Prenatal origin of separate evolution of leukemia in identical twins.

abstract：:Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a highly conserved long non-coding RNA (lncRNA). Overexpression of MALAT1 has been demonstrated to related to poor prognosis of multiple myeloma (MM) patients. Here, we demonstrated that MALAT1 plays important roles in MM DNA repair and cell death. We ...

journal_title：Leukemia

authors： Hu Y,Lin J,Fang H,Fang J,Li C,Chen W,Liu S,Ondrejka S,Gong Z,Reu F,Maciejewski J,Yi Q,Zhao JJ

更新日期：2018-10-01 00:00:00

abstract：:We have previously shown that chronic lymphocytic leukemia (CLL) B cells secrete vascular endothelial growth factor (VEGF) in vitro, have constitutively active VEGF receptors R1 and R2, and respond to exogenous VEGF by specifically upregulating Mcl-1 and XIAP in association with decreased cell death. We found that epi...

journal_title：Leukemia

authors： Lee YK,Shanafelt TD,Bone ND,Strege AK,Jelinek DF,Kay NE

更新日期：2005-04-01 00:00:00

abstract：:In patients with hematologic malignancy, invasive aspergillosis continues to be associated with high mortality even when treated with conventional antifungal therapy. To investigate novel antifungal agents, we compared 53 patients who received posaconazole salvage therapy to 52 contemporary control patients who receiv...

journal_title：Leukemia

authors： Raad II,Hanna HA,Boktour M,Jiang Y,Torres HA,Afif C,Kontoyiannis DP,Hachem RY

更新日期：2008-03-01 00:00:00

abstract：:The chromosomal inversion (16)(p13q22), which is associated with the M4-eosinophilia subtype of human acute myeloid leukemia, causes the fusion of two distinct genes. The polypeptide encoded by the chimeric gene, PEBP2p/CBFp-SMMHC, retains the ability to interact with, and dominantly interfere with the function of pro...

journal_title：Leukemia

authors： Kanto S,Chiba N,Tanaka Y,Fujita S,Endo M,Kamada N,Yoshikawa K,Fukuzaki A,Orikasa S,Watanabe T,Satake M

更新日期：2000-07-01 00:00:00

abstract：:Some anaplastic large cell lymphomas (ALCLs) carry a specific chromosomal translocation, t(2;5)(p23;q35). Recently, we found a novel hyperphosphorylated 80-kDa protein tyrosine kinase, p80, in ALCLs with t(2;5). Subsequent cDNA cloning revealed p80 to be a fusion protein of two genes, the novel tyrosine kinase gene an...

journal_title：Leukemia

authors： Shiota M,Mori S

更新日期：1997-04-01 00:00:00

abstract：:Arsenic has been used since ancient times as a therapeutic agent. However, until recently its use in modern medicine has been restricted to the treatment of a limited number of parasitic infections. In the early 1990s, reports from China described impressive results with arsenic trioxide in patients with de novo, rela...

journal_title：Leukemia

authors： Munshi NC,Tricot G,Desikan R,Badros A,Zangari M,Toor A,Morris C,Anaissie E,Barlogie B

更新日期：2002-09-01 00:00:00

abstract：:Mutations of signal transducing molecules such as Ras have been shown to confer a growth advantage in leukaemic blasts and contribute to the pathogenesis of the disease. Alterations of signal transducing molecules other than Ras may play a role in leukaemogenesis. Knowledge of such mutations could also further our und...

journal_title：Leukemia

authors： Wagner HM,Gale RE,Freeburn RW,Devereux S,Linch DC

更新日期：1994-09-01 00:00:00

abstract：:During T cell selection in the thymic cortex more than 90% of the thymocytes are eliminated by apoptosis. Based on this biology, we propose to define blasts of T cell acute lymphoblastic leukemia (ALL) with the phenotype of cortical thymocytes (CD1+ and/or CD4+ 8+) as selection-related (SR) and all other T-ALL immunop...

journal_title：Leukemia

authors： Niehues T,Kapaun P,Harms DO,Burdach S,Kramm C,Körholz D,Janka-Schaub G,Göbel U

更新日期：1999-04-01 00:00:00

abstract：:Primary myelofibrosis (PMF) is a hematopoietic stem cell (HSC) disease, characterized by aberrant differentiation of all myeloid lineages and profound disruption of the bone marrow niche. PMF samples carry several mutations, but their cell origin and hierarchy in regulating the different waves of clonal and aberrant m...

journal_title：Leukemia

authors： Triviai I,Zeschke S,Rentel J,Spanakis M,Scherer T,Gabdoulline R,Panagiota V,Thol F,Heuser M,Stocking C,Kröger N

更新日期：2019-01-01 00:00:00

abstract：:The phenotypic expression of genetically determined resistance to radiation leukemia virus (RadLV)-induced leukemia in mice has been shown to reside in the bone marrow. Because the bone marrow contains precursors of natural killer (NK) cells, known to play a role in retrovirally induced infections, and because these c...

journal_title：Leukemia

authors： St-Pierre Y,Hugo P,Lemieux S,Lussier G,Potworowski EF

更新日期：1988-08-01 00:00:00

abstract：:Three cell populations with different DNA indices were demonstrated in a case of biphenotypic terminal transferase (TdT)/myeloid-positive acute leukemia which had developed from a pre-leukemic diploid population also expressing biphenotypic features. At the time of development of acute leukemia, flow-cytometric analys...

journal_title：Leukemia

authors： Paietta E,Andreeff M,Papenhausen P,Gucalp R,Wiernik PH

更新日期：1989-01-01 00:00:00

abstract：:Different normal and malignant human B-cell populations were studied with a twofold aim: to define which cytokines are produced in vivo, and to assess the relationship between cytokine production and kinetic state. To analyse normal B-cells representative of different stages of activation and proliferation in vivo, we...

journal_title：Leukemia

authors： Schena M,Gaidano G,Gottardi D,Malavasi F,Larsson LG,Nilsson K,Caligaris-Cappio F

更新日期：1992-02-01 00:00:00

abstract：:In this open-label randomized clinical trial, HLA-identical sibling-matched hematopoietic stem cells (HSC) were transplanted (non-MSCs group, n=15) or cotransplanted with mesenchymal stem cells (MSCs) (MSCs group, n=10) in hematologic malignancy patients. The median number of MSCs infused was 3.4 x 10(5) kg(-1) (range...

journal_title：Leukemia

authors： Ning H,Yang F,Jiang M,Hu L,Feng K,Zhang J,Yu Z,Li B,Xu C,Li Y,Wang J,Hu J,Lou X,Chen H

更新日期：2008-03-01 00:00:00

abstract：:All-trans-retinoic (ATRA) treatment of patients with acute promyelocytic leukemia results in differentiation of the malignant cells and a high complete remission rate. ATRA treatment induced granulocytic differentiation in HL-60 cells as assessed by nitroblue tetrazolium (NBT) reduction, but had no effect on non-speci...

journal_title：Leukemia

authors： Hsu HC,Yang K,Kharbanda S,Clinton S,Datta R,Stone RM

更新日期：1993-03-01 00:00:00

abstract：:The clinical and biologic characteristics of acute myeloid leukemia (AML) with coexpression of lymphoid-associated antigens (Lym+ AML) were studied from 39 cases who represented 24% of 161 newly diagnosed de novo AML. Twenty-seven cases (16.8%) were positive for the expression of T-cell markers (T+ AML) and 12 (7.5%) ...

journal_title：Leukemia

authors： Tien HF,Wang CH,Chen YC,Shen MC,Lin DT,Lin KH

更新日期：1993-05-01 00:00:00

abstract：:Allogeneic stem cell transplantation (allo-SCT) has so far been the most effective immunotherapy for hematological malignancies. However, it is becoming increasingly clear that the immunotherapeutic concepts underlying allo-SCT as well as the traditional dissection of the immune system into innate and adaptive arms ne...

journal_title：Leukemia

authors： Scheper W,Gründer C,Straetemans T,Sebestyen Z,Kuball J

更新日期：2014-06-01 00:00:00

abstract：:Approximately 25% of acute leukemias of the B-cell lineage demonstrate more than two rearranged immunoglobulin heavy chain genes when examined by Southern blot analysis. The origin of the extra bands was investigated by molecular cloning and sequencing of four rearranged genes from one patient's leukemic cells. All fo...

journal_title：Leukemia

authors： Carter M,Neale GA,Kitchingman GR

更新日期：1991-08-01 00:00:00

abstract：:The discovery of EGFR gene amplification in glioblastoma multiforme has prompted interest in experimental therapies to target the receptor on brain tumor cells. To develop an animal model for in vivo study of such strategies, we transfected C6 glioma cells with a plasmid containing the neomycin resistance gene and the...

journal_title：Leukemia

authors： Fenstermaker RA,Capala J,Barth RF,Hujer A,Kung HJ,Kaetzel DM Jr

更新日期：1995-10-01 00:00:00

abstract：:Most modern treatment protocols for acute lymphoblastic leukaemia (ALL) include the analysis of minimal residual disease (MRD). To ensure comparable MRD results between different MRD-polymerase chain reaction (PCR) laboratories, standardization and quality control are essential. The European Study Group on MRD detecti...

journal_title：Leukemia

authors： van der Velden VH,Cazzaniga G,Schrauder A,Hancock J,Bader P,Panzer-Grumayer ER,Flohr T,Sutton R,Cave H,Madsen HO,Cayuela JM,Trka J,Eckert C,Foroni L,Zur Stadt U,Beldjord K,Raff T,van der Schoot CE,van Dongen JJ,Euro

更新日期：2007-04-01 00:00:00

abstract：:Outcomes after unmanipulated haploidentical stem cell transplantation (Haplo) and after unrelated cord blood transplantation (UCBT) are encouraging and have become alternative options to treat patients with high-risk acute leukemia without human leukocyte antigen (HLA) matched donor. We compared outcomes after UCBT an...

journal_title：Leukemia

authors： Ruggeri A,Labopin M,Sanz G,Piemontese S,Arcese W,Bacigalupo A,Blaise D,Bosi A,Huang H,Karakasis D,Koc Y,Michallet M,Picardi A,Sanz J,Santarone S,Sengelov H,Sierra J,Vincent L,Volt F,Nagler A,Gluckman E,Ciceri F

更新日期：2015-09-01 00:00:00

abstract：:The inv(16)(p13q22) chromosomal rearrangement associated with FAB M4Eo acute myeloid leukemia (AML) subtype is characterized by the presence of the CBFbeta/MYH11 fusion transcript that can be used to detect minimal residual disease (MRD). However, qualitative RT-PCR studies of MRD have so far produced conflicting resu...

journal_title：Leukemia

authors： Guerrasio A,Pilatrino C,De Micheli D,Cilloni D,Serra A,Gottardi E,Parziale A,Marmont F,Diverio D,Divona M,Lo Coco F,Saglio G

更新日期：2002-06-01 00:00:00

abstract：:A home care service has been implemented at our center with the aim of offering domiciliary assistance to patients with hematologic malignancies in advanced phase. We report our experience concerning the home management of these patients in the setting of infective complications. Of 151 patients in home care, 70 (46%)...

journal_title：Leukemia

authors： Girmenia C,Moleti ML,Cartoni C,Cedrone M,De Gregoris C,De Sanctis V,Giovannini M,Latagliata R,Niscola P,Romani C,Rondinelli MB,Tosti S,Mandelli F

更新日期：1997-11-01 00:00:00

abstract：:Sequential analysis of chimerism after allogeneic blood stem cell transplantation (BSCT) has been shown to be predictive for graft failure and relapse. We have explored the impact of a novel approach for the quantitative determination of chimerism using a commercial PCR assay with multiplex amplification of nine STR-l...

journal_title：Leukemia

authors： Thiede C,Bornhäuser M,Oelschlägel U,Brendel C,Leo R,Daxberger H,Mohr B,Florek M,Kroschinsky F,Geissler G,Naumann R,Ritter M,Prange-Krex G,Lion T,Neubauer A,Ehninger G

更新日期：2001-02-01 00:00:00

abstract：:In this study, the abilities of constitutive and conditional forms of the three Raf kinases to abrogate the cytokine dependency of FDC-P1 cells were examined. The constitutively active forms (delta) of all three Raf kinases were fused to the hormone-binding domain of the estrogen receptor (ER), rendering their activit...

journal_title：Leukemia

authors： Hoyle PE,Moye PW,Steelman LS,Blalock WL,Franklin RA,Pearce M,Cherwinski H,Bosch E,McMahon M,McCubrey JA

更新日期：2000-04-01 00:00:00

abstract：:The Wilms' tumor gene, WT1, is a tumor marker for leukemic blast cells. The WT1 expression levels were examined for 57 patients with myelodysplastic syndromes (MDS) (refractory anemia (RA), 35; RA with excess of blasts (RAEB) 14; RAEB in transformation (RAEB-t), six; and MDS with fibrosis, two) and 12 patients with ac...

journal_title：Leukemia

authors： Tamaki H,Ogawa H,Ohyashiki K,Ohyashiki JH,Iwama H,Inoue K,Soma T,Oka Y,Tatekawa T,Oji Y,Tsuboi A,Kim EH,Kawakami M,Fuchigami K,Tomonaga M,Toyama K,Aozasa K,Kishimoto T,Sugiyama H

更新日期：1999-03-01 00:00:00

abstract：:The mesenchymal stroma has been shown to play a crucial role in the development of multiple myeloma, partly by secretion of interleukin (IL)-6, that serves as a growth factor for myeloma cells. However, it is still unclear which other stromal molecules are involved in the pathogenesis of this disease. We chose, as a m...

journal_title：Leukemia

authors： Shoham T,Sternberg D,Brosh N,Krupsky M,Barda-Saad M,Zipori D

更新日期：2001-07-01 00:00:00

abstract：:A poorly defined transforming event(s) affects the pluripotential bone marrow (BM) stem cell in myelodysplastic syndromes (MDS), conferring a growth advantage upon it which leads eventually to monoclonal hematopoiesis. The progeny of this transformed ancestor undergo recognizable albeit dysplastic maturation. We propo...

journal_title：Leukemia

authors： Raza A,Mundle S,Shetty V,Alvi S,Chopra H,Span L,Parcharidou A,Dar S,Venugopal P,Borok R,Gezer S,Showel J,Loew J,Robin E,Rifkin S,Alston D,Hernandez B,Shah R,Kaizer H,Gregory S,Preisler H

更新日期：1996-10-01 00:00:00

abstract：:We assessed the epidemiologic progress against childhood and adolescent acute lymphoblastic leukaemia (ALL) in the Netherlands over a 26 year period. ALL patients <18 years were selected from the Netherlands Cancer Registry and the Dutch Childhood Oncology Group. Trend analyses were performed over time and by age grou...

journal_title：Leukemia

authors： Reedijk AMJ,Coebergh JWW,de Groot-Kruseman HA,van der Sluis IM,Kremer LC,Karim-Kos HE,Pieters R

更新日期：2020-08-21 00:00:00

abstract：:The stem cell leukaemia (SCL) gene is a member of the basic helix-loop-helix family of transcription factors and is essential for the development of all haematopoietic lineages. SCL is expressed in pluripotent haematopoietic stem cells and also following commitment to the erythroid, mast and megakaryocytic lineages. T...

journal_title：Leukemia

authors： Fordham JL,Göttgens B,McLaughlin F,Green AR

更新日期：1999-05-01 00:00:00

abstract：:Nasal-type natural killer (NK) cell lymphoma is an infrequent aggressive malignant disease with very poor prognosis. We aimed to explore the possible role of the transcription factor STAT3 in the pathophysiology of this malignancy, as it was involved in oncogenesis and chemoresistance. For this, we established and cha...

journal_title：Leukemia

authors： Coppo P,Gouilleux-Gruart V,Huang Y,Bouhlal H,Bouamar H,Bouchet S,Perrot C,Vieillard V,Dartigues P,Gaulard P,Agbalika F,Douay L,Lassoued K,Gorin NC

更新日期：2009-09-01 00:00:00