Allogeneic bone marrow transplantation improves the outcome of de novo AML with trilineage dysplasia (AML-TLD).

abstract：:PCR-based detection of minimal residual disease (MRD) in children with precursor B cell acute lymphoblastic leukemia (pre-B ALL) by amplification of clone-specific antigen gene rearrangements has been labor-intensive. In this study we present a simpler, yet accurate, method to assess and quantitate MRD in pediatric pr...

journal_title：Leukemia

authors： Mayer SP,Giamelli J,Sandoval C,Roach AS,Fevzi Ozkaynak M,Tugal O,Rovera G,Jayabose S

更新日期：1999-11-01 00:00:00

abstract：:Recent work suggests that chronic lymphocytic leukemia (B-CLL) expressing unmutated immunoglobulin V genes could correspond to the proliferation of naive B cells whereas those expressing mutated genes, may correspond to the proliferation of post-germinal center B cells. Current data from gene profiling expression have...

journal_title：Leukemia

authors： Oppezzo P,Magnac C,Bianchi S,Vuillier F,Tiscornia A,Dumas G,Payelle-Brogard B,Ajchenbaum-Cymbalista F,Dighiero G,Pritsch O

更新日期：2002-12-01 00:00:00

abstract：:In order to assess the proliferative capacity of leukemic subpopulations and to know whether it can be related to the stage of maturation, the expression of two surface antigens identifying distinct steps of leukocyte differentiation (CD15 and CD34) was studied by flow cytometry in correlation with DNA content in 16 c...

journal_title：Leukemia

authors： Campos L,Ffrench M,Guyotat D

更新日期：1990-01-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) cells could be undetectable by flow cytometry or polymerase chain reaction after sequential treatment with fludarabine and Campath-1H. Concern has been raised regarding the ability to mobilize sufficient peripheral blood progenitor cells (PBPCs) for autografting after purine analogue...

journal_title：Leukemia

authors： Montillo M,Tedeschi A,Rossi V,Cairoli R,Pungolino E,Intropido L,Cafro AM,D'Avanzo G,Farioli R,Brando B,Scarpati B,Veronese S,Morra E

更新日期：2004-01-01 00:00:00

abstract：:Long-term disease-free survival following conventional cytotoxic therapy is extremely rare in patients with advanced-stage mantle cell lymphoma (MCL). High-dose conditioning therapy consisting of hyperfractionated total body irradiation (TBI, 14.4 Gy) and cyclophosphamide (200 mg/kg) was therefore offered to 13 patien...

journal_title：Leukemia

authors： Haas R,Brittinger G,Meusers P,Murea S,Goldschmidt H,Wannenmacher M,Hunstein W

更新日期：1996-12-01 00:00:00

abstract：:The adult marrow hematopoietic stem cell biology has largely been based on studies of highly purified stem cells. This is unfortunate because during the stem cell purification the great bulk of stem cells are discarded. These cells are actively proliferating. The final purified stem cell is dormant and not representat...

journal_title：Leukemia

authors： Quesenberry P,Goldberg L

更新日期：2017-08-01 00:00:00

abstract：:CD31/PECAM-1 (platelet endothelial cell adhesion molecule-1) is a 130 kDa integral membrane protein of the immunoglobulin gene superfamily with the distinctive feature of being expressed on several cell types associated with the vascular compartment. In the present study we report a novel, unique CD31 mAb termed IP28A...

journal_title：Leukemia

authors： El-Marsafy S,Carosella ED,Agrawal SG,Gluckman E,Mansur IG,Elhabazi A,Boumsell L,Bensussan A

更新日期：1996-08-01 00:00:00

abstract：:The impact of cancer on outcome of persons with coronavirus disease 2019 (COVID-19) after infection with acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is controversial. We studied 1859 subjects with COVID-19 from seven centers in Wuhan, China, 65 of whom had cancer. We found having cancer was an independent ri...

journal_title：Leukemia

authors： Li Q,Chen L,Li Q,He W,Yu J,Chen L,Cao Y,Chen W,Di Wu,Dong F,Cai L,Ran Q,Li L,Liu Q,Ren W,Gao F,Wang H,Chen Z,Gale RP,Hu Y

更新日期：2020-09-01 00:00:00

abstract：:Polymerase chain reaction (PCR) techniques utilizing clonospecific T cell receptor (TCR) gamma or delta junctional regions constitute broadly applicable strategies to study the clinical relevance of minimal residual disease (MRD) in acute lymphoblastic leukemia (ALL) patients. For the majority of cases current PCR pro...

journal_title：Leukemia

authors： Seriu T,Hansen-Hagge TE,Erz DH,Bartram CR

更新日期：1995-02-01 00:00:00

abstract：:The mesenchymal stroma has been shown to play a crucial role in the development of multiple myeloma, partly by secretion of interleukin (IL)-6, that serves as a growth factor for myeloma cells. However, it is still unclear which other stromal molecules are involved in the pathogenesis of this disease. We chose, as a m...

journal_title：Leukemia

authors： Shoham T,Sternberg D,Brosh N,Krupsky M,Barda-Saad M,Zipori D

更新日期：2001-07-01 00:00:00

abstract：:Various clinical and laboratory observations suggest that the leukaemia cells in chronic myeloid leukaemia (CML) are potentially immunogenic. Whilst the ability of the leukaemia cells to elicit an anti-leukaemic immune response in the allogeneic setting is established, it remains unclear why such anti-leukaemic respon...

journal_title：Leukemia

authors： Coleman S,Throp D,Fisher J,Bailey-Wood R,Lim SH

更新日期：1997-12-01 00:00:00

abstract：:One hundred seventy-nine patients with intermediate or high-grade non-Hodgkin's lymphoma were randomized to receive either ProMACE-CytaBOM (P-C) or MACOP-B (M-B). At last follow-up 71 patients in the P-C arm and 78 in the M-B arm were assessable for response. Forty-one patients treated with P-C (58%) and 49 patients t...

journal_title：Leukemia

authors： Federico M,Moretti G,Gobbi PG,Avanzini P,Cavanna L,Carotenuto M,Lombardo M,Leone G,Pitini V,Abbadessa V

更新日期：1991-01-01 00:00:00

abstract：:The introduction of BCR-ABL tyrosine kinase inhibitors has revolutionized the treatment of chronic myeloid leukemia (CML). A major clinical aim remains the identification and elimination of low-level disease persistence, termed "minimal residual disease". The phenomenon of disease persistence suggests that despite tar...

journal_title：Leukemia

authors： Kinstrie R,Horne GA,Morrison H,Irvine D,Munje C,Castañeda EG,Moka HA,Dunn K,Cassels JE,Parry N,Clarke CJ,Scott MT,Clark RE,Holyoake TL,Wheadon H,Copland M

更新日期：2020-06-01 00:00:00

abstract：:Thirty adult patients with CMML were evaluated to determine prognostic factors that might have an impact on conversion to acute leukemia and survival. Neither leukocyte count nor monocyte count correlated with survival. The median survival for all 30 cases was 41 months. Patients with less than 5% marrow blasts had a ...

journal_title：Leukemia

authors： Storniolo AM,Moloney WC,Rosenthal DS,Cox C,Bennett JM

更新日期：1990-11-01 00:00:00

abstract：:Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained from 2345 acute leukemia patients. Genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and 1...

journal_title：Leukemia

authors： Meyer C,Burmeister T,Gröger D,Tsaur G,Fechina L,Renneville A,Sutton R,Venn NC,Emerenciano M,Pombo-de-Oliveira MS,Barbieri Blunck C,Almeida Lopes B,Zuna J,Trka J,Ballerini P,Lapillonne H,De Braekeleer M,Cazzaniga G,Cor

更新日期：2018-02-01 00:00:00

abstract：:We have investigated the protective effect of human T-cell leukemia virus I (HTLV-I) immune globulin (HTLVIG) against HTLV-I in rabbits. HTLVIG containing 77 mg/ml of IgG was prepared from pooled plasma from seropositive healthy persons. In the first experiment, four groups (A, B, C, and D) of three rabbits were trans...

journal_title：Leukemia

authors： Miyoshi I,Takehara N,Sawada T,Iwahara Y,Kataoka R,Yang D,Hoshino H

更新日期：1992-01-01 00:00:00

abstract：:Recently, it has been clarified that interaction between hematopoietic cells and endothelial cells is important in normal hematopoiesis and leukemogenesis. In this study, we examined the relationship between AML cells and endothelial cells by analyzing the expression profile of angiogenic factors, angiopoietin-1 (Ang-...

journal_title：Leukemia

authors： Watarai M,Miwa H,Shikami M,Sugamura K,Wakabayashi M,Satoh A,Tsuboi K,Imamura A,Mihara H,Katoh Y,Kita K,Nitta M

更新日期：2002-01-01 00:00:00

abstract：:The occurrence of potential leukemia cells (PLC) among bone marrow, spleen, and thymus of AKR mice during the preleukemic period was tested by an in vivo transplantation bioassay. The presence of PLC in 30- and 75-day-old AKR mice was demonstrated mostly among bone marrow cells, less in spleen, and was lacking in thym...

journal_title：Leukemia

authors： Haran-Ghera N,Peled A,Leef F,Hoffman AD,Levy JA

更新日期：1987-05-01 00:00:00

abstract：:Clonal chromosome abnormalities were detected in bone marrow cells of 20 patients with Fanconi anemia investigated at various stages of the disease. Two presented with acute leukemia, six with myelodysplastic syndrome, and 12 had minor or no morphological abnormalities of hematopoietic cells. Abnormalities of chromoso...

journal_title：Leukemia

authors： Maarek O,Jonveaux P,Le Coniat M,Derré J,Berger R

更新日期：1996-11-01 00:00:00

abstract：:FHL2, a member of the four and one half LIM domain protein family, is a critical transcriptional modulator. Here, we identify FHL2 as a critical regulator of hematopoietic stem cells (HSCs) that is essential for maintaining HSC self-renewal under regenerative stress. We find that Fhl2 loss has limited effects on hemat...

journal_title：Leukemia

authors： Hou Y,Wang X,Li L,Fan R,Chen J,Zhu T,Li W,Jiang Y,Mittal N,Wu W,Peace D,Qian Z

更新日期：2015-03-01 00:00:00

abstract：:The optimal donor for a patient undergoing reduced-intensity stem cell transplantation remains a human leukocyte antigen (HLA)-matched relative. Alternative donors such as matched unrelated donors (MUDs), mismatched related donors (haploidentical), or unrelated umbilical cord blood (UCB) units have emerged as options ...

journal_title：Leukemia

authors： Chen YB,Spitzer TR

更新日期：2008-01-01 00:00:00

abstract：:Bone mineral density (BMD) and biochemical markers of bone metabolism were analyzed in 67 adults with ALL (n = 27), AML (n = 14), MDS (n = 6) and CML (n = 20) before and after allogeneic stem cell transplantation (SCT). Median age was 36 years (17-56). Twenty-six out of 53 patients (49%) had osteopenia and osteoporosi...

journal_title：Leukemia

authors： Massenkeil G,Fiene C,Rosen O,Michael R,Reisinger W,Arnold R

更新日期：2001-11-01 00:00:00

abstract：:Molecular biological studies of immunoglobulin (Ig) and T-cell antigen receptor (TCR) genes provide novel approaches to the identification and characterization of the acute lymphoblastic leukemias (ALL). Such studies greatly enhance our understanding of both the cells of origin in these diseases and the order of assem...

journal_title：Leukemia

authors： Felix CA,Poplack DG

更新日期：1991-12-01 00:00:00

abstract：:Population-based studies of classical Hodgkin lymphoma (cHL) in contemporary clinical practice are scarce. The aim of this nationwide population-based study is to assess trends in primary therapy and relative survival (RS) during 1989-2017. We included 9,985 patients with cHL. Radiotherapy alone was virtually not appl...

journal_title：Leukemia

authors： Driessen J,Visser O,Zijlstra JM,Lugtenburg PJ,Plattel WJ,Kersten MJ,Dinmohamed AG

更新日期：2020-05-28 00:00:00

abstract：:Natural killer (NK)-cell malignancies are uncommon diseases. Previously known as polymorphic reticulosis or angiocentric T-cell lymphomas, they are classified by the World Health Organization as NK/T-cell lymphoma, nasal type and aggressive NK-cell leukemia. They are prevalent in Asia and South America, but exceptiona...

journal_title：Leukemia

authors： Kwong YL

更新日期：2005-12-01 00:00:00

abstract：:Clinical characteristics, treatment response and outcome were evaluated in children with Down's syndrome (DS) and acute lymphoblastic leukemia (ALL) as compared to other children with ALL (NDS). Sixty-one DS and 4049 NDS patients, receiving intensive antileukemic treatment during four consecutive trials (ALL-BFM 81, 8...

journal_title：Leukemia

authors： Dördelmann M,Schrappe M,Reiter A,Zimmermann M,Graf N,Schott G,Lampert F,Harbott J,Niemeyer C,Ritter J,Dörffel W,Nessler G,Kühl J,Riehm H

更新日期：1998-05-01 00:00:00

abstract：:Hematopoiesis is orchestrated by interactions between hematopoietic stem/progenitor cells (HSPCs) and stromal cells within bone marrow (BM) niches. Side population (SP) functionality is a major characteristic of HSPCs related to quiescence and resistance to drugs and environmental stresses. At steady state, SP cells a...

journal_title：Leukemia

authors： Malfuson JV,Boutin L,Clay D,Thépenier C,Desterke C,Torossian F,Guerton B,Anginot A,de Revel T,Lataillade JJ,Le Bousse-Kerdilès MC

更新日期：2014-04-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) remains incurable with chemoimmunotherapy, and allogeneic hematopoietic stem cell transplantation (HSCT) offers the potential for cure. We assessed the outcomes of 108 CLL patients undergoing first allogeneic HSCTs, 76 with reduced-intensity (RIC) and 32 with myeloablative conditioni...

journal_title：Leukemia

authors： Brown JR,Kim HT,Armand P,Cutler C,Fisher DC,Ho V,Koreth J,Ritz J,Wu C,Antin JH,Soiffer RJ,Gribben JG,Alyea EP

更新日期：2013-02-01 00:00:00

abstract：:There have been controversies about CD34 and CD38 expression by human cord blood (CB) stem cells. Using the newborn NOD/SCID/beta2-microglobulin-null mouse assay that we recently developed, we examined the in vivo engrafting capability of human CB cells. Almost all of the 4-5 months engrafting cells were found in CD34...

journal_title：Leukemia

authors： Ishikawa F,Livingston AG,Minamiguchi H,Wingard JR,Ogawa M

更新日期：2003-05-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is a progressive disease in which chemotherapy may result in temporary suppression of the peripheral blood lymphocyte count, but cure is not usually possible. Drug resistance mechanisms and the multidrug resistant (MDR) phenotype may be relevant to the therapeutic response. We have s...

journal_title：Leukemia

authors： Holmes JA,Jacobs A,Carter G,Whittaker JA,Bentley DP,Padua RA

更新日期：1990-03-01 00:00:00