Prevention of T-cell lymphoma in AKR/J mice.

abstract：:The introduction of BCR-ABL tyrosine kinase inhibitors has revolutionized the treatment of chronic myeloid leukemia (CML). A major clinical aim remains the identification and elimination of low-level disease persistence, termed "minimal residual disease". The phenomenon of disease persistence suggests that despite tar...

journal_title：Leukemia

authors： Kinstrie R,Horne GA,Morrison H,Irvine D,Munje C,Castañeda EG,Moka HA,Dunn K,Cassels JE,Parry N,Clarke CJ,Scott MT,Clark RE,Holyoake TL,Wheadon H,Copland M

更新日期：2020-06-01 00:00:00

abstract：:This review will summarize the rationale for pursuing investigations into the use of retinoids for pediatric patients with cancer, describe the phase I results of all-trans-retinoic acid (ATRA) in children, and discuss the results of a series of preclinical and clinical pharmacokinetic studies of ATRA. The prognosis f...

journal_title：Leukemia

authors： Adamson PC

更新日期：1994-01-01 00:00:00

abstract：:Though the term apoptosis was originated in pathology and developmental biology as an alternative to necrosis, the tissue necrosis with inflammation is irrelevant to cell culture conditions where apoptosis is mostly studied. Furthermore, no one single morphological feature is either necessary or sufficient to define a...

journal_title：Leukemia

authors： Blagosklonny MV

更新日期：2000-08-01 00:00:00

abstract：:B-cell-specific plasma-membrane proteins are potential targets for either small molecule or antibody-based therapies. We have sought to annotate proteins expressed at the cell surface membrane in patients with chronic lymphocytic leukemia (CLL) using plasma-membrane-based proteomic analysis to identify previously unch...

journal_title：Leukemia

authors： Boyd RS,Adam PJ,Patel S,Loader JA,Berry J,Redpath NT,Poyser HR,Fletcher GC,Burgess NA,Stamps AC,Hudson L,Smith P,Griffiths M,Willis TG,Karran EL,Oscier DG,Catovsky D,Terrett JA,Dyer MJ

更新日期：2003-08-01 00:00:00

abstract：:The alpha chain of the interleukin 2 receptor (IL2R alpha; Tac) was targeted in clinical trials with adult T cell leukemia using murine anti-Tac antibody. Of 19 patients, a single individual achieved a durable complete remission. The mechanism of this action by murine anti-Tac has not been defined. We examined the hyp...

journal_title：Leukemia

authors： Kingsbury GA,Waldmann TA,Junghans RP

更新日期：1998-06-01 00:00:00

abstract：:Housekeeping genes, particularly actin, tubulin, and the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH), are widely used to estimate the amount and integrity of RNA in Northern blotting. In this work, the most reliable housekeeping gene for gene expression analysis of Hodgkin's disease (HD) lymph n...

journal_title：Leukemia

authors： Perfetti V,Manenti G,Dragani TA

更新日期：1991-12-01 00:00:00

abstract：:PRDM1/BLIMP-1, a master regulator of plasma-cell differentiation, is frequently inactivated in activated B-cell-like (ABC) diffuse large B-cell lymphoma (DLBCL) patients. Little is known about its genetic aberrations and relevant clinical implications. A large series of patients with de novo DLBCL was effectively eval...

journal_title：Leukemia

authors： Xia Y,Xu-Monette ZY,Tzankov A,Li X,Manyam GC,Murty V,Bhagat G,Zhang S,Pasqualucci L,Visco C,Dybkaer K,Chiu A,Orazi A,Zu Y,Richards KL,Hsi ED,Choi WW,van Krieken JH,Huh J,Ponzoni M,Ferreri AJ,Møller MB,Parsons

更新日期：2017-03-01 00:00:00

abstract：:A prospective multicenter study was performed to investigate the clinical and molecular results of intensified double induction therapy including high-dose cytarabine (ara-C) in combination with ATRA in newly diagnosed acute promyelocytic leukemia (APL), followed by consolidation and 3 years maintenance therapy. Fifty...

journal_title：Leukemia

authors： Lengfelder E,Reichert A,Schoch C,Haase D,Haferlach T,Löffler H,Staib P,Heyll A,Seifarth W,Saussele S,Fonatsch C,Gassmann W,Ludwig WD,Hochhaus A,Beelen D,Aul C,Sauerland MC,Heinecke A,Hehlmann R,Wörmann B,Hiddemann

更新日期：2000-08-01 00:00:00

abstract：:Myeloperoxidase (MPO) is found in the azurophilic granules of normal myelocytic cells. Cytochemical staining for MPO activity is used clinically to distinguish myeloid from acute lymphoid leukemias (ALL). However, using a highly sensitive RT-PCR technique, it is possible to detect MPO mRNA in otherwise clear ALL. The ...

journal_title：Leukemia

authors： Serrano J,Román J,Jiménez A,Castillejo JA,Navarro JA,Sánchez J,García-Castellanos JM,Martín C,Maldonado J,Torres A

更新日期：1999-02-01 00:00:00

abstract：:Heterozygous and homozygous deletions of chromosome 13q14.3 are found in 50% of patients with B cell CLL, suggesting the presence of one or more tumour suppressor genes within the deleted region. To identify candidate genes from the region, we constructed a map of 13q14.3 using a combination of genomic and cDNA librar...

journal_title：Leukemia

authors： Rowntree C,Duke V,Panayiotidis P,Kotsi P,Palmisano GL,Hoffbrand AV,Foroni L

更新日期：2002-07-01 00:00:00

abstract：:This study has determined the effects of phorbol-12-myristate-13-acetate (PMA) and dimethylsulfoxide (DMSO) on mRNA levels for the serglycin proteoglycan core protein in human erythroleukemia (HEL) cells. We have compared these changes to those for mRNA for other proteins which are known to be synthesized by HEL cells...

journal_title：Leukemia

authors： Schick BP,Thornton RD

更新日期：1993-12-01 00:00:00

abstract：:Histone acetyltransferases (HATs) catalyze the transfer of an acetyl group from acetyl-CoA to lysine residues of histones and play a central role in transcriptional regulation in diverse biological processes. Dysregulation of HAT activity can lead to human diseases including developmental disorders and cancer. Through...

journal_title：Leukemia

authors： Au YZ,Gu M,De Braekeleer E,Gozdecka M,Aspris D,Tarumoto Y,Cooper J,Yu J,Ong SH,Chen X,Tzelepis K,Huntly BJP,Vassiliou G,Yusa K

更新日期：2020-08-06 00:00:00

abstract：:The effects of retinoic acid (RA) on the cell growth and expression of interleukin-2 (IL-2) receptors (IL-2R alpha/p55, Tac, CD25) by the human T lymphotropic virus type I (HTLV-I)-positive T cell lines, HUT102 and ATL-2 were investigated. Incubation of these cells for 48 h with either 13-cis retinoid acid (13-cis RA)...

journal_title：Leukemia

authors： Miyatake JI,Maeda Y

更新日期：1997-03-01 00:00:00

abstract：:Chemotherapy may decrease relapses of acute promyelocytic leukemia (APL) following induction with all-trans retinoic acid (ATRA), however the optimal timing of these two modalities remains to be determined. We treated eight patients with morphologic evidence of APL with intensive induction chemotherapy followed by ATR...

journal_title：Leukemia

authors： Seiter K,Miller WH Jr,Feldman EJ,Ahmed T,Arlin Z

更新日期：1995-01-01 00:00:00

abstract：:This corrects the article DOI: 10.1038/leu.2017.9. ...

journal_title：Leukemia

authors： Schütz C,Inselmann S,Saussele S,Dietz CT,Müller MC,Eigendorff E,Brendel CA,Metzelder SK,Brümmendorf TH,Waller C,Dengler J,Goebeler ME,Herbst R,Freunek G,Hanzel S,Illmer T,Wang Y,Lange T,Finkernagel F,Hehlmann R,Hu

更新日期：2018-04-01 00:00:00

abstract：:We have developed a method to quantify topoisomerase (topo) II activities in partially purified nuclear extracts from human leukemia cells. By virtue of their different pH optima in the reaction buffer, two different topo II activities were found with activity optima at pH 7.9 and at pH 8.9 under high stringency condi...

journal_title：Leukemia

authors： Gieseler F,Glasmacher A,Kämpfe D,Wandt H,Nuessler V,Valsamas S,Kunze J,Wilms K

更新日期：1996-07-01 00:00:00

abstract：:Schedule dependency of idarubicin (Ida) and doxorubicin (Dox) toxicity was investigated in vitro using the K562 human leukemia cell line. For Dox, repeated exposure to the IC30 (d x 3) resulted in comparable survival as single exposure to the total accumulative dose (20%). For Ida, repeated exposure to the IC30 (d x 3...

journal_title：Leukemia

authors： Minderman H,Buscaglia MD,Rustum YM

更新日期：1994-08-01 00:00:00

abstract：:FMS-like tyrosine kinase 3 (FLT3) is a transmembrane protein expressed on normal hematopoietic stem and progenitor cells (HSC) and retained on malignant blasts in acute myeloid leukemia (AML). We engineered CD8+ and CD4+ T-cells expressing a FLT3-specific chimeric antigen receptor (CAR) and demonstrate they confer pot...

journal_title：Leukemia

authors： Jetani H,Garcia-Cadenas I,Nerreter T,Thomas S,Rydzek J,Meijide JB,Bonig H,Herr W,Sierra J,Einsele H,Hudecek M

更新日期：2018-05-01 00:00:00

abstract：:Unlike the case with thrombosis, prognostic models for survival and leukemic transformation (LT) in essential thrombocythemia (ET) are not available. Among 605 patients with ET seen at our institution and followed for a median of 84 months, 155 died and LT was documented in 20 patients (3.3%). In a multivariable analy...

journal_title：Leukemia

authors： Gangat N,Wolanskyj AP,McClure RF,Li CY,Schwager S,Wu W,Tefferi A

更新日期：2007-02-01 00:00:00

abstract：:Cytogenetic and fluorescence in situ hybridization studies have shown the presence of telomeric repeats in translocation present in three patients with hematopoietic malignancies. One had jumping translocations, involving 1q12 and 2q, 16p, and 19q. These sequences were detected by FISH only in derivative chromosomes t...

journal_title：Leukemia

authors： Busson Le Coniat M,Brizard F,Smadja NV,Maarek O,Der Sarkissian H,Berger R

更新日期：2000-09-01 00:00:00

abstract：:Bruton's tyrosine kinase (BTK) inhibitor is a promising novel agent that has potential efficiency in B-cell malignancies. It took approximately 20 years from target discovery to new drug approval. The first-in-class drug ibrutinib creates possibilities for an era of chemotherapy-free management of B-cell malignancies,...

journal_title：Leukemia

authors： Wen T,Wang J,Shi Y,Qian H,Liu P

更新日期：2020-10-29 00:00:00

abstract：:Because of their substantial in vitro synergy, we conducted a dose-escalation study of cyclophosphamide (CP) added to 2-chloro-2'-deoxyadenosine (CdA) in patients with previously treated chronic lymphocytic leukemia and non-Hodgkin's lymphoma. CdA was given at a fixed dose (5.6 mg/m2/day) as a 2-h intravenous (i.v.) i...

journal_title：Leukemia

authors： Van Den Neste E,Louviaux I,Michaux JL,Delannoy A,Michaux L,Sonet A,Bosly A,Doyen C,Mineur P,André M,Straetmans N,Coche E,Venet C,Duprez T,Ferrant A

更新日期：2000-06-01 00:00:00

abstract：:We have previously shown that chronic lymphocytic leukemia (CLL) B cells secrete vascular endothelial growth factor (VEGF) in vitro, have constitutively active VEGF receptors R1 and R2, and respond to exogenous VEGF by specifically upregulating Mcl-1 and XIAP in association with decreased cell death. We found that epi...

journal_title：Leukemia

authors： Lee YK,Shanafelt TD,Bone ND,Strege AK,Jelinek DF,Kay NE

更新日期：2005-04-01 00:00:00

abstract：:The outcome of a cohort of 218 consecutive patients who failed to respond to a single course of standard daunorubicin plus ARAC (three + seven) induction regimen has been retrospectively evaluated to assess the characteristics of this group of AML patients and the effectiveness of second-line induction programs. Seven...

journal_title：Leukemia

authors： Liso V,Iacopino P,Avvisati G,Petti MC,Broccia G,Carotenuto M,Falda M,Fazi P,Lazzarino M,Leoni P,Mirto S,Pucci G,Nobile F,Nosari AM,Specchia G,Stasi R,Tabilio A,Mandelli F

更新日期：1996-09-01 00:00:00

abstract：:t(8;21)(q22;q22) is the most frequently observed karyotypic abnormality associated with acute myeloid leukemia (AML), especially in FAB M2. Clinically, this type of AML often shows eosinophilia and has a high complete remission rate with conventional chemotherapy. t(8;21) AML is also frequently associated with additio...

journal_title：Leukemia

authors： Nishii K,Usui E,Katayama N,Lorenzo F 5th,Nakase K,Kobayashi T,Miwa H,Mizutani M,Tanaka I,Nasu K,Dohy H,Kyo T,Taniwaki M,Ueda T,Kita K,Shiku H

更新日期：2003-04-01 00:00:00

abstract：:Recent evidence has established an important role for leukemia inhibitory factor (LIF) as hematopoietically active cytokine. The present study utilized two different murine bone marrow stromal cell lines, +/+-1.LDA11 and MBA-13, to define regulatory mechanisms of LIF messenger RNA (mRNA) induction. LIF mRNA was not de...

journal_title：Leukemia

authors： Derigs HG,Boswell HS

更新日期：1993-04-01 00:00:00

abstract：:Several tyrosine kinases such as Jak1, Jak3, Lck and Syk are known to participate in IL-2-mediated intracellular signal transduction. Jak1, Lck and Syk are associated with the cytoplasmic domain of the beta chain, whereas Jak3 is associated with the cytoplasmic domain of the gamma chain, which is shared among receptor...

journal_title：Leukemia

authors： Higuchi M,Asao H,Tanaka N,Oda K,Takeshita T,Sugamura K

更新日期：1997-04-01 00:00:00

abstract：:In order to improve leukemia-free survival (LFS) without the treatment-related morbidity of allogeneic bone marrow transplantation or multiple prolonged cycles of consolidation chemotherapy, we evaluated the long-term outcome of autologous transplantation of peripheral blood progenitor cells (PBPCs) as postremission t...

journal_title：Leukemia

authors： Collisson EA,Lashkari A,Malone R,Paquette R,Emmanouilides C,Territo MC,Schiller GJ

更新日期：2003-11-01 00:00:00

abstract：:The authors analyzed twelve patients with symptomatic essential throthrombocythemia (E.T.) diagnosed from 1983 to 1991. Haemorrhagic and thrombotic phenomena were the main presenting features. Treatment consisted mostly of alpha-interferon (IFN-alpha 2b) subcutaneously in dosage ranging from 3 to 5 MU/m2 and hydroxyur...

journal_title：Leukemia

authors： Lopes E,Ribeiro MM,Silva MJ,Gandra M,Principe F,Granato C

更新日期：1992-01-01 00:00:00

abstract：:Jumping translocations (JT) are characterized by the relocalization of the same part of a donor to several recipient chromosomes. Although JT occasionally are constitutional, most are associated with hematologic malignancies. In such cases, JT usually arise during disease progression and are associated with poor progn...

journal_title：Leukemia

authors： Andreasson P,Höglund M,Jonson T,Békàssy A,Mitelman F,Johansson B

更新日期：1998-09-01 00:00:00