Novel antifungal agents as salvage therapy for invasive aspergillosis in patients with hematologic malignancies: posaconazole compared with high-dose lipid formulations of amphotericin B alone or in combination with caspofungin.

abstract：:Tumorigenesis can be considered as pathologically misappropriated tissue regeneration. In this review we will address some unresolved issues that support this concept. First, we will address the issue of the identity of cancer-initiating cells and the presence of cancer stem cells in growing tumors. We will also ask a...

journal_title：Leukemia

authors： Ratajczak MZ,Bujko K,Mack A,Kucia M,Ratajczak J

更新日期：2018-12-01 00:00:00

abstract：:About half of the patients with follicular lymphoma will develop an aggressive B cell lymphoma with morphological changes in growth pattern and cellular morphology. Changes of the immunophenotype, especially of the expression of immunoglobulin (Ig) have been documented less frequently. Multiple tumor samples of two pa...

journal_title：Leukemia

authors： Raghoebier S,Broos L,Kramer MH,van Krieken JH,Kluin-Nelemans JC,van Ommen GJ,Kluin P

更新日期：1995-10-01 00:00:00

abstract：:Although dephosphorylation of tyrosine containing proteins is considered a necessary step in the induction of leukemia cell differentiation by hybrid polar compounds (HPC), the crucial actors in this step remain unknown. We present evidence that tyrosine phosphorylation of JAK1 and JAK2 is down-regulated in murine ery...

journal_title：Leukemia

authors： Arcangeli A,Fontana L,Crociani O,Cherubini A,Hofmann G,Piccini E,Polvani S,D'Amico M,Carlà M,Olivotto M

更新日期：2000-12-01 00:00:00

abstract：:Alterations in the FLT3 gene, including internal tandem duplications (ITDs) and D835 mutations occur frequently in acute myelogenous leukemia. We investigated the prevalence and clinico-biological correlations of FLT3 ITDs and D835 mutations in 90 patients with acute promyelocytic leukemia (APL) receiving the AIDA pro...

journal_title：Leukemia

authors： Noguera NI,Breccia M,Divona M,Diverio D,Costa V,De Santis S,Avvisati G,Pinazzi MB,Petti MC,Mandelli F,Lo Coco F

更新日期：2002-11-01 00:00:00

abstract：:We established the continuous growth of WEHI-3B D+ cells in protein-free chemically defined F-12 medium by stepwise decreases in the concentration of fetal calf serum. This cell line, designated as WEHI-3B-Y1, has now been propagated in protein-free F-12 medium for 3 years. The population-doubling time of the cells in...

journal_title：Leukemia

authors： Kajigaya Y,Ikuta K,Sasaki H,Matsuyama S

更新日期：1990-10-01 00:00:00

abstract：:Identification of agents that target human leukemia stem cells is an important consideration for the development of new therapies. The present study demonstrates that rocaglamide and silvestrol, closely related natural products from the flavagline class of compounds, are able to preferentially kill functionally define...

journal_title：Leukemia

authors： Callahan KP,Minhajuddin M,Corbett C,Lagadinou ED,Rossi RM,Grose V,Balys MM,Pan L,Jacob S,Frontier A,Grever MR,Lucas DM,Kinghorn AD,Liesveld JL,Becker MW,Jordan CT

更新日期：2014-10-01 00:00:00

abstract：:Proto-oncogenes are thought to be involved in cellular differentiation and proliferation. Tumor necrosis factors (TNFs) are specific cytokines that have cytostatic and cytotoxic effects in vitro against a wide range of human tumor cells. We have previously demonstrated that recombinant TNFs (rTNFs) have an antiprolife...

journal_title：Leukemia

authors： Schachner J,Blick M,Freireich E,Gutterman J,Beran M

更新日期：1988-11-01 00:00:00

abstract：:The inhibition of nuclear factor kappa B (NF-kappaB) by, for instance, curcumin is becoming an important new approach in combination with chemotherapy or irradiation for the treatment of a variety of cancers including haematological malignancies. A dose-limiting side effect of anticancer therapy in the gastrointestina...

journal_title：Leukemia

authors： van't Land B,Blijlevens NM,Marteijn J,Timal S,Donnelly JP,de Witte TJ,M'Rabet L

更新日期：2004-02-01 00:00:00

abstract：:The authors analyzed twelve patients with symptomatic essential throthrombocythemia (E.T.) diagnosed from 1983 to 1991. Haemorrhagic and thrombotic phenomena were the main presenting features. Treatment consisted mostly of alpha-interferon (IFN-alpha 2b) subcutaneously in dosage ranging from 3 to 5 MU/m2 and hydroxyur...

journal_title：Leukemia

authors： Lopes E,Ribeiro MM,Silva MJ,Gandra M,Principe F,Granato C

更新日期：1992-01-01 00:00:00

abstract：:This paper describes seven patients with ALL and a hypodiploid karyotype with less than 40 chromosomes. A consideration of these and 15 previously published cases indicates that they may be divided into two groups depending on chromosome number, i.e., less than 30 and 30-39. The less than 30 group are younger and pred...

journal_title：Leukemia

authors： Callen DF,Raphael K,Michael PM,Garson OM

更新日期：1989-10-01 00:00:00

abstract：:In a 56-year-old male patient, receiving chemotherapy after radical surgery for bladder carcinoma, an unusual type of cytoplasmic inclusion was discovered in about 30% of peripheral blood lymphocytes. This was a single, large (about 2 microns in diameter), round or ovoid body, darker than the nucleus and reddish-viole...

journal_title：Leukemia

authors： Rozman M,Vives-Corrons JL,Germá JR,Colomer D,Villamor N,Rozman C

更新日期：1994-12-01 00:00:00

abstract：:Epigenetic deregulation is involved in acute myeloid leukemia (AML) pathogenesis and epigenetic targeting drugs are in clinical trial. Since the first results with histone-deacetylase inhibitors in AML are controversial, novel single and combined treatments need to be explored. It is tempting to combine chromatin-targ...

journal_title：Leukemia

authors： Chaib H,Nebbioso A,Prebet T,Castellano R,Garbit S,Restouin A,Vey N,Altucci L,Collette Y

更新日期：2012-04-01 00:00:00

abstract：:We previously reported that susceptibility to childhood B cell precursor ALL (BCP ALL) is associated with HLA-DPB1 alleles having glutamic acid (E) rather than lysine (K) in the P4 antigenic peptide-binding pocket. Clustering approximately 90% of DPB1 alleles into DPB69E (DP2, 6, 8) and DPB69K (DP1, 3, 4) supertypes r...

journal_title：Leukemia

authors： Taylor GM,Hussain A,Verhage V,Thompson PD,Fergusson WD,Watkins G,Lightfoot T,Harrison CJ,Birch JM,UKCCS Investigators.

更新日期：2009-05-01 00:00:00

abstract：:Children with acute lymphoblastic leukemia (ALL) with > or = 0.01% leukemic cells in the bone marrow after remission induction are at a greater risk of relapse. The most promising methods of detecting minimal residual disease (MRD) are flow cytometric identification of leukemia-associated immunophenotypes and polymera...

journal_title：Leukemia

authors： Neale GA,Coustan-Smith E,Pan Q,Chen X,Gruhn B,Stow P,Behm FG,Pui CH,Campana D

更新日期：1999-08-01 00:00:00

abstract：:We applied a new strategy for the detection of N-ras gene mutations based on LightCycler technology. We designed two sets of amplimers and internal hybridization probes representing N-ras codons 12/13 and codon 61, respectively. Genomic DNAs from 134 childhood acute lymphoblastic leukemia (ALL) patients (83 common ALL...

journal_title：Leukemia

authors： Nakao M,Janssen JW,Seriu T,Bartram CR

更新日期：2000-02-01 00:00:00

abstract：:Retinoic acid receptor (RA) heterodimer (RAR/RXR) activities have been shown to be repressed by transcriptional co-repressor, SMRT/N-CoR, in the absence of the ligand while upon all-trans retionic acid (ATRA) treatment, SMRT/N-CoR is dissociated from RARalpha leading to gene expression by the recruitment of transcript...

journal_title：Leukemia

authors： So CW,Dong S,So CK,Cheng GX,Huang QH,Chen SJ,Chan LC

更新日期：2000-01-01 00:00:00

abstract：:Chronic graft-versus-host disease (GVHD) remains a serious complication after allogeneic hematopoietic stem cell transplantation (HCT). In 2005 the National Institutes of Health (NIH) established new criteria for chronic GVHD based on retrospective data and expert recommendations. We prospectively evaluated the incide...

journal_title：Leukemia

authors： Kuzmina Z,Eder S,Böhm A,Pernicka E,Vormittag L,Kalhs P,Petkov V,Stary G,Nepp J,Knobler R,Just U,Krenn K,Worel N,Greinix HT

更新日期：2012-04-01 00:00:00

abstract：:We have previously reported that constitutive expression of c-fos oncogene allows long-term proliferation of primary mouse bone marrow stromal cells favoring the granulocytic differentiation of myeloid precursors in an in vitro assay. Retrovirus-mediated gene transfer of the human c-fos gene was used here for immortal...

journal_title：Leukemia

authors： Steff AM,Bouaboula M,Mouchiroud G,Arnaud S,Roux P,Cassellas P,Piechaczyk M

更新日期：1996-03-01 00:00:00

abstract：:We investigated the expression of P-glycoprotein (P-gp) in 52 adults with de novo acute myelogenous leukemia (AML) at the initial diagnosis. We tested 52 patients by flow cytometry using the MRK16 monoclonal antibody (MoAb). To investigate the phenotype for multidrug resistance, 41 of the patients were analyzed using ...

journal_title：Leukemia

authors： Ino T,Miyazaki H,Isogai M,Nomura T,Tsuzuki M,Tsuruo T,Ezaki K,Hirano M

更新日期：1994-09-01 00:00:00

abstract：:Children with Down's syndrome (DS) have an increased risk of developing acute lymphoblastic leukemia (ALL) and have a low frequency of established genetic aberrations. We aimed to determine which genetic abnormalities are involved in DS ALL. We studied the frequency and prognostic value of deletions in B-cell developm...

journal_title：Leukemia

authors： Buitenkamp TD,Pieters R,Gallimore NE,van der Veer A,Meijerink JP,Beverloo HB,Zimmermann M,de Haas V,Richards SM,Vora AJ,Mitchell CD,Russell LJ,Schwab C,Harrison CJ,Moorman AV,van den Heuvel-Eibrink MM,den Boer ML,Zwaan

更新日期：2012-10-01 00:00:00

abstract：:Osteolysis resulting in extensive bone damage is a major clinical manifestation of patients with multiple myeloma (MM). The mechanisms of bone resorption in MM are incompletely understood. The final pathway is the generation of activated osteoclasts within bone marrow (BM) microenvironment. To investigate the mechanis...

journal_title：Leukemia

authors： Gregoretti MG,Bergui L,Aragno M,Cremona O,Marchisio PC,Caligaris-Cappio F

更新日期：1995-08-01 00:00:00

abstract：:Myelofibrosis (MF; primary or post-essential thrombocythemia/polycythemia vera) is incurable clonal myeloproliferative disorder, with no effective treatment. Epigenetic changes play an important role in cancer pathogenesis through transcriptional silencing of critical tumor suppressor genes. We conducted a phase-II st...

journal_title：Leukemia

authors： Quintás-Cardama A,Tong W,Kantarjian H,Thomas D,Ravandi F,Kornblau S,Manshouri T,Cortes JE,Garcia-Manero G,Verstovsek S

更新日期：2008-05-01 00:00:00

abstract：:The immune response to leukemia is poorly understood. We postulated that nonmalignant T lymphocytes remaining within bone marrow from children with newly diagnosed ALL could be involved in this immune response. T lymphocytes which expressed gamma delta TCR comprised less than 1% of ALL marrow cells. A preferential out...

journal_title：Leukemia

authors： Duval M,Yotnda P,Bensussan A,Oudhiri N,Guidal C,Rohrlich P,Boumsell L,Grandchamp B,Vilmer E

更新日期：1995-05-01 00:00:00

abstract：:Of 51 infants with acute leukemia, 13 (25%) had contradictory findings on 11q23/MLL rearrangements that were analyzed by cytogenetic and Southern blot methods: seven had rearranged MLL and normal karyotype, four had rearranged MLL and abnormal karyotype with no 11q23 translocation, and two had germline MLL and 11q23 t...

journal_title：Leukemia

authors： Watanabe N,Kobayashi H,Ichiji O,Yoshida MA,Kikuta A,Komada Y,Sekine I,Ishida Y,Horiukoshi Y,Tsunematsu Y,Yano M,Nakadate H,Kaneko Y

更新日期：2003-05-01 00:00:00

abstract：:Secondary chromosomal aberrations reported in the literature were surveyed in acute myeloid or lymphoblastic leukemia (AML or ALL) with one of the following primary abnormalities: in AML, t(1;3), t(1;22), der(1;7), inv(3), t(3;5) +4, del(5q), t(6;9), -7, t(7;11), del(7q), +8, t(8;16), t(8;21), +9, t(9;11), del(9q), t(...

journal_title：Leukemia

authors： Johansson B,Mertens F,Mitelman F

更新日期：1994-06-01 00:00:00

abstract：:The translocation t(11;20)(p15;q11) was found as the sole acquired clonal chromosome abnormality in two patients with acute myeloid leukemia. The bone marrow morphology in both cases corresponded to the M2 subtype of the French-American-British (FAB) classification. None of the patients achieved complete remission, an...

journal_title：Leukemia

authors： Mitelman F,Prigogina EL,Fleischman EW,Frenkel MA,Garwicz S,Heim S,Ilyinskaya GW,Kristoffersson U,Mandahl N,Volkova MA

更新日期：1988-07-01 00:00:00

abstract：:A prospective multicenter study was performed to investigate the clinical and molecular results of intensified double induction therapy including high-dose cytarabine (ara-C) in combination with ATRA in newly diagnosed acute promyelocytic leukemia (APL), followed by consolidation and 3 years maintenance therapy. Fifty...

journal_title：Leukemia

authors： Lengfelder E,Reichert A,Schoch C,Haase D,Haferlach T,Löffler H,Staib P,Heyll A,Seifarth W,Saussele S,Fonatsch C,Gassmann W,Ludwig WD,Hochhaus A,Beelen D,Aul C,Sauerland MC,Heinecke A,Hehlmann R,Wörmann B,Hiddemann

更新日期：2000-08-01 00:00:00

abstract：:The t(9;11)(p21;q23) has been associated with characteristic clinical features and a superior treatment outcome in previously untreated pediatric acute myeloblastic leukemia (AML), but has not been well studied in children with secondary AML. This translocation was detected in 6.7% of de novo and 46% of secondary AML ...

journal_title：Leukemia

authors： Sandoval C,Head DR,Mirro J Jr,Behm FG,Ayers GD,Raimondi SC

更新日期：1992-06-01 00:00:00

abstract：:Myelodysplastic syndromes (MDS) are a group of clonal hematologic disorders found predominantly in the elderly. The molecular mechanisms underlying the development of MDS remain obscure. In order to begin to identify tumor suppressor genes involved in these disorders, we performed a detailed microsatellite allelotype ...

journal_title：Leukemia

authors： Xie D,Hofmann WK,Mori N,Miller CW,Hoelzer D,Koeffler HP

更新日期：2000-05-01 00:00:00

abstract：:We have analyzed the expression of Tdt and CD7 in 335 cases of unequivocal acute myeloid leukemia (AML). Tdt was expressed in 80 (25%) of 321 evaluable cases. Twenty-six of 77 (34%) Tdt+ patients assessable for response, entered complete remission (CR) vs 121 of 209 (58%) Tdt- cases (P < 0.001). CD7 was expressed in 1...

journal_title：Leukemia

authors： Venditti A,Del Poeta G,Buccisano F,Tamburini A,Cox-Froncillo MC,Aronica G,Bruno A,Del Moro B,Epiceno AM,Battaglia A,Forte L,Postorino M,Cordero V,Santinelli S,Amadori S

更新日期：1998-07-01 00:00:00