Abstract：
:Previous studies have indicated that colony-stimulating factors may stimulate myelopoiesis and thus increase the number of circulating white blood cells in patients with hematopoietic failure including aplastic anemia. However, long-term administration of the factor was required to maintain its response. In the present article we report on a patient with severe aplastic anemia undergoing treatment with recombinant human (rh) granulocyte-macrophage colony-stimulating factor (GM-CSF). After an initial response, the patient became refractory to GM-CSF. However, treatment with interleukin (IL)-3 restored responsiveness to GM-CSF, suggesting that IL-3 may have replenished the bone marrow with myelopoietic progenitor cells sensitive to the action of GM-CSF. This observation suggests the value of application of sequentially acting hematopoietic growth factors in aplastic anemia patients.
journal_name
Leukemiajournal_title
Leukemiaauthors
Herrmann F,Lindemann A,Raghavachar A,Heimpel H,Mertelsmann Rsubject
Has Abstractpub_date
1990-10-01 00:00:00pages
671-2issue
10eissn
0887-6924issn
1476-5551journal_volume
4pub_type
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