Extramedullary relapse after favorable molecular response to donor leukocyte infusions for recurring acute leukemia.

abstract：:The hematopoietic system is sustained by a rare population of hematopoietic stem cells (HSCs), which emerge during early embryonic development and then reside in the hypoxic niche of the adult bone marrow microenvironment. Although leptin receptor (Lepr)-expressing stromal cells are well-studied as critical regulators...

journal_title：Leukemia

authors： Trinh T,Ropa J,Aljoufi A,Cooper S,Sinn A,Srour EF,Broxmeyer HE

更新日期：2020-11-07 00:00:00

abstract：:Fourteen patients with abnormalities of chromosome 16q, 13 with acute myelogenous leukaemia (AML), and one with refractory anaemia with excess of blasts (RAEB), are described. Seven patients had inv(16)(p13q22), two had del(16)(q22), and five had other abnormalities of 16q. Six of the seven patients with inv(16) had A...

journal_title：Leukemia

authors： Betts DR,Rohatiner AZ,Evans ML,Rassam SM,Lister TA,Gibbons B

更新日期：1992-12-01 00:00:00

abstract：:To build a risk score (RS) model of fatal intracranial hemorrhage (FICH) in patients with acute leukemia, we retrospectively assessed risk factors in 792 patients newly diagnosed with acute leukemia, 41 of whom had analyzable FICH. We found that female gender (relative risk (RR) = 5.234, P<0.001), acute promyelocytic ...

journal_title：Leukemia

authors： Kim H,Lee JH,Choi SJ,Lee JH,Seol M,Lee YS,Kim WK,Lee JS,Lee KH

更新日期：2006-05-01 00:00:00

abstract：:Patients with chronic lymphocytic leukemia (CLL) have a high risk of bloodstream infections (BSI). BSI cause significant morbidity and mortality among CLL patients; approximately one-third of fatalities in CLL list infections as cause of death. All CLL patients in Denmark diagnosed between 2008 and 2016 were followed ...

journal_title：Leukemia

authors： Andersen MA,Moser CE,Lundgren J,Niemann CU

更新日期：2019-03-01 00:00:00

abstract：:De novo acute myeloid leukemia (AML) with dysplastic features in erythroblasts, granulocytes and megakaryocytes, similar to those in myelodysplastic syndrome (MDS) has been described as AML with trilineage dysplasia (AML-TLD) since 1987. Several reports have suggested that AML-TLD is a subtype of de novo AML in adults...

journal_title：Leukemia

authors： Taguchi J,Miyazaki Y,Yoshida S,Fukushima T,Moriuchi Y,Jinnai I,Matsuo T,Kuriyama K,Tomonaga M

更新日期：2000-11-01 00:00:00

abstract：:Tumor lysis syndrome (TLS) has been described in over 40% of patients with chronic lymphocytic leukemia treated with the cyclin-dependent kinase inhibitor, flavopiridol. We conducted a retrospective analysis to determine predictive factors for TLS. In 116 patients, the incidence of TLS was 46% (95% CI: 36-55%). In uni...

journal_title：Leukemia

authors： Blum KA,Ruppert AS,Woyach JA,Jones JA,Andritsos L,Flynn JM,Rovin B,Villalona-Calero M,Ji J,Phelps M,Johnson AJ,Grever MR,Byrd JC

更新日期：2011-09-01 00:00:00

abstract：:Some evidences suggest that telomere restriction fragment length (TRF-L) is an effective indicator of histopathogenesis in B-cell tumors. As histopathogenesis is relevant for B-cell chronic lymphocytic leukemia (B-CLL) prognosis, TRF-L was assessed by Southern blot in 201 patients and compared to variable immunoglobul...

journal_title：Leukemia

authors： Ricca I,Rocci A,Drandi D,Francese R,Compagno M,Lobetti Bodoni C,De Marco F,Astolfi M,Monitillo L,Vallet S,Calvi R,Ficara F,Omedè P,Rosato R,Gallamini A,Marinone C,Bergui L,Boccadoro M,Tarella C,Ladetto M

更新日期：2007-04-01 00:00:00

abstract：:Protein phosphatase 2A (PP2A) is a human tumor suppressor that inhibits cellular transformation by regulating the activity of several signaling proteins critical for malignant cell behavior. PP2A has been described as a potential therapeutic target in chronic myeloid leukemia, Philadelphia chromosome-positive acute ly...

journal_title：Leukemia

authors： Cristóbal I,Garcia-Orti L,Cirauqui C,Alonso MM,Calasanz MJ,Odero MD

更新日期：2011-04-01 00:00:00

abstract：:Clinical characteristics, treatment response and outcome were evaluated in children with Down's syndrome (DS) and acute lymphoblastic leukemia (ALL) as compared to other children with ALL (NDS). Sixty-one DS and 4049 NDS patients, receiving intensive antileukemic treatment during four consecutive trials (ALL-BFM 81, 8...

journal_title：Leukemia

authors： Dördelmann M,Schrappe M,Reiter A,Zimmermann M,Graf N,Schott G,Lampert F,Harbott J,Niemeyer C,Ritter J,Dörffel W,Nessler G,Kühl J,Riehm H

更新日期：1998-05-01 00:00:00

abstract：:Little is known about the incidence of and risk factor for late effects of infant leukemia. We evaluated 19 children with acute lymphoblastic leukemia and 15 with acute myeloid leukemia who were diagnosed at age 12 months or younger and have survived for more than 5 years after the diagnosis (median length of follow-u...

journal_title：Leukemia

authors： Leung W,Hudson M,Zhu Y,Rivera GK,Ribeiro RC,Sandlund JT,Bowman LC,Evans WE,Kun L,Pui CH

更新日期：2000-07-01 00:00:00

abstract：:Suppression of c-myc expression is observed during induced differentiation of several myeloid cell lines and it has been attributed to the cell growth arrest that accompanies terminal differentiation. To dissect the role of c-Myc in the proliferation-differentiation switch we have studied c-myc expression in K562 cell...

journal_title：Leukemia

authors： Gómez-Casares MT,Delgado MD,Lerga A,Crespo P,Quincoces AF,Richard C,León J

更新日期：1993-11-01 00:00:00

abstract：:The effects of retinoic acid (RA) on the cell growth and expression of interleukin-2 (IL-2) receptors (IL-2R alpha/p55, Tac, CD25) by the human T lymphotropic virus type I (HTLV-I)-positive T cell lines, HUT102 and ATL-2 were investigated. Incubation of these cells for 48 h with either 13-cis retinoid acid (13-cis RA)...

journal_title：Leukemia

authors： Miyatake JI,Maeda Y

更新日期：1997-03-01 00:00:00

abstract：:We describe the use and outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for multiple myeloma (MM) in Europe between January 1990 and December 2012. We identified 7333 patients, median age at allo-HSCT was 51 years (range: 18-78), of whom 4539 (62%) were males. We distinguished three groups: ...

journal_title：Leukemia

authors： Sobh M,Michallet M,Gahrton G,Iacobelli S,van Biezen A,Schönland S,Petersen E,Schaap N,Bonifazi F,Volin L,Meijer E,Niederwieser D,El Cheikh J,Tabrizi R,Fegeux N,Finke J,Bunjes D,Cornelissen J,Einsele H,Bruno B,Pott

更新日期：2016-10-01 00:00:00

abstract：:The AML1 (RUNX1)-MTG8 (ETO) fusion transcription factor generated by the t(8;21) translocation is believed to deregulate the expression of genes that are crucial for normal differentiation and proliferation of hematopoietic progenitors, resulting in acute myelogenous leukemia. To elucidate the role of AML1-MTG8 in leu...

journal_title：Leukemia

authors： Shimada H,Ichikawa H,Ohki M

更新日期：2002-05-01 00:00:00

abstract：:The p210 bcr-abl fusion protein tyrosine kinase oncogene has been implicated in the pathogenesis of chronic granulocytic leukemia (CGL). Specific intracellular functions performed by p210 bcr-abl have recently been delineated. We considered the possibility that p210 bcr-abl may also regulate the abundance of inosine 5...

journal_title：Leukemia

authors： Gharehbaghi K,Burgess GS,Collart FR,Litz-Jackson S,Huberman E,Jayaram HN,Boswell HS

更新日期：1994-08-01 00:00:00

abstract：:Myeloproliferative neoplasms with myelofibrosis (MPN-MF) demonstrate constitutive activation of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling that responds to treatment with the JAK1 and 2 kinase inhibitor (JAKi) ruxolitinib. However, MPN-MF often progresses (~20%) to secondary acu...

journal_title：Leukemia

authors： Saenz DT,Fiskus W,Manshouri T,Rajapakshe K,Krieger S,Sun B,Mill CP,DiNardo C,Pemmaraju N,Kadia T,Parmar S,Sharma S,Coarfa C,Qiu P,Verstovsek S,Bhalla KN

更新日期：2017-03-01 00:00:00

abstract：:The karyotypic abnormalities and clinical data on three patients in whom acute leukemia was diagnosed within the first 6 months of life are presented. The four structural chromosomal rearrangements detected in the bone marrow from these patients, i.e., t(7;12)(q36;p13) and t(1;19)(q11;q11) in case 1, t(2;10;11;12)(q21...

journal_title：Leukemia

authors： Heim S,Békàssy AN,Garwicz S,Heldrup J,Wiebe T,Kristoffersson U,Mandahl N,Mitelman F

更新日期：1987-01-01 00:00:00

abstract：:Outcomes after unmanipulated haploidentical stem cell transplantation (Haplo) and after unrelated cord blood transplantation (UCBT) are encouraging and have become alternative options to treat patients with high-risk acute leukemia without human leukocyte antigen (HLA) matched donor. We compared outcomes after UCBT an...

journal_title：Leukemia

authors： Ruggeri A,Labopin M,Sanz G,Piemontese S,Arcese W,Bacigalupo A,Blaise D,Bosi A,Huang H,Karakasis D,Koc Y,Michallet M,Picardi A,Sanz J,Santarone S,Sengelov H,Sierra J,Vincent L,Volt F,Nagler A,Gluckman E,Ciceri F

更新日期：2015-09-01 00:00:00

abstract：:Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL)-a subtype of Hodgkin lymphoma (HL)-is characterized by a low content of tumor cells, the lymphocyte predominant (LP) cells. Transformation into diffuse large B-cell lymphoma (DLBCL) occurs in about 10% of patients. We performed whole-genome mutation analysis of t...

journal_title：Leukemia

authors： Hartmann S,Schuhmacher B,Rausch T,Fuller L,Döring C,Weniger M,Lollies A,Weiser C,Thurner L,Rengstl B,Brunnberg U,Vornanen M,Pfreundschuh M,Benes V,Küppers R,Newrzela S,Hansmann ML

更新日期：2016-04-01 00:00:00

abstract：:Transcriptional regulation of the HOXA genes is thought to involve CTCF-mediated chromatin loops and the opposing actions of the COMPASS and Polycomb epigenetic complexes. We investigated the role of these mechanisms at the HOXA cluster in AML cells with the common NPM1c mutation, which express both HOXA and HOXB gene...

journal_title：Leukemia

authors： Ghasemi R,Struthers H,Wilson ER,Spencer DH

更新日期：2020-05-12 00:00:00

abstract：:Dysplastic hematopoiesis is the morphological hallmark of myelodysplastic syndromes. Dysplastic features in one or more lineages are also found frequently in bone marrow aspirates from patients with de novo AML and have been associated with an unfavorable prognosis. We asked whether dyshematopoiesis is an independent ...

journal_title：Leukemia

authors： Gahn B,Haase D,Unterhalt M,Drescher M,Schoch C,Fonatsch C,Terstappen LW,Hiddemann W,Büchner T,Bennett JM,Wörmann B

更新日期：1996-06-01 00:00:00

abstract：:CD44 variant isoforms (CD44v) have been shown to be important factors in adverse prognosis in hematological malignancies. To investigate whether CD44 expression is associated with malignant transformation in multiple myeloma, RNA and protein expression of CD44 standard (CD44s) and CD44v4, v6, v9, v10 containing isofor...

journal_title：Leukemia

authors： van Driel M,Günthert U,Stauder R,Joling P,Lokhorst HM,Bloem AC

更新日期：1998-11-01 00:00:00

abstract：:Disturbances in the regulation of the balance between the fibrinolytic and procoagulant properties of leukemic cells may contribute to the coagulopathy of acute leukemia. The coagulant response to a number of stimuli is regulated by the expression of tissue factor, but the role of the plasminogen activator inhibitors,...

journal_title：Leukemia

authors： Dickinson JL,Antalis TM

更新日期：1993-06-01 00:00:00

abstract：:HOX homeobox proteins are key oncogenic drivers in hematopoietic malignancies. Here we demonstrate that HOXA1, HOXA6 and predominantly HOXA9 are able to induce the production of insulin-like growth factor 1 (Igf1). In chromatin immunoprecipitations, HOXA9 bound directly to the putative promoter and a DNase-hypersensit...

journal_title：Leukemia

authors： Steger J,Füller E,Garcia-Cuellar MP,Hetzner K,Slany RK

更新日期：2015-04-01 00:00:00

abstract：:Outcomes for patients with chronic myeloid leukemia (CML) have substantially improved due to advances in drug development and rational treatment intervention strategies. Despite these significant advances there are still unanswered questions on patient management regarding how to more reliably predict treatment failur...

journal_title：Leukemia

authors： Branford S,Kim DDH,Apperley JF,Eide CA,Mustjoki S,Ong ST,Nteliopoulos G,Ernst T,Chuah C,Gambacorti-Passerini C,Mauro MJ,Druker BJ,Kim DW,Mahon FX,Cortes J,Radich JP,Hochhaus A,Hughes TP,International CML Foundation Ge

更新日期：2019-08-01 00:00:00

abstract：:We compared blast cells from adult and pediatric patients with untreated acute lymphoblastic leukemia (ALL) (as separated groups of T-lineage cell and B-lineage cell ALL) to determine if methotrexate (MTX) polyglutamate formation in adult patients might be a contributing cause to the known difference in clinical outco...

journal_title：Leukemia

authors： Göker E,Lin JT,Trippett T,Elisseyeff Y,Tong WP,Niedzwiecki D,Tan C,Steinherz P,Schweitzer BI,Bertino JR

更新日期：1993-07-01 00:00:00

abstract：:Children with acute lymphoblastic leukemia (ALL) with > or = 0.01% leukemic cells in the bone marrow after remission induction are at a greater risk of relapse. The most promising methods of detecting minimal residual disease (MRD) are flow cytometric identification of leukemia-associated immunophenotypes and polymera...

journal_title：Leukemia

authors： Neale GA,Coustan-Smith E,Pan Q,Chen X,Gruhn B,Stow P,Behm FG,Pui CH,Campana D

更新日期：1999-08-01 00:00:00

abstract：:B-cell-specific plasma-membrane proteins are potential targets for either small molecule or antibody-based therapies. We have sought to annotate proteins expressed at the cell surface membrane in patients with chronic lymphocytic leukemia (CLL) using plasma-membrane-based proteomic analysis to identify previously unch...

journal_title：Leukemia

authors： Boyd RS,Adam PJ,Patel S,Loader JA,Berry J,Redpath NT,Poyser HR,Fletcher GC,Burgess NA,Stamps AC,Hudson L,Smith P,Griffiths M,Willis TG,Karran EL,Oscier DG,Catovsky D,Terrett JA,Dyer MJ

更新日期：2003-08-01 00:00:00

abstract：:Exponentially growing human lymphoblasts (culture LS-2) were separated by cell sorting (FACS II, Becton Dickinson) according to their deoxyribonucleic acid (DNA) content, designating them at particular phases of the cell cycle. Prior to cell sorting the DNA has been fluorochrome-labeled with the Hoechst stain H 33342....

journal_title：Leukemia

authors： Pelka-Fleischer R,Fleischer W,Wilmanns W,Sauer H,Schalhorn A

更新日期：1989-05-01 00:00:00

abstract：:Despite the presence of tumor antigens, the paucity of clinically significant T-cell mediated immune responses against human tumors is striking. This may, in part, be because of the inability of cancer cells to function as efficient antigen-presenting cells. For full activation, T cells must receive two signals delive...

journal_title：Leukemia

authors： Gribben JG,Cardoso AA,Schultze JL,Nadler LM

更新日期：1997-05-01 00:00:00