Abstract:
:Point mutations within codon 12 of the Harvey (H-) ras proto-oncogene have recently been implicated in the progression of hemopoietic malignancy, particularly chronic myeloid leukemia. We have analyzed DNA from 170 cases of acute and chronic leukemia by using a restriction fragment length polymorphism. No evidence for clonal allelic H-ras codon 12 activation was found among these cases, which included 23 cases of chronic myeloid leukemia, 12 of which were in accelerated phase or blastic transformation. These data suggest that H-ras codon 12 mutations occur infrequently in hemopoietic neoplasms generally and may be less important in disease progression than has been previously suggested.
journal_name
Leukemiajournal_title
Leukemiaauthors
Browett PJ,Yaxley JC,Norton JDsubject
Has Abstractpub_date
1989-01-01 00:00:00pages
86-8issue
1eissn
0887-6924issn
1476-5551journal_volume
3pub_type
杂志文章相关文献
LEUKEMIA文献大全abstract::Hematopoietic stem/progenitor cells (HSC/P) reside in the bone marrow in distinct anatomic locations (niches) to receive growth, survival and differentiation signals. HSC/P localization and migration between niches depend on cell-cell and cell-matrix interactions, which result from the cooperation of cytokines, chemok...
journal_title:Leukemia
pub_type: 杂志文章
doi:10.1038/sj.leu.2404769
更新日期:2007-08-01 00:00:00
abstract::JAK2V617F is the most common mutation in patients with BCR-ABL negative myeloproliferative neoplasms (MPNs). The eradication of JAK2V617F hematopoietic stem cells (HSCs) is critical for achieving molecular remissions and cure. We investigate the distinct effects of two therapies, ruxolitinib (JAK1/2 inhibitor) and int...
journal_title:Leukemia
pub_type: 杂志文章
doi:10.1038/s41375-019-0638-y
更新日期:2020-04-01 00:00:00
abstract::Immunotherapy with T cell modified with gamma-retroviral or lentiviral (LV) vectors to express a chimeric antigen receptor (CAR) has shown remarkable efficacy in clinical trials. However, the potential for insertional mutagenesis and genotoxicity of viral vectors is a safety concern, and their cost and regulatory dema...
journal_title:Leukemia
pub_type: 杂志文章
doi:10.1038/leu.2016.180
更新日期:2017-01-01 00:00:00
abstract::This corrects the article DOI: 10.1038/leu.2017.9. ...
journal_title:Leukemia
pub_type: 杂志文章,已发布勘误
doi:10.1038/leu.2017.348
更新日期:2018-04-01 00:00:00
abstract::The predominant usage of VH4-34 and V3-21 and reports of stereotyped CDR3s suggest a shared antigenic target of B-cell receptors (BCR) from mantle cell lymphomas (MCL). To identify the target antigens of MCL-BCRs, BCRs from 21 patients and seven MCL cell lines were recombinantly expressed and used for antigen screenin...
journal_title:Leukemia
pub_type: 杂志文章
doi:10.1038/s41375-018-0182-1
更新日期:2019-01-01 00:00:00
abstract::The major cause of early death in acute promyelocytic leukemia (APL), the high risk of a bleeding diathesis is now successfully counteracted within a few days by differentiation therapy using ATRA. Moreover, no resistance to this drug has been recorded during induction when the usual presence of PML/RAR alpha was conf...
journal_title:Leukemia
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::We have carried out a high-resolution whole genome DNA profiling analysis on 100 bone marrow samples from a consecutive series of de novo acute myeloid leukemia (AML) cases. After discarding copy number changes that are known to be genetic polymorphisms, we found that genomic aberrations (GA) in the form of gains or l...
journal_title:Leukemia
pub_type: 杂志文章
doi:10.1038/sj.leu.2404653
更新日期:2007-06-01 00:00:00
abstract::Most modern treatment protocols for acute lymphoblastic leukaemia (ALL) include the analysis of minimal residual disease (MRD). To ensure comparable MRD results between different MRD-polymerase chain reaction (PCR) laboratories, standardization and quality control are essential. The European Study Group on MRD detecti...
journal_title:Leukemia
pub_type: 杂志文章,多中心研究
doi:10.1038/sj.leu.2404586
更新日期:2007-04-01 00:00:00
abstract::Clinical characteristics, treatment response and outcome were evaluated in children with Down's syndrome (DS) and acute lymphoblastic leukemia (ALL) as compared to other children with ALL (NDS). Sixty-one DS and 4049 NDS patients, receiving intensive antileukemic treatment during four consecutive trials (ALL-BFM 81, 8...
journal_title:Leukemia
pub_type: 杂志文章
doi:10.1038/sj.leu.2400989
更新日期:1998-05-01 00:00:00
abstract::Mutations of the GATA1 gene on chromosome X have been found in almost all cases of transient myeloproliferative disorder and acute megakaryoblastic leukemia (AMKL) accompanying Down syndrome (DS). Although most GATA1 mutations lead to the expression of GATA1s lacking the N-terminal activation domain, we recently found...
journal_title:Leukemia
pub_type: 杂志文章
doi:10.1038/sj.leu.2404223
更新日期:2006-06-01 00:00:00
abstract::Smoldering multiple myeloma (SMM) is a biologically heterogeneous, clinically defined entity with a variable rate of progression to symptomatic multiple myeloma (MM). Reliable markers for progression are critical for the development of potential therapeutic interventions. We retrospectively evaluated the predictive va...
journal_title:Leukemia
pub_type: 杂志文章
doi:10.1038/s41375-018-0013-4
更新日期:2018-06-01 00:00:00
abstract::CK2 is a ubiquitously expressed, constitutively active Ser/Thr protein kinase, which is considered the most pleiotropic protein kinase in the human kinome. Such a pleiotropy explains the involvement of CK2 in many cellular events. However, its predominant roles are stimulation of cell growth and prevention of apoptosi...
journal_title:Leukemia
pub_type: 杂志文章,评审
doi:10.1038/leu.2017.301
更新日期:2018-01-01 00:00:00
abstract::CD13/aminopeptidase N (APN) is a cell surface metallopeptidase expressed by normal and leukemic myeloid cells, and by lymphoblasts in 5-10% of acute lymphoid leukemia (ALL) cases, previously classified as 'biphenotypic' or 'mixed-lineage' leukemias. In fresh cells from two early B-lineage, t(9;22)-positive, ALL cases ...
journal_title:Leukemia
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
abstract::In this report, a panel of European myeloma experts discuss the role of pomalidomide in the treatment of relapsed and refractory multiple myeloma (RRMM). Based on the available evidence, the combination of pomalidomide and low-dose dexamethasone is a well-tolerated and effective treatment option for patients with RRMM...
journal_title:Leukemia
pub_type: 杂志文章,评审
doi:10.1038/leu.2014.60
更新日期:2014-08-01 00:00:00
abstract::In this work we have mapped by double-label immunofluorescence the cellular distribution of integrins and their relationship with cytoskeletal proteins in normal and malignant monocytes. In normal monocytes, CD18 and CD11c are concentrated at specific adhesion sites, named podosomes, together with actin, vinculin, and...
journal_title:Leukemia
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract::It is apparent that treatment of Hodgkin's disease can be complicated by the development of secondary leukaemia. Most such leukaemias are of the non-lymphocytic type. We describe here a patient treated for Hodgkin's disease with chemo- and radiotherapy who developed secondary acute lymphoblastic leukaemia with a non-r...
journal_title:Leukemia
pub_type: 杂志文章,评审
doi:
更新日期:1991-07-01 00:00:00
abstract::Acute myeloid leukemia (AML) involves a block in terminal differentiation of the myeloid lineage and uncontrolled proliferation of a progenitor state. Using phorbol myristate acetate (PMA), it is possible to overcome this block in THP-1 cells (an M5-AML containing the MLL-MLLT3 fusion), resulting in differentiation to...
journal_title:Leukemia
pub_type: 杂志文章
doi:10.1038/leu.2009.246
更新日期:2010-02-01 00:00:00
abstract::Self-renewal, as defined by the capacity to yield new colonies following replating, is an important function of leukemic progenitors (L-CFU) to originate self-maintaining clones. In this work, we studied the effect of hyperthermia (41-44 degrees C) on the growth of human L-CFU derived primary colonies and of secondary...
journal_title:Leukemia
pub_type: 杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract::In 2005, the first guidelines were published on the management of patients with multiple myeloma (MM). An expert panel reviewed the currently available literature as the basis for a set of revised and updated consensus guidelines for the diagnosis and management of patients with MM who are not eligible for autologous ...
journal_title:Leukemia
pub_type: 杂志文章,实务指引,评审
doi:10.1038/leu.2009.122
更新日期:2009-10-01 00:00:00
abstract::Risk-adjusted treatment stratification in T-cell acute lymphoblastic leukemias (T-ALLs) is currently based only on early response to chemotherapy. We investigated the prognostic implication of hyperactivation of NOTCH pathway resulting from mutations of NOTCH1 or FBXW7 in children with T-ALL enrolled in EORTC-CLG tria...
journal_title:Leukemia
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/leu.2010.205
更新日期:2010-12-01 00:00:00
abstract::Children of subcontinental (Indian and Pakistani) origin living in the United Arab Emirates (UAE) have previously been shown to have a higher relative frequency of ALL when compared to other ethnic groups. To analyze the possible effect of social class in this difference, a study of socioeconomic factors was conducted...
journal_title:Leukemia
pub_type: 杂志文章
doi:10.1038/sj.leu.2400601
更新日期:1997-04-01 00:00:00
abstract::There have been controversies about CD34 and CD38 expression by human cord blood (CB) stem cells. Using the newborn NOD/SCID/beta2-microglobulin-null mouse assay that we recently developed, we examined the in vivo engrafting capability of human CB cells. Almost all of the 4-5 months engrafting cells were found in CD34...
journal_title:Leukemia
pub_type: 杂志文章
doi:10.1038/sj.leu.2402878
更新日期:2003-05-01 00:00:00
abstract::A single dominant gene Tlsm-1 was found to determine the type of spontaneous lymphomas to be T in the cross between AKR/Ms and SL/Kh. Microsatellite analysis mapped Tlsm-1 at the position 61 cM from centromere of Chr. 7. Study of this segment of T-lymphoma prone AKXD Rl strains also showed association of Tlsm-1 with T...
journal_title:Leukemia
pub_type: 杂志文章
doi:
更新日期:1997-04-01 00:00:00
abstract::The pharmacology of ID and IDOL are of interest in light of the potential utility of ID in the treatment of adult and pediatric leukemia patients. Preclinical activity and cellular pharmacology of ID were suggestive of greater clinical activity when compared with several standard anthracyclines. Most intriguing were d...
journal_title:Leukemia
pub_type: 杂志文章,评审
doi:
更新日期:1992-01-01 00:00:00
abstract::Xenotransplantation of human acute myeloid leukemia (AML) in immunocompromised animals has been critical for defining leukemic stem cells. However, existing immunodeficient strains of mice have short life spans and low levels of AML cell engraftment, hindering long-term evaluation of primary human AML biology. A recen...
journal_title:Leukemia
pub_type: 杂志文章
doi:10.1038/leu.2009.143
更新日期:2009-11-01 00:00:00
abstract::Normal human myeloid cells require certain colony stimulating factors (CSFs) for growth and differentiation. These CSFs are normally produced exogenously by accessory cells. However, human acute myeloid leukemia cells have been found, in certain instances, to have constitutive, endogenous production of one or more of ...
journal_title:Leukemia
pub_type: 杂志文章
doi:
更新日期:1989-09-01 00:00:00
abstract::Acute myeloid leukemia (AML) with minimal differentiation was usually referred to as acute undifferentiated leukemia in the past. With the help of immunophenotyping, this subtype of leukemia was shown to express myeloid antigens on the blasts and was designated AML-M0 by FAB Cooperative Study Group in 1991. Among the ...
journal_title:Leukemia
pub_type: 临床试验,杂志文章
doi:10.1038/sj.leu.2401521
更新日期:1999-10-01 00:00:00
abstract::The discovery of almost identical or 'stereotyped' B-cell receptor immunoglobulins (BcR IG) among unrelated patients with chronic lymphocytic leukemia (CLL) cemented the idea of antigen selection in disease ontogeny and evolution. The systematic analysis of the stereotypy phenomenon in CLL revealed that around one-thi...
journal_title:Leukemia
pub_type: 杂志文章,评审
doi:10.1038/leu.2016.322
更新日期:2017-02-01 00:00:00
abstract::The Wilms' tumor 1 (WT1) gene encodes a transcription factor important for normal cellular development and cell survival. The initial discovery of WT1 as the causative gene in an autosomal-recessive condition identified it as a tumor suppressor gene whose mutations are associated with urogenital disease and the develo...
journal_title:Leukemia
pub_type: 杂志文章,评审
doi:10.1038/sj.leu.2404624
更新日期:2007-05-01 00:00:00
abstract::The AML1 is the most commonly involved transcription factor gene in human leukemias and forms chimeric transcription factor genes, namely, AML1/MTG8 by the t(8;21), AML1/EVI-1 by the t(3;21), and TEL/AML1 by the t(12;21). The AML1a and AML1b, two isoforms of the AML1 protein, are translated from the AML1 gene by the a...
journal_title:Leukemia
pub_type: 杂志文章,评审
doi:
更新日期:1997-04-01 00:00:00