Abstract：
:The observation that wild type p53 may induce cells to undergo either apoptosis or differentiation raises the question of whether these two events share similar p53-dependent pathways. To evaluate the interrelationship between these two p53-dependent processes, our study focused on the human HL-60, a pro-myelocytic p53 non-producer cell line in which p53 expression was introduced and the induction of apoptosis and differentiation was followed under controlled conditions. p53 expression was induced in the HL-60 cell line by infection with the recombinant wild type p53 (p53WT) vaccinia virus. Viral infection gave rise to cells expressing various levels of wild type p53 protein. High levels of p53 protein induced cells to undergo rapid apoptosis, whereas lower levels of p53 protein induced cells to undergo cell differentiation at a more moderate rate of kinetics. These results suggest that p53 protein levels may determine whether a given cell should prefer one pathway over the other to exit the cell cycle.
journal_name
Leukemiajournal_title
Leukemiaauthors
Rotter V,Ronen Dsubject
Has Abstractpub_date
1997-04-01 00:00:00pages
327-30eissn
0887-6924issn
1476-5551journal_volume
11 Suppl 3pub_type
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