Abstract:
:Oncoprotein 18 (Op18) is a major cystolic phosphoprotein constituent of leukemia cells. There is cumulative evidence that suggests a role for Op18 in integrating signals from diverse pathways involved in cell growth. Op18 phosphorylation is induced with proliferation in a variety of cell types, and is essential for cell cycle progression. In this study we analyzed the level of unphosphorylated Op18 and of its major phosphorylated forms, Op18a and Op18b, in a series of 177 childhood acute leukemias by means of quantitative two-dimensional polyacrylamide gel electrophoresis (2-D PAGE). Op18 phosphorylation was significantly correlated with the white blood count at the time of diganosis, and with a high percentage of cells in the S phase. Our findings suggest that strategies to inhibit Op18 expression or phosphorylation may be effective in inhibiting leukemia cell proliferation.
journal_name
Leukemiajournal_title
Leukemiaauthors
Melhem R,Hailat N,Kuick R,Hanash SMdoi
10.1038/sj.leu.2400792subject
Has Abstractpub_date
1997-10-01 00:00:00pages
1690-5issue
10eissn
0887-6924issn
1476-5551journal_volume
11pub_type
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