Activation of Harvey ras oncogene by mutation at codon 12 is very rare in hemopoietic malignancies.

Abstract:

:Point mutations within codon 12 of the Harvey (H-) ras proto-oncogene have recently been implicated in the progression of hemopoietic malignancy, particularly chronic myeloid leukemia. We have analyzed DNA from 170 cases of acute and chronic leukemia by using a restriction fragment length polymorphism. No evidence for clonal allelic H-ras codon 12 activation was found among these cases, which included 23 cases of chronic myeloid leukemia, 12 of which were in accelerated phase or blastic transformation. These data suggest that H-ras codon 12 mutations occur infrequently in hemopoietic neoplasms generally and may be less important in disease progression than has been previously suggested.

journal_name

Leukemia

journal_title

Leukemia

authors

Browett PJ,Yaxley JC,Norton JD

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

86-8

issue

1

eissn

0887-6924

issn

1476-5551

journal_volume

3

pub_type

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