Abstract:
:The role of transforming growth factor-β (TGFβ) signaling in embryological development and tissue homeostasis has been thoroughly characterized. Its canonical downstream cascade is well known, even though its true complexity and other non-canonical pathways are still being explored. TGFβ signaling has been described as an important pathway involved in carcinogenesis and cancer progression. In the hematopoietic compartment, the TGFβ pathway is an important regulator of proliferation and differentiation of different cell types and has been implicated in the pathogenesis of a diverse variety of bone marrow disorders. Due to its importance in hematological diseases, novel inhibitors of this pathway are being developed against a number of hematopoietic disorders, including myelodysplastic syndromes (MDS). In this review, we provide an overview of the TGFβ pathway, focusing on its role in hematopoiesis and impact on myeloid disorders. We will discuss therapeutic interventions with promising results against MDS.
journal_name
Leukemiajournal_title
Leukemiaauthors
Bataller A,Montalban-Bravo G,Soltysiak KA,Garcia-Manero Gdoi
10.1038/s41375-019-0420-1subject
Has Abstractpub_date
2019-05-01 00:00:00pages
1076-1089issue
5eissn
0887-6924issn
1476-5551pii
10.1038/s41375-019-0420-1journal_volume
33pub_type
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