Abstract：
:This paper describes seven patients with ALL and a hypodiploid karyotype with less than 40 chromosomes. A consideration of these and 15 previously published cases indicates that they may be divided into two groups depending on chromosome number, i.e., less than 30 and 30-39. The less than 30 group are younger and predominantly female when compared with the 30-39 group, who are generally older than 40 years and mainly male. In addition, the two groups show different characteristic patterns of chromosome loss. Morphologically, both groups have populations of large and small lymphoblasts containing numerous small vacuoles, and both have common ALL antigen phenotypes. We present the possibility that the ALL patients in the less than 30 group are an example of an age restricted leukemia. There is insufficient data to assess any prognostic differences between the two patient groupings.
journal_name
Leukemiajournal_title
Leukemiaauthors
Callen DF,Raphael K,Michael PM,Garson OMsubject
Has Abstractpub_date
1989-10-01 00:00:00pages
749-52issue
10eissn
0887-6924issn
1476-5551journal_volume
3pub_type
杂志文章相关文献
LEUKEMIA文献大全abstract：:Chronic lymphocytic leukemia (CLL) cells with aggressive clinical properties express lipoprotein lipase (LPL), which generates activating ligands for the nuclear receptor peroxisome proliferator activated receptor (PPAR)α and allows fatty acids to be used as fuel. However, the role of PPARα in CLL is unclear. PPARα wa...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2012.329
更新日期：2013-04-01 00:00:00
abstract：:P38α/β has been described as a tumor-suppressor controlling cell cycle checkpoints and senescence in epithelial malignancies. However, p38α/β also regulates other cellular processes. Here, we describe a role of p38α/β as a regulator of acute lymphoblastic leukemia (ALL) proliferation and survival in experimental ALL m...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2015.153
更新日期：2015-12-01 00:00:00
abstract：:In this report, a Radiation leukemia virus-transformed murine T cell lymphoma is described which is dependent on the interleukin-2 (IL-2) growth factor for proliferation under single cell conditions of growth. It was isolated from a C57BL mouse which had been primed with the Radiation leukemia virus-induced thymoma, C...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1988-02-01 00:00:00
abstract：:Interferon-alpha produces a complete hematologic and cytogenetic remission in approximately 20% of patients with chronic myelogenous leukemia (CML). In this study, we applied fluorescent in situ hybridization (FISH) methodology to examine the possibility that a low level of proliferating Philadelphia-chromosome-positi...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1993-02-01 00:00:00
abstract：:The immunological bone marrow (BM) microenvironment plays a major role in controlling growth and survival of clonal plasma cells (PC); this might translate into different patterns of expression of molecules involved in immune responses on PC from different types of monoclonal gammopathies (MG). We have studied the exp...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2403647
更新日期：2005-03-01 00:00:00
abstract：:Modern therapy for pediatric acute lymphoblastic leukemia (ALL) is based on the principle of risk stratification. One of the most important laboratory features used to accurately risk stratify patients is the presence of specific chromosomal translocation within the leukemic blasts. In this paper, we describe a multip...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2401224
更新日期：1998-12-01 00:00:00
abstract：:Relapse of malignant disease remains the major complication in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) after hematopoietic cell transplantation (HCT) with reduced-intensity conditioning (RIC). In this study, we investigated the predictive value of disease-specific markers (DSMs), d...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2010.283
更新日期：2011-03-01 00:00:00
abstract：:Translocation (15;17)(q22;q12-q21) is a chromosome aberration specifically found in acute promyelocytic leukemia (APL), that generates a chimeric gene between the promyelocytic leukemia (PML) gene on chromosome 15 and the retinoic acid receptor alpha (RARA) gene, on chromosome 17. In the course of molecular investigat...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Translocations involving the immunoglobulin loci are recurring events of B cell oncogenesis. The majority of translocations involve the immunoglobulin heavy chain (IGH) locus, while a minor part involves the immunoglobulin light chain loci consisting of the kappa light chain (IGK) located at 2p11.2 and the lambda ligh...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2402648
更新日期：2002-10-01 00:00:00
abstract：:We investigated the prognosis value of CD34 and P-170 expression in blast cells of adult patients affected by de novo acute myeloid leukemia (AML). CD34 antigen was analyzed by indirect immunofluorescence (IFI) and alkaline phosphatase-labeled streptavidin biotine (AP-LSAB) in 62 patients (median age: 51 years). P-170...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1994-11-01 00:00:00
abstract：:Inorganic arsenic trioxide (As(2)O(3)) is a highly effective treatment for acute promyelocytic leukemia (APL). However, other cancers do not respond well to this form of arsenic at clinically achievable doses. We tested a novel arsenical, S-dimethylarsino-glutathione (darinaparsin) for efficacy in various malignancies...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2008.194
更新日期：2008-10-01 00:00:00
abstract：:From 1987 to 1990, intensive postremission chemotherapy was compared to autologous bone marrow transplant in previously untreated children with AML who received identical induction therapy with two courses of Daunorubicin (DNR) and conventional dose ARA-C (protocol AIEOP LAM 87). Overall, 121 of the 155 eligible patie...
journal_title：Leukemia
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：1992-01-01 00:00:00
abstract：:Myelodysplastic syndromes (MDS) are a group of clonal hematologic disorders found predominantly in the elderly. The molecular mechanisms underlying the development of MDS remain obscure. In order to begin to identify tumor suppressor genes involved in these disorders, we performed a detailed microsatellite allelotype ...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2401717
更新日期：2000-05-01 00:00:00
abstract：:In order to investigate the frequency of HHV-8 in MM patients from another geographic location, we obtained fresh bone marrow (BM) biopsies from Turkish patients with MM (n = 21), monoclonal gammopathy of undetermined significance (MGUS) (n = 2), plasmacytoma (n = 1) with BM plasma cell infiltration, various hematolog...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2402190
更新日期：2001-08-01 00:00:00
abstract：:In a 56-year-old male patient, receiving chemotherapy after radical surgery for bladder carcinoma, an unusual type of cytoplasmic inclusion was discovered in about 30% of peripheral blood lymphocytes. This was a single, large (about 2 microns in diameter), round or ovoid body, darker than the nucleus and reddish-viole...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：:The role of endothelial progenitor cell (EPC)-mediated vasculogenesis in hematological malignancies is not well explored. Here, we showed that EPCs are mobilized from the bone marrow (BM) to the peripheral blood at early stages of multiple myeloma (MM); and recruited to MM cell-colonized BM niches. Using EPC-defective...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2016.3
更新日期：2016-05-01 00:00:00
abstract：:Current MRD studies in T-cell acute lymphoblastic leukemia (T-ALL) mainly use T-cell receptor gamma, delta and SIL-TAL1 gene rearrangements as MRD-PCR targets. However, low frequency or limited diversity of these markers restricts the number of evaluable patients, particularly because two markers are recommended for M...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2403263
更新日期：2004-04-01 00:00:00
abstract：:The main reason for the unfavorable clinical outcome of BCR-ABL1-positive acute lymphoblastic leukemia (ALL) is genetic instability. However, how normal B-cell precursors acquire the genetic changes that lead to transformation has not yet been completely defined. We investigated the expression of the activation-induce...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2009.197
更新日期：2010-01-01 00:00:00
abstract：:The INK4A/ARF locus yields two tumor suppressors, p16INK4A and p14ARF, and is frequently deleted in human tumors. We studied their mRNA expressions in 41 hematopoietic cell lines and in 137 patients with hematological malignancies; we used a quantitative reverse transcription-PCR assay. Normal peripheral bloods, bone ...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2401557
更新日期：1999-11-01 00:00:00
abstract：:This work represents an update of our experience on mobilization and transplantation of peripheral blood progenitor cells (PBPC) collected during the early recovery phase after chemotherapy in patients with chronic myelogenous leukemia. The collection of Ph-negative precursor cells occurred in 13/19 (68%) patients mob...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1996-06-01 00:00:00
abstract：:In this study we have analyzed the chromosomal changes in the preleukemic phase in SJL/J mice treated with radiation and acute myeloid leukemias (AMLs) induced by radiation alone or with additional corticosteroid treatment. SJL/J mice exposed to 300 rad whole body irradiation developed a low incidence of AML (20-25%) ...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：:Eight new cases (five adults and three children) of acute leukemia characterized by the presence in bone marrow cells of a t(4;11)(q21;q23)and one similar case, a child, with a t(1;11)(p32;q23) are reported. All patients were diagnosed as having acute lymphoblastic leukemia (ALL) with high-risk features. Immunological...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:The purpose of this paper was to ascertain whether results obtained in cell cultures of AML clonogenic blast cells would provide a useful model for a clinical regimen that combines fludarabine (F-ara-AMP) and cytosine arabinoside (ara-C). In the cultures the nucleoside F-ara-A was used. Blast cells from the continuous...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：:Chronic myeloid leukemia (CML) relapse after allogeneic stem cell transplantation (SCT) is a relatively frequent situation, which is correlated to disease status, time from diagnosis to transplant and T-cell depletion. We evaluated the potential for early minimal residual disease (MRD) BCR-ABL quantification to predic...
journal_title：Leukemia
pub_type： 临床试验,杂志文章
doi：10.1038/sj.leu.2404170
更新日期：2006-05-01 00:00:00
abstract：:T-cell acute lymphoblastic leukemia (T-ALL) is associated with chromosomal aberrations characterized by juxtaposition of proto-oncogenes to T-cell receptor gene loci (TCR), resulting in the deregulated transcription of these proto-oncogenes. Here, we describe the molecular characterization of a novel chromosomal aberr...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2403619
更新日期：2005-02-01 00:00:00
abstract：:CAMAL (common antigen in myelogenous acute leukemia) is an antigenic preparation isolated in this laboratory from the bone marrow or peripheral blood cells of persons with myeloid leukemias and shown in an immunoperoxidase slide test to be diagnostic of these leukemias. CAMAL has been shown to be inhibitory to myelopo...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1993-09-01 00:00:00
abstract：:Retinoids have significant antiproliferative effect against chronic myelogenous leukemia (CML) cells in vitro. We conducted a pilot study to investigate the clinical effect of all-trans retinoic acid (ATRA) in patients with CML. Thirteen patients with Philadelphia chromosome (Ph)-positive CML in late chronic phase (n=...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2400682
更新日期：1997-07-01 00:00:00
abstract：:A human acute lymphoblastic leukemia (ALL) cell line, BALM-9, was established from the peripheral blood specimen of a immunoglobin (lg) phenotype, the established BALM-9 cell line expressed both kappa and lambda light (L) chains simultaneously in a range of 30-80%. Two-color flow cytometric analysis demonstrated that ...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：:We report the results of a phase I dose escalation trial of the multikinase inhibitor sorafenib in relapsed and refractory acute leukemia patients using an intermittent dosing regimen. Fifteen patients with advanced leukemia (12 with acute myeloid leukemia, 2 with acute lymphoblastic leukemia, 1 with biphenotypic) and...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2010.132
更新日期：2010-08-01 00:00:00
abstract：:Forty of the 550 patients (7%) entered to the 11q23 Workshop had secondary (s) acute lymphoblastic leukemia (nine cases), s-acute myeloid leukemia (25 cases, predominantly of FAB type M5), s-acute leukemia unspecified (one case) or s-myelodysplastic syndrome (five cases) following treatment for a primary malignancy. B...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2401021
更新日期：1998-05-01 00:00:00
