Clinical relevance of in vitro chemoresistance in childhood acute myeloid leukemia.

abstract：:APL-associated hemostasis disorders result from at least two distinct mechanisms due to the release of procoagulant activities and plasminogen activators from the leukemic cells. These two mechanisms (thrombin activation and plasmin activation) may cleave the fibrinogen molecule, but their respective roles in low fibr...

journal_title：Leukemia

authors： Dombret H,Scrobohaci ML,Daniel MT,Micléa JM,Castaigne S,Chomienne C,Fenaux P,Degos L

更新日期：1995-01-01 00:00:00

abstract：:Toll-like receptors (TLRs) constitute a family of nonpolymorphic receptors that are devoted to pathogen recognition. In this work, we have explored the impact of TLR ligands (TLR-L) on human hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs). We show that HSCs and HPCs have a comparable pattern ...

journal_title：Leukemia

authors： De Luca K,Frances-Duvert V,Asensio MJ,Ihsani R,Debien E,Taillardet M,Verhoeyen E,Bella C,Lantheaume S,Genestier L,Defrance T

更新日期：2009-11-01 00:00:00

abstract：:The AML1/ETO fusion transcript can be detected by reverse transcription polymerase chain reaction (RT-PCR) in patients with t(8;21)-associated acute myeloid leukemia (AML) in long-term complete remission (CR). Quantitation of the amount of the fusion transcript during CR may therefore be more predictive of cure or rel...

journal_title：Leukemia

authors： Marcucci G,Livak KJ,Bi W,Strout MP,Bloomfield CD,Caligiuri MA

更新日期：1998-09-01 00:00:00

abstract：:Autoradiographic analysis of the binding of radiolabeled murine IL-6 to murine cells revealed that blast cells, megakaryocytic and monocytic cells in the marrow expressed receptors but not erythroid, eosinophilic or neutrophilic granulocytic cells. In the thymus, spleen and lymph nodes, most cells expressing receptors...

journal_title：Leukemia

authors： McKinstry W,Metcalf D,Li CL

更新日期：1994-10-01 00:00:00

abstract：:Only two classes of chemotherapeutic agents have shown activity in acute myeloid leukemia (AML): ara-C and topoisomerase II reactive agents. Frontline combinations of these agents produce complete response (CR) rates of 70% and long-term event free survival rates of 25%. New agents with different mechanisms of action ...

journal_title：Leukemia

authors： Kantarjian HM,Estey EH,Keating MA

更新日期：1996-04-01 00:00:00

abstract：:Some evidences suggest that telomere restriction fragment length (TRF-L) is an effective indicator of histopathogenesis in B-cell tumors. As histopathogenesis is relevant for B-cell chronic lymphocytic leukemia (B-CLL) prognosis, TRF-L was assessed by Southern blot in 201 patients and compared to variable immunoglobul...

journal_title：Leukemia

authors： Ricca I,Rocci A,Drandi D,Francese R,Compagno M,Lobetti Bodoni C,De Marco F,Astolfi M,Monitillo L,Vallet S,Calvi R,Ficara F,Omedè P,Rosato R,Gallamini A,Marinone C,Bergui L,Boccadoro M,Tarella C,Ladetto M

更新日期：2007-04-01 00:00:00

abstract：:c-MYC (hereafter MYC) overexpression has been recognized in aggressive B-cell lymphomas and linked to adverse prognosis. MYC activation results in widespread repression of micro-RNA (miRNA) expression and associated with lymphoma aggressive progression. Our recent study identified a MYC-miRNA-EZH2 feed-forward loop li...

journal_title：Leukemia

authors： Zhao X,Lwin T,Zhang X,Huang A,Wang J,Marquez VE,Chen-Kiang S,Dalton WS,Sotomayor E,Tao J

更新日期：2013-12-01 00:00:00

abstract：:Immunoglobulin and T cell receptor gene rearrangement and expression were investigated within B cell acute lymphoblastic leukemias (ALLs) that are thought to be representative of the early stages of normal human B cell development. Although the immunoglobulin heavy chain locus is rearranged in leukemic cells from all ...

journal_title：Leukemia

authors： Kinnon C,Katz F

更新日期：1989-11-01 00:00:00

abstract：:In this work we have mapped by double-label immunofluorescence the cellular distribution of integrins and their relationship with cytoskeletal proteins in normal and malignant monocytes. In normal monocytes, CD18 and CD11c are concentrated at specific adhesion sites, named podosomes, together with actin, vinculin, and...

journal_title：Leukemia

authors： Gaidano G,Bergui L,Schena M,Gaboli M,Cremona O,Marchisio PC,Caligaris-Cappio F

更新日期：1990-10-01 00:00:00

abstract：:Children with acute lymphoblastic leukemia (ALL) with > or = 0.01% leukemic cells in the bone marrow after remission induction are at a greater risk of relapse. The most promising methods of detecting minimal residual disease (MRD) are flow cytometric identification of leukemia-associated immunophenotypes and polymera...

journal_title：Leukemia

authors： Neale GA,Coustan-Smith E,Pan Q,Chen X,Gruhn B,Stow P,Behm FG,Pui CH,Campana D

更新日期：1999-08-01 00:00:00

abstract：:Malignant cells of patients with cutaneous T cell lymphoma (CTCL) are of monoclonal origin and of the CD4+/CD45RO+ subset. Since unlike their normal counterparts, triggering of their TCR/CD3 in vitro elicits only a weak mitogenic response, we set out to determine which of the signal transduction molecules initiated by...

journal_title：Leukemia

authors： Fargnoli MC,Edelson RL,Berger CL,Chimenti S,Couture C,Mustelin T,Halaban R

更新日期：1997-08-01 00:00:00

abstract：:Conditionally replicating adenoviruses (CRAds) represent a promising new platform for anticancer therapy. However, CRAds have been evaluated little in hematopoietic malignancies because of the lack of expression of coxsackie adenovirus receptor (CAR) on their cell surface. In this study, we showed that CAR was express...

journal_title：Leukemia

authors： Qian W,Liu J,Tong Y,Yan S,Yang C,Yang M,Liu X

更新日期：2008-02-01 00:00:00

abstract：:To develop an effective immunotherapy for B-lineage acute lymphoblastic leukemia (ALL), bispecific monoclonal antibodies (bsAb) were raised by cell fusion of two hybridoma cell lines secreting CD3 and CD19 antibodies. The resulting bispecific antibody contains two different specificities within a single antibody molec...

journal_title：Leukemia

authors： Csóka M,Strauss G,Debatin KM,Moldenhauer G

更新日期：1996-11-01 00:00:00

abstract：:The serine/threonine kinase Akt, a downstream effector of phosphatidylinositol 3-kinase (PI3K), is known to play an important role in antiapoptotic signaling and has been implicated in the aggressiveness of a number of different human cancers including acute myeloid leukemia (AML). The progression of myelodysplastic s...

journal_title：Leukemia

authors： Nyåkern M,Tazzari PL,Finelli C,Bosi C,Follo MY,Grafone T,Piccaluga PP,Martinelli G,Cocco L,Martelli AM

更新日期：2006-02-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) cells could be undetectable by flow cytometry or polymerase chain reaction after sequential treatment with fludarabine and Campath-1H. Concern has been raised regarding the ability to mobilize sufficient peripheral blood progenitor cells (PBPCs) for autografting after purine analogue...

journal_title：Leukemia

authors： Montillo M,Tedeschi A,Rossi V,Cairoli R,Pungolino E,Intropido L,Cafro AM,D'Avanzo G,Farioli R,Brando B,Scarpati B,Veronese S,Morra E

更新日期：2004-01-01 00:00:00

abstract：:A patient with Philadelphia positive (Ph'+) acute lymphoblastic leukemia (ALL), in remission for over 4 years, developed an acute myeloblastic leukemia (AML), M2-type. During the second disease, the blast cells displayed a typical t(8;21)(q22;q22) translocation, in the absence of the Ph' chromosome. This is the first ...

journal_title：Leukemia

authors： De Cuia MR,Alimena G,Gastaldi R,Spiriti MA,Giona F,Mancini M,Mandelli F

更新日期：1989-04-01 00:00:00

abstract：:Unexplained clusters of childhood leukaemia have generated concern that they may be causally related to environmental exposure to ionising radiation. The workshop provides in-depth examination of the aetiology of childhood leukaemia, patterns of clustering exhibited by cases and the influence of exposure to ionising r...

journal_title：Leukemia

authors： Alexander FE,Greaves MF

更新日期：1998-08-01 00:00:00

abstract：:Interleukin-4 inhibits several monocyte functions like A23187-induced expression of cytokines and c-fos and c-jun proto-oncogene mRNA expression. In an attempt to elucidate the mechanism by which this inhibitive effect is mediated, we compared the effect of IL-4 on A23187-induced c-fos and c-jun mRNA expression in con...

journal_title：Leukemia

authors： Dokter WH,Sierdsema SJ,Esselink MT,Halie MR,Vellenga E

更新日期：1994-07-01 00:00:00

abstract：:The myeloproliferative neoplasms (MPNs) are characterized by hematopoietic stem/progenitor cell (HSPC) expansion and overproduction of mature blood cells. The JAK2V617F mutation is present in hematopoietic cells in a majority of patients with MPNs, but the mechanism(s) responsible for MPN stem cell expansion remain in...

journal_title：Leukemia

authors： Zhan H,Ma Y,Lin CH,Kaushansky K

更新日期：2016-12-01 00:00:00

abstract：:The discovery of almost identical or 'stereotyped' B-cell receptor immunoglobulins (BcR IG) among unrelated patients with chronic lymphocytic leukemia (CLL) cemented the idea of antigen selection in disease ontogeny and evolution. The systematic analysis of the stereotypy phenomenon in CLL revealed that around one-thi...

journal_title：Leukemia

authors： Stamatopoulos K,Agathangelidis A,Rosenquist R,Ghia P

更新日期：2017-02-01 00:00:00

abstract：:All-trans retinoic acid (ATRA) has recently been shown to synergize with the inhibitory effect of interferon alpha (IFN alpha) on the growth of malignant cells isolated from solid tumors. We investigated whether ATRA could potentiate the inhibitory effects of IFN alpha on the proliferation of leukemic progenitors in c...

journal_title：Leukemia

authors： Mahon FX,Chahine H,Barbot C,Pigeonnier V,Jazwiec B,Reiffers J,Ripoche J

更新日期：1997-05-01 00:00:00

abstract：:The study was designed to compare clofarabine plus daunorubicin vs daunorubicin/ara-C in older patients with acute myeloid leukaemia (AML) or high-risk myelodysplastic syndrome (MDS). Eight hundred and six untreated patients in the UK NCRI AML16 trial with AML/high-risk MDS (median age, 67 years; range 56-84) and norm...

journal_title：Leukemia

authors： Burnett AK,Russell NH,Hills RK,Kell J,Nielsen OJ,Dennis M,Cahalin P,Pocock C,Ali S,Burns S,Freeman S,Milligan D,Clark RE

更新日期：2017-02-01 00:00:00

abstract：:To evaluate current detection methods for FIP1L1-PDGFRA in hypereosinophilic syndrome (HES), we developed a means to rapidly amplify genomic break points. We screened 202 cases and detected genomic junctions in all samples previously identified as RT-PCR positive (n=43). Genomic fusions were amplified by single step P...

journal_title：Leukemia

authors： Score J,Walz C,Jovanovic JV,Jones AV,Waghorn K,Hidalgo-Curtis C,Lin F,Grimwade D,Grand F,Reiter A,Cross NC

更新日期：2009-02-01 00:00:00

abstract：:Cytogenetic and fluorescence in situ hybridization studies have shown the presence of telomeric repeats in translocation present in three patients with hematopoietic malignancies. One had jumping translocations, involving 1q12 and 2q, 16p, and 19q. These sequences were detected by FISH only in derivative chromosomes t...

journal_title：Leukemia

authors： Busson Le Coniat M,Brizard F,Smadja NV,Maarek O,Der Sarkissian H,Berger R

更新日期：2000-09-01 00:00:00

abstract：:Adhesion molecules and stromal cell-derived factor-1 (SDF-1)/CXCR4 signaling play key role in homing and mobilization of hematopoietic progenitor (HPC) and hematopoietic cancer clonogenic cells (HCC). High expression of VLA-4 is required for homing of HPC and HCC, whereas downregulation of these molecules is required ...

journal_title：Leukemia

authors： Gazitt Y

更新日期：2004-01-01 00:00:00

abstract：:ET is a chronic myeloproliferative disorder rarely evolving into AML, sometimes preceded by a myelodysplastic syndrome (MDS). Such transformations mostly occur in patients treated with radiophosphorous ((32)P) or alkylating agents, especially busulfan. Recently, concern has also arisen about the long-term safety of hy...

journal_title：Leukemia

authors： Bernasconi P,Boni M,Cavigliano PM,Calatroni S,Brusamolino E,Passamonti F,Volpe G,Pistorio A,Giardini I,Rocca B,Caresana M,Lazzarino M,Bernasconi C

更新日期：2002-10-01 00:00:00

abstract：:It has become apparent that regulation of protein translation is an important determinant in controlling cell growth and leukemic transformation. The phosphoinositide 3-kinase (PI3K)/phosphatase and tensin homologue deleted on chromosome ten (PTEN)/Akt/mammalian target of rapamycin (mTOR) pathway is often implicated i...

journal_title：Leukemia

authors： Martelli AM,Evangelisti C,Chappell W,Abrams SL,Bäsecke J,Stivala F,Donia M,Fagone P,Nicoletti F,Libra M,Ruvolo V,Ruvolo P,Kempf CR,Steelman LS,McCubrey JA

更新日期：2011-07-01 00:00:00

abstract：:We studied changes in peripheral blood and bone marrow biopsy specimens obtained before, during, and after recombinant alpha 2b-interferon (IFN-alpha 2b) therapy in 25 patients with hairy cell leukemia. During therapy, only 1 patient showed no improvement in at least one of the parameters monitored. Granulocytopenia, ...

journal_title：Leukemia

authors： Bardawil RG,Ratain MJ,Golomb HM,Bitter MA,Groves C,Vardiman JW

更新日期：1987-04-01 00:00:00

abstract：:We have recently identified a human homolog of a fungal nuclear migration protein (hNUDC) that binds specifically with the extracellular domain of thrombopoietin receptor (Mpl). Preliminary studies with human CD34(+) cells cultured in serum-free medium and normal mice showed that hNUDC appears to act as a cytokine, tr...

journal_title：Leukemia

authors： Tang YS,Zhang YP,Xu P

更新日期：2008-05-01 00:00:00

abstract：:Eventually, gene therapy may be a valid option for chronic viral infections, including retroviral infections. Human retroviral diseases fit two categories: (1) those that result from a monoclonal outgrowth of a human T-cell leukemia virus type I (HTLV-I)-infected cell, as in the case of adult T cell leukemia (ATL); an...

journal_title：Leukemia

authors： Essex M,Matsuda Z,Yu X,Lee TH

更新日期：1995-10-01 00:00:00