当前位置： SCI文献检索 > LEUKEMIA期刊下所有文献 > Cyclooxygenase-1, but not -2, is upregulated in NB4 leukemic cells and human primary promyelocytic blasts during differentiation.

Cyclooxygenase-1, but not -2, is upregulated in NB4 leukemic cells and human primary promyelocytic blasts during differentiation.

Abstract：

:Cyclooxygenase (COX)-1 or -2 and specific prostaglandin (PG) synthases catalyze the formation of various PGs. We investigated the expression and activity of COX-1 and -2 during granulocyte-oriented maturation induced by all-trans-retinoic acid (ATRA) of NB4 cells, originated from a human acute promyelocytic leukemia (APL), and in blasts from APL patients. The expression of COX isoenzymes or prostaglandin synthases was also investigated in circulating granulocytes and human bone marrow. COX-1 was expressed and enzymatically active in NB4 cells and primary blasts. COX-1 mRNA and protein were induced by ATRA. COX-1 protein increased approximately 2-3.5-fold by culture day 3 in NB4 cells and primary blasts, while basal COX-2 expression was very low and unaffected by ATRA. COX-1-dependent PGE(2) biosynthesis increased during differentiation approx. 5-fold. Indomethacin and the selective COX-1 inhibitor SC-560, but not selective COX-2 inhibition, impaired NB4 differentiation, reducing NADPH-oxidase activity, CD11b and CD11c expression. The immunohistochemistry of granulocytes and myeloid precursors in the bone marrow showed a large prevalence of COX-1 as compared to COX-2. In conclusion, COX-1 is induced during ATRA-dependent maturation and appears to contribute to myeloid differentiation both in vitro and ex vivo, and COX-1 activity may potentiate the differentiation of human APL.Leukemia (2004) 18, 1373-1379. doi:10.1038/sj.leu.2403407 Published online 10 June 2004

journal_name

Leukemia

journal_title

Leukemia

authors

Rocca B,Morosetti R,Habib A,Maggiano N,Zassadowski F,Ciabattoni G,Chomienne C,Papp B,Ranelletti FO

doi

10.1038/sj.leu.2403407

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

1373-9

issue

8

eissn

0887-6924

issn

1476-5551

pii

2403407

journal_volume

18

pub_type

杂志文章

相关文献

LEUKEMIA文献大全
  • Neutralization of (NK-cell-derived) B-cell activating factor by Belimumab restores sensitivity of chronic lymphoid leukemia cells to direct and Rituximab-induced NK lysis.

    abstract：:Natural killer (NK) cells are cytotoxic lymphocytes that substantially contribute to the therapeutic benefit of antitumor antibodies like Rituximab, a crucial component in the treatment of B-cell malignancies. In chronic lymphocytic leukemia (CLL), the ability of NK cells to lyse the malignant cells and to mediate ant...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2015.50

    authors： Wild J,Schmiedel BJ,Maurer A,Raab S,Prokop L,Stevanović S,Dörfel D,Schneider P,Salih HR

    更新日期：2015-08-01 00:00:00

  • Treatment of resistant disease.

    abstract：:Resistant AML encompasses two groups of patients: those with refractory leukemia and those whose leukemia has relapsed. Refractory leukemia is disease that does not respond to initial induction chemotherapy with cytarabine and an anthracycline. Patients with refractory leukemia are likely to have disease with adverse ...

    journal_title：Leukemia

    pub_type： 杂志文章,评审

    doi：

    authors： Schiller GJ

    更新日期：1998-09-01 00:00:00

  • Cellular and molecular studies on the early stages of human hematopoietic differentiation in culture of pure progenitors.

    abstract：:Methodology has been developed that enables virtually complete purification and recovery of early hematopoietic progenitors from human adult blood, a minority of which is multipotent and endowed with self-renewal capacities, i.e., exhibits stem cell properties. This report briefly reviews: (i) the key steps involved i...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Pelosi E,Testa U,Gabbianelli M,Valtieri M,Montesoro E,Samoggia P,Mastroberardino G,Isacchi G,Peschle C

    更新日期：1992-11-01 00:00:00

  • Detection of minimal residual disease in chronic myeloid leukemia patients after bone marrow transplantation by polymerase chain reaction.

    abstract：:We used a modification of the polymerase chain reaction (PCR) to amplify the specific bcr-abl mRNA from 14 patients with chronic myeloid leukemia (CML) who had previously received non T cell depleted allogenic bone marrow transplantation (BMT). Two types of reactions were used: a single step amplification with 5' and ...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Delfau MH,Kerckaert JP,Collyn d'Hooghe M,Fenaux P,Laï JL,Jouet JP,Grandchamp B

    更新日期：1990-01-01 00:00:00

  • Role of cytokines in the treatment of acute leukemias: a review.

    abstract：:Myeloid growth factors, such as granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor, have been used to decrease the duration of chemotherapy-induced neutropenia and thereby reduce the incidence and severity of infections in various regimens used to treat acute myeloid leukemia an...

    journal_title：Leukemia

    pub_type： 杂志文章,评审

    doi：10.1038/sj.leu.2404152

    authors： Ravandi F

    更新日期：2006-04-01 00:00:00

  • Effects of p38α/β inhibition on acute lymphoblastic leukemia proliferation and survival in vivo.

    abstract：:P38α/β has been described as a tumor-suppressor controlling cell cycle checkpoints and senescence in epithelial malignancies. However, p38α/β also regulates other cellular processes. Here, we describe a role of p38α/β as a regulator of acute lymphoblastic leukemia (ALL) proliferation and survival in experimental ALL m...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2015.153

    authors： Alsadeq A,Strube S,Krause S,Carlet M,Jeremias I,Vokuhl C,Loges S,Aguirre-Ghiso JA,Trauzold A,Cario G,Stanulla M,Schrappe M,Schewe DM

    更新日期：2015-12-01 00:00:00

  • Randomized comparison of prophylactic and minimal residual disease-triggered imatinib after allogeneic stem cell transplantation for BCR-ABL1-positive acute lymphoblastic leukemia.

    abstract：:Minimal residual disease (MRD) after allogeneic stem cell transplantation (SCT) for Ph+ acute lymphoblastic leukemia (ALL) is predictive of relapse. Imatinib administration subsequent to SCT may prevent relapse, but the role of scheduling and its impact on outcome are not known. In a prospective, randomized multicente...

    journal_title：Leukemia

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1038/leu.2012.352

    authors： Pfeifer H,Wassmann B,Bethge W,Dengler J,Bornhäuser M,Stadler M,Beelen D,Vucinic V,Burmeister T,Stelljes M,Faul C,Dreger P,Kiani A,Schäfer-Eckart K,Schwerdtfeger R,Lange E,Kubuschok B,Horst HA,Gramatzki M,Brück P,S

    更新日期：2013-06-01 00:00:00

  • Is acute promyelocytic leukemia a curable disease? Treatment strategy for a long-term survival.

    abstract：:The major cause of early death in acute promyelocytic leukemia (APL), the high risk of a bleeding diathesis is now successfully counteracted within a few days by differentiation therapy using ATRA. Moreover, no resistance to this drug has been recorded during induction when the usual presence of PML/RAR alpha was conf...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Degos L

    更新日期：1994-01-01 00:00:00

  • Differences between BCL2-break positive and negative follicular lymphoma unraveled by whole-exome sequencing.

    abstract：:Depending on disease stage follicular lymphoma (FL) lack the t(14;18) in ~15-~50% of cases. Nevertheless, most of these cases express BCL2. To elucidate mechanisms triggering BCL2 expression and promoting pathogenesis in t(14;18)-negative FL, exonic single-nucleotide variant (SNV) profiles of 28 t(14;18)-positive and ...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2017.270

    authors： Zamò A,Pischimarov J,Schlesner M,Rosenstiel P,Bomben R,Horn H,Grieb T,Nedeva T,López C,Haake A,Richter J,Trümper L,Lawerenz C,Klapper W,Möller P,Hummel M,Lenze D,Szczepanowski M,Flossbach L,Schreder M,Gattei V,O

    更新日期：2018-03-01 00:00:00

  • Schedule-dependent efficacy of idarubicin (Ida) and doxorubicin (Dox).

    abstract：:Schedule dependency of idarubicin (Ida) and doxorubicin (Dox) toxicity was investigated in vitro using the K562 human leukemia cell line. For Dox, repeated exposure to the IC30 (d x 3) resulted in comparable survival as single exposure to the total accumulative dose (20%). For Ida, repeated exposure to the IC30 (d x 3...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Minderman H,Buscaglia MD,Rustum YM

    更新日期：1994-08-01 00:00:00

  • High-dose methotrexate therapy significantly improved survival of adult acute lymphoblastic leukemia: a phase III study by JALSG.

    abstract：:High-dose methotrexate (Hd-MTX) therapy has recently been applied to the treatment of adult acute lymphoblastic leukemia (ALL) based on pediatric protocols; however, its effectiveness for adult ALL has not yet been confirmed in a rigorous manner. We herein conducted a randomized phase III trial comparing Hd-MTX therap...

    journal_title：Leukemia

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/leu.2017.283

    authors： Sakura T,Hayakawa F,Sugiura I,Murayama T,Imai K,Usui N,Fujisawa S,Yamauchi T,Yujiri T,Kakihana K,Ito Y,Kanamori H,Ueda Y,Miyata Y,Kurokawa M,Asou N,Ohnishi K,Ohtake S,Kobayashi Y,Matsuo K,Kiyoi H,Miyazaki Y,Na

    更新日期：2018-03-01 00:00:00

  • Stromal cell-mediated transcriptional regulation of the CD13/aminopeptidase N gene in leukemic cells.

    abstract：:CD13/aminopeptidase N (APN) is a cell surface metallopeptidase expressed by normal and leukemic myeloid cells, and by lymphoblasts in 5-10% of acute lymphoid leukemia (ALL) cases, previously classified as 'biphenotypic' or 'mixed-lineage' leukemias. In fresh cells from two early B-lineage, t(9;22)-positive, ALL cases ...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Saito M,Kumagai M,Okazaki T,Nakazawa S,Shapiro LH,Look AT,Campana D

    更新日期：1995-09-01 00:00:00

  • Cellular resistance mechanisms with impact on the therapy of multiple myeloma.

    abstract：:Multiple myeloma (MM) is characterized by bone marrow infiltration with abnormal plasma cells which synthesize monoclonal immunoglobulins (Ig) or Ig fragments. Regularly, MM cells exhibit a high intrinsic resistance to available chemotherapeutic strategies. A number of cellular alterations including the cellular membr...

    journal_title：Leukemia

    pub_type： 杂志文章,评审

    doi：

    authors： Gieseler F,Nüssler V

    更新日期：1997-12-01 00:00:00

  • tal-1 deletions in T-cell acute lymphoblastic leukemia as PCR target for detection of minimal residual disease.

    abstract：:Polymerase chain reaction (PCR) techniques based on amplification and identification of leukemia-specific DNA sequences provide a sensitive diagnostic method for detection of minimal residual disease (MRD) with a detection limit of 10(-5) to 10(-6) (1-10 malignant cells in 10(6) normal cells). To date, the main leukem...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Breit TM,Beishuizen A,Ludwig WD,Mol EJ,Adriaansen HJ,van Wering ER,van Dongen JJ

    更新日期：1993-12-01 00:00:00

  • Effects of the farnesyl transferase inhibitor R115777 on normal and leukemic hematopoiesis.

    abstract：:Patients with acute myelogenous leukemia or myelodysplastic syndrome may respond to farnesyl transferase inhibitors (FTIs) with partial or complete response rates noted in about 30% of such patients. FTIs prevent the attachment of a lipid farnesyl moiety to dependent proteins prior to their insertion into the plasma m...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2403063

    authors： Liesveld JL,Lancet JE,Rosell KE,Menon A,Lu C,McNair C,Abboud CN,Rosenblatt JD

    更新日期：2003-09-01 00:00:00

  • Linkage of proliferative and maturational abnormalities in chronic myelogenous leukemia and relevance to treatment.

    abstract：:Despite recent advances in our understanding of the molecular and biological abnormalities in chronic myelogenous leukemia (CML) this new knowledge has not yet led to significant improvements in treatment. We have reviewed what is known and still unknown about the molecular and biological abnormalities in CML that may...

    journal_title：Leukemia

    pub_type： 杂志文章,评审

    doi：

    authors： Clarkson B,Strife A

    更新日期：1993-11-01 00:00:00

  • Inhibition of proliferation and CD25 down-regulation by retinoic acid in human adult T cell leukemia cells.

    abstract：:The effects of retinoic acid (RA) on the cell growth and expression of interleukin-2 (IL-2) receptors (IL-2R alpha/p55, Tac, CD25) by the human T lymphotropic virus type I (HTLV-I)-positive T cell lines, HUT102 and ATL-2 were investigated. Incubation of these cells for 48 h with either 13-cis retinoid acid (13-cis RA)...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2400593

    authors： Miyatake JI,Maeda Y

    更新日期：1997-03-01 00:00:00

  • Deficiency of a phosphatidylinositol-anchored cell adhesion molecule influences haemopoietic progenitor binding to marrow stroma in chronic myeloid leukaemia.

    abstract：:The interactions between haemopoietic progenitor cells and marrow stromal cells that are essential for the regulation of normal haemopoiesis are defective in chronic phase chronic myeloid leukaemia (CML). The presence of primitive progenitor cells (blast colony-forming cells, Bl-CFC) in the blood of patients with CML ...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Gordon MY,Atkinson J,Clarke D,Dowding CR,Goldman JM,Grimsley PG,Siczkowski M,Greaves MF

    更新日期：1991-08-01 00:00:00

  • Prognostic impact of RAS-pathway mutations in patients with myelofibrosis.

    abstract：:RAS-pathway mutations are recurrent events in myeloid malignancies. However, there is limited data on the significance of RAS-pathway mutations in patients with myelofibrosis (MF). We analyzed next-generation sequencing data of 16 genes, including RAS-pathway genes, from 723 patients with primary and secondary MF acro...

    journal_title：Leukemia

    pub_type： 杂志文章,多中心研究

    doi：10.1038/s41375-019-0603-9

    authors： Santos FPS,Getta B,Masarova L,Famulare C,Schulman J,Datoguia TS,Puga RD,Alves Paiva RM,Arcila ME,Hamerschlak N,Kantarjian HM,Levine RL,Campregher PV,Rampal RK,Verstovsek S

    更新日期：2020-03-01 00:00:00

  • A new myeloproliferative disorder associated with chromosomal translocations involving 8p11: a review.

    abstract：:Chromosomal breakpoints associated with malignancy are known to cluster at particular regions of the karyotype. Based on a review of the literature we have identified a novel leukaemia syndrome associated with translocations involving 8p11. This syndrome is distinct from the previously described translocation t(8;16)(...

    journal_title：Leukemia

    pub_type： 杂志文章,评审

    doi：

    authors： Macdonald D,Aguiar RC,Mason PJ,Goldman JM,Cross NC

    更新日期：1995-10-01 00:00:00

  • New chemotherapeutic agents in acute myeloid leukemia.

    abstract：:Only two classes of chemotherapeutic agents have shown activity in acute myeloid leukemia (AML): ara-C and topoisomerase II reactive agents. Frontline combinations of these agents produce complete response (CR) rates of 70% and long-term event free survival rates of 25%. New agents with different mechanisms of action ...

    journal_title：Leukemia

    pub_type： 杂志文章,评审

    doi：

    authors： Kantarjian HM,Estey EH,Keating MA

    更新日期：1996-04-01 00:00:00

  • Quality assurance in RT-PCR-based BCR/ABL diagnostics--results of an interlaboratory test and a standardization approach.

    abstract：:Here we describe the results of an interlaboratory test for RT-PCR-based BCR/ABL analysis. The test was organized in two parts. The number of participating laboratories in the first and second part was 27 and 20, respectively. In the first part samples containing various concentrations of plasmids with the ela2, b2a2 ...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2401899

    authors： Burmeister T,Maurer J,Aivado M,Elmaagacli AH,Grünebach F,Held KR,Hess G,Hochhaus A,Höppner W,Lentes KU,Lübbert M,Schäfer KL,Schafhausen P,Schmidt CA,Schüler F,Seeger K,Seelig R,Thiede C,Viehmann S,Weber C,Wilhelm

    更新日期：2000-10-01 00:00:00

  • Antigen receptor stereotypy in chronic lymphocytic leukemia.

    abstract：:The discovery of almost identical or 'stereotyped' B-cell receptor immunoglobulins (BcR IG) among unrelated patients with chronic lymphocytic leukemia (CLL) cemented the idea of antigen selection in disease ontogeny and evolution. The systematic analysis of the stereotypy phenomenon in CLL revealed that around one-thi...

    journal_title：Leukemia

    pub_type： 杂志文章,评审

    doi：10.1038/leu.2016.322

    authors： Stamatopoulos K,Agathangelidis A,Rosenquist R,Ghia P

    更新日期：2017-02-01 00:00:00

  • Intensive chemotherapy in childhood myelodysplastic syndrome. A comparison with results in acute myeloid leukemia.

    abstract：:Myelodysplastic syndrome (MDS) in children is often considered as a variant of acute myeloid leukemia (AML) and frequently treated as such. However, there are very few reported data on the outcome following AML treatment. We analyzed 20 consecutive cases of de novo MDS treated in Denmark according to the NOPHO AML pro...

    journal_title：Leukemia

    pub_type： 临床试验,杂志文章

    doi：

    authors： Hasle H,Kerndrup G,Yssing M,Clausen N,Ostergaard E,Jacobsen N,Jacobsen BB

    更新日期：1996-08-01 00:00:00

  • Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1.

    abstract：:Targeted therapies are frequently combined with standard cytotoxic drugs to enhance clinical response. Targeting the B-cell lymphoma 2 (BCL-2) family of proteins is an attractive option to combat chemoresistance in leukemia. Preclinical and clinical studies indicate modest single-agent activity with selective BCL-2 in...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2017.243

    authors： Teh TC,Nguyen NY,Moujalled DM,Segal D,Pomilio G,Rijal S,Jabbour A,Cummins K,Lackovic K,Blombery P,Thompson E,Ekert PG,Lessene G,Glaser SP,Huang DCS,Roberts AW,Guthridge MA,Wei AH

    更新日期：2018-02-01 00:00:00

  • Characterisation of non-concordance in the T-cell receptor gamma chain genes at presentation and clinical relapse in acute lymphoblastic leukemia.

    abstract：:We have analysed the structure of the T-cell receptor gamma chain (TCRG) genes in a panel of biopsies taken from 24 patients with acute lymphoblastic leukemia (ALL) (13 cALL, one pre-B ALL, two null ALL and eight T-ALL) at presentation and at clinical relapse. In the majority of cases (18/24) the structure of these ge...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Taylor JJ,Rowe D,Kylefjord H,Chessells J,Katz F,Proctor SJ,Middleton PG

    更新日期：1994-01-01 00:00:00

  • Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (flt-1) autocrine loop in human leukemia cells MOLT-4.

    abstract：:The mechanism by which aplidine, a marine natural product in early clinical development as an anticancer agent, induces cell growth inhibition and apoptosis has been investigated in the human leukemia cell line MOLT-4. This cell line is characterized not only by the ability to secrete VEGF, but also for the presence o...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/sj.leu.2402788

    authors： Broggini M,Marchini SV,Galliera E,Borsotti P,Taraboletti G,Erba E,Sironi M,Jimeno J,Faircloth GT,Giavazzi R,D'Incalci M

    更新日期：2003-01-01 00:00:00

  • A novel arsenical has antitumor activity toward As2O3-resistant and MRP1/ABCC1-overexpressing cell lines.

    abstract：:Inorganic arsenic trioxide (As(2)O(3)) is a highly effective treatment for acute promyelocytic leukemia (APL). However, other cancers do not respond well to this form of arsenic at clinically achievable doses. We tested a novel arsenical, S-dimethylarsino-glutathione (darinaparsin) for efficacy in various malignancies...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2008.194

    authors： Diaz Z,Mann KK,Marcoux S,Kourelis M,Colombo M,Komarnitsky PB,Miller WH Jr

    更新日期：2008-10-01 00:00:00

  • A robust xenotransplantation model for acute myeloid leukemia.

    abstract：:Xenotransplantation of human acute myeloid leukemia (AML) in immunocompromised animals has been critical for defining leukemic stem cells. However, existing immunodeficient strains of mice have short life spans and low levels of AML cell engraftment, hindering long-term evaluation of primary human AML biology. A recen...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：10.1038/leu.2009.143

    authors： Sanchez PV,Perry RL,Sarry JE,Perl AE,Murphy K,Swider CR,Bagg A,Choi JK,Biegel JA,Danet-Desnoyers G,Carroll M

    更新日期：2009-11-01 00:00:00

  • Action of interferons in hairy cell leukemia.

    abstract：:We have investigated the direct effects of interferon (IFN) on hairy cells (HCs) isolated from patients with hairy cell leukemia using one- and two-dimensional gel electrophoresis. We have previously characterized the induction of synthesis of 10-16 specific proteins by IFN-alpha 2b in HCs, as analyzed by one-dimensio...

    journal_title：Leukemia

    pub_type： 杂志文章

    doi：

    authors： Samuels BL,Rosner MC,Giometti CS,Golomb HM,Brownstein BH

    更新日期：1987-04-01 00:00:00