Abstract:
:The phenotypic expression of genetically determined resistance to radiation leukemia virus (RadLV)-induced leukemia in mice has been shown to reside in the bone marrow. Because the bone marrow contains precursors of natural killer (NK) cells, known to play a role in retrovirally induced infections, and because these cells have been suggested as participating in resistance to radiation-induced leukemia, it was pertinent to establish whether their levels differed in strains of mice susceptible and resistant to leukemia. We therefore tested splenic NK cell levels in C57BL/Ka (susceptible) and B10.A(5R) (resistant) mice before viral inoculation, immediately after viral inoculation, and throughout the preleukemic period and showed that they were not different. This indicates that splenic NK cell levels have no bearing on the resistance to RadLV-induced leukemia and that other immune or non-immune mechanisms must be sought.
journal_name
Leukemiajournal_title
Leukemiaauthors
St-Pierre Y,Hugo P,Lemieux S,Lussier G,Potworowski EFsubject
Has Abstractpub_date
1988-08-01 00:00:00pages
551-3issue
8eissn
0887-6924issn
1476-5551journal_volume
2pub_type
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