Gastroesophageal reflux disease and asthma: a longitudinal study in UK general practice.


STUDY OBJECTIVES:Gastroesophageal reflux disease (GERD) and asthma are common causes for consultation in primary care, but the relationship between the two remains unclear. The aim of our study was to investigate the temporal relationship between first diagnoses of GERD and asthma in general practice. METHODS:We used the UK General Practice Research Database to identify a cohort of patients with a first diagnosis of GERD (n = 5,653) and another cohort of patients with a first diagnosis of asthma (n = 9,712) during 1996, which we compared with age-matched and sex-matched control cohorts drawn from the general population without either diagnosis. We investigated the incidence of a GERD diagnosis among the asthma patients and control subjects, and the incidence of an asthma diagnosis among the GERD patients and control subjects during a mean follow-up period of 3 years. We calculated the relative risk (RR) of these diagnoses using Cox regression analysis and examined the risk associated with medication use using nested case-control analysis. RESULTS:The incidence rates of GERD and asthma among the control cohorts were 4.4 and 3.8 per 1,000 person-years, respectively. During the follow-up period, the RR of an incident asthma diagnosis in patients with a new diagnosis of GERD was 1.2 (95% confidence interval [CI], 0.9 to 1.6), while the RR of an incident GERD diagnosis among patients with a new diagnosis of asthma was 1.5 (95% CI, 1.2 to 1.8) after adjustment for age, sex, smoking, prior comorbidity, and number of health-care contacts. This increased risk was mainly seen during the first year of follow-up. The prior use of prescription medications for asthma and GERD had no significant effects on the risk of GERD and asthma diagnosis, respectively. CONCLUSIONS:Patients with asthma are at a significantly increased risk of developing GERD, mainly during the first year following diagnosis. A nonsignificant increase in the risk of developing asthma was evident among GERD patients. The relationship between GERD and asthma warrants further investigation.






Ruigómez A,Rodríguez LA,Wallander MA,Johansson S,Thomas M,Price D




Has Abstract


2005-07-01 00:00:00
















  • Persisting symptoms despite permanent pacing. Incidence, causes, and follow-up.

    abstract::Persisting symptoms, consisting of palpitations, dizziness, or syncope, were found in 49 of 570 consecutively followed patients (8.6 percent) with permanent pacemakers (PM). Among 540 patients with ventricular PM, 19 had syncope and 24 dizziness; among 30 patients with dual-chamber PM, five had palpitations and one di...


    pub_type: 杂志文章


    authors: Hoffman A,Jost M,Pfisterer M,Burkart F,Burckhardt D

    更新日期:1984-02-01 00:00:00

  • Breathlessness in patients with severe chronic airflow limitation. Physiologic correlations.

    abstract::We wished to identify the physiologic abnormalities that distinguish severely breathless (SB) patients with chronic airflow limitation (CAL) from mildly breathless (MB) patients. Thirty-seven patients with stable, advanced CAL (FEV1 = 38 +/- 10 percent predicted, mean +/- SD) were separated into two distinct groups, S...


    pub_type: 杂志文章


    authors: O'Donnell DE,Webb KA

    更新日期:1992-09-01 00:00:00

  • How should we measure arm exercise capacity in patients with COPD? A systematic review.

    abstract:BACKGROUND:There are no recommendations on how to measure arm exercise capacity in individuals with COPD. The objectives of this study were (1) to synthesize the literature on measures of arm exercise capacity in individuals with COPD, (2) to describe the psychometric properties and the target construct of each measure...


    pub_type: 杂志文章,评审


    authors: Janaudis-Ferreira T,Beauchamp MK,Goldstein RS,Brooks D

    更新日期:2012-01-01 00:00:00

  • Pulmonary function and high-resolution CT findings in patients with an inherited form of pulmonary fibrosis, Hermansky-Pudlak syndrome, due to mutations in HPS-1.

    abstract:OBJECTIVE:To describe and correlate pulmonary function and high-resolution CT (HRCT) scan scores in individuals with a high risk for development of pulmonary fibrosis, ie, Hermansky-Pudlak syndrome (HPS) patients with mutations in the HPS-1 gene. DESIGN:Cross-sectional analysis of consecutive, eligible patients. PATI...


    pub_type: 杂志文章


    authors: Brantly M,Avila NA,Shotelersuk V,Lucero C,Huizing M,Gahl WA

    更新日期:2000-01-01 00:00:00

  • Use of a highly purified alpha 1-antitrypsin standard to establish ranges for the common normal and deficient alpha 1-antitrypsin phenotypes.

    abstract::Diagnosis of the hereditary disorder alpha 1-antitrypsin (alpha 1AT) deficiency is critically dependent on quantification of serum levels of alpha 1AT, a 52-kDa antiprotease that serves to protect the lung from destruction by neutrophil elastase. Although the measurement of serum alpha 1AT levels is not difficult, the...


    pub_type: 杂志文章


    authors: Brantly ML,Wittes JT,Vogelmeier CF,Hubbard RC,Fells GA,Crystal RG

    更新日期:1991-09-01 00:00:00

  • Akinesis becoming dyskinesis during dobutamine stress echocardiography. A predictor of poor functional recovery after surgical revascularization.

    abstract:BACKGROUND:Akinesis becoming dyskinesis at high-dose dobutamine stress echocardiography (DSE) has been disregarded as a marker of myocardial ischemia. However, to our knowledge, the relationship between this pattern and myocardial viability has not been assessed. METHODS:We studied 42 patients with myocardial infarcti...


    pub_type: 杂志文章


    authors: Elhendy A,Cornel JH,Roelandt JR,van Domburg RT,Fioretti PM

    更新日期:1996-07-01 00:00:00

  • A 61-Year-Old Caribbean Man With Thrush and Acute Respiratory Failure.

    abstract:CASE PRESENTATION:A 61-year-old Caribbean man presented to the ED with dyspnea that had progressed over the previous week with associated cough and high fevers. Four days prior to admission, his primary care physician noted oral thrush and obtained a chest radiograph that revealed a right middle lobe infiltrate. He was...


    pub_type: 杂志文章


    authors: Gong J,Melamud A,Koenig S

    更新日期:2018-07-01 00:00:00

  • Left ventricular function in myocardial infarction. Predictive value during negative low-level exercise three weeks postinfarction.

    abstract::To evaluate whether the response of left ventricular pump function during low-level exercise in the early postinfarction period can anticipate its change during the first year after acute myocardial infarction (MI), global and regional ejection fractions (EF) were investigated using radionuclide angiography in 52 cons...


    pub_type: 杂志文章


    authors: Iwasaka T,Sugiura T,Nakamura S,Okubo N,Inada M

    更新日期:1992-08-01 00:00:00

  • Sleep-disordered breathing in Down syndrome.

    abstract::OSA is associated with significant adverse outcomes with far-reaching health-care implications. OSA is much more common and severe in patients with Down syndrome (DS) than in the general population, yet there is a striking lack of literature in this area. In this review article, we have summarized the current state of...


    pub_type: 杂志文章,评审


    authors: Lal C,White DR,Joseph JE,van Bakergem K,LaRosa A

    更新日期:2015-02-01 00:00:00

  • Screening of pediatric sleep-disordered breathing: a proposed unbiased discriminative set of questions using clinical severity scales.

    abstract:BACKGROUND:Identification of sleep-disordered breathing (SDB) using questionnaires is critical from a clinical and research perspective. However, which questions to use and how well such questionnaires perform has thus far been fraught with substantial uncertainty. We aimed at delineating the usefulness of a set of que...


    pub_type: 杂志文章


    authors: Spruyt K,Gozal D

    更新日期:2012-12-01 00:00:00

  • The "lung shift" in treated schistosomiasis. Bronchoalveolar lavage evidence of eosinophilic pneumonia.

    abstract::There is conflicting and incomplete information in the literature on the pulmonary reaction which can occur following treatment of schistosomiasis. We examined the pulmonary function, bronchoalveolar lavage profile, and lung histopathology of a patient with pneumonia and peripheral eosinophilia following oxaminquine c...


    pub_type: 杂志文章


    authors: Davidson BL,el-Kassimi F,Uz-Zaman A,Pillai DK

    更新日期:1986-03-01 00:00:00

  • Gastric and esophageal intramucosal PCO2 (PiCO2) during endotoxemia: assessment of raw PiCO2 and PCO2 gradients as indicators of hypoperfusion in a canine model of septic shock.

    abstract:STUDY OBJECTIVES:To validate capnometric recirculating gas tonometry (CRGT) for continuously monitoring gut intramucosal PCO2 (PiCO2) in a septic shock model, and to compare gastric vs esophageal PCO2 vs intramucosal-arterial PCO2 gradients. INTERVENTIONS:CRTG catheters were placed in the stomach and esophagus of six ...


    pub_type: 杂志文章


    authors: Guzman JA,Lacoma FJ,Kruse JA

    更新日期:1998-04-01 00:00:00

  • The effects of smoking on the signal-averaged electrocardiogram in normal subjects.

    abstract::Tobacco smoking increases the risk of sudden cardiac death, possibly by altering the substrate for propagation or sustainment of ventricular tachyarrhythmias. To test this hypothesis, 15 long-term smokers without known coronary artery disease abstained from tobacco smoking for 12 h, after which they underwent SAECG be...


    pub_type: 杂志文章


    authors: Sperry RE,Vacek JL,Smith GS

    更新日期:1991-01-01 00:00:00

  • Bronchial hyperresponsiveness in asthmatic children. Correlation with macrophages and eosinophils in broncholavage fluid.

    abstract::Bronchial responsiveness assessed by histamine bronchial challenge testing in 22 children with chronic stable asthma was compared with the number of inflammatory cells per milliliter of broncholavage fluid obtained by fiberoptic bronchoscopy. Hyperresponsiveness was closely correlated with increased counts of eosinoph...


    pub_type: 杂志文章


    authors: Ferguson AC,Wong FW

    更新日期:1989-11-01 00:00:00

  • Recovery of the ventilatory and upper airway muscles and exercise performance after type A botulism.

    abstract::We studied six patients with type A botulism to determine the degree of initial respiratory compromise and to quantitate the time course and extent of recovery of the ventilatory and upper airway muscles and exercise performance. The VM weakness was identified in all patients early after botulism. Upper airway muscle ...


    pub_type: 杂志文章


    authors: Wilcox PG,Morrison NJ,Pardy RL

    更新日期:1990-09-01 00:00:00

  • Vasodilator therapy-induced pacemaker syndrome.

    abstract::Disabling presyncopal attacks were provoked in a patient with a sinus nodal disorder and cardiac pacemaker by treatment with antianginal vasodilators. At cardiac catheterization a severe fall in aortic pressure was documented during ventricular pacing, when desynchronized atrial contractions coincided with ventricular...


    pub_type: 杂志文章


    authors: Toivonen LK,Pohjola-Sintonen S

    更新日期:1987-06-01 00:00:00

  • Two-dimensional echocardiographic features of bicuspid aortic valve.

    abstract::The two-dimensional cross-sectional echocardiographic diagnosis of bicuspid aortic valves is described and compared with results of M-mode echocardiograms. Aortic valve anatomy was determined in 19 selected patients by angiography, and confirmed in five by direct surgical visualization. Using an eccentricity index (EI...


    pub_type: 杂志文章


    authors: Fowles RE,Martin RP,Abrams JM,Schapira JN,French JW,Popp RL

    更新日期:1979-04-01 00:00:00

  • Evaluation of the Winthrop-University Hospital criteria to identify Legionella pneumonia.

    abstract:STUDY OBJECTIVE:To measure the ability of a set of clinical parameters, the Winthrop-University Hospital (WUH) criteria, to identify Legionella pneumonia while discriminating against bacteremic pneumococcal pneumonia at the time of hospitalization for community-acquired pneumonia (CAP). DESIGN:Retrospective case-contr...


    pub_type: 杂志文章


    authors: Gupta SK,Imperiale TF,Sarosi GA

    更新日期:2001-10-01 00:00:00

  • Fluid therapy in resuscitated sepsis: less is more.

    abstract::Fluid infusion may be lifesaving in patients with severe sepsis, especially in the earliest phases of treatment. Following initial resuscitation, however, fluid boluses often fail to augment perfusion and may be harmful. In this review, we seek to compare and contrast the impact of fluids in early and later sepsis; sh...


    pub_type: 杂志文章,评审


    authors: Durairaj L,Schmidt GA

    更新日期:2008-01-01 00:00:00

  • Left upper lobe mass and diffuse reticular-nodular infiltrate.

    abstract::We encountered a clinical problem in a young man who presented with a left upper lobe mass and a diffuse reticular-nodular infiltrate. We thought we had appropriately applied Murphy's Law (the famed bank robber who "went where the money is"), and Ockham's Razor (the philosopher William of Ockham [1285 to 1349]-"Entiti...


    pub_type: 杂志文章


    authors: Jackson HD,Carney KJ,Knautz MA,Tenholder MF

    更新日期:1994-06-01 00:00:00

  • The influence of high-frequency jet ventilation with varying cardiac-cycle specific synchronization on cardiac output in ARDS.

    abstract:BACKGROUND:Previous studies have shown "beat-to-beat" variation in systemic BP with high-frequency jet ventilation (HFJV). However, it is not clear if such changes are paralleled by changes in cardiac output. OBJECTIVE:To characterize the effect of HFJV near or equal to the heart rate (HR) on beat-to-beat cardiac outp...


    pub_type: 杂志文章,评审


    authors: Angus DC,Lidsky NM,Dotterweich LM,Pinsky MR

    更新日期:1997-12-01 00:00:00

  • Incidence of VTE and Bleeding Among Hospitalized Patients With Coronavirus Disease 2019: A Systematic Review and Meta-analysis.

    abstract:BACKGROUND:Individual studies have reported widely variable rates for VTE and bleeding among hospitalized patients with coronavirus disease 2019 (COVID-19). RESEARCH QUESTION:What is the incidence of VTE and bleeding among hospitalized patients with COVID-19? METHODS:In this systematic review and meta-analysis, 15 st...


    pub_type: 杂志文章


    authors: Jiménez D,García-Sanchez A,Rali P,Muriel A,Bikdeli B,Ruiz-Artacho P,Le Mao R,Rodríguez C,Hunt BJ,Monreal M

    更新日期:2020-11-17 00:00:00

  • Maximum insufflation capacity.

    abstract:OBJECTIVE:To investigate the effect of deep lung insufflations on maximum insufflation capacities (MICs) and peak cough flows (PCFs) for patients with neuromuscular disease. METHOD:Forty-three patients with neuromuscular disease were trained in stacking delivered volumes of air to deep lung insufflation and were presc...


    pub_type: 杂志文章


    authors: Kang SW,Bach JR

    更新日期:2000-07-01 00:00:00

  • Closure of a tracheoesophageal fistula by bronchoscopic application of fibrin glue and decontamination of the oral cavity.

    abstract::A tracheoesophageal fistula was successfully closed with a fibrin adhesive applied by means of a fiberoptic bronchoscope, instead of by esophagoscopy. To facilitate closure of the fistula, the technique was combined with decontamination of the oral cavity, to avoid bacterial contamination. The procedure is proposed as...


    pub_type: 杂志文章


    authors: Antonelli M,Cicconetti F,Vivino G,Gasparetto A

    更新日期:1991-08-01 00:00:00

  • Transmission of Mycobacterium tuberculosis to a funeral director during routine embalming.

    abstract::Several studies have shown that funeral directors have an increased risk of tuberculosis (TB). Although there is indirect evidence of transmission of TB from cadavers to mortuary workers, there is only one recently documented case in the literature. We report here another case of occupationally acquired TB in a funera...


    pub_type: 杂志文章


    authors: Lauzardo M,Lee P,Duncan H,Hale Y

    更新日期:2001-02-01 00:00:00

  • Roxithromycin reduces the degree of bronchial hyperresponsiveness in children with asthma.

    abstract::We evaluated the effects of a new semisynthetic macrolide antibiotic, roxithromycin, on the bronchial hyperresponsiveness to histamine in children with asthma. Twelve hospitalized asthmatic children, aged 11 to 15 years (mean age, 12.9 years), were enrolled in this study. They were treated with 150 mg of roxithromycin...


    pub_type: 临床试验,杂志文章


    authors: Shimizu T,Kato M,Mochizuki H,Tokuyama K,Morikawa A,Kuroume T

    更新日期:1994-08-01 00:00:00

  • The effect of glucagon on the pulmonary transvascular fluid filtration rate.

    abstract::Administration of glucagon has been shown to decrease pulmonary vascular resistance, but its primary site of action is undetermined. Whether this is on the arterial or venous side of the capillary would be reflected in the microvascular hydrostatic pressure. We used the pulmonary flow of lymph, a sensitive index of th...


    pub_type: 杂志文章


    authors: Demling RH,Manohar M,Will J

    更新日期:1978-08-01 00:00:00

  • Nodular pulmonary opacities in patients with rheumatoid arthritis. A diagnostic dilemma.

    abstract::Nodular opacities are a well-known pulmonary manifestation of rheumatoid arthritis (RA), occurring most often in seropositive men who smoke and have subcutaneous nodules. In the past 15 years two cases of lung carcinoma presenting as pulmonary nodules have been reported in patients with rheumatoid disease. We present ...


    pub_type: 杂志文章


    authors: Jolles H,Moseley PL,Peterson MW

    更新日期:1989-11-01 00:00:00

  • Significance of a plasma D-dimer test in patients with primary pulmonary hypertension.

    abstract:BACKGROUND:D-dimer, a degradation product of fibrin, has been increasingly used as a marker or prognostic factor in various thrombotic diseases. OBJECTIVE:To assess the significance of a d-dimer test in patients with primary pulmonary hypertension (PPH). PATIENTS AND METHODS:Fourteen patients with PPH (12 women and 2...


    pub_type: 杂志文章


    authors: Shitrit D,Bendayan D,Bar-Gil-Shitrit A,Huerta M,Rudensky B,Fink G,Kramer MR

    更新日期:2002-11-01 00:00:00

  • Diagnosis of causes for acute respiratory distress by pressure-volume curves.

    abstract::The determination of effective dynamic and static relationships between pressure and volume aided in the diagnosis of pulmonary disease, its course, and the effects of therapy in 22 patients receiving continuous mechanical ventilation. These measurements were made on multiple occasions early in the course of mechanica...


    pub_type: 杂志文章


    authors: Bone RC

    更新日期:1976-12-01 00:00:00