Abstract:
OBJECTIVE:To elucidate whether serum adiponectin is associated with renal function, low-grade inflammatory markers, metabolic control, and insulin resistance in type 1 diabetic patients with and without nephropathy. RESEARCH DESIGN AND METHODS:A total of 189 type 1 diabetic patients from the Finnish Diabetic Nephropathy Study were divided into three groups based on their urinary albumin excretion rate (AER): patients with normal AER (n = 66) had no antihypertensive medication, while patients with microalbuminuria (n = 63) or macroalbuminuria (n = 60) were all treated with an ACE inhibitor. Renal function was estimated with the Cockcroft-Gault formula. Adiponectin was measured by an in-house time-resolved immunofluorometric assay. RESULTS:Adiponectin concentrations were higher in women than in men, but since there was no significant difference in sex distribution between the groups, data were pooled. Adiponectin concentrations were higher in patients with macroalbuminuria (19.8 +/- 12.0 mg/l) than in patients with microalbuminuria (13.1 +/- 4.8 mg/l) or normoalbuminuria (11.8 +/- 4.2 mg/l). In a univariate analysis, adiponectin was positively associated with creatinine (r = 0.41; P < 0.0001), AER (r = 0.33; P < 0.0001), interleukin-6 (r = 0.22; P = 0.002), systolic blood pressure (r = 0.22; P = 0.004), HbA(1c) (r = 0.17; P = 0.02), total cholesterol (r = 0.16; P = 0.03), and HDL cholesterol (r = 0.16; P = 0.03) and negatively with estimated glomerular filtration rate (GFR; r = -0.52; P < 0.0001) and waist-to-hip ratio (WHR; r = -0.16; P = 0.03). In a multiple linear regression analysis including the above variables, estimated GFR, AER, and WHR were independently associated with adiponectin levels (r(2) = 0.32). CONCLUSIONS:Serum adiponectin concentrations are increased in type 1 diabetic patients with nephropathy, and levels are further associated with renal insufficiency.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Saraheimo M,Forsblom C,Fagerudd J,Teppo AM,Pettersson-Fernholm K,Frystyk J,Flyvbjerg A,Groop PH,FinnDiane study group.doi
10.2337/diacare.28.6.1410subject
Has Abstractpub_date
2005-06-01 00:00:00pages
1410-4issue
6eissn
0149-5992issn
1935-5548pii
28/6/1410journal_volume
28pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:This study compares the time-action profile of inhaled insulin (INH; Exubera) with that of subcutaneously injected insulin lispro (ILP) or regular human insulin (RHI) in healthy volunteers. RESEARCH DESIGN AND METHODS:In this open-label, randomized, three-way, crossover study, 17 healthy male volunteers were...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.28.5.1077
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between diabetes characteristics, medical history, foot deformity, sensory neuropathy, and plantar foot pressure. RESEARCH DESIGN AND METHODS:There were 517 subjects from a cohort of diabetic veterans enrolled in a prospective study of risk factors for foot complications who contri...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.6.965
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:A combined analysis of whether islet cell autoantibodies (ICAs) are cross-reactive with mouse pancreas, with glutamate decarboxylase (GAD) antibodies, and with 64K antibodies was performed in a large sample of recently diagnosed type I diabetic patients. The disappearance rates of these different autoantibodi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.17.10.1115
更新日期:1994-10-01 00:00:00
abstract::Whereas self-monitoring of blood glucose (SMBG) is the recommended source of information on which to make self-care decisions, patients frequently use estimates of their own blood glucose (BG). This study evaluated whether patients with insulin-dependent diabetes mellitus (IDDM) could learn to improve accuracy of BG e...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.12.5.313
更新日期:1989-05-01 00:00:00
abstract:OBJECTIVE:There is considerable interest in identifying biomarkers that predict high risk for the development of macrovascular complications in patients with diabetes. Therefore, the longitudinal association between subclinical atherosclerosis as measured by internal carotid artery intima-media thickness (IMT) and acut...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc14-2877
更新日期:2015-07-01 00:00:00
abstract::Secondary failure to oral hypoglycemic agents (OHAs) is a possible outcome for non-insulin-dependent diabetes mellitus (NIDDM) patients and poses a serious therapeutic problem. In this study, we evaluated the effect of adding a single bedtime low-dose NPH insulin injection to the previous ineffective sulfonylurea ther...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.12.8.582
更新日期:1989-09-01 00:00:00
abstract:OBJECTIVE:Subjects with type 1 diabetes are at high risk for many long-term complications, including early mortality and coronary artery disease (CAD). Few data are available on which to base goal levels for two major risk factors, namely blood pressure and lipid/lipoproteins. The objective of this study was to determi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.24.6.1053
更新日期:2001-06-01 00:00:00
abstract::OBJECTIVE We evaluated relationships of oral glucose tolerance testing (OGTT)-derived measures of insulin sensitivity and pancreatic β-cell function with indices of diabetes complications in a cross-sectional study of patients with type 2 diabetes who are free of overt cardiovascular or renal disease. RESEARCH DESIGN ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1880
更新日期:2014-01-01 00:00:00
abstract::Epidemiological studies performed over the past 40 years have shown that the prevalence of diagnosed diabetes has increased dramatically in the U.S. and that a substantial proportion of the population has undiagnosed diabetes, impaired fasting glucose, and impaired glucose tolerance. Diabetes is most prevalent in mino...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.3.c11
更新日期:1998-12-01 00:00:00
abstract::Biosynthetic human insulin (BHI) was compared with highly purified human pancreatic and pork insulin with regard to its ability to bind to erythrocytes of normal and insulin-dependent diabetic subjects (type I diabetes). The binding affinity or capacity of erythrocyte from both normal and diabetic subjects were compar...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.4.2.215
更新日期:1981-03-01 00:00:00
abstract:OBJECTIVE:Success after islet transplantation can be defined in terms of insulin independence, C-peptide secretion, or glycemic control. These measures are interdependent and all need to be considered in evaluating beta-cell function after islet transplantation. For the current study, a composite beta-score was develop...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.28.2.343
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:Nonalcoholic fatty liver disease is highly prevalent in obese and type 2 diabetic individuals and is strongly associated with dyslipidemia and inflammation. Weight loss and/or pharmacotherapy are commonly used to correct these abnormalities. RESEARCH DESIGN AND METHODS:We performed a 16-week intervention tri...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc09-1765
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:To address whether hemodynamic responses in the cerebral arteries and OAs may be altered in patients with diabetic retinopathy. We used TCD to evaluate the effects of changes in BP, posture, and exercise on MCA and OA blood flow velocities. RESEARCH DESIGN AND METHODS:We evaluated 13 patients with BDR, 19 wi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.16.2.476
更新日期:1993-02-01 00:00:00
abstract::One-third of men with obesity or type 2 diabetes have subnormal free testosterone concentrations. The lower free testosterone concentrations are observed in obese men at all ages, including adolescents at completion of puberty. The gonadotropin concentrations in these males are inappropriately normal; thus, these pati...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/dc17-2510
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:Emerging evidence suggests that peripheral neuropathy begins in the early stages of diabetes pathogenesis. Our objective was to describe the prevalence of peripheral neuropathy and nerve dysfunction according to glucose tolerance and metabolic syndrome status and examine how these conditions are associated wi...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc14-2585
更新日期:2015-05-01 00:00:00
abstract::A total of 1467 black patients (911 in Atlanta, 556 in Memphis) were selected (1969-70) and followed longitudinally and prospectively until death (404 patients) or through 31 December 1979, when 676 were alive and active and 387 were lost to follow-up. The women/men ratio in each cohort was 4.7/1. Women had more exces...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.7.1.25
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVE:This study compared heart rate variability (HRV) parameters in youth with and without type 1 diabetes and explored potential contributors of altered HRV. RESEARCH DESIGN AND METHODS:HRV parameters were measured among 354 youth with type 1 diabetes (mean age 18.8 years, diabetes duration 9.8 years, and mean A...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc12-0463
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Transforming growth factor (TGF)-beta1 is overexpressed in diabetes as a consequence of hyperglycemia and the creation of early glycated end products and may be responsible for the characteristic structural renal changes associated with diabetes. We sought to examine the role of both urinary and circulating T...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.25.12.2320
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVE:The goal of the study was to examine risk factors in the prediction of coronary heart disease (CHD) and differences in men and women in the EURODIAB Prospective Complications Study. RESEARCH DESIGN AND METHODS:Baseline risk factors and CHD at follow-up were assessed in 2,329 type 1 diabetic patients without ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.27.2.530
更新日期:2004-02-01 00:00:00
abstract:OBJECTIVE:No study has been conducted to evaluate the association between avascular necrosis of the femoral head and diabetes. This study's aim was to assess this issue in Taiwan. RESEARCH DESIGN AND METHODS:A population-based cohort study was performed to analyze the database of Taiwan's National Health Insurance Pro...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc18-1258
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:Available basal insulin formulations do not provide a constant and reliable 24-h insulin supply. We compared the efficacy and safety of glargine (a long-acting insulin analog) and NPH insulins in insulin-naive type 2 diabetic patients treated with oral antidiabetic agents. RESEARCH DESIGN AND METHODS:There w...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diacare.23.8.1130
更新日期:2000-08-01 00:00:00
abstract::Stress is a potential contributor to chronic hyperglycemia in diabetes. Stress has long been shown to have major effects on metabolic activity. Energy mobilization is a primary result of the fight or flight response. Stress stimulates the release of various hormones, which can result in elevated blood glucose levels. ...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.15.10.1413
更新日期:1992-10-01 00:00:00
abstract:OBJECTIVE:Diabetes is one of the most common chronic diseases and a leading cause of morbidity and mortality in the U.S. Although our ability to treat diabetes and its associated complications has significantly improved, presentation with uncontrolled diabetes leading to ketoacidosis remains a significant problem. RES...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc17-1379
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the role of metabolic control in the progression of diabetic retinopathy during pregnancy. RESEARCH DESIGN AND METHODS:We conducted a prospective cohort study of 155 diabetic women in the Diabetes in Early Pregnancy Study followed from the periconceptional period to 1 month postpartum. Fundus pho...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.18.5.631
更新日期:1995-05-01 00:00:00
abstract:OBJECTIVE:Ipragliflozin, a sodium-glucose cotransporter 2 inhibitor, stimulates glycosuria and lowers glycemia in patients with type 2 diabetes (T2DM). The objective of this study was to assess the pharmacodynamics of ipragliflozin in T2DM patients with impaired renal function. RESEARCH DESIGN AND METHODS:Glycosuria w...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1503
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:We previously showed that in patients with diabetes mellitus, glycated hemoglobin (HbA1c) monitoring outside international guidance on testing frequency is widespread. Here we examined the relationship between testing frequency and diabetes control to test the hypothesis that retest interval is linked to chan...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc14-0297
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:Peripheral neuropathy is the most frequent neurological complication in diabetic patients. The diagnosis is established by both clinical neurological examination and demonstration of reduced epidermal nerve fibers in skin biopsies (1). Whereas the decrease of free nerve endings has been extensively studied in...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc07-1832
更新日期:2008-06-01 00:00:00
abstract::This commentary/review briefly considers the diverse criteria recommended for classification of overweight infants. Macrosomia continues to be a vexing problem for both obstetricians and pediatricians. Among the various techniques possible for use in assessing body composition, none are more practical than body weight...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.22.7.1201
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVE:Fat metabolism is increasingly implicated in the pathogenesis of type 2 diabetes. Endurance training has been shown to prevent hepatic steatosis and to alter skeletal muscle fat metabolism, and regional free fatty acid (FFA) uptake adaptations were suggested as a mechanism. Thus, we tested whether endurance t...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.9.2172
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVE:Hypoglycemic symptoms have been reported by more than half of pancreas transplantation (PTX) recipients. To better understand the mechanism for the hypoglycemia documented in some of these patients, we studied the glucose and pancreatic hormone response to Sustacal in patients with and without hypoglycemia fo...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.17.9.988
更新日期:1994-09-01 00:00:00