SETD2-mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia.

abstract：:Multiple myeloma is a deadly hematopoietic malignancy. Despite therapeutic advances such as autologous stem cell transplantation and novel chemotherapeutics, multiple myeloma remains incurable. Multiple myeloma cell localization in the bone marrow and the cross-talk with the bone niche trigger dramatic alterations in ...

journal_title：Leukemia

authors： Colombo M,Mirandola L,Platonova N,Apicella L,Basile A,Figueroa AJ,Cobos E,Chiriva-Internati M,Chiaramonte R

更新日期：2013-04-01 00:00:00

abstract：:Graft-versus-host disease (GVHD) remains a major immunological complication after allogeneic bone marrow transplantation (allo-BMT), but also favors development of the beneficial graft-versus-leukemia (GVL) effect. A patient with AML-M4 (inv (16)) is described, who was given non-myeloablative remission reinduction the...

journal_title：Leukemia

authors： Vandenberghe P,Verhoef GE,Emonds MP,Demuynck H,Zachée P,De Wolf-Peeters C,Decorte R,Cassiman JJ,Boogaerts MA

更新日期：1997-10-01 00:00:00

abstract：:BCL2 is deregulated in diffuse large B-cell lymphoma (DLBCL) by the t(14;18) translocation, gene amplification and/or nuclear factor-κB signaling. RNA-seq data have recently shown that BCL2 is the most highly mutated gene in germinal center B-cell (GCB) DLBCL. We have sequenced BCL2 in 298 primary DLBCL biopsies, 131 ...

journal_title：Leukemia

authors： Schuetz JM,Johnson NA,Morin RD,Scott DW,Tan K,Ben-Nierah S,Boyle M,Slack GW,Marra MA,Connors JM,Brooks-Wilson AR,Gascoyne RD

更新日期：2012-06-01 00:00:00

abstract：:Patients with acute myelogenous leukemia or myelodysplastic syndrome may respond to farnesyl transferase inhibitors (FTIs) with partial or complete response rates noted in about 30% of such patients. FTIs prevent the attachment of a lipid farnesyl moiety to dependent proteins prior to their insertion into the plasma m...

journal_title：Leukemia

authors： Liesveld JL,Lancet JE,Rosell KE,Menon A,Lu C,McNair C,Abboud CN,Rosenblatt JD

更新日期：2003-09-01 00:00:00

abstract：:Patients with hairy cell leukemia (HCL) are prone to opportunistic infections, which suggests an impaired T-cell functioning. To investigate a possible mechanism of such an impairment, we determined the numbers of naive and memory T cells by measuring the expression of CD45R0 on CD4+ and CD8+ T cells in 23 HCL patient...

journal_title：Leukemia

authors： van der Horst FA,van der Marel A,den Ottolander GJ,Kluin-Nelemans HC

更新日期：1993-01-01 00:00:00

abstract：:Burkitt lymphoma (BL) has a characteristic clinical presentation, morphology, immunophenotype and primary chromosomal aberration, that is, the translocation t(8;14)(q24;q32) or its variants. However, diagnostic dilemmas may arise in daily practice due to overlap of BL with subsets of other aggressive, mature B-cell ly...

journal_title：Leukemia

authors： Boerma EG,Siebert R,Kluin PM,Baudis M

更新日期：2009-02-01 00:00:00

abstract：:CAMAL (common antigen in myelogenous acute leukemia) is an antigenic preparation isolated in this laboratory from the bone marrow or peripheral blood cells of persons with myeloid leukemias and shown in an immunoperoxidase slide test to be diagnostic of these leukemias. CAMAL has been shown to be inhibitory to myelopo...

journal_title：Leukemia

authors： Leitch HA,Buskard N,Levy JG

更新日期：1993-09-01 00:00:00

abstract：:Sequential analysis of chimerism after allogeneic blood stem cell transplantation (BSCT) has been shown to be predictive for graft failure and relapse. We have explored the impact of a novel approach for the quantitative determination of chimerism using a commercial PCR assay with multiplex amplification of nine STR-l...

journal_title：Leukemia

authors： Thiede C,Bornhäuser M,Oelschlägel U,Brendel C,Leo R,Daxberger H,Mohr B,Florek M,Kroschinsky F,Geissler G,Naumann R,Ritter M,Prange-Krex G,Lion T,Neubauer A,Ehninger G

更新日期：2001-02-01 00:00:00

abstract：:Minimal residual disease (MRD) after allogeneic stem cell transplantation (SCT) for Ph+ acute lymphoblastic leukemia (ALL) is predictive of relapse. Imatinib administration subsequent to SCT may prevent relapse, but the role of scheduling and its impact on outcome are not known. In a prospective, randomized multicente...

journal_title：Leukemia

authors： Pfeifer H,Wassmann B,Bethge W,Dengler J,Bornhäuser M,Stadler M,Beelen D,Vucinic V,Burmeister T,Stelljes M,Faul C,Dreger P,Kiani A,Schäfer-Eckart K,Schwerdtfeger R,Lange E,Kubuschok B,Horst HA,Gramatzki M,Brück P,S

更新日期：2013-06-01 00:00:00

abstract：:Myeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized by chronic proliferation of hematopoietic progenitors. We studied the telomere length (TL) of 335 MPN patients and 93 gender- and age-matched controls using a quantitative PCR method (relative TL calculated as the ratio of the amount of t...

journal_title：Leukemia

authors： Bernard L,Belisle C,Mollica L,Provost S,Roy DC,Gilliland DG,Levine RL,Busque L

更新日期：2009-02-01 00:00:00

abstract：:In patients with hematologic malignancy, invasive aspergillosis continues to be associated with high mortality even when treated with conventional antifungal therapy. To investigate novel antifungal agents, we compared 53 patients who received posaconazole salvage therapy to 52 contemporary control patients who receiv...

journal_title：Leukemia

authors： Raad II,Hanna HA,Boktour M,Jiang Y,Torres HA,Afif C,Kontoyiannis DP,Hachem RY

更新日期：2008-03-01 00:00:00

abstract：:As typical disorders of the elderly, myelodysplastic syndromes (MDSs) are relatively unusual in childhood. Nevertheless, up to 17% of cases of pediatric acute myeloid leukemia may have a preleukemic phase. In young patients, the goal of treatment is eradication of the preleukemic malignant clone and reconstitution of ...

journal_title：Leukemia

authors： Locatelli F,Pession A,Bonetti F,Maserati E,Prete L,Pedrazzoli P,Zecca M,Prete A,Paolucci P,Cazzola M

更新日期：1994-05-01 00:00:00

abstract：:A novel erythroid cell line, RM10, was established from a long-term bone marrow culture of a patient with chronic myelogenous leukemia (CML). RM10 cells were positive for periodic acid Schiff (PAS), but negative for peroxidase and dual esterase. RM10 cells had la, pre B (CD10), myeloid (CD13, CD14, CD33) and erythroid...

journal_title：Leukemia

authors： Hirata J,Sato H,Takahira H,Shiokawa S,Endo T,Nishimura J,Katsuno M,Masuda S,Sasaki R,Fukumaki Y

更新日期：1990-05-01 00:00:00

abstract：:About half of the patients with follicular lymphoma will develop an aggressive B cell lymphoma with morphological changes in growth pattern and cellular morphology. Changes of the immunophenotype, especially of the expression of immunoglobulin (Ig) have been documented less frequently. Multiple tumor samples of two pa...

journal_title：Leukemia

authors： Raghoebier S,Broos L,Kramer MH,van Krieken JH,Kluin-Nelemans JC,van Ommen GJ,Kluin P

更新日期：1995-10-01 00:00:00

abstract：:The discovery of almost identical or 'stereotyped' B-cell receptor immunoglobulins (BcR IG) among unrelated patients with chronic lymphocytic leukemia (CLL) cemented the idea of antigen selection in disease ontogeny and evolution. The systematic analysis of the stereotypy phenomenon in CLL revealed that around one-thi...

journal_title：Leukemia

authors： Stamatopoulos K,Agathangelidis A,Rosenquist R,Ghia P

更新日期：2017-02-01 00:00:00

abstract：:Multiple myeloma (MM) is a plasma cell tumor marked by clonal evolution and preceded by a premalignant stage, which progresses via molecular pathway deregulation, including MYC activation. This activation relates to translocation or gain of the MYC locus and deregulation of upstream pathways such as IRF4, DIS3/LIN28B/...

journal_title：Leukemia

authors： Jovanović KK,Roche-Lestienne C,Ghobrial IM,Facon T,Quesnel B,Manier S

更新日期：2018-06-01 00:00:00

abstract：:ADMIRE was a multicenter, randomized-controlled, open, phase IIB superiority trial in previously untreated chronic lymphocytic leukemia. Conventional front-line therapy in fit patients is fludarabine, cyclophosphamide and rituximab (FCR). Initial evidence from non-randomized phase II trials suggested that the addition...

journal_title：Leukemia

authors： Munir T,Howard DR,McParland L,Pocock C,Rawstron AC,Hockaday A,Varghese A,Hamblin M,Bloor A,Pettitt A,Fegan C,Blundell J,Gribben JG,Phillips D,Hillmen P

更新日期：2017-10-01 00:00:00

abstract：:Injection of a dual tropic virus (DTV) isolated from a T cell lymphoma AKR/J mice into the thymus of 14 day old AKR/J puppies accelerates lymphoma development; 90-100% of the injected mice develop the disease within 120 days. In contrast a cell free centrifuge CFC-666 prepared B cell lymphoma of AKR/J origin injected ...

journal_title：Leukemia

authors： Peled A,Haran-Ghera N

更新日期：1988-12-01 00:00:00

abstract：:Hematopoietic stem cell transplantation is becoming an increasingly important approach to treatment of different malignant and non-malignant disorders. There is thus growing demand for diagnostic assays permitting the surveillance of donor/recipient chimerism posttransplant. Current techniques are heterogeneous, rende...

journal_title：Leukemia

authors： Lion T,Watzinger F,Preuner S,Kreyenberg H,Tilanus M,de Weger R,van Loon J,de Vries L,Cavé H,Acquaviva C,Lawler M,Crampe M,Serra A,Saglio B,Colnaghi F,Biondi A,van Dongen JJ,van der Burg M,Gonzalez M,Alcoceba M,Bar

更新日期：2012-08-01 00:00:00

abstract：:A patient with large granular lymphocyte (LGL) expansion (T-gamma lymphocytosis), neutropenia and thrombocytopenia was studied longitudinally. Analysis of peripheral blood mononuclear cells (PBMC) demonstrated an unusual large proportion of CD3+ T-lymphocytes expressing a gamma delta T-cell receptor (TcR-gamma delta)....

journal_title：Leukemia

authors： van Oostveen JW,Breit TM,de Wolf JT,Brandt RM,Smit JW,van Dongen JJ,Borst J,Melief CJ

更新日期：1992-05-01 00:00:00

abstract：:Following the publication of this article, the authors noted that Patrick M. Vanderboom was inadvertently omitted from the author list. The correct author list is as follows: Sanjay Kumar, David Murray, Surendra Dasari, Paolo Milani, David Barnidge, Benjamin Madden, Patrick M. Vanderboom, Taxiarchis Kourelis, Bonnie A...

journal_title：Leukemia

authors： Kumar S,Murray D,Dasari S,Milani P,Barnidge D,Madden B,Kourelis T,Arendt B,Merlini G,Ramirez-Alvarado M,Dispenzieri A

更新日期：2019-04-01 00:00:00

abstract：:We analyzed mRNA expression of the flt3 gene in 30 patients with acute myeloid leukemia (AML) and 50 with acute lymphoblastic leukemia (ALL). Using reverse transcriptase-polymerase chain reaction (RT-PCR), expression of flt3 was observed in 61 patients; 22 (73%) with AML and 39 (78%) with ALL. Among these, five patien...

journal_title：Leukemia

authors： Nakao M,Yokota S,Iwai T,Kaneko H,Horiike S,Kashima K,Sonoda Y,Fujimoto T,Misawa S

更新日期：1996-12-01 00:00:00

abstract：:Recent molecular-genetic studies have revealed that in the majority of patients with secondary leukemia induced by topoisomerase II (topo II) inhibitors and also with infantile acute leukemia (IAL), the breakpoints are clustered within scaffold attachment regions (SARs) of 3'-MLL-bcr near exon 9. Genistein, abundant i...

journal_title：Leukemia

authors： Abe T

更新日期：1999-03-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Leukemia

authors： Prutsch N,Gurnhofer E,Suske T,Liang HC,Schlederer M,Roos S,Wu LC,Simonitsch-Klupp I,Alvarez-Hernandez A,Kornauth C,Leone DA,Svinka J,Eferl R,Limberger T,Aufinger A,Shirsath N,Wolf P,Hielscher T,Sternberg C,Aberger F

更新日期：2020-11-01 00:00:00

abstract：:Deletions from the derivative chromosome 9, der(9), of the translocation, t(9;22)(q34;q11), at the site of the ABL/BCR fusion gene, have been demonstrated by fluorescence in situ hybridisation (FISH), in both Philadelphia chromosome (Ph)-positive chronic myeloid leukaemia (CML) and acute lymphoblastic leukaemia (ALL)....

journal_title：Leukemia

authors： Robinson HM,Martineau M,Harris RL,Barber KE,Jalali GR,Moorman AV,Strefford JC,Broadfield ZJ,Cheung KL,Harrison CJ

更新日期：2005-04-01 00:00:00

abstract：:The AML1 (RUNX1)-MTG8 (ETO) fusion transcription factor generated by the t(8;21) translocation is believed to deregulate the expression of genes that are crucial for normal differentiation and proliferation of hematopoietic progenitors, resulting in acute myelogenous leukemia. To elucidate the role of AML1-MTG8 in leu...

journal_title：Leukemia

authors： Shimada H,Ichikawa H,Ohki M

更新日期：2002-05-01 00:00:00

abstract：:This study demonstrates that the human bone marrow mononuclear cell fraction that adheres to plastic during a 2-h incubation period includes stromal precursors and hematopoietic progenitor cells that can sustain hematopoiesis for at least 5 weeks in a long-term culture (LTC) system. Delta (delta) assays were performed...

journal_title：Leukemia

authors： Gordon MY

更新日期：1994-05-01 00:00:00

abstract：:The adult marrow hematopoietic stem cell biology has largely been based on studies of highly purified stem cells. This is unfortunate because during the stem cell purification the great bulk of stem cells are discarded. These cells are actively proliferating. The final purified stem cell is dormant and not representat...

journal_title：Leukemia

authors： Quesenberry P,Goldberg L

更新日期：2017-08-01 00:00:00

abstract：:MUM1 (multiple myeloma oncogene 1)/IRF4 (interferon regulatory factor 4) is a transcription factor that is activated as a result of t(6;14)(p25;q32) in multiple myeloma. MUM1 expression is seen in various B-cell lymphomas and predicts an unfavorable outcome in some lymphoma subtypes. To elucidate its role in B-cell ma...

journal_title：Leukemia

authors： Uranishi M,Iida S,Sanda T,Ishida T,Tajima E,Ito M,Komatsu H,Inagaki H,Ueda R

更新日期：2005-08-01 00:00:00

abstract：:To assess the efficacy and toxicity of HAA regimen (homoharritonine 4 mg/m2/day, days 1-3; cytarabine 150 mg/m2/day, days 1-7; aclarubicin 12 mg/m2/day, days 1-7) as an induction therapy in the treatment of de novo acute myeloid leukemia (AML), 48 patients with newly diagnosed AML, aged 35 (14-57) years, were entered ...

journal_title：Leukemia

authors： Jin J,Jiang DZ,Mai WY,Meng HT,Qian WB,Tong HY,Huang J,Mao LP,Tong Y,Wang L,Chen ZM,Xu WL

更新日期：2006-08-01 00:00:00