Abstract：
:Fourteen patients (M/F, 6/8; age, 48/23-64 yrs) with relapsing or primary resistant intermediate-high grade non-Hodgkin lymphomas were treated with ARA-C (2 g/m2 x 4 on days 1 and 2), DDP (100 mg/m2 96 hr infusion) and VP-16 (150 mg/m2 on days 1, 2 and 3). GM-CSF or placebo was administered from the 5th day until neutrophil count reached greater than or equal to 1000/microliters on 2 consecutive days. Three PR and 6 CR were documented. Two CR pts are still in CR at 19 and 23.5 months. With the exception of one case of cerebral haemorrhage, life-threatening liver toxicity, exfoliative colitis, capillary leak syndrome and anaphylactoid reaction, the protocol regimen provoked only modest haematological and extra-haematological toxicities.
journal_name
Leukemiajournal_title
Leukemiaauthors
Liberati AM,Cinieri S,Schippa M,Di Clemente F,Filippo S,Grignani Fsubject
Has Abstractpub_date
1991-01-01 00:00:00pages
119-22eissn
0887-6924issn
1476-5551journal_volume
5 Suppl 1pub_type
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