Differences between BCL2-break positive and negative follicular lymphoma unraveled by whole-exome sequencing.

abstract：:Reliable detection of JAK2-V617F is critical for accurate diagnosis of myeloproliferative neoplasms (MPNs); in addition, sensitive mutation-specific assays can be applied to monitor disease response. However, there has been no consistent approach to JAK2-V617F detection, with assays varying markedly in performance, af...

journal_title：Leukemia

authors： Jovanovic JV,Ivey A,Vannucchi AM,Lippert E,Oppliger Leibundgut E,Cassinat B,Pallisgaard N,Maroc N,Hermouet S,Nickless G,Guglielmelli P,van der Reijden BA,Jansen JH,Alpermann T,Schnittger S,Bench A,Tobal K,Wilkins B,Cu

更新日期：2013-10-01 00:00:00

abstract：:Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained from 2345 acute leukemia patients. Genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and 1...

journal_title：Leukemia

authors： Meyer C,Burmeister T,Gröger D,Tsaur G,Fechina L,Renneville A,Sutton R,Venn NC,Emerenciano M,Pombo-de-Oliveira MS,Barbieri Blunck C,Almeida Lopes B,Zuna J,Trka J,Ballerini P,Lapillonne H,De Braekeleer M,Cazzaniga G,Cor

更新日期：2018-02-01 00:00:00

abstract：:There is increasing evidence that HOX homeobox genes play a role in leukemogenesis. Recent studies have demonstrated that enforced co-expression of HOXA9 and MEIS1 in murine marrow leads to rapid development of myeloid leukemia, and that these proteins exhibit cooperative DNA binding. However, it is unclear whether co...

journal_title：Leukemia

authors： Lawrence HJ,Rozenfeld S,Cruz C,Matsukuma K,Kwong A,Kömüves L,Buchberg AM,Largman C

更新日期：1999-12-01 00:00:00

abstract：:Despite considerable advances in the treatment of multiple myeloma (MM) in the last decade, a substantial proportion of patients do not respond to current therapies or have a short duration of response. Furthermore, these treatments can have notable morbidity and are not uniformly tolerated in all patients. As there i...

journal_title：Leukemia

authors： Shah N,Chari A,Scott E,Mezzi K,Usmani SZ

更新日期：2020-04-01 00:00:00

abstract：:In order to assess the proliferative capacity of leukemic subpopulations and to know whether it can be related to the stage of maturation, the expression of two surface antigens identifying distinct steps of leukocyte differentiation (CD15 and CD34) was studied by flow cytometry in correlation with DNA content in 16 c...

journal_title：Leukemia

authors： Campos L,Ffrench M,Guyotat D

更新日期：1990-01-01 00:00:00

abstract：:CD44 variant isoforms (CD44v) have been shown to be important factors in adverse prognosis in hematological malignancies. To investigate whether CD44 expression is associated with malignant transformation in multiple myeloma, RNA and protein expression of CD44 standard (CD44s) and CD44v4, v6, v9, v10 containing isofor...

journal_title：Leukemia

authors： van Driel M,Günthert U,Stauder R,Joling P,Lokhorst HM,Bloem AC

更新日期：1998-11-01 00:00:00

abstract：:Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by clonal proliferation of plasma cells and a heterogenous genomic landscape. Copy number and structural changes due to chromosomal instability (CIN) are common features of MM. In this review, we describe how primary and secondary genetic event...

journal_title：Leukemia

authors： Neuse CJ,Lomas OC,Schliemann C,Shen YJ,Manier S,Bustoros M,Ghobrial IM

更新日期：2020-11-01 00:00:00

abstract：:Only two classes of chemotherapeutic agents have shown activity in acute myeloid leukemia (AML): ara-C and topoisomerase II reactive agents. Frontline combinations of these agents produce complete response (CR) rates of 70% and long-term event free survival rates of 25%. New agents with different mechanisms of action ...

journal_title：Leukemia

authors： Kantarjian HM,Estey EH,Keating MA

更新日期：1996-04-01 00:00:00

abstract：:Eventually, gene therapy may be a valid option for chronic viral infections, including retroviral infections. Human retroviral diseases fit two categories: (1) those that result from a monoclonal outgrowth of a human T-cell leukemia virus type I (HTLV-I)-infected cell, as in the case of adult T cell leukemia (ATL); an...

journal_title：Leukemia

authors： Essex M,Matsuda Z,Yu X,Lee TH

更新日期：1995-10-01 00:00:00

abstract：:Allelic losses on chromosome 12p12-13 are associated with childhood acute lymphoblastic leukemia (ALL) and several solid neoplasias, suggesting the presence of a tumor suppressor locus. The recent construction of a transcription map of this locus has enabled the identification of eight genes, of which five were previo...

journal_title：Leukemia

authors： Montpetit A,Larose J,Boily G,Langlois S,Trudel N,Sinnett D

更新日期：2004-09-01 00:00:00

abstract：:PCR-based monitoring of minimal residual disease (MRD) in acute leukemias can be achieved via detection of fusion gene transcripts of chromosome aberrations or detection of immunoglobulin (Ig) and T cell receptor (TCR) gene rearrangements. We wished to assess whether both PCR targets are complementary in acute myeloid...

journal_title：Leukemia

authors： Boeckx N,Willemse MJ,Szczepanski T,van der Velden VH,Langerak AW,Vandekerckhove P,van Dongen JJ

更新日期：2002-03-01 00:00:00

abstract：:An increasing number of variants of unknown significance are being identified in leukemia patients with the application of deep sequencing and these include CSF3R cytoplasmic mutations. Previous studies have demonstrated oncogenic potential of certain CSF3R truncation mutations prior to internalization motifs. However...

journal_title：Leukemia

authors： Zhang H,Reister Schultz A,Luty S,Rofelty A,Su Y,Means S,Bottomly D,Wilmot B,McWeeney SK,Tyner JW

更新日期：2017-12-01 00:00:00

abstract：:Resistant AML encompasses two groups of patients: those with refractory leukemia and those whose leukemia has relapsed. Refractory leukemia is disease that does not respond to initial induction chemotherapy with cytarabine and an anthracycline. Patients with refractory leukemia are likely to have disease with adverse ...

journal_title：Leukemia

authors： Schiller GJ

更新日期：1998-09-01 00:00:00

abstract：:Modern therapy for pediatric acute lymphoblastic leukemia (ALL) is based on the principle of risk stratification. One of the most important laboratory features used to accurately risk stratify patients is the presence of specific chromosomal translocation within the leukemic blasts. In this paper, we describe a multip...

journal_title：Leukemia

authors： Scurto P,Hsu Rocha M,Kane JR,Williams WK,Haney DM,Conn WP,Shurtleff SA,Downing JR

更新日期：1998-12-01 00:00:00

abstract：:Toll-like receptors (TLRs) constitute a family of nonpolymorphic receptors that are devoted to pathogen recognition. In this work, we have explored the impact of TLR ligands (TLR-L) on human hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs). We show that HSCs and HPCs have a comparable pattern ...

journal_title：Leukemia

authors： De Luca K,Frances-Duvert V,Asensio MJ,Ihsani R,Debien E,Taillardet M,Verhoeyen E,Bella C,Lantheaume S,Genestier L,Defrance T

更新日期：2009-11-01 00:00:00

abstract：:We describe the use and outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for multiple myeloma (MM) in Europe between January 1990 and December 2012. We identified 7333 patients, median age at allo-HSCT was 51 years (range: 18-78), of whom 4539 (62%) were males. We distinguished three groups: ...

journal_title：Leukemia

authors： Sobh M,Michallet M,Gahrton G,Iacobelli S,van Biezen A,Schönland S,Petersen E,Schaap N,Bonifazi F,Volin L,Meijer E,Niederwieser D,El Cheikh J,Tabrizi R,Fegeux N,Finke J,Bunjes D,Cornelissen J,Einsele H,Bruno B,Pott

更新日期：2016-10-01 00:00:00

abstract：:The optimal donor for a patient undergoing reduced-intensity stem cell transplantation remains a human leukocyte antigen (HLA)-matched relative. Alternative donors such as matched unrelated donors (MUDs), mismatched related donors (haploidentical), or unrelated umbilical cord blood (UCB) units have emerged as options ...

journal_title：Leukemia

authors： Chen YB,Spitzer TR

更新日期：2008-01-01 00:00:00

abstract：:Transformation of post-myeloproliferative neoplasms into secondary (s) AML exhibit poor clinical outcome. In addition to increased JAK-STAT and PI3K-AKT signaling, post-MPN sAML blast progenitor cells (BPCs) demonstrate increased nuclear β-catenin levels and TCF7L2 (TCF4) transcriptional activity. Knockdown of β-caten...

journal_title：Leukemia

authors： Saenz DT,Fiskus W,Manshouri T,Mill CP,Qian Y,Raina K,Rajapakshe K,Coarfa C,Soldi R,Bose P,Borthakur G,Kadia TM,Khoury JD,Masarova L,Nowak AJ,Sun B,Saenz DN,Kornblau SM,Horrigan S,Sharma S,Qiu P,Crews CM,Versto

更新日期：2019-06-01 00:00:00

abstract：:Tumor cells in chronic lymphocytic leukemia (CLL) are more prone to apoptosis when cultured ex vivo, because they lack prosurvival signals furnished in vivo via B-cell receptor (BCR)-dependent and -independent pathways. This study compared the susceptibility of unmutated (UM) and mutated (M) CLL B cells to spontaneous...

journal_title：Leukemia

authors： Coscia M,Pantaleoni F,Riganti C,Vitale C,Rigoni M,Peola S,Castella B,Foglietta M,Griggio V,Drandi D,Ladetto M,Bosia A,Boccadoro M,Massaia M

更新日期：2011-05-01 00:00:00

abstract：:All-trans retinoic acid (ATRA) has recently been shown to synergize with the inhibitory effect of interferon alpha (IFN alpha) on the growth of malignant cells isolated from solid tumors. We investigated whether ATRA could potentiate the inhibitory effects of IFN alpha on the proliferation of leukemic progenitors in c...

journal_title：Leukemia

authors： Mahon FX,Chahine H,Barbot C,Pigeonnier V,Jazwiec B,Reiffers J,Ripoche J

更新日期：1997-05-01 00:00:00

abstract：:The ubiquitin-proteasome system is an important regulator of cell growth and apoptosis. The potential of specific proteasome inhibitors to act as novel anti-cancer agents is currently under intensive investigation. Several proteasome inhibitors exert anti-tumour activity in vivo and potently induce apoptosis in tumour...

journal_title：Leukemia

authors： Almond JB,Cohen GM

更新日期：2002-04-01 00:00:00

abstract：:A case of an infant male with Down's syndrome, pancytopenia, and a relative lymphocytosis is presented. A bone marrow aspirate and crushed marrow biopsy were evaluated by microscopy and flow cytometry. A population of immature lymphoid cells positive for CD10 (CALLA) and CD19 (Leu 12) was initially interpreted as sugg...

journal_title：Leukemia

authors： Richard G,Brody J,Sun T

更新日期：1993-11-01 00:00:00

abstract：:Cell lines of myeloid origin have been shown to express interleukin-2 receptors (IL-2R). Here, we demonstrate the expression of IL-2R alpha and IL-R beta on the CML blast cell line K562 by FACS analysis and cross-linking assay. Furthermore, we examined the effect of IL-2 on leukemic progenitor growth, employing K562 a...

journal_title：Leukemia

authors： Dilloo D,Hanenberg H,Lion T,Burdach S

更新日期：1995-03-01 00:00:00

abstract：:In Philadelphia chromosome (Ph1)-positive acute lymphoblastic leukemia (ALL), some cytogenetic studies have suggested clonal derivation from a multipotential stem cell. The role of the product of the chimeric gene, P190, is not, however, well understood. We examined the expression of P190-type bcr/abl in single hemato...

journal_title：Leukemia

authors： Sadamura S,Umemura T,Hirata J,Takahira H,Yufu Y,Abe Y,Nishimura J,Nawata H

更新日期：1992-08-01 00:00:00

abstract：:Although reciprocal chromosomal translocations are not typical for B-cell chronic lymphocytic leukemia (B-CLL), we identified the novel t(1;6)(p35.3;p25.2) in eight patients with this disorder. Interestingly, all cases showed lack of somatically mutated IgV(H). Clinical, morphological, immunologic, and genetic feature...

journal_title：Leukemia

authors： Michaux L,Wlodarska I,Rack K,Stul M,Criel A,Maerevoet M,Marichal S,Demuynck H,Mineur P,Kargar Samani K,Van Hoof A,Ferrant A,Marynen P,Hagemeijer A

更新日期：2005-01-01 00:00:00

abstract：:Injection of a dual tropic virus (DTV) isolated from a T cell lymphoma AKR/J mice into the thymus of 14 day old AKR/J puppies accelerates lymphoma development; 90-100% of the injected mice develop the disease within 120 days. In contrast a cell free centrifuge CFC-666 prepared B cell lymphoma of AKR/J origin injected ...

journal_title：Leukemia

authors： Peled A,Haran-Ghera N

更新日期：1988-12-01 00:00:00

abstract：:The lysozyme (LZM) gene provides a very useful model for studies of phagocyte maturation, because its protein synthesis is increased during myelopoiesis and thus most abundant in terminally differentiated and activated phagoyctes. LZM gene expression and DNA methylation were examined in various normal and transformed ...

journal_title：Leukemia

authors： Lübbert M,Henschler R,Kreutz M,Andreesen R,Mertelsmann R,Herrmann F

更新日期：1997-07-01 00:00:00

abstract：:Reverse transcriptase-polymerase chain reaction is a recent technique in the diagnosis and assessment of minimal residual disease of acute promyelocytic leukemia, by amplification, of the different PML-RARalpha transcripts resulting from the t(15;17) translocation. The main issues addressed by the Second Workshop on P...

journal_title：Leukemia

authors：

更新日期：1996-02-01 00:00:00

abstract：:The efficacy of antibody-based immunotherapy is due to the activation of apoptosis, the engagement of antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity (CDC). We developed a novel strategy to enhance CDC using bispecific antibodies (bsAbs) that neutralize the C-regulators CD55 and CD59 to ...

journal_title：Leukemia

authors： Macor P,Secco E,Mezzaroba N,Zorzet S,Durigutto P,Gaiotto T,De Maso L,Biffi S,Garrovo C,Capolla S,Tripodo C,Gattei V,Marzari R,Tedesco F,Sblattero D

更新日期：2015-02-01 00:00:00

abstract：:Fourteen patients (M/F, 6/8; age, 48/23-64 yrs) with relapsing or primary resistant intermediate-high grade non-Hodgkin lymphomas were treated with ARA-C (2 g/m2 x 4 on days 1 and 2), DDP (100 mg/m2 96 hr infusion) and VP-16 (150 mg/m2 on days 1, 2 and 3). GM-CSF or placebo was administered from the 5th day until neut...

journal_title：Leukemia

authors： Liberati AM,Cinieri S,Schippa M,Di Clemente F,Filippo S,Grignani F

更新日期：1991-01-01 00:00:00