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A classification based on T cell selection-related phenotypes identifies a subgroup of childhood T-ALL with favorable outcome in the COALL studies.

Abstract：

:During T cell selection in the thymic cortex more than 90% of the thymocytes are eliminated by apoptosis. Based on this biology, we propose to define blasts of T cell acute lymphoblastic leukemia (ALL) with the phenotype of cortical thymocytes (CD1+ and/or CD4+ 8+) as selection-related (SR) and all other T-ALL immunophenotypes as non-selection-related (NSR). The COALL cooperative treatment studies for childhood ALL offer a tool to study the outcome in T-ALL subgroups as children with T-ALL are allocated uniformly to the high risk arm of the protocol. In the COALL-85, -89 and -92 protocols, 39/83 cases presented as SR and 44/83 cases as NSR. Five-year event-free survival of SR phenotype is significantly better compared to the NSR group (0.87 +/- 0.06 vs 0.66 +/- 0.07, log rank test, P = 0.01). T-ALL with SR phenotype is a distinct subgroup of leukemia with excellent prognosis under a high risk treatment protocol.

journal_name

Leukemia

journal_title

Leukemia

authors

Niehues T,Kapaun P,Harms DO,Burdach S,Kramm C,Körholz D,Janka-Schaub G,Göbel U

doi

10.1038/sj.leu.2401382

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

614-7

issue

4

eissn

0887-6924

issn

1476-5551

journal_volume

13

pub_type

杂志文章

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