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Genetic predisposition for multiple myeloma.

Abstract：

:Multiple myeloma (MM) is the second most common blood malignancy. Epidemiological family studies going back to the 1920s have provided evidence for familial aggregation, suggesting a subset of cases have an inherited genetic background. Recently, studies aimed at explaining this phenomenon have begun to provide direct evidence for genetic predisposition to MM. Genome-wide association studies have identified common risk alleles at 24 independent loci. Sequencing studies of familial cases and kindreds have begun to identify promising candidate genes where variants with strong effects on MM risk might reside. Finally, functional studies are starting to give insight into how identified risk alleles promote the development of MM. Here, we review recent findings in MM predisposition field, and highlight open questions and future directions.

journal_name

Leukemia

journal_title

Leukemia

authors

Pertesi M,Went M,Hansson M,Hemminki K,Houlston RS,Nilsson B

doi

10.1038/s41375-019-0703-6

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

697-708

issue

3

eissn

0887-6924

issn

1476-5551

pii

10.1038/s41375-019-0703-6

journal_volume

34

pub_type

杂志文章,评审

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