Insulin-like growth factor 1 is a direct HOXA9 target important for hematopoietic transformation.

abstract：:The response of human acute myelogenous leukemia (AML) cells to four different hematopoietic growth factors (granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-1 beta (IL-1beta), interleukin-3 (IL-3), and stem cell factor (SCF)) and the relationship of the proliferative response of the AML cells to...

journal_title：Leukemia

authors： Tsuzuki M,Ezaki K,Maruyama F,Ino T,Kojima H,Okamoto M,Yamaguchi T,Nomura T,Miyazaki H,Wakita M,Matsui T,Hirano M

更新日期：1997-12-01 00:00:00

abstract：:Clonal chromosome abnormalities were detected in bone marrow cells of 20 patients with Fanconi anemia investigated at various stages of the disease. Two presented with acute leukemia, six with myelodysplastic syndrome, and 12 had minor or no morphological abnormalities of hematopoietic cells. Abnormalities of chromoso...

journal_title：Leukemia

authors： Maarek O,Jonveaux P,Le Coniat M,Derré J,Berger R

更新日期：1996-11-01 00:00:00

abstract：:Little is known about the incidence of and risk factor for late effects of infant leukemia. We evaluated 19 children with acute lymphoblastic leukemia and 15 with acute myeloid leukemia who were diagnosed at age 12 months or younger and have survived for more than 5 years after the diagnosis (median length of follow-u...

journal_title：Leukemia

authors： Leung W,Hudson M,Zhu Y,Rivera GK,Ribeiro RC,Sandlund JT,Bowman LC,Evans WE,Kun L,Pui CH

更新日期：2000-07-01 00:00:00

abstract：:Deletion and translocation involving the bands 11q14 and 11q21 have been detected in five patients with T cell acute lymphoblastic leukemia (ALL). The breakpoint on chromosome 11 was on the same band as that previously described in some acute nonlymphocytic leukemias: monocytic or myelomocytic. The existence of a new ...

journal_title：Leukemia

authors： Berger R,Le Coniat M,Derré J,Vecchione D,Chen SJ

更新日期：1989-08-01 00:00:00

abstract：:The notion that inherited predisposition contributes to the development of haematological malignancies is generally thought of as being a relatively new idea. However, Videbaek made a clear enunciation of such a hypothesis in 1947, from a study of tumour incidence in relatives of patients with different leukaemias. To...

journal_title：Leukemia

authors： Jønsson V,Houlston RS,Catovsky D,Yuille MR,Hilden J,Olsen JH,Fajber M,Brandt B,Sellick G,Allinson R,Wiik A

更新日期：2005-06-01 00:00:00

abstract：:The expression of the myeloperoxidase (MPO) gene was studied, by means of Northern blot analysis in 14 cases of acute myeloid leukemia (AML), 11 cases of chronic myeloid leukemia (CML), and 6 cases of CML blast crisis, and in HL60 cells before and after induction of terminal differentiation with retinoic acid (RA), ph...

journal_title：Leukemia

authors： Ferrari S,Tagliafico E,Ceccherelli G,Selleri L,Calabretta B,Donelli A,Temperani P,Sarti M,Sacchi S,Emilia G

更新日期：1989-06-01 00:00:00

abstract：:East Asians, Asian Indians and Amerindians have a five to ten-fold lower age-adjusted incidence rate (AAIR) of chronic lymphocytic leukaemia (CLL) compared with persons of predominately European descent. The data we review suggest a genetic rather than environmental basis for this discordance. All these populations ar...

journal_title：Leukemia

authors： Yang S,Varghese AM,Sood N,Chiattone C,Akinola NO,Huang X,Gale RP

更新日期：2020-10-19 00:00:00

abstract：:Mitochondrial genome instability has recently been demonstrated in a wide variety of human tumours and is implicated in the development of the myelodysplastic syndromes, a heterogeneous group of haematological disorders with an increased risk of malignant transformation. We therefore investigated the incidence of soma...

journal_title：Leukemia

authors： He L,Luo L,Proctor SJ,Middleton PG,Blakely EL,Taylor RW,Turnbull DM

更新日期：2003-12-01 00:00:00

abstract：:These ECOG trials have demonstrated that progressive increments in the intensity of post-remission therapy result in improving long-term, disease-free survival in adults with AML. The median duration of disease-free survival and long-term outcome from different post-remission therapies are summarized in Table 4. [tabl...

journal_title：Leukemia

authors： Cassileth PA,Andersen JW,Bennett JM,Harrington DP,Hines JD,Lazarus HM,Mazza JJ,McGlave PP,O'Connell MJ,Paietta E

更新日期：1992-01-01 00:00:00

abstract：:Recurrent chromosomal rearrangements are observed in many leukemia subtypes. Recently, it has been shown that several of these translocations/inversions were associated with the loss of sequences located in the vicinity of the chromosomal breakpoints. So far, such deletions have not been described for the t(8;21) tran...

journal_title：Leukemia

authors： Godon C,Proffitt J,Dastugue N,Lafage-Pochitaloff M,Mozziconacci MJ,Talmant P,Hackbarth M,Bataille R,Avet-Loiseau H

更新日期：2002-09-01 00:00:00

abstract：:Multiple myeloma (MM) is the second most common blood malignancy. Epidemiological family studies going back to the 1920s have provided evidence for familial aggregation, suggesting a subset of cases have an inherited genetic background. Recently, studies aimed at explaining this phenomenon have begun to provide direct...

journal_title：Leukemia

authors： Pertesi M,Went M,Hansson M,Hemminki K,Houlston RS,Nilsson B

更新日期：2020-03-01 00:00:00

abstract：:Adult BL/6 mice are highly sensitive to lymphomagnesis by the radiation leukemia virus variant A-RadLV (80-100% T-cell lymphoma incidence after a latency of 70-110 days). This study shows that the in vivo elimination of T-cell subsets (including suppressor and cytotoxic T-cells) achieved by the repeated administration...

journal_title：Leukemia

authors： Haran-Ghera N,Peled A

更新日期：1991-06-01 00:00:00

abstract：:To determine the frequency and prognostic significance of recently described genetic lesions in pediatric acute lymphoblastic leukemia (ALL), all cases with available leukemic cell samples treated on St Jude Study XII were analyzed by molecular techniques for alterations of the p16, MLL and ETV6 genes. Homozygous p16 ...

journal_title：Leukemia

authors： Rubnitz JE,Behm FG,Pui CH,Evans WE,Relling MV,Raimondi SC,Harrison PL,Sandlund JT,Ribeiro RC,Grosveld G,Downing JR

更新日期：1997-08-01 00:00:00

abstract：:Transformation of post-myeloproliferative neoplasms into secondary (s) AML exhibit poor clinical outcome. In addition to increased JAK-STAT and PI3K-AKT signaling, post-MPN sAML blast progenitor cells (BPCs) demonstrate increased nuclear β-catenin levels and TCF7L2 (TCF4) transcriptional activity. Knockdown of β-caten...

journal_title：Leukemia

authors： Saenz DT,Fiskus W,Manshouri T,Mill CP,Qian Y,Raina K,Rajapakshe K,Coarfa C,Soldi R,Bose P,Borthakur G,Kadia TM,Khoury JD,Masarova L,Nowak AJ,Sun B,Saenz DN,Kornblau SM,Horrigan S,Sharma S,Qiu P,Crews CM,Versto

更新日期：2019-06-01 00:00:00

abstract：:Although dephosphorylation of tyrosine containing proteins is considered a necessary step in the induction of leukemia cell differentiation by hybrid polar compounds (HPC), the crucial actors in this step remain unknown. We present evidence that tyrosine phosphorylation of JAK1 and JAK2 is down-regulated in murine ery...

journal_title：Leukemia

authors： Arcangeli A,Fontana L,Crociani O,Cherubini A,Hofmann G,Piccini E,Polvani S,D'Amico M,Carlà M,Olivotto M

更新日期：2000-12-01 00:00:00

abstract：:The involvement of the BCRlABL fusion gene in patients with Philadelphia (Ph) chromosome positive chronic myeloid leukaemia (CML) and acute lymphoblastic leukaemia (ALL) is well characterised, but the molecular events underlying the cases of Ph-negative CML and ALL that lack BCR gene involvement and those that cause t...

journal_title：Leukemia

authors： Melo JV,Goldman JM

更新日期：1992-08-01 00:00:00

abstract：:Human promonocytic cell line U937 cells can be induced to differentiate into macrophages by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA). TPA treatment induced the expression of the monocytic differentiation markers CD11b and CD36, with concomitant morphological changes. Moreover, TPA enhanced reactive ox...

journal_title：Leukemia

authors： Yamamoto T,Sakaguchi N,Hachiya M,Nakayama F,Yamakawa M,Akashi M

更新日期：2009-04-01 00:00:00

abstract：:We investigated the effect of the histone deacetylase inhibitors (HDIs), trichostatin A and trapoxin A on leukemia cells and cell lines from the viewpoint of differentiation induction. TSA induced differentiation in erythroid cell lines by itself, whereas it synergistically enhanced the differentiation that was direct...

journal_title：Leukemia

authors： Kosugi H,Towatari M,Hatano S,Kitamura K,Kiyoi H,Kinoshita T,Tanimoto M,Murate T,Kawashima K,Saito H,Naoe T

更新日期：1999-09-01 00:00:00

abstract：:The M07e megakaryoblastic leukemia cell line is strictly dependent on either interleukin 3 (IL-3) or granulocyte-macrophage colony-stimulating factor (GM-CSF) for continuous growth. This study shows that recombinant human stem-cell factor (rhSCF) can completely replace these lymphokines in supporting the continued pro...

journal_title：Leukemia

authors： Kiss C,Cesano A,Zsebö KM,Clark SC,Santoli D

更新日期：1993-02-01 00:00:00

abstract：:The International Acute Lymphoblastic Leukemia Working Group, the so-called 'Ponte di Legno Workshop' has led to substantial progress in international collaboration in leukemia research. On April 27-28, 2005, the 8th Meeting was held in Vienna, Austria, to continue the discussions about special common treatment elemen...

journal_title：Leukemia

authors： Gadner H,Masera G,Schrappe M,Eden T,Benoit Y,Harrison C,Nachman J,Pui CH

更新日期：2006-01-01 00:00:00

abstract：:We have investigated the direct effects of interferon (IFN) on hairy cells (HCs) isolated from patients with hairy cell leukemia using one- and two-dimensional gel electrophoresis. We have previously characterized the induction of synthesis of 10-16 specific proteins by IFN-alpha 2b in HCs, as analyzed by one-dimensio...

journal_title：Leukemia

authors： Samuels BL,Rosner MC,Giometti CS,Golomb HM,Brownstein BH

更新日期：1987-04-01 00:00:00

abstract：:With the sequencing of the human genome and the development of new genomic technologies, biomedical discovery has been transformed. The applications of these new approaches are ever-expanding from disease classification, to identification of new targets, to outcome prediction. A logical next step is the integration of...

journal_title：Leukemia

authors： Stegmaier K

更新日期：2009-07-01 00:00:00

abstract：:Since graft-versus-leukemia (GVL) is the main weapon for disease eradication after reduced intensity conditioning (RIC) allogeneic SCT, the availability of sensitive and specific techniques to monitor changes in tumor load after transplant are especially helpful. These minimal residual disease techniques would allow a...

journal_title：Leukemia

authors： Pérez-Simón JA,Caballero D,Diez-Campelo M,Lopez-Pérez R,Mateos G,Cañizo C,Vazquez L,Vidriales B,Mateos MV,Gonzalez M,San Miguel JF

更新日期：2002-08-01 00:00:00

abstract：:In this report, a Radiation leukemia virus-transformed murine T cell lymphoma is described which is dependent on the interleukin-2 (IL-2) growth factor for proliferation under single cell conditions of growth. It was isolated from a C57BL mouse which had been primed with the Radiation leukemia virus-induced thymoma, C...

journal_title：Leukemia

authors： O'Neill HC

更新日期：1988-02-01 00:00:00

abstract：:We compared blast cells from adult and pediatric patients with untreated acute lymphoblastic leukemia (ALL) (as separated groups of T-lineage cell and B-lineage cell ALL) to determine if methotrexate (MTX) polyglutamate formation in adult patients might be a contributing cause to the known difference in clinical outco...

journal_title：Leukemia

authors： Göker E,Lin JT,Trippett T,Elisseyeff Y,Tong WP,Niedzwiecki D,Tan C,Steinherz P,Schweitzer BI,Bertino JR

更新日期：1993-07-01 00:00:00

abstract：:Of 240 Japanese children with acute lymphoblastic leukemia (ALL) treated between 1983 and 1990, 75 (31%) had normal diploidy, 47 (20%) hyperdiploidy with more than 50 chromosomes, 18 (8%) hyperdiploidy with 47-50 chromosomes, 77 (32%) pseudodiploidy, 22 (9%) hypodiploidy and one hypotetraploidy in the leukemic cells. ...

journal_title：Leukemia

authors： Kobayashi H,Maseki N,Homma C,Sakurai M,Kaneko Y

更新日期：1994-11-01 00:00:00

abstract：:Imatinib has pronounced antileukemic activity in Ph+ALL, although responses are usually short. To determine whether imatinib may facilitate allogeneic SCT in relapsed or refractory Ph+ALL, we evaluated 46 consecutive, not previously transplanted patients who were enrolled in phase II studies of imatinib. Of 30 patient...

journal_title：Leukemia

authors： Wassmann B,Pfeifer H,Scheuring U,Klein SA,Gökbuget N,Binckebanck A,Martin H,Gschaidmeier H,Hoelzer D,Ottmann OG

更新日期：2002-12-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) are multipotent cells, which exhibit broad immunosuppressive activities. Moreover, they may be administered irrespectively of human leukocyte antigen (HLA) compatibility, without inducing life-threatening immunological reactions, as they express no HLA class II and limited HLA class I ...

journal_title：Leukemia

authors： Balan A,Lucchini G,Schmidt S,Schneider A,Tramsen L,Kuçi S,Meisel R,Bader P,Lehrnbecher T

更新日期：2014-10-01 00:00:00

abstract：:Several studies involving identical twins with concordant leukemia and retrospective scrutiny of archived neonatal blood spots have shown that the TEL-AML1 fusion gene in childhood acute lymphoblastic leukemia (ALL) frequently arises before birth. A prenatal origin of childhood leukemia was further supported by the de...

journal_title：Leukemia

authors： Teuffel O,Betts DR,Dettling M,Schaub R,Schäfer BW,Niggli FK

更新日期：2004-10-01 00:00:00

abstract：:Epigenetic deregulation is involved in acute myeloid leukemia (AML) pathogenesis and epigenetic targeting drugs are in clinical trial. Since the first results with histone-deacetylase inhibitors in AML are controversial, novel single and combined treatments need to be explored. It is tempting to combine chromatin-targ...

journal_title：Leukemia

authors： Chaib H,Nebbioso A,Prebet T,Castellano R,Garbit S,Restouin A,Vey N,Altucci L,Collette Y

更新日期：2012-04-01 00:00:00