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AML patients with Down syndrome have a high cure rate with AML-BFM therapy with reduced dose intensity.

Abstract：

:Despite improved prognosis in acute myelogenous leukaemia (AML) children with Down syndrome (DS), therapy-related toxicity remained a problem. We compared 67 DS patients from study AML-BFM 98 with 51 DS patients of the previous study AML-BFM 93, and the non-DS groups of both studies. Compared to non-DS patients, DS patients were treated with reduced anthracycline doses, without high-dose cytarabine/mitoxantrone and without cranial irradiation. AML-DS patients were in median 1.8 years old, and 102/118 (86%) showed the typical morphology of acute megakaryoblastic leukaemia. In study 93, seven DS patients did not receive AML-specific chemotherapy, and treatment modifications were more common. Results improved significantly for patients treated in study 98 with a 3-year survival of 91+/-4 vs 70+/-7% in study 93 (P=0.001). There were no differences in outcome concerning the age groups 0-

journal_name

Leukemia

journal_title

Leukemia

authors

Creutzig U,Reinhardt D,Diekamp S,Dworzak M,Stary J,Zimmermann M

doi

10.1038/sj.leu.2403814

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

1355-60

issue

8

eissn

0887-6924

issn

1476-5551

pii

2403814

journal_volume

19

pub_type

临床试验,杂志文章

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