Translocation t(8;13) in a patient with T cell lymphoma and features of a myeloproliferative syndrome.

abstract：:v-erb-B is the principal transforming gene of avian erythroblastosis virus, a replication defective retrovirus that transforms erythroid and fibroblast cells in vitro and causes erythroleukemia and fibrosarcoma in vivo. We have used a recombinant murine retrovirus, based on the truncated genome of Moloney murine leuke...

journal_title：Leukemia

authors： Miller M,Kennewell A,Symonds G

更新日期：1992-01-01 00:00:00

abstract：:Genomic analyses of chronic lymphocytic leukemia (CLL) identified somatic mutations and associations of clonal diversity with adverse outcomes. Clonal evolution likely has therapeutic implications but its dynamic is less well studied. We studied clonal composition and prognostic value of seven recurrently mutated driv...

journal_title：Leukemia

authors： Leeksma AC,Taylor J,Wu B,Gardner JR,He J,Nahas M,Gonen M,Alemayehu WG,Te Raa D,Walther T,Hüllein J,Dietrich S,Claus R,de Boer F,de Heer K,Dubois J,Dampmann M,Dürig J,van Oers MHJ,Geisler CH,Eldering E,Levine RL

更新日期：2019-02-01 00:00:00

abstract：:Cytogenetic and fluorescence in situ hybridization studies have shown the presence of telomeric repeats in translocation present in three patients with hematopoietic malignancies. One had jumping translocations, involving 1q12 and 2q, 16p, and 19q. These sequences were detected by FISH only in derivative chromosomes t...

journal_title：Leukemia

authors： Busson Le Coniat M,Brizard F,Smadja NV,Maarek O,Der Sarkissian H,Berger R

更新日期：2000-09-01 00:00:00

abstract：:Tyrosine kinase inhibitors have revolutionized the treatment of chronic myeloid leukemia (CML), offering patients several targeted therapeutic options that provide the possibility of sustained remissions and prolonged survival. With the availability of imatinib, nilotinib and dasatinib, physicians must weigh the effic...

journal_title：Leukemia

authors： Giles FJ,O'Dwyer M,Swords R

更新日期：2009-10-01 00:00:00

abstract：:Multiple myeloma (MM) is a plasma cell tumor marked by clonal evolution and preceded by a premalignant stage, which progresses via molecular pathway deregulation, including MYC activation. This activation relates to translocation or gain of the MYC locus and deregulation of upstream pathways such as IRF4, DIS3/LIN28B/...

journal_title：Leukemia

authors： Jovanović KK,Roche-Lestienne C,Ghobrial IM,Facon T,Quesnel B,Manier S

更新日期：2018-06-01 00:00:00

abstract：:The three DNA methyltransferase (DNMT)-inhibiting cytosine nucleoside analogues, azacitidine, decitabine and zebularine, which are currently studied as nonintensive therapy for myelodysplastic syndromes and acute myeloid leukemia (AML), differ in structure and metabolism, suggesting that they may have differential mol...

journal_title：Leukemia

authors： Flotho C,Claus R,Batz C,Schneider M,Sandrock I,Ihde S,Plass C,Niemeyer CM,Lübbert M

更新日期：2009-06-01 00:00:00

abstract：:Bruton's tyrosine kinase (BTK) inhibitor is a promising novel agent that has potential efficiency in B-cell malignancies. It took approximately 20 years from target discovery to new drug approval. The first-in-class drug ibrutinib creates possibilities for an era of chemotherapy-free management of B-cell malignancies,...

journal_title：Leukemia

authors： Wen T,Wang J,Shi Y,Qian H,Liu P

更新日期：2020-10-29 00:00:00

abstract：:The standard paradigm of embryologic development and adult tissue reconstitution posits unidirectional, hierarchical lineages. The presumed mechanisms underlying these differentiative pathways are gene restrictions, such as methylation and heterochromatin formation, which are commonly described as irreversible. Howeve...

journal_title：Leukemia

authors： Theise ND,Krause DS

更新日期：2002-04-01 00:00:00

abstract：:The tie receptor tyrosine kinase mRNA was originally identified as an amplified product in reverse transcription-polymerase chain reaction analysis of human K562 leukemia cell RNA. In situ hybridization analysis revealed that the corresponding mouse gene is expressed predominantly in endothelial cells. We have explore...

journal_title：Leukemia

authors： Armstrong E,Korhonen J,Silvennoinen O,Cleveland JL,Lieberman MA,Alitalo R

更新日期：1993-10-01 00:00:00

abstract：:In patients with hematologic malignancy, invasive aspergillosis continues to be associated with high mortality even when treated with conventional antifungal therapy. To investigate novel antifungal agents, we compared 53 patients who received posaconazole salvage therapy to 52 contemporary control patients who receiv...

journal_title：Leukemia

authors： Raad II,Hanna HA,Boktour M,Jiang Y,Torres HA,Afif C,Kontoyiannis DP,Hachem RY

更新日期：2008-03-01 00:00:00

abstract：:Less-intense remission induction regimens for adults with newly diagnosed acute myeloid leukemia (AML) aim to reduce treatment-related mortality (TRM), here defined as death within 4 weeks after starting induction therapy. This assumes that TRM rates are similar to the 15-20% observed 20 years ago. Herein we test this...

journal_title：Leukemia

authors： Othus M,Kantarjian H,Petersdorf S,Ravandi F,Godwin J,Cortes J,Pierce S,Erba H,Faderl S,Appelbaum FR,Estey E

更新日期：2014-02-01 00:00:00

abstract：:Dasatinib treatment markedly increases the number of large granular lymphocytes (LGLs) in a proportion of Ph+ leukemia patients, which associates with a better prognosis. The lymphocytosis is predominantly observed in cytomegalovirus (CMV)-seropositive patients, yet detectable CMV reactivation exists only in a small f...

journal_title：Leukemia

authors： Ishiyama K,Kitawaki T,Sugimoto N,Sozu T,Anzai N,Okada M,Nohgawa M,Hatanaka K,Arima N,Ishikawa T,Tabata S,Onaka T,Oka S,Nakabo Y,Amakawa R,Matsui M,Moriguchi T,Takaori-Kondo A,Kadowaki N

更新日期：2017-01-01 00:00:00

abstract：:Thirty-two adult patients with acute leukemia were treated with continuous infusion carboplatin and etoposide at eight different dose levels. Dose limiting toxicity was encountered at doses of carboplatin of 310 mg/m2 per day for 5 days (total 1550 mg/m2 per course) and etoposide 150 mg/m2 per day for 5 days (total do...

journal_title：Leukemia

authors： Lee EJ,Reck K,Carter C,Hodges S,Schiffer CA

更新日期：1993-10-01 00:00:00

abstract：:RT-PCR assays used to detect acute promyelocytic leukemia (APL) are generally considered less sensitive than those for other hematological malignancies, such as CGL. Most patients with APL express del(17q)-derived RAR alpha-PML transcripts as well as the putative leukemogenic PML-RAR alpha associated with add(15q). We...

journal_title：Leukemia

authors： Grimwade D,Howe K,Langabeer S,Burnett A,Goldstone A,Solomon E

更新日期：1996-01-01 00:00:00

abstract：:Adolescents had lower rates of remission induction and shorter event-free survival than younger children in this study of consecutively treated patients with acute lymphoblastic leukemia (ALL). When compared to the younger patients (ages 1-9 years; n = 995), adolescents (ages 10-21 years; n = 338) were significantly m...

journal_title：Leukemia

authors： Santana VM,Dodge RK,Crist WM,Rivera GK,Look AT,Behm FG,Raimondi SC,Pui CH

更新日期：1990-02-01 00:00:00

abstract：:Human T cell leukemia virus type-I (HTLV-I), the etiologic agent of adult T cell leukemia (ATL) transforms human T cells in vitro and in vivo. Tax, the major transactivator of HTLV-I is critical for the initial events involved in transformation, however, the later steps required for progression from an IL-2 dependent ...

journal_title：Leukemia

authors： Gartenhaus RB,Wang P

更新日期：1995-12-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are known for being multi-potent. However, they also possess anticancer properties, which has prompted efforts to adapt MSCs for anticancer therapies. However, MSCs have also been widely implicated in pathways that contribute to tumor growth. Numerous studies have been conducted to adapt ...

journal_title：Leukemia

authors： Lee MW,Ryu S,Kim DS,Lee JW,Sung KW,Koo HH,Yoo KH

更新日期：2019-03-01 00:00:00

abstract：:Myelofibrosis (MF; primary or post-essential thrombocythemia/polycythemia vera) is incurable clonal myeloproliferative disorder, with no effective treatment. Epigenetic changes play an important role in cancer pathogenesis through transcriptional silencing of critical tumor suppressor genes. We conducted a phase-II st...

journal_title：Leukemia

authors： Quintás-Cardama A,Tong W,Kantarjian H,Thomas D,Ravandi F,Kornblau S,Manshouri T,Cortes JE,Garcia-Manero G,Verstovsek S

更新日期：2008-05-01 00:00:00

abstract：:The mechanism by which aplidine, a marine natural product in early clinical development as an anticancer agent, induces cell growth inhibition and apoptosis has been investigated in the human leukemia cell line MOLT-4. This cell line is characterized not only by the ability to secrete VEGF, but also for the presence o...

journal_title：Leukemia

authors： Broggini M,Marchini SV,Galliera E,Borsotti P,Taraboletti G,Erba E,Sironi M,Jimeno J,Faircloth GT,Giavazzi R,D'Incalci M

更新日期：2003-01-01 00:00:00

abstract：:Employing a multicolour flow cytometry assay, 133 B-chronic lymphocytic leukaemia (B-CLL) cases were analysed for surface expression of CD38. Based on a cut-off value of 20%, CLL patients were categorised into a CD38-positive (> or = 20%, n = 56) and a CD38-negative subgroup (< 20%, n = 77) and separately analysed for...

journal_title：Leukemia

authors： Dürig J,Naschar M,Schmücker U,Renzing-Köhler K,Hölter T,Hüttmann A,Dührsen U

更新日期：2002-01-01 00:00:00

abstract：:Polymerase chain reaction (PCR) assessment of clonal T-cell receptor (TCR) and immunoglobulin (Ig) gene rearrangements is an important diagnostic tool in mature T-cell neoplasms. However, lack of standardized primers and PCR protocols has hampered comparability of data in previous clonality studies. To obtain referenc...

journal_title：Leukemia

authors： Brüggemann M,White H,Gaulard P,Garcia-Sanz R,Gameiro P,Oeschger S,Jasani B,Ott M,Delsol G,Orfao A,Tiemann M,Herbst H,Langerak AW,Spaargaren M,Moreau E,Groenen PJ,Sambade C,Foroni L,Carter GI,Hummel M,Bastard C,D

更新日期：2007-02-01 00:00:00

abstract：:The effects of retinoic acid (RA) on the cell growth and expression of interleukin-2 (IL-2) receptors (IL-2R alpha/p55, Tac, CD25) by the human T lymphotropic virus type I (HTLV-I)-positive T cell lines, HUT102 and ATL-2 were investigated. Incubation of these cells for 48 h with either 13-cis retinoid acid (13-cis RA)...

journal_title：Leukemia

authors： Miyatake JI,Maeda Y

更新日期：1997-03-01 00:00:00

abstract：:Epidemiological studies have demonstrated an increased leukemia incidence following ionizing radiation exposure, but to date, the target cells and underlying mechanisms of radiation leukemogenesis remain largely unidentified. We engineered a mouse model carrying a different fluorescent marker on each chromosome 2, loc...

journal_title：Leukemia

authors： Verbiest T,Finnon R,Brown N,Cruz-Garcia L,Finnon P,O'Brien G,Ross E,Bouffler S,Scudamore CL,Badie C

更新日期：2018-06-01 00:00:00

abstract：:The notion that inherited predisposition contributes to the development of haematological malignancies is generally thought of as being a relatively new idea. However, Videbaek made a clear enunciation of such a hypothesis in 1947, from a study of tumour incidence in relatives of patients with different leukaemias. To...

journal_title：Leukemia

authors： Jønsson V,Houlston RS,Catovsky D,Yuille MR,Hilden J,Olsen JH,Fajber M,Brandt B,Sellick G,Allinson R,Wiik A

更新日期：2005-06-01 00:00:00

abstract：:The clinical and laboratory features of 23 patients with a characteristic form of splenic lymphoma with circulating "villous" lymphocytes (SLVL) are described and compared with those of other B cell disorders with preferential splenic involvement. SLVL affects predominantly men in their early 70's and is characterized...

journal_title：Leukemia

authors： Melo JV,Robinson DS,Gregory C,Catovsky D

更新日期：1987-04-01 00:00:00

abstract：:We previously demonstrated that the EVI-1 gene was transcriptionally activated in the 3q21q26 syndrome and chromosomal breakpoints at 3q26 were clustered within 400 Kb of the EVI-1 gene. Since thrombocytosis is often observed in the 3q21q26 syndrome, we first mapped the thrombopoietin (TPO) gene and then we examined f...

journal_title：Leukemia

authors： Suzukawa K,Satoh H,Taniwaki M,Yokota J,Morishita K

更新日期：1995-08-01 00:00:00

abstract：:Proliferation in vitro of the murine hemopoietic cell line FDC-P1 is dependent on stimulation by granulocyte-macrophage colony stimulating factor or multipotential colony stimulating factor. Although immortalized, the cells are not tumorigenic on subcutaneous inoculation. Intravenous injection of FDC-P1 cells into syn...

journal_title：Leukemia

authors： Dührsen U,Metcalf D

更新日期：1988-06-01 00:00:00

abstract：:CD31/PECAM-1 (platelet endothelial cell adhesion molecule-1) is a 130 kDa integral membrane protein of the immunoglobulin gene superfamily with the distinctive feature of being expressed on several cell types associated with the vascular compartment. In the present study we report a novel, unique CD31 mAb termed IP28A...

journal_title：Leukemia

authors： El-Marsafy S,Carosella ED,Agrawal SG,Gluckman E,Mansur IG,Elhabazi A,Boumsell L,Bensussan A

更新日期：1996-08-01 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) is a pleiotropic cytokine which has recently been shown to delay fludarabine-induced apoptosis in B cell chronic lymphocytic leukemia (B-CLL) cells. To investigate the potential mechanism of bFGF-mediated delay of apoptosis, two EBV-transformed B prolymphocytic cell lines (JVM-2, ...

journal_title：Leukemia

authors： König A,Menzel T,Lynen S,Wrazel L,Rosén A,Al-Katib A,Raveche E,Gabrilove JL

更新日期：1997-02-01 00:00:00

abstract：:Deregulated methylation of cytosine in DNA is a frequent finding in malignancy that is reflected by general genomic hypomethylation and regional hypermethylation that includes the myogenic gene Myf-3. In this study of 198 DNA samples from 186 patients with a wide range of lymphoproliferative disorders (LPD), the methy...

journal_title：Leukemia

authors： Taylor JM,Kay PH,Spagnolo DV

更新日期：2001-04-01 00:00:00