Abstract：
:Suppression of c-myc expression is observed during induced differentiation of several myeloid cell lines and it has been attributed to the cell growth arrest that accompanies terminal differentiation. To dissect the role of c-Myc in the proliferation-differentiation switch we have studied c-myc expression in K562 cells exposed to several chemical agents. This model system allowed us to discriminate between the growth arrest and differentiation phenomena as well as the induction of differentiation along two different lineages (erythroid and myelomonocytic). Our results showed that c-myc expression did not significantly decrease when growth inhibition is reversible, either by treatment with a differentiating agent such as hydroxyurea (which induced erythroid differentiation) or by a non-differentiating agent such as interferon-alpha. In contrast, c-myc expression decreased when cells underwent terminal differentiation, either along the myelomonocytic (by 12-O-tetradecanoylphorbol-13-acetate) or erythroid (by 1-beta-D-arabinofuranosylcytosine) lineages. These results indicated that c-myc down-regulation is not obligatory for growth arrest and non-terminal differentiation of human myeloid cells. In contrast, c-myc down-regulation occurred in terminal differentiation, but induction of myelomonocytic differentiation resulted in a greater loss of c-myc mRNA than induction of erythroid differentiation.
journal_name
Leukemiajournal_title
Leukemiaauthors
Gómez-Casares MT,Delgado MD,Lerga A,Crespo P,Quincoces AF,Richard C,León Jsubject
Has Abstractpub_date
1993-11-01 00:00:00pages
1824-33issue
11eissn
0887-6924issn
1476-5551journal_volume
7pub_type
杂志文章相关文献
LEUKEMIA文献大全abstract：:Donor leukocyte infusions (DLI) have turned out to be an efficient way to re-establish complete remission (CR) in chronic myeloid leukemia (CML) patients relapsing after allogeneic bone marrow transplantation (BMT). In these patients, absence of PCR bcr-abl fusion transcripts confirmed the potency of donor leukocytes ...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2401144
更新日期：1998-11-01 00:00:00
abstract：:Inhibitory proteins for Cdks (CKIs) are involved in cell cycle arrest induced by anti-mitotic factors, chemicals, or DNA damage in mammalian cells. High cell density also induces cell cycle arrest with unreplicated genomic DNA even in the presence of mitotic dose of the growth factors, termed contact inhibition. Altho...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1997-04-01 00:00:00
abstract：:In vitro enzymatic amplification and direct sequencing were used to detect and characterize t(14;18) recombination junctions in peripheral blood and bone marrow mononuclear cell preparations from patients with follicular lymphoma in remission. Samples from 24/44 patients were found to be positive for translocations in...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：:Eight new cases (five adults and three children) of acute leukemia characterized by the presence in bone marrow cells of a t(4;11)(q21;q23)and one similar case, a child, with a t(1;11)(p32;q23) are reported. All patients were diagnosed as having acute lymphoblastic leukemia (ALL) with high-risk features. Immunological...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Hematopoietic stem cells are identified based on their functional ability to migrate via the blood circulation of transplanted recipients, to home to the host bone marrow and to durably repopulate this organ with high levels of maturing myeloid and lymphoid cells. While a small pool of undifferentiated stem cells with...
journal_title：Leukemia
pub_type： 杂志文章,评审
doi：10.1038/sj.leu.2402684
更新日期：2002-10-01 00:00:00
abstract：:Identification of agents that target human leukemia stem cells is an important consideration for the development of new therapies. The present study demonstrates that rocaglamide and silvestrol, closely related natural products from the flavagline class of compounds, are able to preferentially kill functionally define...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2014.93
更新日期：2014-10-01 00:00:00
abstract：:Current guidelines for smoldering multiple myeloma (SMM) recommend active monitoring until the onset of multiple myeloma (MM) before initiating treatment or enrollment in a clinical trial. Earlier intervention may delay progression to MM. In CENTAURUS, 123 patients with intermediate-risk or high-risk SMM were randomly...
journal_title：Leukemia
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/s41375-020-0718-z
更新日期：2020-07-01 00:00:00
abstract：:We studied changes in peripheral blood and bone marrow biopsy specimens obtained before, during, and after recombinant alpha 2b-interferon (IFN-alpha 2b) therapy in 25 patients with hairy cell leukemia. During therapy, only 1 patient showed no improvement in at least one of the parameters monitored. Granulocytopenia, ...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1987-04-01 00:00:00
abstract：:Relapse of malignant disease remains the major complication in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) after hematopoietic cell transplantation (HCT) with reduced-intensity conditioning (RIC). In this study, we investigated the predictive value of disease-specific markers (DSMs), d...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2010.283
更新日期：2011-03-01 00:00:00
abstract：:Molecular analysis of T cell receptor (TCR) genes is frequently used to prove or exclude clonality and thereby support the diagnosis of suspect T cell proliferations. PCR techniques are more and more being used for molecular clonality studies. The main disadvantage of the PCR-based detection of clonal TCR gene rearran...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2400887
更新日期：1997-12-01 00:00:00
abstract：:It has been proposed that adoptive immunotherapy, for the treatment of relapsed AML, with cytotoxic T lymphocytes which show a relative specificity for the leukemic cells may have the advantage of maximizing the beneficial anti-leukemic effect whilst minimizing the probability of graft-versus-host disease. In this stu...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2402013
更新日期：2001-02-01 00:00:00
abstract：:CD79 is a heterodimeric molecule comprising two polypeptide chains, B29 (CD79b) and mb-1 (CD79a). It is physically linked in the surface of B cells to membrane immunoglobulin, forming the B cell antigen receptor complex. Expression of the mb-1 (CD79a) chain has been studied in leukaemias and shown to be present in mos...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1996-05-01 00:00:00
abstract：:Mesenchymal stromal cells (MSCs) possess broad immunomodulatory capacities that are currently investigated for potential clinical application in treating autoimmune disorders. Third-party MSCs suppress alloantigen-induced proliferation of peripheral blood mononuclear cells providing the rationale for clinical use in g...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2014.273
更新日期：2014-12-01 00:00:00
abstract：:Dipeptidylpeptidase 4 (DPP4/CD26) enzymatically cleaves select penultimate amino acids of proteins, including colony-stimulating factors (CSFs), and has been implicated in cellular regulation. To better understand the role of DPP4 regulation of hematopoiesis, we analyzed the activity of DPP4 on the surface of immature...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2017.98
更新日期：2017-11-01 00:00:00
abstract：:Continuous leukemia-lymphoma cell lines are important research tools, in particular as starting material for the cloning of recurrent translocations. In 1998, we established the continuous leukemia cell line MUTZ-5 and its two simultaneous sister cell lines MUTZ-6 and MUTZ-7. The primary specimen was obtained from the...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2402212
更新日期：2001-09-01 00:00:00
abstract：:The standard paradigm of embryologic development and adult tissue reconstitution posits unidirectional, hierarchical lineages. The presumed mechanisms underlying these differentiative pathways are gene restrictions, such as methylation and heterochromatin formation, which are commonly described as irreversible. Howeve...
journal_title：Leukemia
pub_type： 杂志文章,评审
doi：10.1038/sj.leu.2402445
更新日期：2002-04-01 00:00:00
abstract：:The added value of IKZF1 gene deletion (IKZF1(del)) as a stratifying criterion in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is still debated. We performed a comprehensive analysis of the impact of IKZF1(del) in a large cohort of children (n=1223) with BCR-ABL1-negative BCP-ALL treated in the EORTC-CLG tr...
journal_title：Leukemia
pub_type： 杂志文章,随机对照试验
doi：10.1038/leu.2015.134
更新日期：2015-11-01 00:00:00
abstract：:The fusion transcript AML1/ETO corresponding to translocation t(8;21)(q22;q22) can be found in approximately 7-12% of childhood de novo AML. Despite the favorable prognosis, some of these patients relapse. Most of MRD studies so far were performed on adults treated not uniformly. Therefore, we analyzed the follow-up o...
journal_title：Leukemia
pub_type： 杂志文章,多中心研究
doi：10.1038/sj.leu.2402959
更新日期：2003-06-01 00:00:00
abstract：:Normal human myeloid cells require certain colony stimulating factors (CSFs) for growth and differentiation. These CSFs are normally produced exogenously by accessory cells. However, human acute myeloid leukemia cells have been found, in certain instances, to have constitutive, endogenous production of one or more of ...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1989-09-01 00:00:00
abstract：:Interleukin 12 (IL-12; natural killer cell stimulatory factor, NKSF; cytotoxic lymphocyte maturation factor, CLMF) was studied for its effects on the survival and generation of hemopoietic progenitors (CFU-C, CAFC day 7-14) and long-term culture initiating stem cells (CAFC day 28-35) by post-5-fluorouracil (FU) bone m...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1993-09-01 00:00:00
abstract：:In a 56-year-old male patient, receiving chemotherapy after radical surgery for bladder carcinoma, an unusual type of cytoplasmic inclusion was discovered in about 30% of peripheral blood lymphocytes. This was a single, large (about 2 microns in diameter), round or ovoid body, darker than the nucleus and reddish-viole...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：:Recurrent chromosomal rearrangements are observed in many leukemia subtypes. Recently, it has been shown that several of these translocations/inversions were associated with the loss of sequences located in the vicinity of the chromosomal breakpoints. So far, such deletions have not been described for the t(8;21) tran...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2402585
更新日期：2002-09-01 00:00:00
abstract：:Chronic myeloid leukemia (CML) relapse after allogeneic stem cell transplantation (SCT) is a relatively frequent situation, which is correlated to disease status, time from diagnosis to transplant and T-cell depletion. We evaluated the potential for early minimal residual disease (MRD) BCR-ABL quantification to predic...
journal_title：Leukemia
pub_type： 临床试验,杂志文章
doi：10.1038/sj.leu.2404170
更新日期：2006-05-01 00:00:00
abstract：:The AML1 (RUNX1)-MTG8 (ETO) fusion transcription factor generated by the t(8;21) translocation is believed to deregulate the expression of genes that are crucial for normal differentiation and proliferation of hematopoietic progenitors, resulting in acute myelogenous leukemia. To elucidate the role of AML1-MTG8 in leu...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2402465
更新日期：2002-05-01 00:00:00
abstract：:Imatinib is a highly effective therapy for chronic phase-chronic myeloid leukaemia (CP-CML) patients; however, responses to frontline imatinib are variable. The human organic cation transporter 1 (OCT1; SLC22A1) has been reported to be the main influx transporter involved in imatinib uptake into CML cells. Furthermore...
journal_title：Leukemia
pub_type： 杂志文章,评审
doi：10.1038/leu.2015.170
更新日期：2015-10-01 00:00:00
abstract：:The purpose of this study was to determine the incidence of and pharmacokinetic parameters associated with the development of transient encephalopathy following the administration of high-dose methotrexate and intrathecal chemotherapy in children with acute lymphoblastic leukemia (ALL). Two hundred and fifty-nine chil...
journal_title：Leukemia
pub_type： 临床试验,杂志文章
doi：10.1038/sj.leu.2401098
更新日期：1998-08-01 00:00:00
abstract：:A relationship was proved between constitutive activity of leukemic cell c-jun-N-terminal kinase (JNK) and treatment failure in AML. Specifically, early treatment failure was predicted by the presence of constitutive JNK activity. The mechanistic origins of this association was sought. A multidrug resistant leukemic c...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2402457
更新日期：2002-05-01 00:00:00
abstract：:We have investigated the activity of ITF2357, a novel hydroxamate histone deacetylase inhibitor, on multiple myeloma (MM) and acute myelogenous leukemia (AML) cells in vitro and in vivo. ITF2357 induced apoptosis in 8/9 MM and 6/7 AML cell lines, as well as 4/4 MM and 18/20 AML freshly isolated cases, with a mean IC(5...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2404860
更新日期：2007-09-01 00:00:00
abstract：:The NUP214-ABL1 fusion kinase has recently been identified in 6% of patients with T-cell acute lymphoblastic leukemia. In contrast to the more common oncogenic ABL1 fusion BCR-ABL1, NUP214-ABL1 localizes to the nuclear pore complexes and has attenuated transforming properties in hematopoietic cells and in mouse bone m...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2008.242
更新日期：2008-12-01 00:00:00
abstract：:The proto-oncogene c-Jun has been implicated in the control of cell proliferation and differentiation and more recently in the regulation of apoptosis. We have previously reported the involvement of c-Jun in the erythroid differentiation block in murine erythroleukemia (MEL) cells. As reported here, we investigated th...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2402350
更新日期：2002-02-01 00:00:00
