Abstract：
:Immunoglobulin and T cell receptor gene rearrangement and expression were investigated within B cell acute lymphoblastic leukemias (ALLs) that are thought to be representative of the early stages of normal human B cell development. Although the immunoglobulin heavy chain locus is rearranged in leukemic cells from all of these patients, only cells from pre-B ALL patients express mu chain protein. We have shown, however, that immunoglobulin heavy chain transcripts are expressed at levels similar to those found in normal B cells in all of these leukemic cell types and, in addition, some of the leukemias with a more mature phenotype also express immunoglobulin light chain mRNA. In contrast, leukemic cells which had rearranged T cell receptor gamma chain genes were not found to express gamma chain transcripts, indicating that the transcription of immunoglobulin and T cell receptor genes in these cells may be regulated in a lineage-specific manner.
journal_name
Leukemiajournal_title
Leukemiaauthors
Kinnon C,Katz Fsubject
Has Abstractpub_date
1989-11-01 00:00:00pages
808-12issue
11eissn
0887-6924issn
1476-5551journal_volume
3pub_type
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