Midazolam potentiates nociceptive behavior, sensitizes cutaneous reflexes, and is devoid of sedative action in neonatal rats.

abstract：BACKGROUND:Reduction of nocturnal obstructive events during lateral position in patients with obstructive sleep apnea was previously reported. However, little information is available regarding mechanisms of the improvement and the precise pharyngeal site influenced by the lateral position. The authors tested the hypot...

journal_title：Anesthesiology

authors： Isono S,Tanaka A,Nishino T

更新日期：2002-10-01 00:00:00

abstract：:It is now well established that the pathophysiology of the malignant hyperthermia (MH) syndrome is related to a malfunction of intracellular calcium homeostasis. Magnesium plays important roles in the basic contractile properties of muscle, and many of its actions are antagonistic to those of calcium. The aim of this ...

journal_title：Anesthesiology

authors： Lopez JR,Sanchez V,Lopez I,Ryan JF,Mendoza M,Sreter FA,Allen PD

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Propofol and isoflurane anesthesia were studied previously with functional brain imaging in humans to begin identifying key brain areas involved with mediating anesthetic-induced unconsciousness. The authors describe an additional positron emission tomography study of halothane's in vivo cerebral metabolic e...

journal_title：Anesthesiology

authors： Alkire MT,Pomfrett CJ,Haier RJ,Gianzero MV,Chan CM,Jacobsen BP,Fallon JH

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:It is not always possible to predict when tracheal intubation will be difficult or impossible. The authors wanted to determine whether indirect laryngoscopy could identify patients in whom intubation was difficult. METHODS:Indirect laryngoscopy was done in 2,504 patients. The Wilson risk sum score and the m...

journal_title：Anesthesiology

authors： Yamamoto K,Tsubokawa T,Shibata K,Ohmura S,Nitta S,Kobayashi T

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Patient blood management combines the use of several transfusion alternatives. Integrated use of erythropoietin, cell saver, and/or postoperative drain reinfusion devices on allogeneic erythrocyte use was evaluated using a restrictive transfusion threshold. METHODS:In a factorial design, adult elective hip-...

journal_title：Anesthesiology

authors： So-Osman C,Nelissen RG,Koopman-van Gemert AW,Kluyver E,Pöll RG,Onstenk R,Van Hilten JA,Jansen-Werkhoven TM,van den Hout WB,Brand R,Brand A

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:The analgesic efficacy and side effect profile of intravenous parecoxib, a novel cyclooxygenase type-2 (COX-2) inhibitor, was assessed in a double-blinded, placebo-controlled study involving patients undergoing major gynecologic surgical procedures. METHODS:After Institutional Review Board approval, 60 cons...

journal_title：Anesthesiology

authors： Tang J,Li S,White PF,Chen X,Wender RH,Quon R,Sloninsky A,Naruse R,Kariger R,Webb T,Norel E

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Isoflurane-anesthetized rats have better outcome from global cerebral ischemia than rats anesthetized with fentanyl and nitrous oxide. The authors wanted to determine whether circulating catecholamine concentrations depend on the anesthetic agent and whether sympathetic ganglionic blockade affects anesthetic...

journal_title：Anesthesiology

authors： Mackensen GB,Nellgård B,Miura Y,Chu CT,Dexter F,Pearlstein RD,Warner DS

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Clonidine produces analgesia after spinal injection by activating alpha2-adrenergic receptors. Recently, clonidine has been demonstrated to increase spinal release of norepinephrine (NE) in vivo, in contrast to that anticipated by classic presynaptic autoinhibition. The purpose of the current study was to de...

journal_title：Anesthesiology

authors： Li X,Zhao Z,Pan HL,Eisenach JC,Paqueron X

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Preoperative anemia is frequent in patients undergoing orthopedic surgery. The purpose of this study was to assess the preoperative increase of hemoglobin in iron deficiency anemia patients treated with intravenous iron. METHODS:After obtaining written informed consent, 20 patients with iron deficiency anem...

journal_title：Anesthesiology

authors： Theusinger OM,Leyvraz PF,Schanz U,Seifert B,Spahn DR

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Reduced spinal excitability contributes to the suppression of movement responses to noxious stimuli during the anesthetic state. This study examines and compares presynaptic and postsynaptic effects of two anesthetics in the human spinal cord. METHODS:The authors tested two parameters during the administrat...

journal_title：Anesthesiology

authors： Baars JH,Benzke M,von Dincklage F,Reiche J,Schlattmann P,Rehberg B

更新日期：2007-10-01 00:00:00

abstract：:Central and peripheral pulmonary mucociliary clearance was assessed by tantalum bronchography and serial chest roentgenograms in dogs. Thiopental, 25 mg/kg, did not change clearance from awake values. Halothane 1.2 MAC, for six hours, delayed both central and peripheral clearance by at least three hours. After halotha...

journal_title：Anesthesiology

authors： Forbes AR,Gamsu G

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine the relationship of four postanesthesia care unit (PACU) cardiovascular events to long-term outcomes (unplanned critical care admission or mortality) and to evaluate the contribution of anesthetic management compared with other perioperative factors in predicting th...

journal_title：Anesthesiology

authors： Rose DK,Cohen MM,DeBoer DP

更新日期：1996-04-01 00:00:00

abstract：:Clonidine, an alpha 2-adrenergic agonist, can potentiate opioid-induced analgesia. In a double-blind placebo-controlled study in human volunteers, we sought to determine whether clonidine also potentiates opioid-induced respiratory depression. Hypercapnic ventilatory responses (minute ventilation, mean inspiratory flo...

journal_title：Anesthesiology

authors： Jarvis DA,Duncan SR,Segal IS,Maze M

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:Local anesthetics were suggested to have a potential for neurotoxicity in both clinical reports and laboratory experiments. Growing neurons have been shown to be susceptible to the toxic effects of local anesthetics in culture. These findings have generated the interest in factors that would rescue the neuro...

journal_title：Anesthesiology

authors： Radwan IA,Saito S,Goto F

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Initial anesthetic-induced hypothermia results largely from core-to-peripheral redistribution of heat. Nifedipine administration may minimize hypothermia by inducing vasodilation well before induction of anesthesia. Although vasodilation would redistribute heat to peripheral tissues, thermoregulatory respons...

journal_title：Anesthesiology

authors： Vassilieff N,Rosencher N,Sessler DI,Conseiller C,Lienhart A

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Propofol can be associated with delayed awakening after prolonged infusion. The aim of this study was to characterize the preclinical pharmacology of AZD-3043, a positive allosteric modulator of the γ-aminobutyric acid type A (GABA(A)) receptor containing a metabolically labile ester moiety. The authors post...

journal_title：Anesthesiology

authors： Egan TD,Obara S,Jenkins TE,Jaw-Tsai SS,Amagasu S,Cook DR,Steffensen SC,Beattie DT

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:During muscular exercise, a negative correlation has been demonstrated between the value of mixed venous oxygen saturation (SvO2) and the level of muscular work, expressed at each level as the ratio of oxygen uptake (VO2) to each subject's maximal oxygen uptake (VO2max). Because the immediate postoperative p...

journal_title：Anesthesiology

authors： Viale JP,Annat G,Lehot JJ,Quard S,Quintin L,Parlow J,Durand PG,Zabot JM,Villard J,Estanove S

更新日期：1994-02-01 00:00:00

abstract：:Carotid endarterectomy requires temporary surgical occlusion of the involved carotid artery. During occlusion, the minimally acceptable (critical) internal carotid artery stump pressure is reported to be 50 torr, whereas for regional cerebral blood flow (rCBF), a critical range is reported to be 18-24 ml/100 g/min. Du...

journal_title：Anesthesiology

authors： McKay RD,Sundt TM,Michenfelder JD,Gronert GA,Messick JM,Sharbrough FW,Piepgras DG

更新日期：1976-10-01 00:00:00

abstract：BACKGROUND:Perfluorocarbon liquids are being used experimentally and in clinical trials for the treatment of acute lung injury. Their resemblance to inhaled anesthetic agents suggests the possibility of application by vaporization. The authors' aim was to develop the technical means for perfluorocarbon vaporization and...

journal_title：Anesthesiology

authors： Bleyl JU,Ragaller M,Tschö U,Regner M,Kanzow M,Hübler M,Rasche S,Albrecht M

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Studies have shown that permissive hypotension for uncontrolled hemorrhagic shock can result in good resuscitation outcome. The ideal target mean arterial pressure (MAP) and the tolerance time for permissive hypotension have not been determined. METHODS:To elucidate the ideal target MAP and tolerance time f...

journal_title：Anesthesiology

authors： Li T,Zhu Y,Hu Y,Li L,Diao Y,Tang J,Liu L

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The anticonvulsant gabapentin, proven effective for neuropathic pain in two large, placebo-controlled clinical trials, is widely used for treatment of chronic pain. Preclinical studies have demonstrated analgesic and antiallodynic effects in models involving neuronal sensitization and nerve injury, without a...

journal_title：Anesthesiology

authors： Dirks J,Petersen KL,Rowbotham MC,Dahl JB

更新日期：2002-07-01 00:00:00

abstract：:Although suppression of thermoregulatory mechanisms by anesthetics is generally assumed, the extent to which thermoregulation is active during general anesthesia is not known. The only thermoregulatory responses available to anesthetized, hypothermic patients are vasoconstriction and non-shivering thermogenesis. To te...

journal_title：Anesthesiology

authors： Sessler DI,Olofsson CI,Rubinstein EH,Beebe JJ

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND:The abundance of a specific sodium channel subunit (SkM2) appeared to be altered in vitro in cell cultures from persons susceptible to malignant hyperthermia. This study sought to determine whether these findings are artifacts of cell culture or whether they may be relevant to malignant hyperthermia. METHOD...

journal_title：Anesthesiology

authors： Fletcher JE,Wieland SJ,Karan SM,Beech J,Rosenberg H

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:The authors investigated the efficacy of bilateral suprazygomatic maxillary nerve block (SMB) for postoperative pain relief in infants undergoing cleft palate repair. METHODS:In this prospective, double-blind, single-site, randomized, and parallel-arm controlled trial, 60 children were assigned to undergo b...

journal_title：Anesthesiology

authors： Chiono J,Raux O,Bringuier S,Sola C,Bigorre M,Capdevila X,Dadure C

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:The general anesthetics, isoflurane and sevoflurane, cause developmental abnormalities in neonatal animal models via incompletely understood mechanisms. Despite many common molecular targets, isoflurane and sevoflurane exhibit substantial differences in their actions. The authors sought to determine whether ...

journal_title：Anesthesiology

authors： Seubert CN,Zhu W,Pavlinec C,Gravenstein N,Martynyuk AE

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:To assess changing patterns of injury and liability associated with central venous or pulmonary artery catheters, the authors analyzed closed malpractice claims for central catheter injuries in the American Society of Anesthesiologists Closed Claims database. METHODS:All claims for which a central catheter ...

journal_title：Anesthesiology

authors： Domino KB,Bowdle TA,Posner KL,Spitellie PH,Lee LA,Cheney FW

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Halogenated anesthetics potentiate the positive inotropic effects of alpha- and beta-adrenoceptor stimulations. Although diabetes mellitus induces significant myocardial abnormalities, the interaction of halogenated anesthetics and adrenoceptor stimulation in diabetic myocardium remains unknown. METHODS:Lef...

journal_title：Anesthesiology

authors： Amour J,David JS,Vivien B,Coriat P,Riou B

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Intrathecal sufentanil (ITS) is frequently used to provide analgesia during labor. Decreases in blood pressure and sensory changes in this circumstance suggest that ITS may have a local anesthetic effect and thus cause a sympathectomy. To determine whether ITS given to laboring women causes a sympathectomy, ...

journal_title：Anesthesiology

authors： Riley ET,Walker D,Hamilton CL,Cohen SE

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:Obesity is an important risk factor for surgical site infections. The incidence of surgical wound infections is directly related to tissue perfusion and oxygenation. Fat tissue mass expands without a concomitant increase in blood flow per cell, which might result in a relative hypoperfusion with decreased ti...

journal_title：Anesthesiology

authors： Kabon B,Nagele A,Reddy D,Eagon C,Fleshman JW,Sessler DI,Kurz A

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:The Pediatric Perioperative Cardiac Arrest (POCA) Registry was formed in 1994 in an attempt to determine the clinical factors and outcomes associated with cardiac arrest in anesthetized children. METHODS:Institutions that provide anesthesia for children are voluntarily enrolled in the POCA Registry. A repre...

journal_title：Anesthesiology

authors： Morray JP,Geiduschek JM,Ramamoorthy C,Haberkern CM,Hackel A,Caplan RA,Domino KB,Posner K,Cheney FW

更新日期：2000-07-01 00:00:00