Localization of the human CD40 gene to chromosome 20, bands q12-q13.2.

abstract：:B-cell acute lymphoblastic leukemia (B-ALL) is often associated with chromosomal translocations leading to the deregulation of proto-oncogenes. MicroRNAs can also be affected by chromosomal alterations and thus contribute to carcinogenesis. The microRNA, miR-125b-1, is overexpressed in B-ALL cases with the t(11;14)(q2...

journal_title：Leukemia

authors： Puissegur MP,Eichner R,Quelen C,Coyaud E,Mari B,Lebrigand K,Broccardo C,Nguyen-Khac F,Bousquet M,Brousset P

更新日期：2012-10-01 00:00:00

abstract：:We have investigated the protective effect of human T-cell leukemia virus I (HTLV-I) immune globulin (HTLVIG) against HTLV-I in rabbits. HTLVIG containing 77 mg/ml of IgG was prepared from pooled plasma from seropositive healthy persons. In the first experiment, four groups (A, B, C, and D) of three rabbits were trans...

journal_title：Leukemia

authors： Miyoshi I,Takehara N,Sawada T,Iwahara Y,Kataoka R,Yang D,Hoshino H

更新日期：1992-01-01 00:00:00

abstract：:Deletions from the derivative chromosome 9, der(9), of the translocation, t(9;22)(q34;q11), at the site of the ABL/BCR fusion gene, have been demonstrated by fluorescence in situ hybridisation (FISH), in both Philadelphia chromosome (Ph)-positive chronic myeloid leukaemia (CML) and acute lymphoblastic leukaemia (ALL)....

journal_title：Leukemia

authors： Robinson HM,Martineau M,Harris RL,Barber KE,Jalali GR,Moorman AV,Strefford JC,Broadfield ZJ,Cheung KL,Harrison CJ

更新日期：2005-04-01 00:00:00

abstract：:Reduced-intensity conditioning (RIC) regimens have been increasingly used as an alternative to conventional myeloablative conditioning (MAC) regimens for elderly patients, for patients medically infirm to qualify for conventional allogeneic stem cell transplantation (SCT), and for disorders in which traditional MAC-SC...

journal_title：Leukemia

authors： Jiménez M,Ercilla G,Martínez C

更新日期：2007-08-01 00:00:00

abstract：:Hematopoietic stem cell transplantation is becoming an increasingly important approach to treatment of different malignant and non-malignant disorders. There is thus growing demand for diagnostic assays permitting the surveillance of donor/recipient chimerism posttransplant. Current techniques are heterogeneous, rende...

journal_title：Leukemia

authors： Lion T,Watzinger F,Preuner S,Kreyenberg H,Tilanus M,de Weger R,van Loon J,de Vries L,Cavé H,Acquaviva C,Lawler M,Crampe M,Serra A,Saglio B,Colnaghi F,Biondi A,van Dongen JJ,van der Burg M,Gonzalez M,Alcoceba M,Bar

更新日期：2012-08-01 00:00:00

abstract：:We used fluorescence in situ hybridization (FISH) to metaphase chromosomes with BCR and ABL cosmid probes in conjunction with the polymerase chain reaction (PCR) to study the mechanism by which the ABL proto-oncogene is inserted into a morphologically normal chromosome 22 in patients with Ph-negative chronic myeloid l...

journal_title：Leukemia

authors： Lazaridou A,Chase A,Melo J,Garicochea B,Diamond J,Goldman J

更新日期：1994-03-01 00:00:00

abstract：:Myeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized by chronic proliferation of hematopoietic progenitors. We studied the telomere length (TL) of 335 MPN patients and 93 gender- and age-matched controls using a quantitative PCR method (relative TL calculated as the ratio of the amount of t...

journal_title：Leukemia

authors： Bernard L,Belisle C,Mollica L,Provost S,Roy DC,Gilliland DG,Levine RL,Busque L

更新日期：2009-02-01 00:00:00

abstract：:This report summarizes recent findings in the field of basic and translational apoptosis research which were presented at the 1st Conference on 'Mechanisms of Cell Death and Disease: Advances in Therapeutic Intervention' organized by the European School of Hematology and the University of Texas MD Anderson Cancer Cent...

journal_title：Leukemia

authors： Daniel PT

更新日期：2000-12-01 00:00:00

abstract：:Detection of minimal residual disease (MRD) is the most sensitive method to evaluate treatment response and one of the strongest predictors of outcome in childhood acute lymphoblastic leukemia (ALL). The 10-year update on the I-BFM-SG MRD study 91 demonstrates stable results (event-free survival), that is, standard ri...

journal_title：Leukemia

authors： Flohr T,Schrauder A,Cazzaniga G,Panzer-Grümayer R,van der Velden V,Fischer S,Stanulla M,Basso G,Niggli FK,Schäfer BW,Sutton R,Koehler R,Zimmermann M,Valsecchi MG,Gadner H,Masera G,Schrappe M,van Dongen JJ,Biondi A,B

更新日期：2008-04-01 00:00:00

abstract：:Human T cell leukemia virus type-I (HTLV-I), the etiologic agent of adult T cell leukemia (ATL) transforms human T cells in vitro and in vivo. Tax, the major transactivator of HTLV-I is critical for the initial events involved in transformation, however, the later steps required for progression from an IL-2 dependent ...

journal_title：Leukemia

authors： Gartenhaus RB,Wang P

更新日期：1995-12-01 00:00:00

abstract：:Immunofluorescent staining of peripheral blood mononuclear cells with the monoclonal antibody anti-HC2 combined with phase microscopic examination identified leukemic hairy cells in nine of 13 patients (69%) evaluated at Memorial Hospital prior to treatment with recombinant alpha-interferon (rIFN-alpha A). The remaini...

journal_title：Leukemia

authors： Berman E,Posnett DN

更新日期：1987-04-01 00:00:00

abstract：:The combination of the anti-viral agents, zidovudine (AZT) and interferon-alpha (IFN), is a potent treatment of HTLV-I-associated adult T cell leukemia/lymphoma (ATL). In this study we investigate the possible mechanism of action of this combination by examining several cellular parameters including cell proliferation...

journal_title：Leukemia

authors： Bazarbachi A,Nasr R,El-Sabban ME,Mahé A,Mahieux R,Gessain A,Darwiche N,Dbaibo G,Kersual J,Zermati Y,Dianoux L,Chelbi-Alix MK,de Thé H,Hermine O

更新日期：2000-04-01 00:00:00

abstract：:We have investigated the activity of ITF2357, a novel hydroxamate histone deacetylase inhibitor, on multiple myeloma (MM) and acute myelogenous leukemia (AML) cells in vitro and in vivo. ITF2357 induced apoptosis in 8/9 MM and 6/7 AML cell lines, as well as 4/4 MM and 18/20 AML freshly isolated cases, with a mean IC(5...

journal_title：Leukemia

authors： Golay J,Cuppini L,Leoni F,Micò C,Barbui V,Domenghini M,Lombardi L,Neri A,Barbui AM,Salvi A,Pozzi P,Porro G,Pagani P,Fossati G,Mascagni P,Introna M,Rambaldi A

更新日期：2007-09-01 00:00:00

abstract：:We report the results of a phase I dose escalation trial of the multikinase inhibitor sorafenib in relapsed and refractory acute leukemia patients using an intermittent dosing regimen. Fifteen patients with advanced leukemia (12 with acute myeloid leukemia, 2 with acute lymphoblastic leukemia, 1 with biphenotypic) and...

journal_title：Leukemia

authors： Pratz KW,Cho E,Levis MJ,Karp JE,Gore SD,McDevitt M,Stine A,Zhao M,Baker SD,Carducci MA,Wright JJ,Rudek MA,Smith BD

更新日期：2010-08-01 00:00:00

abstract：:Transplantation of normal and malignant human hematopoietic cells into severe combined immunodeficient (SCID) mice allows for evaluation of long-term growth abilities of these cells and provides a preclinical model for therapeutic interventions. However, large numbers of cells are required for successful engraftment i...

journal_title：Leukemia

authors： Terpstra W,Leenen PJ,van den Bos C,Prins A,Loenen WA,Verstegen MM,van Wyngaardt S,van Rooijen N,Wognum AW,Wagemaker G,Wielenga JJ,Löwenberg B

更新日期：1997-07-01 00:00:00

abstract：:The microenvironments of leukemia and cancer are critical for multiple stages of malignancies, and they are an attractive therapeutic target. While skeletal abnormalities are commonly seen in children with acute lymphoblastic leukemia (ALL) prior to initiating osteotoxic therapy, little is known about the alterations ...

journal_title：Leukemia

authors： Cheung LC,Tickner J,Hughes AM,Skut P,Howlett M,Foley B,Oommen J,Wells JE,He B,Singh S,Chua GA,Ford J,Mullighan CG,Kotecha RS,Kees UR

更新日期：2018-11-01 00:00:00

abstract：:Oncoprotein 18 (Op18) is a major cystolic phosphoprotein constituent of leukemia cells. There is cumulative evidence that suggests a role for Op18 in integrating signals from diverse pathways involved in cell growth. Op18 phosphorylation is induced with proliferation in a variety of cell types, and is essential for ce...

journal_title：Leukemia

authors： Melhem R,Hailat N,Kuick R,Hanash SM

更新日期：1997-10-01 00:00:00

abstract：:In this report, a Radiation leukemia virus-transformed murine T cell lymphoma is described which is dependent on the interleukin-2 (IL-2) growth factor for proliferation under single cell conditions of growth. It was isolated from a C57BL mouse which had been primed with the Radiation leukemia virus-induced thymoma, C...

journal_title：Leukemia

authors： O'Neill HC

更新日期：1988-02-01 00:00:00

abstract：:A relationship was proved between constitutive activity of leukemic cell c-jun-N-terminal kinase (JNK) and treatment failure in AML. Specifically, early treatment failure was predicted by the presence of constitutive JNK activity. The mechanistic origins of this association was sought. A multidrug resistant leukemic c...

journal_title：Leukemia

authors： Cripe LD,Gelfanov VM,Smith EA,Spigel DR,Phillips CA,Gabig TG,Jung SH,Fyffe J,Hartman AD,Kneebone P,Mercola D,Burgess GS,Boswell HS

更新日期：2002-05-01 00:00:00

abstract：:Patients with normal-karyotype acute myelogenous leukemia (NKAML) may have undetected genetic abnormalities that could affect prognosis. Screening for known AML-specific genetic abnormalities using the reverse transcription polymerase chain reaction (RT-PCR) may help in arriving at a more definitive prognosis. To test...

journal_title：Leukemia

authors： Sarriera JE,Albitar M,Estrov Z,Gidel C,Aboul-Nasr R,Manshouri T,Kornblau S,Chang KS,Kantarjian H,Estey E

更新日期：2001-01-01 00:00:00

abstract：:We have previously shown that all-trans retinoic acid (ATRA) increases the number of CFU-GM colonies grown from unseparated human bone marrow cells with crude sources of colony stimulating factors. In this study, we further characterized the effect of ATRA on the growth of CFU-GM stimulated by individual cytokines fro...

journal_title：Leukemia

authors： Douer D,Ramezani L,Parker J,Levine AM

更新日期：2000-05-01 00:00:00

abstract：:Housekeeping genes, particularly actin, tubulin, and the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH), are widely used to estimate the amount and integrity of RNA in Northern blotting. In this work, the most reliable housekeeping gene for gene expression analysis of Hodgkin's disease (HD) lymph n...

journal_title：Leukemia

authors： Perfetti V,Manenti G,Dragani TA

更新日期：1991-12-01 00:00:00

abstract：:T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological cancer characterized by skewed epigenetic patterns, raising the possibility of therapeutically targeting epigenetic factors in this disease. Here we report that among different cancer types, epigenetic factor TET1 is highly expressed in T-ALL a...

journal_title：Leukemia

authors： Bamezai S,Demir D,Pulikkottil AJ,Ciccarone F,Fischbein E,Sinha A,Borga C,Te Kronnie G,Meyer LH,Mohr F,Götze M,Caiafa P,Debatin KM,Döhner K,Döhner H,González-Menéndez I,Quintanilla-Fend L,Herold T,Jeremias I,Feuring-

更新日期：2020-05-15 00:00:00

abstract：:APL-associated hemostasis disorders result from at least two distinct mechanisms due to the release of procoagulant activities and plasminogen activators from the leukemic cells. These two mechanisms (thrombin activation and plasmin activation) may cleave the fibrinogen molecule, but their respective roles in low fibr...

journal_title：Leukemia

authors： Dombret H,Scrobohaci ML,Daniel MT,Micléa JM,Castaigne S,Chomienne C,Fenaux P,Degos L

更新日期：1995-01-01 00:00:00

abstract：:This phase 1 dose-escalation study evaluated pomalidomide, bortezomib (subcutaneous (SC) or intravenous (IV)) and low-dose dexamethasone (LoDEX) in lenalidomide-refractory and proteasome inhibitor-exposed relapsed or relapsed and refractory multiple myeloma (RRMM). In 21-day cycles, patients received pomalidomide (1-4...

journal_title：Leukemia

authors： Richardson PG,Hofmeister CC,Raje NS,Siegel DS,Lonial S,Laubach J,Efebera YA,Vesole DH,Nooka AK,Rosenblatt J,Doss D,Zaki MH,Bensmaine A,Herring J,Li Y,Watkins L,Chen MS,Anderson KC

更新日期：2017-12-01 00:00:00

abstract：:The cyclin-dependent kinase inhibitors known as p15, p16, p18 and p19 have been suggested as candidates for tumor suppressor genes. The main genetic alterations are deletions (bi- or monoallelic) or 5' CpG island methylation of p15 and p16; very few cases or cell lines had p18 or p19 deletions or hypermethylation. Hyp...

journal_title：Leukemia

authors： Drexler HG

更新日期：1998-06-01 00:00:00

abstract：:A novel erythroid cell line, RM10, was established from a long-term bone marrow culture of a patient with chronic myelogenous leukemia (CML). RM10 cells were positive for periodic acid Schiff (PAS), but negative for peroxidase and dual esterase. RM10 cells had la, pre B (CD10), myeloid (CD13, CD14, CD33) and erythroid...

journal_title：Leukemia

authors： Hirata J,Sato H,Takahira H,Shiokawa S,Endo T,Nishimura J,Katsuno M,Masuda S,Sasaki R,Fukumaki Y

更新日期：1990-05-01 00:00:00

abstract：:Despite many years of meticulous immunophenotyping of childhood acute lymphoblastic leukaemia (ALL) cases the prognostic significance of some subtypes remains unclear. The Medical Research Council UKALLXI trial (1990-1996) in which uniform treatment has been given to 2090 children with ALL below the age of 18 years an...

journal_title：Leukemia

authors： Hann IM,Richards SM,Eden OB,Hill FG

更新日期：1998-08-01 00:00:00

abstract：:The polymerase chain reaction (PCR) allows the detection of minimal amounts of nucleic sequences and has been successfully used to test for the chronic myeloid leukemia-specific bcr/abl transcripts. We studied blood samples from 17 patients who had undergone allogeneic bone marrow transplantation for CML, using a modi...

journal_title：Leukemia

authors： Pignon JM,Henni T,Amselem S,Vidaud M,Duquesnoy P,Vernant JP,Kuentz M,Cordonnier C,Rochant H,Goossens M

更新日期：1990-02-01 00:00:00

abstract：:In chronic lymphocytic leukemia (CLL), stabilizing mutations of NOTCH1, affecting up to 10-15% of cases, have been associated to poor prognosis, disease progression and refractoriness to chemotherapy. NOTCH1 mutations are significantly overrepresented in trisomy 12 CLL, a disease subset frequently expressing CD49d, th...

journal_title：Leukemia

authors： Benedetti D,Tissino E,Pozzo F,Bittolo T,Caldana C,Perini C,Martorelli D,Bravin V,D'Agaro T,Rossi FM,Bomben R,Santinelli E,Zaja F,Pozzato G,Chiarenza A,Di Raimondo F,Del Poeta G,Rossi D,Gaidano G,Dal Bo M,Gattei V

更新日期：2018-03-01 00:00:00