Myeloid to lymphoid clonal succession following autologous transplantation in second chronic phase of chronic myeloid leukaemia.

abstract：:Oligoclonal B cell proliferation, as defined by the presence of more than one leukemic clone, has been detected in approximately 20% to 30% of patients with acute lymphoblastic leukemia (ALL) using PCR or Southern blotting. An accurate assessment of these populations is required to avoid false negative measurements of...

journal_title：Leukemia

authors： Moreira I,Papaioannou M,Mortuza FY,Gameiro P,Palmisano GL,Harrison CJ,Prentice HG,Mehta AB,Hoffbrand AV,Foroni L

更新日期：2001-10-01 00:00:00

abstract：:A total of 28 children and nine adults with relapsed T-ALL were analyzed for the configuration of their T-cell receptor (TCR) and TAL1 genes at diagnosis and relapse to evaluate their stability throughout the disease course. A total of 150 clonal TCR and TAL1 gene rearrangements were identified in the 37 patients at d...

journal_title：Leukemia

authors： Szczepański T,van der Velden VH,Raff T,Jacobs DC,van Wering ER,Brüggemann M,Kneba M,van Dongen JJ

更新日期：2003-11-01 00:00:00

abstract：:Acute myeloid leukemia (AML) with minimal differentiation was usually referred to as acute undifferentiated leukemia in the past. With the help of immunophenotyping, this subtype of leukemia was shown to express myeloid antigens on the blasts and was designated AML-M0 by FAB Cooperative Study Group in 1991. Among the ...

journal_title：Leukemia

authors： Huang SY,Tang JL,Jou ST,Tsay W,Hu CH,Lin DT,Lin KS,Lin KS,Wang CH,Chen YC,Shen MC,Tien HF

更新日期：1999-10-01 00:00:00

abstract：:We evaluated the synergistic activity of AS101 (ammonium trichloro-(dioxoethylene-0-0')-tellurate) with the protein kinase C (PKC) activators, Bryostatin-1 and phorbol-12-myristate-13-acetate (PMA), on human myelocytic leukemia cell differentiation in vitro, and in a mouse model. Use of AS101 with Bryostatin-1 or with...

journal_title：Leukemia

authors： Hayun M,Okun E,Hayun R,Gafter U,Albeck M,Longo DL,Sredni B

更新日期：2007-07-01 00:00:00

abstract：:Positive selection of CD34+ cells has applications in diagnostic pathology, in peripheral blood and bone marrow transplantation, and in studies on the function and regulation of primitive haemopoietic stem cells. Antibody-coated magnetic microspheres (dynabeads) can be used to isolate these cells by positive selection...

journal_title：Leukemia

authors： Grimsley PG,Amos TA,Gordon MY,Greaves MF

更新日期：1993-06-01 00:00:00

abstract：:Mitochondrial genome instability has recently been demonstrated in a wide variety of human tumours and is implicated in the development of the myelodysplastic syndromes, a heterogeneous group of haematological disorders with an increased risk of malignant transformation. We therefore investigated the incidence of soma...

journal_title：Leukemia

authors： He L,Luo L,Proctor SJ,Middleton PG,Blakely EL,Taylor RW,Turnbull DM

更新日期：2003-12-01 00:00:00

abstract：:HOX homeobox proteins are key oncogenic drivers in hematopoietic malignancies. Here we demonstrate that HOXA1, HOXA6 and predominantly HOXA9 are able to induce the production of insulin-like growth factor 1 (Igf1). In chromatin immunoprecipitations, HOXA9 bound directly to the putative promoter and a DNase-hypersensit...

journal_title：Leukemia

authors： Steger J,Füller E,Garcia-Cuellar MP,Hetzner K,Slany RK

更新日期：2015-04-01 00:00:00

abstract：:We studied both serum-free colony-forming unit-megakaryocyte (CFU-meg) numbers and serum thrombopoietin (TPO) levels in 14 patients with aplastic anemia (AA), 37 patients with myelodysplastic syndromes (MDS) and 23 patients with idiopathic thrombocytopenic purpura (ITP) to assess thrombopoiesis in these thrombocytopen...

journal_title：Leukemia

authors： Wang W,Matsuo T,Yoshida S,Mori H,Miyazaki Y,Kuriyama K,Tomonaga M

更新日期：2000-10-01 00:00:00

abstract：:It has been reported that stroma-dependent cultures support proliferation of hematopoietic stem cells (HSC). In order to investigate the effect of soluble stromal factors, we developed short-term serum-low liquid cultures in which the effect of stroma-conditioned media (SCM) from the murine FBMD-1, and human L87/4 and...

journal_title：Leukemia

authors： Breems DA,Blokland EA,Ploemacher RE

更新日期：1997-01-01 00:00:00

abstract：:We have shown a new phenomenon demonstrating that BALB/c female mice mated to C57BL/6 males during a year (7-10 pregnancies) develop AIDS-like disease or acute leukemia after an additional immunization with fixed ConA activated paternal (C57BL/6) lymphocytes. The AIDS-like disease is sexually and vertically transmissi...

journal_title：Leukemia

authors： Ter-Grigorov V,Krifuks O,Liubashevsky E,Nyska A,Toder V,Trainin Z

更新日期：1997-04-01 00:00:00

abstract：:Adolescents had lower rates of remission induction and shorter event-free survival than younger children in this study of consecutively treated patients with acute lymphoblastic leukemia (ALL). When compared to the younger patients (ages 1-9 years; n = 995), adolescents (ages 10-21 years; n = 338) were significantly m...

journal_title：Leukemia

authors： Santana VM,Dodge RK,Crist WM,Rivera GK,Look AT,Behm FG,Raimondi SC,Pui CH

更新日期：1990-02-01 00:00:00

abstract：:Only two classes of chemotherapeutic agents have shown activity in acute myeloid leukemia (AML): ara-C and topoisomerase II reactive agents. Frontline combinations of these agents produce complete response (CR) rates of 70% and long-term event free survival rates of 25%. New agents with different mechanisms of action ...

journal_title：Leukemia

authors： Kantarjian HM,Estey EH,Keating MA

更新日期：1996-04-01 00:00:00

abstract：:Primary myelofibrosis (PMF) is a hematopoietic stem cell (HSC) disease, characterized by aberrant differentiation of all myeloid lineages and profound disruption of the bone marrow niche. PMF samples carry several mutations, but their cell origin and hierarchy in regulating the different waves of clonal and aberrant m...

journal_title：Leukemia

authors： Triviai I,Zeschke S,Rentel J,Spanakis M,Scherer T,Gabdoulline R,Panagiota V,Thol F,Heuser M,Stocking C,Kröger N

更新日期：2019-01-01 00:00:00

abstract：:Runt-related transcription factor 1 (RUNX1) is essential for normal hematopoiesis. RUNX1 mutations have rarely been reported in chronic myelomonocytic leukemia (CMML). We examined RUNX1 mutations in 81 patients with CMML at initial diagnosis. Mutational analysis was performed on bone marrow samples by direct sequencin...

journal_title：Leukemia

authors： Kuo MC,Liang DC,Huang CF,Shih YS,Wu JH,Lin TL,Shih LY

更新日期：2009-08-01 00:00:00

abstract：:We have previously shown that all-trans retinoic acid (ATRA) increases the number of CFU-GM colonies grown from unseparated human bone marrow cells with crude sources of colony stimulating factors. In this study, we further characterized the effect of ATRA on the growth of CFU-GM stimulated by individual cytokines fro...

journal_title：Leukemia

authors： Douer D,Ramezani L,Parker J,Levine AM

更新日期：2000-05-01 00:00:00

abstract：:Abnormalities of several cell-cycle regulatory genes including cyclin D1, p16CDKN2 and p15CDKN2B have been described in B cell non-Hodgkin's lymphoma (B-NHL). We describe a new B-NHL cell line (Granta 519), with concurrent abnormalities of the cyclin D1, pl6CDKN2 and pl5CDKN2B genes. An independent clinical case of ma...

journal_title：Leukemia

authors： Jadayel DM,Lukas J,Nacheva E,Bartkova J,Stranks G,De Schouwer PJ,Lens D,Bartek J,Dyer MJ,Kruger AR,Catovsky D

更新日期：1997-01-01 00:00:00

abstract：:The clinical and biologic characteristics of acute myeloid leukemia (AML) with coexpression of lymphoid-associated antigens (Lym+ AML) were studied from 39 cases who represented 24% of 161 newly diagnosed de novo AML. Twenty-seven cases (16.8%) were positive for the expression of T-cell markers (T+ AML) and 12 (7.5%) ...

journal_title：Leukemia

authors： Tien HF,Wang CH,Chen YC,Shen MC,Lin DT,Lin KH

更新日期：1993-05-01 00:00:00

abstract：:Self-renewal, as defined by the capacity to yield new colonies following replating, is an important function of leukemic progenitors (L-CFU) to originate self-maintaining clones. In this work, we studied the effect of hyperthermia (41-44 degrees C) on the growth of human L-CFU derived primary colonies and of secondary...

journal_title：Leukemia

authors： Moriyama Y,Nikkuni K,Saito H,Aoki A,Kishi K,Takahashi M,Shibata A

更新日期：1991-04-01 00:00:00

abstract：:The growth of B-cell precursor acute lymphoblastic leukemic (BCP ALL) cells in vitro is dependent on interactions with bone marrow (BM) stromal cells. We have recently demonstrated that the rate of cell division of BCP ALL cells increases when cultured in direct contact with BM stromal cells. In this study we describe...

journal_title：Leukemia

authors： Ashley DM,Bol SJ,Tucker DP,Waugh CM,Kannourakis G

更新日期：1995-01-01 00:00:00

abstract：:The clinical, hematological, and cytogenetic data from two young adults with acute myeloid leukemia (AML) FAB type M1 is described. At diagnosis, cytogenetic investigation revealed the presence of the translocation t(6;9)(p23;q34). Bone marrow basophilia was not detected in either patient nor was there any evidence of...

journal_title：Leukemia

authors： Lillington DM,MacCallum PK,Lister TA,Gibbons B

更新日期：1993-04-01 00:00:00

abstract：:Immunoglobulin light chain amyloidosis is a protein deposition disorder where the precursor protein represents a monoclonal immunoglobulin light or heavy chain. Deposition in viscera results in restrictive cardiomyopathy, nephrotic range proteinuria, demyelinating peripheral neuropathy, hepatomegaly and malabsorption ...

journal_title：Leukemia

authors： Gertz MA

更新日期：2012-02-01 00:00:00

abstract：:Multiple myeloma is the second most frequent hematological cancer after lymphoma and remains an incurable disease. The pervasive support provided by the bone marrow microenvironment to myeloma cells is crucial for their survival. Here, an unbiased assessment of receptor tyrosine kinases overexpressed in myeloma identi...

journal_title：Leukemia

authors： Frenquelli M,Caridi N,Antonini E,Storti F,Viganò V,Gaviraghi M,Occhionorelli M,Bianchessi S,Bongiovanni L,Spinelli A,Marcatti M,Belloni D,Ferrero E,Karki S,Brambilla P,Martinelli-Boneschi F,Colla S,Ponzoni M,DePinho R

更新日期：2020-01-01 00:00:00

abstract：:The t(9;11)(p21;q23) has been associated with characteristic clinical features and a superior treatment outcome in previously untreated pediatric acute myeloblastic leukemia (AML), but has not been well studied in children with secondary AML. This translocation was detected in 6.7% of de novo and 46% of secondary AML ...

journal_title：Leukemia

authors： Sandoval C,Head DR,Mirro J Jr,Behm FG,Ayers GD,Raimondi SC

更新日期：1992-06-01 00:00:00

abstract：:In this study we have analyzed the chromosomal changes in the preleukemic phase in SJL/J mice treated with radiation and acute myeloid leukemias (AMLs) induced by radiation alone or with additional corticosteroid treatment. SJL/J mice exposed to 300 rad whole body irradiation developed a low incidence of AML (20-25%) ...

journal_title：Leukemia

authors： Trakhtenbrot L,Krauthgamer R,Resnitzky P,Haran-Ghera N

更新日期：1988-08-01 00:00:00

abstract：:The effect of imatinib on chlorambucil (CLB) cytotoxicity in chronic lymphocytic leukemia (CLL) lymphocytes was examined in vitro. Imatinib sensitizes the WSU and I83 human CLL cell lines, 10- and two-fold, respectively, to CLB. Furthermore, in primary cultures of malignant B-lymphocytes obtained from 12 patients with...

journal_title：Leukemia

authors： Aloyz R,Grzywacz K,Xu ZY,Loignon M,Alaoui-Jamali MA,Panasci L

更新日期：2004-03-01 00:00:00

abstract：:The presence of rare malignant stem cells supplying a hierarchy of malignant cells has recently been reported. In human acute myelogenous leukemia (AML), the leukemia stem cells (LSCs) have been phenotypically restricted within the CD34+CD38- fraction. To understand the origin of malignant cells in primary human B-pre...

journal_title：Leukemia

authors： Kong Y,Yoshida S,Saito Y,Doi T,Nagatoshi Y,Fukata M,Saito N,Yang SM,Iwamoto C,Okamura J,Liu KY,Huang XJ,Lu DP,Shultz LD,Harada M,Ishikawa F

更新日期：2008-06-01 00:00:00

abstract：:The number of allogeneic transplants from unrelated donors has grown in the past decade in part because of the expansion of the donor registry size. Patient survival has improved due to the selection of more closely matched donors and the development of effective infection prophylaxis. Relapse-free survival remains li...

journal_title：Leukemia

authors： Anasetti C

更新日期：2000-03-01 00:00:00

abstract：:Imatinib is a highly effective therapy for chronic phase-chronic myeloid leukaemia (CP-CML) patients; however, responses to frontline imatinib are variable. The human organic cation transporter 1 (OCT1; SLC22A1) has been reported to be the main influx transporter involved in imatinib uptake into CML cells. Furthermore...

journal_title：Leukemia

authors： Watkins DB,Hughes TP,White DL

更新日期：2015-10-01 00:00:00

abstract：:The T-lineage phenotype in children with acute lymphoblastic leukaemia (ALL) is associated with in vitro drug resistance and a higher relapse-risk compared to a precursor B phenotype. Our study was aimed to investigate whether mutations in the ATM gene occur in childhood T-lineage acute lymphoblastic leukaemia (T-ALL)...

journal_title：Leukemia

authors： Meier M,den Boer ML,Hall AG,Irving JA,Passier M,Minto L,van Wering ER,Janka-Schaub GE,Pieters R

更新日期：2005-11-01 00:00:00

abstract：:Four randomized prospective studies on interferon alpha (IFN) in CML report varying degrees of prolongation of the chronic phase of CML and of survival as compared to conventional therapies. There is agreement that IFN prolongs survival as compared to standard busulfan. There is disagreement, however, as to which degr...

journal_title：Leukemia

authors： Hehlmann R,Willer A,Heimpel H,Hasford J,Kolb HJ,Pralle H,Hossfeld DK,Queisser W,Löffler H,Hochhaus A,Tobler A,Lengfelder E,Berger U,Leib-Mösch C

更新日期：1997-04-01 00:00:00