Abstract:
:The authors analyzed twelve patients with symptomatic essential throthrombocythemia (E.T.) diagnosed from 1983 to 1991. Haemorrhagic and thrombotic phenomena were the main presenting features. Treatment consisted mostly of alpha-interferon (IFN-alpha 2b) subcutaneously in dosage ranging from 3 to 5 MU/m2 and hydroxyurea (HU) in conventional dosage. A clinical response was seen in seven patients treated with IFN-alpha 2b (4 CR and 2 PR), and in four patients treated with HU (3 CR and 1 PR). No significant side effects were observed. Our findings indicate that IFN-alpha 2b offers a non-leukaemogenic and very promising therapeutic alternative for E.T.
journal_name
Leukemiajournal_title
Leukemiaauthors
Lopes E,Ribeiro MM,Silva MJ,Gandra M,Principe F,Granato Csubject
Has Abstractpub_date
1992-01-01 00:00:00pages
138S-140Seissn
0887-6924issn
1476-5551journal_volume
6 Suppl 3pub_type
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