当前位置： SCI文献检索 > LEUKEMIA期刊下所有文献 > Detection of additional JH/BCL2 translocations in follicular lymphoma.

Detection of additional JH/BCL2 translocations in follicular lymphoma.

Abstract：

:In vitro enzymatic amplification and direct sequencing were used to detect and characterize t(14;18) recombination junctions in peripheral blood and bone marrow mononuclear cell preparations from patients with follicular lymphoma in remission. Samples from 24/44 patients were found to be positive for translocations involving the major breakpoint region of the BCL2 gene. In samples from seven patients two distinct t(14;18) translocations were shown to be present simultaneously; in one case the second translocation involved the minor cluster region of the BCL2 gene. Biopsy tissue obtained earlier in the course of the disease was available from five of these patients and was shown to contain one of the translocations in each case, but both translocations in only one. Further remission blood and bone marrow samples from the group were also examined. This led to the detection of both translocations in separate samples obtained at different times in a total of four out of the seven cases. In two of the remaining three patients the second translocation could not be amplified from further samples, but in both cases the search led to the identification of a third translocation, again only detectable in a single sample. These findings demonstrate that JH/BCL2 translocations can occur more than once during the course of follicular lymphoma. They suggest that biclonal follicular lymphoma may be more common than has previously been recognized but also raise the possibility that the translocation arises sporadically in the normal lymphoid cells of this group of patients.

journal_name

Leukemia

journal_title

Leukemia

authors

Price CG,Tuszynski A,Watt SM,Murdoch SJ,Lister TA,Young BD

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

548-54

issue

7

eissn

0887-6924

issn

1476-5551

journal_volume

5

pub_type

杂志文章

相关文献

LEUKEMIA文献大全
  • Effective in vivo induction of NKG2D ligands in acute myeloid leukaemias by all-trans-retinoic acid or sodium valproate.

    abstract：:Engagement of NKG2D by their ligands (NKG2D-L), as the human major histocompatibility complex class I-related molecules MIC-A and the UL16-binding proteins, on cytolytic lymphocytes leads to the enhancement of antitumour effector functions. These ligands are missing or expressed at very low levels on leukaemic cells; ...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2008.354

    authors： Poggi A,Catellani S,Garuti A,Pierri I,Gobbi M,Zocchi MR

    更新日期：2009-04-01 00:00:00

  • Inhibition of proliferation and CD25 down-regulation by retinoic acid in human adult T cell leukemia cells.

    abstract：:The effects of retinoic acid (RA) on the cell growth and expression of interleukin-2 (IL-2) receptors (IL-2R alpha/p55, Tac, CD25) by the human T lymphotropic virus type I (HTLV-I)-positive T cell lines, HUT102 and ATL-2 were investigated. Incubation of these cells for 48 h with either 13-cis retinoid acid (13-cis RA)...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2400593

    authors： Miyatake JI,Maeda Y

    更新日期：1997-03-01 00:00:00

  • Detection of low abundance mRNA of myeloid specific genes in cells of acute and chronic lymphoid leukemias by cRNA hybridization.

    abstract：:The hybridization to a complementary RNA (cRNA) probe both in situ and in solution was used to assay tiny amounts of mRNA of the lactoferrin (LF) and myeloperoxidase (MPO) genes in normal bone marrow cells and in acute and chronic lymphoid leukemias. Evidence is reported that this technique is much more sensitive than...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Ferrari S,Ceccherelli G,Tagliafico E,Zucchini P,Manfredini R,Torelli G,Emilia G,Torelli U

    更新日期：1990-10-01 00:00:00

  • A multiplex RT-PCR assay for the detection of chimeric transcripts encoded by the risk-stratifying translocations of pediatric acute lymphoblastic leukemia.

    abstract：:Modern therapy for pediatric acute lymphoblastic leukemia (ALL) is based on the principle of risk stratification. One of the most important laboratory features used to accurately risk stratify patients is the presence of specific chromosomal translocation within the leukemic blasts. In this paper, we describe a multip...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2401224

    authors： Scurto P,Hsu Rocha M,Kane JR,Williams WK,Haney DM,Conn WP,Shurtleff SA,Downing JR

    更新日期：1998-12-01 00:00:00

  • Detection and molecular monitoring of FIP1L1-PDGFRA-positive disease by analysis of patient-specific genomic DNA fusion junctions.

    abstract：:To evaluate current detection methods for FIP1L1-PDGFRA in hypereosinophilic syndrome (HES), we developed a means to rapidly amplify genomic break points. We screened 202 cases and detected genomic junctions in all samples previously identified as RT-PCR positive (n=43). Genomic fusions were amplified by single step P...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2008.309

    authors： Score J,Walz C,Jovanovic JV,Jones AV,Waghorn K,Hidalgo-Curtis C,Lin F,Grimwade D,Grand F,Reiter A,Cross NC

    更新日期：2009-02-01 00:00:00

  • A prospective, randomized, double-blind study, comparing unirradiated to irradiated white blood cell transfusions in acute leukemia patients.

    abstract：:A prospective, randomized double-blind study comparing the effects of irradiated and unirradiated white blood cells was conducted in 108 acute leukemia patients with life-threatening infections, refractory to antibiotics. The study demonstrated no significant improvement in 30-day survival or overall survival. Transfu...

    journal_title：Leukemia

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/leu.2012.301

    authors： Freireich EJ,Lichtiger B,Mattiuzzi G,Martinez F,Reddy V,Kyle Wathen J

    更新日期：2013-04-01 00:00:00

  • Clonal diversity of recurrently mutated genes in myelodysplastic syndromes.

    abstract：:Recent studies suggest that most cases of myelodysplastic syndrome (MDS) are clonally heterogeneous, with a founding clone and multiple subclones. It is not known whether specific gene mutations typically occur in founding clones or subclones. We screened a panel of 94 candidate genes in a cohort of 157 patients with ...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2013.58

    authors： Walter MJ,Shen D,Shao J,Ding L,White BS,Kandoth C,Miller CA,Niu B,McLellan MD,Dees ND,Fulton R,Elliot K,Heath S,Grillot M,Westervelt P,Link DC,DiPersio JF,Mardis E,Ley TJ,Wilson RK,Graubert TA

    更新日期：2013-06-01 00:00:00

  • Large deletions 5' to the ETO breakpoint are recurrent events in patients with t(8;21) acute myeloid leukemia.

    abstract：:Recurrent chromosomal rearrangements are observed in many leukemia subtypes. Recently, it has been shown that several of these translocations/inversions were associated with the loss of sequences located in the vicinity of the chromosomal breakpoints. So far, such deletions have not been described for the t(8;21) tran...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2402585

    authors： Godon C,Proffitt J,Dastugue N,Lafage-Pochitaloff M,Mozziconacci MJ,Talmant P,Hackbarth M,Bataille R,Avet-Loiseau H

    更新日期：2002-09-01 00:00:00

  • Stat3 mutations impact on overall survival in large granular lymphocyte leukemia: a single-center experience of 205 patients.

    abstract：:Large granular lymphocyte leukemia (LGLL) is a rare and chronic lymphoproliferative disorder characterized by the clonal expansion of LGLs. LGLL patients can be asymptomatic or develop cytopenia, mostly neutropenia. Somatic STAT3 and STAT5b mutations have been recently reported in approximately 40% of patients. The ai...

    journal_title：Leukemia

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41375-019-0644-0

    authors： Barilà G,Teramo A,Calabretto G,Vicenzetto C,Gasparini VR,Pavan L,Leoncin M,Vedovato S,Frigo AC,Facco M,Semenzato G,Zambello R

    更新日期：2020-04-01 00:00:00

  • Interleukin-4-mediated inhibition of C-Fos mRNA expression: role of the lipoxygenase directed pathway.

    abstract：:Interleukin-4 inhibits several monocyte functions like A23187-induced expression of cytokines and c-fos and c-jun proto-oncogene mRNA expression. In an attempt to elucidate the mechanism by which this inhibitive effect is mediated, we compared the effect of IL-4 on A23187-induced c-fos and c-jun mRNA expression in con...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Dokter WH,Sierdsema SJ,Esselink MT,Halie MR,Vellenga E

    更新日期：1994-07-01 00:00:00

  • Distinct antigen expression related to DNA ploidy in a case of biphenotypic leukemia.

    abstract：:Three cell populations with different DNA indices were demonstrated in a case of biphenotypic terminal transferase (TdT)/myeloid-positive acute leukemia which had developed from a pre-leukemic diploid population also expressing biphenotypic features. At the time of development of acute leukemia, flow-cytometric analys...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Paietta E,Andreeff M,Papenhausen P,Gucalp R,Wiernik PH

    更新日期：1989-01-01 00:00:00

  • A phase I/II study of imatinib plus reinduction therapy for c-kit-positive relapsed/refractory acute myeloid leukemia: inhibition of Akt activation correlates with complete response.

    abstract：:This phase I/II study evaluated imatinib as a c-kit inhibitor combined with mitoxantrone, etoposide and cytarabine therapy for patients with primary refractory or relapsed c-kit+ acute myeloid leukemia (AML). Imatinib was escalated through three dose levels in successive six patient cohorts. The combination was well t...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2011.34

    authors： Brandwein JM,Hedley DW,Chow S,Schimmer AD,Yee KW,Schuh AC,Gupta V,Xu W,Kamel-Reid S,Minden MD

    更新日期：2011-06-01 00:00:00

  • Impact of salvage regimens on response and overall survival in acute myeloid leukemia with induction failure.

    abstract：:We evaluated the impact of salvage regimens and allogeneic hematopoietic cell transplantation (allo-HCT) in acute myeloid leukemia (AML) with induction failure. Between 1993 and 2009, 3324 patients with newly diagnosed AML were enrolled in 5 prospective treatment trials of the German-Austrian AML Study Group. After fi...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2017.23

    authors： Wattad M,Weber D,Döhner K,Krauter J,Gaidzik VI,Paschka P,Heuser M,Thol F,Kindler T,Lübbert M,Salih HR,Kündgen A,Horst HA,Brossart P,Götze K,Nachbaur D,Köhne CH,Ringhoffer M,Wulf G,Held G,Salwender H,Benner A,G

    更新日期：2017-06-01 00:00:00

  • Comparative value of post-remission treatment in cytogenetically normal AML subclassified by NPM1 and FLT3-ITD allelic ratio.

    abstract：:Post-remission treatment (PRT) in patients with cytogenetically normal (CN) acute myeloid leukemia (AML) in first complete remission (CR1) is debated. We studied 521 patients with CN-AML in CR1, for whom mutational status of NPM1 and FLT3-ITD was available, including the FLT3-ITD allelic ratio. PRT consisted of reduce...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2016.183

    authors： Versluis J,In 't Hout FE,Devillier R,van Putten WL,Manz MG,Vekemans MC,Legdeur MC,Passweg JR,Maertens J,Kuball J,Biemond BJ,Valk PJ,van der Reijden BA,Meloni G,Schouten HC,Vellenga E,Pabst T,Willemze R,Löwenberg B,O

    更新日期：2017-01-01 00:00:00

  • Differences between BCL2-break positive and negative follicular lymphoma unraveled by whole-exome sequencing.

    abstract：:Depending on disease stage follicular lymphoma (FL) lack the t(14;18) in ~15-~50% of cases. Nevertheless, most of these cases express BCL2. To elucidate mechanisms triggering BCL2 expression and promoting pathogenesis in t(14;18)-negative FL, exonic single-nucleotide variant (SNV) profiles of 28 t(14;18)-positive and ...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2017.270

    authors： Zamò A,Pischimarov J,Schlesner M,Rosenstiel P,Bomben R,Horn H,Grieb T,Nedeva T,López C,Haake A,Richter J,Trümper L,Lawerenz C,Klapper W,Möller P,Hummel M,Lenze D,Szczepanowski M,Flossbach L,Schreder M,Gattei V,O

    更新日期：2018-03-01 00:00:00

  • New insight on the role of extrachromosomal retroviral DNA.

    abstract：:During infection with different retroviruses, high levels of unintegrated extrachromosomal DNA accumulate in infected cells. While extrachromosomal linear DNA is the immediate precursor of the integrated provirus, the function, if any, of extrachromosomal circular DNA has been unclear. Several groups have attempted to...

    journal_title：Leukemia

    pub_type： 杂志文章,评审

    doi：10.1038/sj.leu.2400776

    authors： Cara A,Reitz MS Jr

    更新日期：1997-09-01 00:00:00

  • Myeloid to lymphoid clonal succession following autologous transplantation in second chronic phase of chronic myeloid leukaemia.

    abstract：:A 23-year-old male found to have Philadelphia chromosome-positive chronic myeloid leukemia (CML) in May 1987 suffered a myeloid blastic transformation in April 1993. A second chronic phase was achieved after treatment with daunorubicin and cytosine arabinoside and the patient then underwent autologous bone marrow tran...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Spencer A,Vulliamy T,Chase A,Goldman JM

    更新日期：1995-12-01 00:00:00

  • The vascular niche: home for normal and malignant hematopoietic stem cells.

    abstract：:Hematopoietic stem cells (HSCs) are uniquely capable of self-renewal and provision of all of the mature elements of the blood and immune system throughout the lifetime of an individual. HSC self-renewal is regulated by both intrinsic mechanisms and extrinsic signals mediated via specialized microenvironments or 'niche...

    journal_title：Leukemia

    pub_type： 杂志文章,评审

    doi：10.1038/leu.2011.236

    authors： Doan PL,Chute JP

    更新日期：2012-01-01 00:00:00

  • Minimally differentiated acute myeloid leukemia in Taiwan: predominantly occurs in children less than 3 years and adults between 51 and 70 years.

    abstract：:Acute myeloid leukemia (AML) with minimal differentiation was usually referred to as acute undifferentiated leukemia in the past. With the help of immunophenotyping, this subtype of leukemia was shown to express myeloid antigens on the blasts and was designated AML-M0 by FAB Cooperative Study Group in 1991. Among the ...

    journal_title：Leukemia

    pub_type： 临床试验,杂志文章

    doi：10.1038/sj.leu.2401521

    authors： Huang SY,Tang JL,Jou ST,Tsay W,Hu CH,Lin DT,Lin KS,Lin KS,Wang CH,Chen YC,Shen MC,Tien HF

    更新日期：1999-10-01 00:00:00

  • tal-1 deletions in T-cell acute lymphoblastic leukemia as PCR target for detection of minimal residual disease.

    abstract：:Polymerase chain reaction (PCR) techniques based on amplification and identification of leukemia-specific DNA sequences provide a sensitive diagnostic method for detection of minimal residual disease (MRD) with a detection limit of 10(-5) to 10(-6) (1-10 malignant cells in 10(6) normal cells). To date, the main leukem...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Breit TM,Beishuizen A,Ludwig WD,Mol EJ,Adriaansen HJ,van Wering ER,van Dongen JJ

    更新日期：1993-12-01 00:00:00

  • Multiple myeloma oncogene 1 (MUM1)/interferon regulatory factor 4 (IRF4) upregulates monokine induced by interferon-gamma (MIG) gene expression in B-cell malignancy.

    abstract：:MUM1 (multiple myeloma oncogene 1)/IRF4 (interferon regulatory factor 4) is a transcription factor that is activated as a result of t(6;14)(p25;q32) in multiple myeloma. MUM1 expression is seen in various B-cell lymphomas and predicts an unfavorable outcome in some lymphoma subtypes. To elucidate its role in B-cell ma...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2403833

    authors： Uranishi M,Iida S,Sanda T,Ishida T,Tajima E,Ito M,Komatsu H,Inagaki H,Ueda R

    更新日期：2005-08-01 00:00:00

  • Is the mdr 1 gene relevant in chronic lymphocytic leukemia?

    abstract：:Chronic lymphocytic leukemia (CLL) is a progressive disease in which chemotherapy may result in temporary suppression of the peripheral blood lymphocyte count, but cure is not usually possible. Drug resistance mechanisms and the multidrug resistant (MDR) phenotype may be relevant to the therapeutic response. We have s...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Holmes JA,Jacobs A,Carter G,Whittaker JA,Bentley DP,Padua RA

    更新日期：1990-03-01 00:00:00

  • Epidemiology of bloodstream infections in patients with chronic lymphocytic leukemia: a longitudinal nation-wide cohort study.

    abstract：:Patients with chronic lymphocytic leukemia (CLL) have a high risk of bloodstream infections (BSI). BSI cause significant morbidity and mortality among CLL patients; approximately one-third of fatalities in CLL list infections as cause of death. All CLL patients in Denmark diagnosed between 2008 and 2016 were followed ...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/s41375-018-0316-5

    authors： Andersen MA,Moser CE,Lundgren J,Niemann CU

    更新日期：2019-03-01 00:00:00

  • TET1 promotes growth of T-cell acute lymphoblastic leukemia and can be antagonized via PARP inhibition.

    abstract：:T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological cancer characterized by skewed epigenetic patterns, raising the possibility of therapeutically targeting epigenetic factors in this disease. Here we report that among different cancer types, epigenetic factor TET1 is highly expressed in T-ALL a...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/s41375-020-0864-3

    authors： Bamezai S,Demir D,Pulikkottil AJ,Ciccarone F,Fischbein E,Sinha A,Borga C,Te Kronnie G,Meyer LH,Mohr F,Götze M,Caiafa P,Debatin KM,Döhner K,Döhner H,González-Menéndez I,Quintanilla-Fend L,Herold T,Jeremias I,Feuring-

    更新日期：2020-05-15 00:00:00

  • Prognostic factors for hyperdiploid-myeloma: effects of chromosome 13 deletions and IgH translocations.

    abstract：:Chromosomal hyperdiploidy is the defining genetic signature in 40-50% of myeloma (MM) patients. We characterize hyperdiploid-MM (H-MM) in terms of its clinical and prognostic features in a cohort of 220 H-MM patients entered into clinical trials. Hyperdiploid-myeloma is associated with male sex, kappa immunoglobulin s...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2404172

    authors： Chng WJ,Santana-Dávila R,Van Wier SA,Ahmann GJ,Jalal SM,Bergsagel PL,Chesi M,Trendle MC,Jacobus S,Blood E,Oken MM,Henderson K,Kyle RA,Gertz MA,Lacy MQ,Dispenzieri A,Greipp PR,Fonseca R

    更新日期：2006-05-01 00:00:00

  • Downregulation of Mcl-1 through GSK-3β activation contributes to arsenic trioxide-induced apoptosis in acute myeloid leukemia cells.

    abstract：:Arsenic trioxide (ATO) induces disease remission in acute promyelocytic leukemia (APL) patients, but not in non-APL acute myeloid leukemia (AML) patients. ATO at therapeutic concentrations (1-2 μM) induces APL NB4, but not non-APL HL-60, cells to undergo apoptosis through the mitochondrial pathway. The role of antiapo...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2012.180

    authors： Wang R,Xia L,Gabrilove J,Waxman S,Jing Y

    更新日期：2013-02-01 00:00:00

  • Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells.

    abstract：:Multidrug resistance (MDR), a significant impediment to the successful treatment of cancer clinically, has been attributed to the overexpression of P-glycoprotein (P-gp), a plasma membrane multidrug efflux transporter. P-gp maintains sublethal intracellular drug concentrations by virtue of its drug efflux capacity. Th...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2009.76

    authors： Bebawy M,Combes V,Lee E,Jaiswal R,Gong J,Bonhoure A,Grau GE

    更新日期：2009-09-01 00:00:00

  • Establishment and characterization of a new erythropoietin-dependent acute myeloid leukemia cell line, AS-E2.

    abstract：:We have established an erythropoietin-dependent human leukemia cell line, AS-E2, from a patient with acute myeloid leukemia. These cells have many characteristics of late erythroid progenitor cells, they are positive for CD36, Glycophorin A, and CD71 but negative for CD41, and positive for benzidine and PAS staining. ...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2400838

    authors： Miyazaki Y,Kuriyama K,Higuchi M,Tsushima H,Sohda H,Imai N,Saito M,Kondo T,Tomonaga M

    更新日期：1997-11-01 00:00:00

  • Genetic, phenotypic and clinical features of acute lymphoblastic leukemias expressing myeloperoxidase mRNA detected by RT-PCR.

    abstract：:Myeloperoxidase (MPO) is found in the azurophilic granules of normal myelocytic cells. Cytochemical staining for MPO activity is used clinically to distinguish myeloid from acute lymphoid leukemias (ALL). However, using a highly sensitive RT-PCR technique, it is possible to detect MPO mRNA in otherwise clear ALL. The ...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2401305

    authors： Serrano J,Román J,Jiménez A,Castillejo JA,Navarro JA,Sánchez J,García-Castellanos JM,Martín C,Maldonado J,Torres A

    更新日期：1999-02-01 00:00:00

  • P-glycoprotein (P-170) and CD34 expression in adult acute myeloid leukemia (AML).

    abstract：:We investigated the prognosis value of CD34 and P-170 expression in blast cells of adult patients affected by de novo acute myeloid leukemia (AML). CD34 antigen was analyzed by indirect immunofluorescence (IFI) and alkaline phosphatase-labeled streptavidin biotine (AP-LSAB) in 62 patients (median age: 51 years). P-170...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Lamy T,Goasguen JE,Mordelet E,Grulois I,Dauriac C,Drenou B,Chaperon J,Fauchet R,le Prise PY

    更新日期：1994-11-01 00:00:00