当前位置： SCI文献检索 > LEUKEMIA期刊下所有文献 > Ethnic and geographic diversity of chronic lymphocytic leukaemia.

Ethnic and geographic diversity of chronic lymphocytic leukaemia.

Abstract：

:East Asians, Asian Indians and Amerindians have a five to ten-fold lower age-adjusted incidence rate (AAIR) of chronic lymphocytic leukaemia (CLL) compared with persons of predominately European descent. The data we review suggest a genetic rather than environmental basis for this discordance. All these populations arose from a common African Black ancestor but different clades have different admixture with archaic hominins including Neanderthals, Denisovans and Homo erectus, which may explain different CLL incidences. There are also some differences in clinical laboratory and molecular co-variates of CLL between these populations. Because the true age-adjusted incidence rate in African Blacks is unknown it is not possible to determine whether modern Europeans acquired susceptibility to CLL or the other populations lost susceptibility and/or developed resistance to developing CLL. We also found other B-cell lymphomas and T- and NK-cell cancers had different incidences in the populations we studied. These data provide clues to determining the cause(s) of CLL.

journal_name

Leukemia

journal_title

Leukemia

authors

Yang S,Varghese AM,Sood N,Chiattone C,Akinola NO,Huang X,Gale RP

doi

10.1038/s41375-020-01057-5

subject

Has Abstract

pub_date

2020-10-19 00:00:00

eissn

0887-6924

issn

1476-5551

pii

10.1038/s41375-020-01057-5

pub_type

杂志文章

相关文献

LEUKEMIA文献大全
  • Clonal diversity predicts adverse outcome in chronic lymphocytic leukemia.

    abstract：:Genomic analyses of chronic lymphocytic leukemia (CLL) identified somatic mutations and associations of clonal diversity with adverse outcomes. Clonal evolution likely has therapeutic implications but its dynamic is less well studied. We studied clonal composition and prognostic value of seven recurrently mutated driv...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/s41375-018-0215-9

    authors： Leeksma AC,Taylor J,Wu B,Gardner JR,He J,Nahas M,Gonen M,Alemayehu WG,Te Raa D,Walther T,Hüllein J,Dietrich S,Claus R,de Boer F,de Heer K,Dubois J,Dampmann M,Dürig J,van Oers MHJ,Geisler CH,Eldering E,Levine RL

    更新日期：2019-02-01 00:00:00

  • Four subclones with distinct immunoglobulin light chain phenotypes. (kappa+lambda+, kappa+, lambda+ and kappa-lambda-) from acute leukemia.

    abstract：:A human acute lymphoblastic leukemia (ALL) cell line, BALM-9, was established from the peripheral blood specimen of a immunoglobin (lg) phenotype, the established BALM-9 cell line expressed both kappa and lambda light (L) chains simultaneously in a range of 30-80%. Two-color flow cytometric analysis demonstrated that ...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Matsuo Y,Nakamura S,Ariyasu T,Terao R,Imajyo K,Tsubota T,Kuwahara K,Sakaguchi N

    更新日期：1996-04-01 00:00:00

  • Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1.

    abstract：:Minimal residual disease (MRD) is a powerful prognostic factor in acute lymphoblastic leukemia (ALL) and is used for patient stratification and treatment decisions, but its precise role in Philadelphia chromosome positive ALL is less clear. This uncertainty results largely from methodological differences relating to t...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/s41375-019-0413-0

    authors： Pfeifer H,Cazzaniga G,van der Velden VHJ,Cayuela JM,Schäfer B,Spinelli O,Akiki S,Avigad S,Bendit I,Borg K,Cavé H,Elia L,Reshmi SC,Gerrard G,Hayette S,Hermanson M,Juh A,Jurcek T,Chillón MC,Homburg C,Martinelli G,

    更新日期：2019-08-01 00:00:00

  • Intrinsic differences between the catalytic properties of the oncogenic NUP214-ABL1 and BCR-ABL1 fusion protein kinases.

    abstract：:The NUP214-ABL1 fusion kinase has recently been identified in 6% of patients with T-cell acute lymphoblastic leukemia. In contrast to the more common oncogenic ABL1 fusion BCR-ABL1, NUP214-ABL1 localizes to the nuclear pore complexes and has attenuated transforming properties in hematopoietic cells and in mouse bone m...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2008.242

    authors： De Keersmaecker K,Versele M,Cools J,Superti-Furga G,Hantschel O

    更新日期：2008-12-01 00:00:00

  • Prevention of T-cell lymphoma in AKR/J mice.

    abstract：:Injection of a dual tropic virus (DTV) isolated from a T cell lymphoma AKR/J mice into the thymus of 14 day old AKR/J puppies accelerates lymphoma development; 90-100% of the injected mice develop the disease within 120 days. In contrast a cell free centrifuge CFC-666 prepared B cell lymphoma of AKR/J origin injected ...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Peled A,Haran-Ghera N

    更新日期：1988-12-01 00:00:00

  • Myeloid surface antigen expression in adult acute lymphoblastic leukemia.

    abstract：:The expression of myeloid surface markers was investigated in 41 cases of untreated adult acute lymphoblastic leukemia (ALL). Nineteen cases (46%) reacted with at least one myeloid monoclonal antibody (CD15 in 16 cases, CD13 in 10 cases, CD14 in five cases, and CD33 in four cases). Double-staining confirmed the coexpr...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Guyotat D,Campos L,Shi ZH,Charrin C,Treille D,Magaud JP,Fiere D

    更新日期：1990-09-01 00:00:00

  • Molecular mechanisms of tumor progression in chronic myeloproliferative disorders.

    abstract：:We have investigated the involvement of tumor suppressor genes (p53 and RB1) and dominantly acting oncogenes (Ras family genes) in BCR/ABL positive and negative chronic myeloproliferative disorders (CMPD) at different stages of the disease, including 26 cases of BCR/ABL+ chronic myeloid leukemia (CML) blast crisis, 9 ...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Gaidano G,Guerrasio A,Serra A,Rege-Cambrin G,Saglio G

    更新日期：1994-04-01 00:00:00

  • Update of St Jude Study XI for childhood acute lymphoblastic leukemia.

    abstract：:We treated 358 children with non-B-cell acute lymphoblastic leukemia with intensive multiagent chemotherapy (St. Jude Study XI) in a risk-directed study which used very intensive induction and consolidation therapy followed by continuation treatment comprised of rotating drug pairs given for the entire duration of the...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Rivera GK,Pui CH,Hancock ML,Mahmoud H,Santana V,Sandlund JT,Hurwitz C,Ribeiro R,Furman W,Crist WM

    更新日期：1992-01-01 00:00:00

  • Quantitation of leukemia clone-specific antigen gene rearrangements by a single-step PCR and fluorescence-based detection method.

    abstract：:PCR-based detection of minimal residual disease (MRD) in children with precursor B cell acute lymphoblastic leukemia (pre-B ALL) by amplification of clone-specific antigen gene rearrangements has been labor-intensive. In this study we present a simpler, yet accurate, method to assess and quantitate MRD in pediatric pr...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2401530

    authors： Mayer SP,Giamelli J,Sandoval C,Roach AS,Fevzi Ozkaynak M,Tugal O,Rovera G,Jayabose S

    更新日期：1999-11-01 00:00:00

  • Activation of T cell cytotoxicity against autologous common acute lymphoblastic leukemia (cALL) blasts by CD3xCD19 bispecific antibody.

    abstract：:To develop an effective immunotherapy for B-lineage acute lymphoblastic leukemia (ALL), bispecific monoclonal antibodies (bsAb) were raised by cell fusion of two hybridoma cell lines secreting CD3 and CD19 antibodies. The resulting bispecific antibody contains two different specificities within a single antibody molec...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Csóka M,Strauss G,Debatin KM,Moldenhauer G

    更新日期：1996-11-01 00:00:00

  • CD56dimCD16neg cells are responsible for natural cytotoxicity against tumor targets.

    abstract：:The activation of natural killer (NK) cells leads to degranulation and secretion of cytotoxic granula. During this process, the lytic granule membrane protein CD107a becomes detectable at the cell surface. Based on this phenomenon, we have analyzed by a novel flow cytometry-based assay, the number and phenotype of NK ...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2403704

    authors： Penack O,Gentilini C,Fischer L,Asemissen AM,Scheibenbogen C,Thiel E,Uharek L

    更新日期：2005-05-01 00:00:00

  • How to manage primary amyloidosis.

    abstract：:Immunoglobulin light chain amyloidosis is a protein deposition disorder where the precursor protein represents a monoclonal immunoglobulin light or heavy chain. Deposition in viscera results in restrictive cardiomyopathy, nephrotic range proteinuria, demyelinating peripheral neuropathy, hepatomegaly and malabsorption ...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2011.219

    authors： Gertz MA

    更新日期：2012-02-01 00:00:00

  • Prognostic factors for patients with chronic myeloid leukaemia in chronic phase treated with imatinib mesylate after failure of interferon alfa.

    abstract：:We assessed clinical results in 145 patients with chronic myeloid leukaemia in chronic phase who satisfied criteria for interferon-alpha failure and were thus eligible for treatment with imatinib at the Hammersmith Hospital. We used univariate and multivariate analyses to develop a risk score based on features defined...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2402996

    authors： Marin D,Marktel S,Bua M,Szydlo RM,Franceschino A,Nathan I,Foot N,Crawley C,Na Nakorn T,Olavarria E,Lennard A,Neylon A,O'Brien SG,Goldman JM,Apperley JF

    更新日期：2003-08-01 00:00:00

  • Rapid amplification of immunoglobulin heavy chain switch (IGHS) translocation breakpoints using long-distance inverse PCR.

    abstract：:Molecular cloning of immunoglobulin heavy chain (IGH) translocation breakpoints identifies genes of biological importance in the development of normal and malignant B cells. Long-distance inverse PCR (LDI-PCR) was first applied to amplification of IGH gene translocations targeted to the joining (IGHJ) regions. We repo...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2403500

    authors： Sonoki T,Willis TG,Oscier DG,Karran EL,Siebert R,Dyer MJ

    更新日期：2004-12-01 00:00:00

  • Laying the foundation for genomically-based risk assessment in chronic myeloid leukemia.

    abstract：:Outcomes for patients with chronic myeloid leukemia (CML) have substantially improved due to advances in drug development and rational treatment intervention strategies. Despite these significant advances there are still unanswered questions on patient management regarding how to more reliably predict treatment failur...

    journal_title：Leukemia

    pub_type： 杂志文章,评审

    doi：10.1038/s41375-019-0512-y

    authors： Branford S,Kim DDH,Apperley JF,Eide CA,Mustjoki S,Ong ST,Nteliopoulos G,Ernst T,Chuah C,Gambacorti-Passerini C,Mauro MJ,Druker BJ,Kim DW,Mahon FX,Cortes J,Radich JP,Hochhaus A,Hughes TP,International CML Foundation Ge

    更新日期：2019-08-01 00:00:00

  • Integrin distribution and cytoskeleton organization in normal and malignant monocytes.

    abstract：:In this work we have mapped by double-label immunofluorescence the cellular distribution of integrins and their relationship with cytoskeletal proteins in normal and malignant monocytes. In normal monocytes, CD18 and CD11c are concentrated at specific adhesion sites, named podosomes, together with actin, vinculin, and...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Gaidano G,Bergui L,Schena M,Gaboli M,Cremona O,Marchisio PC,Caligaris-Cappio F

    更新日期：1990-10-01 00:00:00

  • AML patients with Down syndrome have a high cure rate with AML-BFM therapy with reduced dose intensity.

    abstract：:Despite improved prognosis in acute myelogenous leukaemia (AML) children with Down syndrome (DS), therapy-related toxicity remained a problem. We compared 67 DS patients from study AML-BFM 98 with 51 DS patients of the previous study AML-BFM 93, and the non-DS groups of both studies. Compared to non-DS patients, DS pa...

    journal_title：Leukemia

    pub_type： 临床试验,杂志文章

    doi：10.1038/sj.leu.2403814

    authors： Creutzig U,Reinhardt D,Diekamp S,Dworzak M,Stary J,Zimmermann M

    更新日期：2005-08-01 00:00:00

  • CD34(+) or CD34(-): which is the more primitive?

    abstract：:Remarkable progress has been achieved in the characterization and isolation of primitive hematopoietic stem cells (HSC). HSC represent a very small subset of hematopoietic cells and provide self-renewal, possess differentiation capacity and allow a constant supply of the entire hematopoietic cell spectrum. Until recen...

    journal_title：Leukemia

    pub_type： 杂志文章,评审

    doi：10.1038/sj.leu.2402620

    authors： Engelhardt M,Lübbert M,Guo Y

    更新日期：2002-09-01 00:00:00

  • Deletion 5q in myelodysplastic syndrome: a paradigm for the study of hemizygous deletions in cancer.

    abstract：:Hemizygous deletions are common molecular abnormalities in cancer. In some cases, these deletions highlight chromosomal loci containing tumor suppressor genes that undergo homozygous inactivation. In other cases, hemizygous deletions cause disease by allelic insufficiency for one or more genes. As the intact allele ha...

    journal_title：Leukemia

    pub_type： 杂志文章,评审

    doi：10.1038/leu.2009.53

    authors： Ebert BL

    更新日期：2009-07-01 00:00:00

  • Progress against childhood and adolescent acute lymphoblastic leukaemia in the Netherlands, 1990-2015.

    abstract：:We assessed the epidemiologic progress against childhood and adolescent acute lymphoblastic leukaemia (ALL) in the Netherlands over a 26 year period. ALL patients <18 years were selected from the Netherlands Cancer Registry and the Dutch Childhood Oncology Group. Trend analyses were performed over time and by age grou...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/s41375-020-01024-0

    authors： Reedijk AMJ,Coebergh JWW,de Groot-Kruseman HA,van der Sluis IM,Kremer LC,Karim-Kos HE,Pieters R

    更新日期：2020-08-21 00:00:00

  • Mesenchymal stem cells in suppression or progression of hematologic malignancy: current status and challenges.

    abstract：:Mesenchymal stem cells (MSCs) are known for being multi-potent. However, they also possess anticancer properties, which has prompted efforts to adapt MSCs for anticancer therapies. However, MSCs have also been widely implicated in pathways that contribute to tumor growth. Numerous studies have been conducted to adapt ...

    journal_title：Leukemia

    pub_type： 杂志文章,评审

    doi：10.1038/s41375-018-0373-9

    authors： Lee MW,Ryu S,Kim DS,Lee JW,Sung KW,Koo HH,Yoo KH

    更新日期：2019-03-01 00:00:00

  • Therapy-related myelodysplastic syndrome after autologous stem cell transplantation for breast cancer.

    abstract：:Therapy-related myelodysplastic syndrome and acute myelogenous leukemia (t-MDS/AML) are serious complications of chemotherapy and radiotherapy for cancer. High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) may be associated with an increased incidence of these complications. The frequency o...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2402631

    authors： Nichols G,de Castro K,Wei LX,Griffin M,Lin N,Oratzi A,Murty VV,Troxel A,Vahdat L,Hesdorffer C

    更新日期：2002-09-01 00:00:00

  • Long-term outcome of patients with newly diagnosed chronic myeloid leukemia: a randomized comparison of stem cell transplantation with drug treatment.

    abstract：:Tyrosine kinase inhibitors represent today's treatment of choice in chronic myeloid leukemia (CML). Allogeneic hematopoietic stem cell transplantation (HSCT) is regarded as salvage therapy. This prospective randomized CML-study IIIA recruited 669 patients with newly diagnosed CML between July 1997 and January 2004 fro...

    journal_title：Leukemia

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1038/leu.2015.281

    authors： Gratwohl A,Pfirrmann M,Zander A,Kröger N,Beelen D,Novotny J,Nerl C,Scheid C,Spiekermann K,Mayer J,Sayer HG,Falge C,Bunjes D,Döhner H,Ganser A,Schmidt-Wolf I,Schwerdtfeger R,Baurmann H,Kuse R,Schmitz N,Wehmeier A,

    更新日期：2016-03-01 00:00:00

  • Stroma-conditioned media improve expansion of human primitive hematopoietic stem cells and progenitor cells.

    abstract：:It has been reported that stroma-dependent cultures support proliferation of hematopoietic stem cells (HSC). In order to investigate the effect of soluble stromal factors, we developed short-term serum-low liquid cultures in which the effect of stroma-conditioned media (SCM) from the murine FBMD-1, and human L87/4 and...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2400530

    authors： Breems DA,Blokland EA,Ploemacher RE

    更新日期：1997-01-01 00:00:00

  • P-glycoprotein expression as unfavorable prognostic factor in acute myeloid leukemia.

    abstract：:In order to further define the role of the MDR1 gene in acute myeloid leukemia (AML), we determined the association between the presence of P-glycoprotein on leukemic cells and the efficacy of therapy in patients with AML. Immunocytochemistry with monoclonal antibody C219 was performed to demonstrate the presence of P...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Zöchbauer S,Gsur A,Brunner R,Kyrle PA,Lechner K,Pirker R

    更新日期：1994-06-01 00:00:00

  • Increased resistance to methotrexate in human hematopoietic cells after gene transfer of the Ser31 DHFR mutant.

    abstract：:Retroviral gene transfer into hematopoietic cells has many experimental as well as clinical applications. Although transduction efficiency of retroviral vectors is higher than with conventional methods, selection of successfully transduced cells may become mandatory for efficient in vivo transfer. We have been evaluat...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Flasshove M,Banerjee D,Bertino JR,Moore MA

    更新日期：1995-10-01 00:00:00

  • High-dose methotrexate therapy significantly improved survival of adult acute lymphoblastic leukemia: a phase III study by JALSG.

    abstract：:High-dose methotrexate (Hd-MTX) therapy has recently been applied to the treatment of adult acute lymphoblastic leukemia (ALL) based on pediatric protocols; however, its effectiveness for adult ALL has not yet been confirmed in a rigorous manner. We herein conducted a randomized phase III trial comparing Hd-MTX therap...

    journal_title：Leukemia

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/leu.2017.283

    authors： Sakura T,Hayakawa F,Sugiura I,Murayama T,Imai K,Usui N,Fujisawa S,Yamauchi T,Yujiri T,Kakihana K,Ito Y,Kanamori H,Ueda Y,Miyata Y,Kurokawa M,Asou N,Ohnishi K,Ohtake S,Kobayashi Y,Matsuo K,Kiyoi H,Miyazaki Y,Na

    更新日期：2018-03-01 00:00:00

  • TET1 promotes growth of T-cell acute lymphoblastic leukemia and can be antagonized via PARP inhibition.

    abstract：:T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological cancer characterized by skewed epigenetic patterns, raising the possibility of therapeutically targeting epigenetic factors in this disease. Here we report that among different cancer types, epigenetic factor TET1 is highly expressed in T-ALL a...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/s41375-020-0864-3

    authors： Bamezai S,Demir D,Pulikkottil AJ,Ciccarone F,Fischbein E,Sinha A,Borga C,Te Kronnie G,Meyer LH,Mohr F,Götze M,Caiafa P,Debatin KM,Döhner K,Döhner H,González-Menéndez I,Quintanilla-Fend L,Herold T,Jeremias I,Feuring-

    更新日期：2020-05-15 00:00:00

  • A comparison of clofarabine with ara-C, each in combination with daunorubicin as induction treatment in older patients with acute myeloid leukaemia.

    abstract：:The study was designed to compare clofarabine plus daunorubicin vs daunorubicin/ara-C in older patients with acute myeloid leukaemia (AML) or high-risk myelodysplastic syndrome (MDS). Eight hundred and six untreated patients in the UK NCRI AML16 trial with AML/high-risk MDS (median age, 67 years; range 56-84) and norm...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2016.225

    authors： Burnett AK,Russell NH,Hills RK,Kell J,Nielsen OJ,Dennis M,Cahalin P,Pocock C,Ali S,Burns S,Freeman S,Milligan D,Clark RE

    更新日期：2017-02-01 00:00:00

  • SETD2-mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia.

    abstract：:Previously, we identified SETD2 loss-of-function mutations in 22% of MLL-rearranged (MLLr) acute leukemia patients, implicating a mechanism for cooperativity between SETD2 mutations and MLL fusions. However, the detailed mechanism of how SETD2-H3K36me3 downregulation accelerates MLLr leukemia remains unclear. Here, we...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2017.339

    authors： Bu J,Chen A,Yan X,He F,Dong Y,Zhou Y,He J,Zhan D,Lin P,Hayashi Y,Sun Y,Zhang Y,Xiao Z,Grimes HL,Wang QF,Huang G

    更新日期：2018-04-01 00:00:00