KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements.

abstract：:All-trans-retinoic (ATRA) treatment of patients with acute promyelocytic leukemia results in differentiation of the malignant cells and a high complete remission rate. ATRA treatment induced granulocytic differentiation in HL-60 cells as assessed by nitroblue tetrazolium (NBT) reduction, but had no effect on non-speci...

journal_title：Leukemia

authors： Hsu HC,Yang K,Kharbanda S,Clinton S,Datta R,Stone RM

更新日期：1993-03-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) cells with aggressive clinical properties express lipoprotein lipase (LPL), which generates activating ligands for the nuclear receptor peroxisome proliferator activated receptor (PPAR)α and allows fatty acids to be used as fuel. However, the role of PPARα in CLL is unclear. PPARα wa...

journal_title：Leukemia

authors： Spaner DE,Lee E,Shi Y,Wen F,Li Y,Tung S,McCaw L,Wong K,Gary-Gouy H,Dalloul A,Ceddia R,Gorzcynski R

更新日期：2013-04-01 00:00:00

abstract：:Eventually, gene therapy may be a valid option for chronic viral infections, including retroviral infections. Human retroviral diseases fit two categories: (1) those that result from a monoclonal outgrowth of a human T-cell leukemia virus type I (HTLV-I)-infected cell, as in the case of adult T cell leukemia (ATL); an...

journal_title：Leukemia

authors： Essex M,Matsuda Z,Yu X,Lee TH

更新日期：1995-10-01 00:00:00

abstract：:Approximately 25% of acute leukemias of the B-cell lineage demonstrate more than two rearranged immunoglobulin heavy chain genes when examined by Southern blot analysis. The origin of the extra bands was investigated by molecular cloning and sequencing of four rearranged genes from one patient's leukemic cells. All fo...

journal_title：Leukemia

authors： Carter M,Neale GA,Kitchingman GR

更新日期：1991-08-01 00:00:00

abstract：:Donor leukocyte infusions (DLI) have turned out to be an efficient way to re-establish complete remission (CR) in chronic myeloid leukemia (CML) patients relapsing after allogeneic bone marrow transplantation (BMT). In these patients, absence of PCR bcr-abl fusion transcripts confirmed the potency of donor leukocytes ...

journal_title：Leukemia

authors： Berthou C,Léglise MC,Herry A,Balcon D,Hardy E,Lessard M,Abgrall JF

更新日期：1998-11-01 00:00:00

abstract：:Therapy-related myelodysplastic syndrome and acute myelogenous leukemia (t-MDS/AML) are serious complications of chemotherapy and radiotherapy for cancer. High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) may be associated with an increased incidence of these complications. The frequency o...

journal_title：Leukemia

authors： Nichols G,de Castro K,Wei LX,Griffin M,Lin N,Oratzi A,Murty VV,Troxel A,Vahdat L,Hesdorffer C

更新日期：2002-09-01 00:00:00

abstract：:Natural killer (NK)-cell malignancies are uncommon diseases. Previously known as polymorphic reticulosis or angiocentric T-cell lymphomas, they are classified by the World Health Organization as NK/T-cell lymphoma, nasal type and aggressive NK-cell leukemia. They are prevalent in Asia and South America, but exceptiona...

journal_title：Leukemia

authors： Kwong YL

更新日期：2005-12-01 00:00:00

abstract：:Deletion and translocation involving the bands 11q14 and 11q21 have been detected in five patients with T cell acute lymphoblastic leukemia (ALL). The breakpoint on chromosome 11 was on the same band as that previously described in some acute nonlymphocytic leukemias: monocytic or myelomocytic. The existence of a new ...

journal_title：Leukemia

authors： Berger R,Le Coniat M,Derré J,Vecchione D,Chen SJ

更新日期：1989-08-01 00:00:00

abstract：:The EU-supported EuroFlow Consortium aimed at innovation and standardization of immunophenotyping for diagnosis and classification of hematological malignancies by introducing 8-color flow cytometry with fully standardized laboratory procedures and antibody panels in order to achieve maximally comparable results among...

journal_title：Leukemia

authors： Kalina T,Flores-Montero J,van der Velden VH,Martin-Ayuso M,Böttcher S,Ritgen M,Almeida J,Lhermitte L,Asnafi V,Mendonça A,de Tute R,Cullen M,Sedek L,Vidriales MB,Pérez JJ,te Marvelde JG,Mejstrikova E,Hrusak O,Szczepańs

更新日期：2012-09-01 00:00:00

abstract：:PCR-based monitoring of minimal residual disease (MRD) in acute leukemias can be achieved via detection of fusion gene transcripts of chromosome aberrations or detection of immunoglobulin (Ig) and T cell receptor (TCR) gene rearrangements. We wished to assess whether both PCR targets are complementary in acute myeloid...

journal_title：Leukemia

authors： Boeckx N,Willemse MJ,Szczepanski T,van der Velden VH,Langerak AW,Vandekerckhove P,van Dongen JJ

更新日期：2002-03-01 00:00:00

abstract：:Cellular stressors induce various outcomes including inhibition of cell proliferation and cell death. Sodium salicylate (SA), a plant stress hormone, can suppress the proliferation or cause apoptosis in certain mammalian cancer cells. Plant stress hormones are activators of cellular responses, including cell death, to...

journal_title：Leukemia

authors： Fingrut O,Flescher E

更新日期：2002-04-01 00:00:00

abstract：:Hematopoietic stem cells are identified based on their functional ability to migrate via the blood circulation of transplanted recipients, to home to the host bone marrow and to durably repopulate this organ with high levels of maturing myeloid and lymphoid cells. While a small pool of undifferentiated stem cells with...

journal_title：Leukemia

authors： Lapidot T,Kollet O

更新日期：2002-10-01 00:00:00

abstract：:We have used a 4-day MTT colorimetric assay to study drug sensitivity of leucocytes from leukaemia patients and from normal donors. Response to Adriamycin, vincristine, aclacinomycin A, 3'-deamino-3'-morpholino-13-deoxo-10-hydroxycarminomycin (MX2), and melphalan has been determined, together with the effects of the r...

journal_title：Leukemia

authors： Lambert E,Rees JK,Twentyman PR

更新日期：1992-10-01 00:00:00

abstract：:Membrane-derived vesicles (MV) are released from the surface of activated eucaryotic cells and exert pleiotropic effects on surrounding cells. Since the maintenance of pluripotency and undifferentiated propagation of embryonic stem (ES) cells in vitro requires tight cell to cell contacts and effective intercellular si...

journal_title：Leukemia

authors： Ratajczak J,Miekus K,Kucia M,Zhang J,Reca R,Dvorak P,Ratajczak MZ

更新日期：2006-05-01 00:00:00

abstract：:Arsenic trioxide (ATO) induces disease remission in acute promyelocytic leukemia (APL) patients, but not in non-APL acute myeloid leukemia (AML) patients. ATO at therapeutic concentrations (1-2 μM) induces APL NB4, but not non-APL HL-60, cells to undergo apoptosis through the mitochondrial pathway. The role of antiapo...

journal_title：Leukemia

authors： Wang R,Xia L,Gabrilove J,Waxman S,Jing Y

更新日期：2013-02-01 00:00:00

abstract：:The blast cells of acute myeloblastic leukemia may be considered as a renewal population maintained by stem cells that are capable of both self-renewal and differentiation. Blast stem cells grow in culture usually when stimulated by growth factors normally active on myelopoietic cells. Two culture methods permit an ev...

journal_title：Leukemia

authors： Miyauchi J,Kelleher CA,Wong GG,Yang YC,Clark SC,Minkin S,Minden MD,McCulloch EA

更新日期：1988-06-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Leukemia

authors： Thastrup M,Marquart HV,Levinsen M,Grell K,Abrahamsson J,Albertsen BK,Frandsen TL,Harila-Saari A,Lähteenmäki PM,Niinimäki R,Pronk CJ,Ulvmoen A,Vaitkevičienė G,Taskinen M,Schmiegelow K,Nordic Society of Pediatric Hematology a

更新日期：2020-10-01 00:00:00

abstract：:Commercial human chorionic gonadotrophin (HCG) preparations decrease the tumorigenicity of human tumors in immunodeficient mice and induce apoptotic cell death in animal tumor models. Preliminary studies in humans have demonstrated tumor regression in patients with Kaposi's sarcoma given intralesional injections of HC...

journal_title：Leukemia

authors： Feldman EJ,Seiter K,Chiao JW,Halicka HD,Traganos F,Fatora SR,McMichael J,Baskind P,Goff H,Beer M,Ahmed T,Darzynkiewicz Z

更新日期：1998-11-01 00:00:00

abstract：:The purpose of this study was to determine the incidence of and pharmacokinetic parameters associated with the development of transient encephalopathy following the administration of high-dose methotrexate and intrathecal chemotherapy in children with acute lymphoblastic leukemia (ALL). Two hundred and fifty-nine chil...

journal_title：Leukemia

authors： Rubnitz JE,Relling MV,Harrison PL,Sandlund JT,Ribeiro RC,Rivera GK,Thompson SJ,Evans WE,Pui CH

更新日期：1998-08-01 00:00:00

abstract：:We used a modification of the polymerase chain reaction (PCR) to amplify the specific bcr-abl mRNA from 14 patients with chronic myeloid leukemia (CML) who had previously received non T cell depleted allogenic bone marrow transplantation (BMT). Two types of reactions were used: a single step amplification with 5' and ...

journal_title：Leukemia

authors： Delfau MH,Kerckaert JP,Collyn d'Hooghe M,Fenaux P,Laï JL,Jouet JP,Grandchamp B

更新日期：1990-01-01 00:00:00

abstract：:Following the publication of this article, the authors noted that Patrick M. Vanderboom was inadvertently omitted from the author list. The correct author list is as follows: Sanjay Kumar, David Murray, Surendra Dasari, Paolo Milani, David Barnidge, Benjamin Madden, Patrick M. Vanderboom, Taxiarchis Kourelis, Bonnie A...

journal_title：Leukemia

authors： Kumar S,Murray D,Dasari S,Milani P,Barnidge D,Madden B,Kourelis T,Arendt B,Merlini G,Ramirez-Alvarado M,Dispenzieri A

更新日期：2019-04-01 00:00:00

abstract：:A murine megakaryoblastic cell line growing in protein-free culture (L8057Y5) was established from an experimentally induced murine leukemia (MK8057). Most of the Y5 cells were small and blast-like, with 2-4N in DNA content. Also, large cells possessing a lobulated nucleus characteristic of megakaryocytes, which showe...

journal_title：Leukemia

authors： Sasaki H,Kajigaya Y,Hirabayashi Y,Funabiki T,Inoue T,Yokota T,Ikuta K,Arai K,Matsuyama S

更新日期：1991-05-01 00:00:00

abstract：:Despite considerable advances in the treatment of multiple myeloma (MM) in the last decade, a substantial proportion of patients do not respond to current therapies or have a short duration of response. Furthermore, these treatments can have notable morbidity and are not uniformly tolerated in all patients. As there i...

journal_title：Leukemia

authors： Shah N,Chari A,Scott E,Mezzi K,Usmani SZ

更新日期：2020-04-01 00:00:00

abstract：:In order to investigate the frequency of HHV-8 in MM patients from another geographic location, we obtained fresh bone marrow (BM) biopsies from Turkish patients with MM (n = 21), monoclonal gammopathy of undetermined significance (MGUS) (n = 2), plasmacytoma (n = 1) with BM plasma cell infiltration, various hematolog...

journal_title：Leukemia

authors： Beksac M,Ma M,Akyerli C,DerDanielian M,Zhang L,Liu J,Arat M,Konuk N,Koc H,Ozcelik T,Vescio R,Berenson JR

更新日期：2001-08-01 00:00:00

abstract：:We assessed clinical results in 145 patients with chronic myeloid leukaemia in chronic phase who satisfied criteria for interferon-alpha failure and were thus eligible for treatment with imatinib at the Hammersmith Hospital. We used univariate and multivariate analyses to develop a risk score based on features defined...

journal_title：Leukemia

authors： Marin D,Marktel S,Bua M,Szydlo RM,Franceschino A,Nathan I,Foot N,Crawley C,Na Nakorn T,Olavarria E,Lennard A,Neylon A,O'Brien SG,Goldman JM,Apperley JF

更新日期：2003-08-01 00:00:00

abstract：:The t(9;11)(p21;q23) has been associated with characteristic clinical features and a superior treatment outcome in previously untreated pediatric acute myeloblastic leukemia (AML), but has not been well studied in children with secondary AML. This translocation was detected in 6.7% of de novo and 46% of secondary AML ...

journal_title：Leukemia

authors： Sandoval C,Head DR,Mirro J Jr,Behm FG,Ayers GD,Raimondi SC

更新日期：1992-06-01 00:00:00

abstract：:The occurrence of leukemia in a gene therapy trial for SCID-X1 has highlighted insertional mutagenesis as an adverse effect. Although retroviral integration near the T-cell acute lymphoblastic leukemia (T-ALL) oncogene LIM-only protein 2 (LMO2) appears to be a common event, it is unclear why LMO2 was preferentially ta...

journal_title：Leukemia

authors： Pike-Overzet K,de Ridder D,Weerkamp F,Baert MR,Verstegen MM,Brugman MH,Howe SJ,Reinders MJ,Thrasher AJ,Wagemaker G,van Dongen JJ,Staal FJ

更新日期：2007-04-01 00:00:00

abstract：:CD40 is a surface glycoprotein, member of the nerve growth factor receptor family, which is expressed on B cells and plays an important role in their development, growth, and differentiation. Using chromosomal in situ hybridization, we localized the CD40 gene to the long arm of chromosome 20, bands q12-q13.2. This loc...

journal_title：Leukemia

authors： Lafage-Pochitaloff M,Herman P,Birg F,Galizzi JP,Simonetti J,Mannoni P,Banchereau J

更新日期：1994-07-01 00:00:00

abstract：:We investigated the prognosis value of CD34 and P-170 expression in blast cells of adult patients affected by de novo acute myeloid leukemia (AML). CD34 antigen was analyzed by indirect immunofluorescence (IFI) and alkaline phosphatase-labeled streptavidin biotine (AP-LSAB) in 62 patients (median age: 51 years). P-170...

journal_title：Leukemia

authors： Lamy T,Goasguen JE,Mordelet E,Grulois I,Dauriac C,Drenou B,Chaperon J,Fauchet R,le Prise PY

更新日期：1994-11-01 00:00:00

abstract：:Specific myeloid-related and inositide-specific gene mutations can be linked to myelodysplastic syndromes (MDS) pathogenesis and therapy. Here, 44 higher-risk MDS patients were treated with azacitidine and lenalidomide and mutations analyses were performed at baseline and during the therapy. Results were then correlat...

journal_title：Leukemia

authors： Follo MY,Pellagatti A,Armstrong RN,Ratti S,Mongiorgi S,De Fanti S,Bochicchio MT,Russo D,Gobbi M,Miglino M,Parisi S,Martinelli G,Cavo M,Luiselli D,McCubrey JA,Suh PG,Manzoli L,Boultwood J,Finelli C,Cocco L

更新日期：2019-09-01 00:00:00