Photoradiation therapy in advanced carcinoma of the trachea and bronchus.

Abstract:

:Photoradiation therapy is a new technique being investigated for the treatment of solid malignant tumors. In this study, 17 patients with advanced, recurrent, biopsy-proven malignant lesions of the trachea or main-stem bronchus were treated by photoradiation therapy. Patients received hematoporphyrin derivative intravenously three days prior to light therapy. The light was delivered from a fiberoptic fiber attached to the output beam of a dye laser (633 +/- 3 nm). The fiber was passed through the large channel of a bronchoscope (Olympus BF 2T). Of the 17 patients, two had no measurable response to the photoradiation therapy, six had partial necrosis of the tumor, seven patients had a greater than 50 percent reduction in the intraluminal volume of tumor, and two were lost to follow-up. Survival ranged from 5 to 210 days (median survival, 40 days). Complications of the treatment were significant in this group of advanced-stage patients and included excessive secretions, fever, pneumonia, and abscess formation.

journal_name

Chest

journal_title

Chest

authors

Vincent RG,Dougherty TJ,Rao U,Boyle DG,Potter WR

doi

10.1378/chest.85.1.29

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

29-33

issue

1

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)40138-2

journal_volume

85

pub_type

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