A model system for leukemic transformation of immortalized hemopoietic cells in irradiated recipient mice.

abstract：:Patients with hairy cell leukemia (HCL) are prone to opportunistic infections, which suggests an impaired T-cell functioning. To investigate a possible mechanism of such an impairment, we determined the numbers of naive and memory T cells by measuring the expression of CD45R0 on CD4+ and CD8+ T cells in 23 HCL patient...

journal_title：Leukemia

authors： van der Horst FA,van der Marel A,den Ottolander GJ,Kluin-Nelemans HC

更新日期：1993-01-01 00:00:00

abstract：:Novel approaches have been designed to treat leukemia based on our understanding of the genetic and biochemical lesions present in different malignancies. This meeting report summarizes some of the recent advances in leukemia treatment. Based on the discoveries of cellular oncogenes, chromosomal translocations, monocl...

journal_title：Leukemia

authors： Larson RA,Daley GQ,Schiffer CA,Porcu P,Pui CH,Marie JP,Steelman LS,Bertrand FE,McCubrey JA

更新日期：2003-12-01 00:00:00

abstract：:The three DNA methyltransferase (DNMT)-inhibiting cytosine nucleoside analogues, azacitidine, decitabine and zebularine, which are currently studied as nonintensive therapy for myelodysplastic syndromes and acute myeloid leukemia (AML), differ in structure and metabolism, suggesting that they may have differential mol...

journal_title：Leukemia

authors： Flotho C,Claus R,Batz C,Schneider M,Sandrock I,Ihde S,Plass C,Niemeyer CM,Lübbert M

更新日期：2009-06-01 00:00:00

abstract：:We studied the organization, diversification and clinical significance of the immunoglobulin light chain (IgL) variable region genes expressed in 17 kappa-chain and 16 lambda-chain producing multiple myeloma (MM) samples. The V genes from 31 MM samples had over 84.9% homology to the known germline Vkappa/lambda genes,...

journal_title：Leukemia

authors： Kiyoi H,Naito K,Ohno R,Saito H,Naoe T

更新日期：1998-04-01 00:00:00

abstract：:Single-colony karyotyping (SCK) and reverse-transcription polymerase chain reaction (RT-PCR) are two increasingly used techniques for the quantification of leukemic colonies generated by chronic myelogenous leukemia (CML) cell fractions purged or selected in vitro. Recently, the existence of Philadelphia (Ph) chromoso...

journal_title：Leukemia

authors： Savoldo B,Sammarelli G,Dotti G,Garau D,Regazzi E,Cilloni D,Tabilio A,Rizzoli V,Carlo-Stella C

更新日期：1998-03-01 00:00:00

abstract：:RAS-pathway mutations are recurrent events in myeloid malignancies. However, there is limited data on the significance of RAS-pathway mutations in patients with myelofibrosis (MF). We analyzed next-generation sequencing data of 16 genes, including RAS-pathway genes, from 723 patients with primary and secondary MF acro...

journal_title：Leukemia

authors： Santos FPS,Getta B,Masarova L,Famulare C,Schulman J,Datoguia TS,Puga RD,Alves Paiva RM,Arcila ME,Hamerschlak N,Kantarjian HM,Levine RL,Campregher PV,Rampal RK,Verstovsek S

更新日期：2020-03-01 00:00:00

abstract：:A monoclonal antibody (17F11) was raised by immunization of a Balb/c mouse with leukemic blasts from a patient with acute non-lymphocytic leukemia (ANLL). This antibody recognizes most leukemic blasts of myeloid but not of lymphoid lineage and no peripheral blood cells. By screening NIH-3T3 fibroblasts transfected wit...

journal_title：Leukemia

authors： Bühring HJ,Ullrich A,Schaudt K,Müller CA,Busch FW

更新日期：1991-10-01 00:00:00

abstract：:Natural killer (NK)-cell malignancies are uncommon diseases. Previously known as polymorphic reticulosis or angiocentric T-cell lymphomas, they are classified by the World Health Organization as NK/T-cell lymphoma, nasal type and aggressive NK-cell leukemia. They are prevalent in Asia and South America, but exceptiona...

journal_title：Leukemia

authors： Kwong YL

更新日期：2005-12-01 00:00:00

abstract：:The combination of the anti-viral agents, zidovudine (AZT) and interferon-alpha (IFN), is a potent treatment of HTLV-I-associated adult T cell leukemia/lymphoma (ATL). In this study we investigate the possible mechanism of action of this combination by examining several cellular parameters including cell proliferation...

journal_title：Leukemia

authors： Bazarbachi A,Nasr R,El-Sabban ME,Mahé A,Mahieux R,Gessain A,Darwiche N,Dbaibo G,Kersual J,Zermati Y,Dianoux L,Chelbi-Alix MK,de Thé H,Hermine O

更新日期：2000-04-01 00:00:00

abstract：:Since graft-versus-leukemia (GVL) is the main weapon for disease eradication after reduced intensity conditioning (RIC) allogeneic SCT, the availability of sensitive and specific techniques to monitor changes in tumor load after transplant are especially helpful. These minimal residual disease techniques would allow a...

journal_title：Leukemia

authors： Pérez-Simón JA,Caballero D,Diez-Campelo M,Lopez-Pérez R,Mateos G,Cañizo C,Vazquez L,Vidriales B,Mateos MV,Gonzalez M,San Miguel JF

更新日期：2002-08-01 00:00:00

abstract：:This paper describes seven patients with ALL and a hypodiploid karyotype with less than 40 chromosomes. A consideration of these and 15 previously published cases indicates that they may be divided into two groups depending on chromosome number, i.e., less than 30 and 30-39. The less than 30 group are younger and pred...

journal_title：Leukemia

authors： Callen DF,Raphael K,Michael PM,Garson OM

更新日期：1989-10-01 00:00:00

abstract：:The non-obese diabetic-severe combined immunodeficiency (NOD-SCID) mouse is a convenient host for human hematopoietic tissues and cells. Human fetal bone fragments engrafted subcutaneously in NOD-SCID mice sustain human hematopoiesis for several months. MS5 murine bone marrow stromal cells were transfected by electrop...

journal_title：Leukemia

authors： Brouard N,Chapel A,Neildez-Nguyen TM,Granotier C,Khazaal I,Péault B,Thierry D

更新日期：1998-07-01 00:00:00

abstract：:It has been proposed that adoptive immunotherapy, for the treatment of relapsed AML, with cytotoxic T lymphocytes which show a relative specificity for the leukemic cells may have the advantage of maximizing the beneficial anti-leukemic effect whilst minimizing the probability of graft-versus-host disease. In this stu...

journal_title：Leukemia

authors： Woiciechowsky A,Regn S,Kolb HJ,Roskrow M

更新日期：2001-02-01 00:00:00

abstract：:Reliable detection of JAK2-V617F is critical for accurate diagnosis of myeloproliferative neoplasms (MPNs); in addition, sensitive mutation-specific assays can be applied to monitor disease response. However, there has been no consistent approach to JAK2-V617F detection, with assays varying markedly in performance, af...

journal_title：Leukemia

authors： Jovanovic JV,Ivey A,Vannucchi AM,Lippert E,Oppliger Leibundgut E,Cassinat B,Pallisgaard N,Maroc N,Hermouet S,Nickless G,Guglielmelli P,van der Reijden BA,Jansen JH,Alpermann T,Schnittger S,Bench A,Tobal K,Wilkins B,Cu

更新日期：2013-10-01 00:00:00

abstract：:The response of human acute myelogenous leukemia (AML) cells to four different hematopoietic growth factors (granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-1 beta (IL-1beta), interleukin-3 (IL-3), and stem cell factor (SCF)) and the relationship of the proliferative response of the AML cells to...

journal_title：Leukemia

authors： Tsuzuki M,Ezaki K,Maruyama F,Ino T,Kojima H,Okamoto M,Yamaguchi T,Nomura T,Miyazaki H,Wakita M,Matsui T,Hirano M

更新日期：1997-12-01 00:00:00

abstract：:A home care service has been implemented at our center with the aim of offering domiciliary assistance to patients with hematologic malignancies in advanced phase. We report our experience concerning the home management of these patients in the setting of infective complications. Of 151 patients in home care, 70 (46%)...

journal_title：Leukemia

authors： Girmenia C,Moleti ML,Cartoni C,Cedrone M,De Gregoris C,De Sanctis V,Giovannini M,Latagliata R,Niscola P,Romani C,Rondinelli MB,Tosti S,Mandelli F

更新日期：1997-11-01 00:00:00

abstract：:Novel techniques were used to detect which cell lineages were affected by monosomy 7 in a patient who had myelodysplastic syndrome and later developed acute leukemia. The patient had had paroxysmal nocturnal hemoglobinuria for 20 years before developing refractory anemia with excess of blasts. Cytogenetic analysis at ...

journal_title：Leukemia

authors： Kere J,Knuutila S,Ruutu T,Leskinen R,de la Chapelle A

更新日期：1988-02-01 00:00:00

abstract：:Genomic analyses of chronic lymphocytic leukemia (CLL) identified somatic mutations and associations of clonal diversity with adverse outcomes. Clonal evolution likely has therapeutic implications but its dynamic is less well studied. We studied clonal composition and prognostic value of seven recurrently mutated driv...

journal_title：Leukemia

authors： Leeksma AC,Taylor J,Wu B,Gardner JR,He J,Nahas M,Gonen M,Alemayehu WG,Te Raa D,Walther T,Hüllein J,Dietrich S,Claus R,de Boer F,de Heer K,Dubois J,Dampmann M,Dürig J,van Oers MHJ,Geisler CH,Eldering E,Levine RL

更新日期：2019-02-01 00:00:00

abstract：:The interactions between haemopoietic progenitor cells and marrow stromal cells that are essential for the regulation of normal haemopoiesis are defective in chronic phase chronic myeloid leukaemia (CML). The presence of primitive progenitor cells (blast colony-forming cells, Bl-CFC) in the blood of patients with CML ...

journal_title：Leukemia

authors： Gordon MY,Atkinson J,Clarke D,Dowding CR,Goldman JM,Grimsley PG,Siczkowski M,Greaves MF

更新日期：1991-08-01 00:00:00

abstract：:Therapy-related myelodysplastic syndrome and acute myelogenous leukemia (t-MDS/AML) are serious complications of chemotherapy and radiotherapy for cancer. High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) may be associated with an increased incidence of these complications. The frequency o...

journal_title：Leukemia

authors： Nichols G,de Castro K,Wei LX,Griffin M,Lin N,Oratzi A,Murty VV,Troxel A,Vahdat L,Hesdorffer C

更新日期：2002-09-01 00:00:00

abstract：:Many agents have been known to induce the differentiation of HL-60 cells. However, only a small number of reports on the basophilic differentiation of this cell line are known. In this study we show that the exposure of HL-60 cells to chloroquine induces to differentiate into basophils. This chloroquine-induced change...

journal_title：Leukemia

authors： Sasaki R,Furukawa Y,Okada K,Nakamura M,Yamane Y,Miura Y,Eguchi M

更新日期：1997-04-01 00:00:00

abstract：:We used fluorescence in situ hybridization (FISH) to metaphase chromosomes with BCR and ABL cosmid probes in conjunction with the polymerase chain reaction (PCR) to study the mechanism by which the ABL proto-oncogene is inserted into a morphologically normal chromosome 22 in patients with Ph-negative chronic myeloid l...

journal_title：Leukemia

authors： Lazaridou A,Chase A,Melo J,Garicochea B,Diamond J,Goldman J

更新日期：1994-03-01 00:00:00

abstract：:In B-CLL IgV(H) genes mutational status is a major prognostic factor. Since sequencing of IgV(H) genes is not available in most laboratories, an easily performed surrogate assay is desirable. To identify the best surrogate assay, and to better discriminate prognostic subgroups we analyzed clinical and biological data ...

journal_title：Leukemia

authors： Magnac C,Porcher R,Davi F,Nataf J,Payelle-Brogard B,Tang RP,Oppezzo P,Lévy V,Dighiero G,Ajchenbaum-Cymbalista F

更新日期：2003-01-01 00:00:00

abstract：:Thirty-two adult patients with acute leukemia were treated with continuous infusion carboplatin and etoposide at eight different dose levels. Dose limiting toxicity was encountered at doses of carboplatin of 310 mg/m2 per day for 5 days (total 1550 mg/m2 per course) and etoposide 150 mg/m2 per day for 5 days (total do...

journal_title：Leukemia

authors： Lee EJ,Reck K,Carter C,Hodges S,Schiffer CA

更新日期：1993-10-01 00:00:00

abstract：:The lens epithelium-derived growth factor (LEDGF/p75) tethers the mixed-lineage leukemia (MLL1) protein complex to chromatin. Likewise, LEDGF/p75 tethers the HIV-1 pre-integration complex to chromatin. We previously demonstrated that expression of the C-terminal fragment fused to enhanced green fluorescent protein (eG...

journal_title：Leukemia

authors： Méreau H,De Rijck J,Cermáková K,Kutz A,Juge S,Demeulemeester J,Gijsbers R,Christ F,Debyser Z,Schwaller J

更新日期：2013-06-01 00:00:00

abstract：:Monitoring of BCR-ABL transcripts has become established practice in the management of chronic myeloid leukemia. However, nucleic acid amplification techniques are prone to variations which limit the reliability of real-time quantitative PCR (RQ-PCR) for clinical decision making, highlighting the need for standardizat...

journal_title：Leukemia

authors： Saldanha J,Silvy M,Beaufils N,Arlinghaus R,Barbany G,Branford S,Cayuela JM,Cazzaniga G,Gonzalez M,Grimwade D,Kairisto V,Miyamura K,Lawler M,Lion T,Macintyre E,Mahon FX,Muller MC,Ostergaard M,Pfeifer H,Saglio G,Saw

更新日期：2007-07-01 00:00:00

abstract：:Since in vitro observations indicated that all-trans retinoic acid (ATRA), especially in combination with IFNalpha, can exert significant suppressive effects on Ph+ cells, we investigated the effects and the pharmacokinetic profile of ATRA in a selected cohort of patients with Ph+ chronic myeloid leukemia (CML) in chr...

journal_title：Leukemia

authors： Russo D,Regazzi M,Sacchi S,Visani G,Lazzarino M,Avvisati G,Pelicci PG,Dastoli G,Grandi C,Iacona I,Candoni A,Grattoni R,Galieni P,Rupoli S,Liberati AM,Maiolo AT

更新日期：1998-04-01 00:00:00

abstract：:We have used a 4-day MTT colorimetric assay to study drug sensitivity of leucocytes from leukaemia patients and from normal donors. Response to Adriamycin, vincristine, aclacinomycin A, 3'-deamino-3'-morpholino-13-deoxo-10-hydroxycarminomycin (MX2), and melphalan has been determined, together with the effects of the r...

journal_title：Leukemia

authors： Lambert E,Rees JK,Twentyman PR

更新日期：1992-10-01 00:00:00

abstract：:The inhibition of nuclear factor kappa B (NF-kappaB) by, for instance, curcumin is becoming an important new approach in combination with chemotherapy or irradiation for the treatment of a variety of cancers including haematological malignancies. A dose-limiting side effect of anticancer therapy in the gastrointestina...

journal_title：Leukemia

authors： van't Land B,Blijlevens NM,Marteijn J,Timal S,Donnelly JP,de Witte TJ,M'Rabet L

更新日期：2004-02-01 00:00:00

abstract：:Secondary chromosomal aberrations reported in the literature were surveyed in acute myeloid or lymphoblastic leukemia (AML or ALL) with one of the following primary abnormalities: in AML, t(1;3), t(1;22), der(1;7), inv(3), t(3;5) +4, del(5q), t(6;9), -7, t(7;11), del(7q), +8, t(8;16), t(8;21), +9, t(9;11), del(9q), t(...

journal_title：Leukemia

authors： Johansson B,Mertens F,Mitelman F

更新日期：1994-06-01 00:00:00