Abstract：
:Fourteen patients with abnormalities of chromosome 16q, 13 with acute myelogenous leukaemia (AML), and one with refractory anaemia with excess of blasts (RAEB), are described. Seven patients had inv(16)(p13q22), two had del(16)(q22), and five had other abnormalities of 16q. Six of the seven patients with inv(16) had AML M4Eo and, following treatment with adriamycin, cytosine arabinoside, and 6-thioguanine, all achieved complete remission (CR). Neither patient with del(16)(q22) had typical M4Eo morphology at diagnosis; CR was achieved in one and one had resistant leukaemia. Patients with other abnormalities of 16q had blasts of diverse morphology and, although morphologically abnormal eosinophils were seen in three patients, this was not as marked as in the patients with inv(16). CR was achieved in two of the four patients with other abnormalities of 16q but duration of remission was short in both cases. These results suggest that most patients with del(16)(q22) and other abnormalities of 16q22 do not have typical AML M4Eo. Such patients tend to have a worse prognosis, and are more likely to have complex karyotypes typical of secondary leukaemia.
journal_name
Leukemiajournal_title
Leukemiaauthors
Betts DR,Rohatiner AZ,Evans ML,Rassam SM,Lister TA,Gibbons Bsubject
Has Abstractpub_date
1992-12-01 00:00:00pages
1250-6issue
12eissn
0887-6924issn
1476-5551journal_volume
6pub_type
杂志文章,评审相关文献
LEUKEMIA文献大全abstract：:The expansion of the Philadelphia (Ph) chromosome positive clone in chronic myeloid leukemia (CML) may depend on its capacity to suppress the proliferation of Ph-negative stem cells, but this proliferative advantage might, in certain circumstances, be reversible. Various lines of evidence suggest that Ph-negative cell...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1991-06-01 00:00:00
abstract：:P38α/β has been described as a tumor-suppressor controlling cell cycle checkpoints and senescence in epithelial malignancies. However, p38α/β also regulates other cellular processes. Here, we describe a role of p38α/β as a regulator of acute lymphoblastic leukemia (ALL) proliferation and survival in experimental ALL m...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2015.153
更新日期：2015-12-01 00:00:00
abstract：:In Philadelphia chromosome (Ph1)-positive acute lymphoblastic leukemia (ALL), some cytogenetic studies have suggested clonal derivation from a multipotential stem cell. The role of the product of the chimeric gene, P190, is not, however, well understood. We examined the expression of P190-type bcr/abl in single hemato...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：:We analyzed the long-term outcome of 1011 patients treated in five successive clinical trials (Total Therapy Studies 11, 12, 13A, 13B, and 14) between 1984 and 1999. The event-free survival improved significantly (P=0.003) from the first two trials conducted in the 1980s to the three more recent trials conducted in th...
journal_title：Leukemia
pub_type： 临床试验,杂志文章
doi：10.1038/leu.2009.252
更新日期：2010-02-01 00:00:00
abstract：:This review will summarize the rationale for pursuing investigations into the use of retinoids for pediatric patients with cancer, describe the phase I results of all-trans-retinoic acid (ATRA) in children, and discuss the results of a series of preclinical and clinical pharmacokinetic studies of ATRA. The prognosis f...
journal_title：Leukemia
pub_type： 临床试验,杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:Oncoprotein 18 (Op18) is a major cystolic phosphoprotein constituent of leukemia cells. There is cumulative evidence that suggests a role for Op18 in integrating signals from diverse pathways involved in cell growth. Op18 phosphorylation is induced with proliferation in a variety of cell types, and is essential for ce...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2400792
更新日期：1997-10-01 00:00:00
abstract：:Human T-lymphotropic virus type I (HTLV-I) is the etiological agent of adult T-cell leukemia/lymphoma (ATL) and of tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). In both diseases, expression of viral message can generally only be demonstrated by the reverse transcriptase-polymerase chain reaction...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:PRDM1/BLIMP-1, a master regulator of plasma-cell differentiation, is frequently inactivated in activated B-cell-like (ABC) diffuse large B-cell lymphoma (DLBCL) patients. Little is known about its genetic aberrations and relevant clinical implications. A large series of patients with de novo DLBCL was effectively eval...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2016.243
更新日期：2017-03-01 00:00:00
abstract：:Major molecular remission (MMR) is an important therapy goal in chronic myeloid leukemia (CML). So far, MMR is not a failure criterion according to ELN management recommendation leading to uncertainties when to change therapy in CML patients not reaching MMR after 12 months. At monthly landmarks, for different molecul...
journal_title：Leukemia
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41375-018-0055-7
更新日期：2018-05-01 00:00:00
abstract：:Multiple myeloma (MM) is a plasma cell tumor marked by clonal evolution and preceded by a premalignant stage, which progresses via molecular pathway deregulation, including MYC activation. This activation relates to translocation or gain of the MYC locus and deregulation of upstream pathways such as IRF4, DIS3/LIN28B/...
journal_title：Leukemia
pub_type： 杂志文章,评审
doi：10.1038/s41375-018-0036-x
更新日期：2018-06-01 00:00:00
abstract：:Disturbances in the regulation of the balance between the fibrinolytic and procoagulant properties of leukemic cells may contribute to the coagulopathy of acute leukemia. The coagulant response to a number of stimuli is regulated by the expression of tissue factor, but the role of the plasminogen activator inhibitors,...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1993-06-01 00:00:00
abstract：:High-dose methotrexate (Hd-MTX) therapy has recently been applied to the treatment of adult acute lymphoblastic leukemia (ALL) based on pediatric protocols; however, its effectiveness for adult ALL has not yet been confirmed in a rigorous manner. We herein conducted a randomized phase III trial comparing Hd-MTX therap...
journal_title：Leukemia
pub_type： 杂志文章,随机对照试验
doi：10.1038/leu.2017.283
更新日期：2018-03-01 00:00:00
abstract：:The presence of CD19 in myelomatous plasma cells (MM-PCs) correlates with adverse prognosis in multiple myeloma (MM). Although CD19 expression is upregulated by CD81, this marker has been poorly investigated and its prognostic value in MM remains unknown. We have analyzed CD81 expression by multiparameter flow cytomet...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2012.42
更新日期：2012-08-01 00:00:00
abstract：:We evaluated the synergistic activity of AS101 (ammonium trichloro-(dioxoethylene-0-0')-tellurate) with the protein kinase C (PKC) activators, Bryostatin-1 and phorbol-12-myristate-13-acetate (PMA), on human myelocytic leukemia cell differentiation in vitro, and in a mouse model. Use of AS101 with Bryostatin-1 or with...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2404746
更新日期：2007-07-01 00:00:00
abstract：:We evaluated the impact of salvage regimens and allogeneic hematopoietic cell transplantation (allo-HCT) in acute myeloid leukemia (AML) with induction failure. Between 1993 and 2009, 3324 patients with newly diagnosed AML were enrolled in 5 prospective treatment trials of the German-Austrian AML Study Group. After fi...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2017.23
更新日期：2017-06-01 00:00:00
abstract：:Myeloproliferative neoplasm (MPN)-associated myelofibrosis is a MPN characterized by bone marrow fibrosis, cytopenias, splenomegaly and constitutional symptoms. Pomalidomide, an immune-modifying drug, is reported to improve anaemia and thrombocytopenia in some patients with MPN-associated myelofibrosis. We designed a ...
journal_title：Leukemia
pub_type： 杂志文章,多中心研究
doi：10.1038/leu.2016.299
更新日期：2017-04-01 00:00:00
abstract：:The expression of the myeloperoxidase (MPO) gene was studied, by means of Northern blot analysis in 14 cases of acute myeloid leukemia (AML), 11 cases of chronic myeloid leukemia (CML), and 6 cases of CML blast crisis, and in HL60 cells before and after induction of terminal differentiation with retinoic acid (RA), ph...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1989-06-01 00:00:00
abstract：:To determine the frequency and prognostic significance of recently described genetic lesions in pediatric acute lymphoblastic leukemia (ALL), all cases with available leukemic cell samples treated on St Jude Study XII were analyzed by molecular techniques for alterations of the p16, MLL and ETV6 genes. Homozygous p16 ...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2400779
更新日期：1997-08-01 00:00:00
abstract：:The proto-oncogene c-Jun has been implicated in the control of cell proliferation and differentiation and more recently in the regulation of apoptosis. We have previously reported the involvement of c-Jun in the erythroid differentiation block in murine erythroleukemia (MEL) cells. As reported here, we investigated th...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2402350
更新日期：2002-02-01 00:00:00
abstract：:Osteopontin (OPN) is a multifunctional bone matrix glycoprotein that is involved in angiogenesis, cell survival and tumor progression. In this study we show that human myeloma cells directly produce OPN and express its major regulating gene Runx2/Cbfa1. The activity of Runx2/Cbfa1 protein in human myeloma cells has al...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2403976
更新日期：2005-12-01 00:00:00
abstract：:The high efficacy of the standard treatment of chronic myeloid leukemia (CML) with imatinib has prompted the need for accurate methods to monitor response at levels below the landmark of complete cytogenetic remission. Quantification of BCR-ABL transcripts has proven to be the most sensitive method available, and has ...
journal_title：Leukemia
pub_type： 杂志文章,评审
doi：10.1038/leu.2009.168
更新日期：2009-11-01 00:00:00
abstract：:To assess the efficacy and toxicity of HAA regimen (homoharritonine 4 mg/m2/day, days 1-3; cytarabine 150 mg/m2/day, days 1-7; aclarubicin 12 mg/m2/day, days 1-7) as an induction therapy in the treatment of de novo acute myeloid leukemia (AML), 48 patients with newly diagnosed AML, aged 35 (14-57) years, were entered ...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2404287
更新日期：2006-08-01 00:00:00
abstract：:Immunotherapy with T cell modified with gamma-retroviral or lentiviral (LV) vectors to express a chimeric antigen receptor (CAR) has shown remarkable efficacy in clinical trials. However, the potential for insertional mutagenesis and genotoxicity of viral vectors is a safety concern, and their cost and regulatory dema...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2016.180
更新日期：2017-01-01 00:00:00
abstract：:Infants less than 1 year of age at diagnosis of acute lymphoblastic leukemia (ALL) have a poor prognosis, which has been attributed primarily to a breakpoint in chromosomal band 11q23 or the MLL gene. Most infants with an 11q23 breakpoint have a t(4;11)(q21 ;q23). We studied the cytogenetics of the leukemia cells of 5...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2401413
更新日期：1999-05-01 00:00:00
abstract：:In order to obtain more insight into the nature of the abnormal in vitro colony formation in myelodysplastic syndromes (MDS), we investigated the kinetics of the colony formation of 23 MDS cases in response to recombinant human interleukin-3 (IL-3), Granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyt...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：:Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene have been found at high frequency in cell lines derived from a variety of adult solid tumors. In order to investigate the status of the CDKN2 gene in cell lines established from childhood acute lymphoblastic leukemia (ALL), we surveyed 25 lines representing the maj...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1995-07-01 00:00:00
abstract：:The molecular basis for autonomous growth of malignant forms of human T lymphocytes is not known. It can be investigated by functional responses of malignant cells in comparison with untransformed counterparts. At least two pathways (the CD2 and CD3 pathways) of human T-cell activation have been recently defined on th...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
abstract：:The hematopoietic growth factors are glycoproteins that can be produced by recombinant DNA technology. They have many potential clinical uses in acute leukemia; several areas have been explored extensively and much data are available from clinical trials. Other areas are of potential interest, but have a paucity of cl...
journal_title：Leukemia
pub_type： 杂志文章,评审
doi：10.1038/sj.leu.2400592
更新日期：1997-03-01 00:00:00
abstract：:Allogeneic haemopoietic cell transplant (allo-HCT) may be curative in acute myeloid leukaemia (AML) in second complete remission (CR2) but the impact of reduced intensity (RIC) versus myeloablative conditioning (MAC) is uncertain. The Acute Leukaemia Working Party of the European Society for Blood and Bone Marrow Tran...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/s41375-019-0527-4
更新日期：2020-01-01 00:00:00
abstract：:There have been controversies about CD34 and CD38 expression by human cord blood (CB) stem cells. Using the newborn NOD/SCID/beta2-microglobulin-null mouse assay that we recently developed, we examined the in vivo engrafting capability of human CB cells. Almost all of the 4-5 months engrafting cells were found in CD34...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2402878
更新日期：2003-05-01 00:00:00
