Abstract:
:Steroid receptor activation in developing brain influences a variety of cellular processes that endure into adulthood, altering both behavior and physiology. We report that estrogen receptors can be activated in a ligand-independent manner within developing brain by membrane dopamine receptors. Neonatal treatment with either estradiol or a dopamine D1 receptor agonist can increase the expression of an estrogen receptor-regulated gene (i.e. progestin receptors) and later juvenile social play. More importantly, increases in social play behavior induced by neonatal treatment with estradiol or a dopamine D1 receptor agonist can be prevented by prior treatment with an estrogen receptor antagonist. This suggests that changes in dopamine transmission in developing brain can activate estrogen receptors in a ligand-independent manner to influence gene expression and have lasting consequences on social behavior.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Olesen KM,Jessen HM,Auger CJ,Auger APdoi
10.1210/en.2005-0498subject
Has Abstractpub_date
2005-09-01 00:00:00pages
3705-12issue
9eissn
0013-7227issn
1945-7170pii
en.2005-0498journal_volume
146pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::PRL gene expression in the anterior pituitary has been the focus of intensive investigation for many years, but very little information is available on the actual dynamics by which this process occurs in individual mammotrope cells. Here, we used single cell bioluminescent imaging microscopy and a recently refined rep...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.143.3.8682
更新日期:2002-03-01 00:00:00
abstract::Recent work has implicated stimulatory kisspeptin neurons in the arcuate nucleus (ARC) as important for seasonal changes in reproductive function in sheep, but earlier studies support a role for inhibitory A15 dopaminergic (DA) neurons in the suppression of GnRH (and LH) pulse frequency in the nonbreeding (anestrous) ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1611
更新日期:2012-12-01 00:00:00
abstract::Previous studies have shown that increased sodium chloride in drinking water failed to suppress serum renin activity (SRA) in the etheranesthetized rat. In the absence of anesthesia, sodium chloride decreased SRA by 76% and serum aldosterone by 72%. Deoxycorticosterone acetate, when given alone, produced similar resul...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-6-1394
更新日期:1975-12-01 00:00:00
abstract::The GnRH neurosecretory system undergoes marked structural and functional changes throughout life. The initial goal of this study was to examine the neuroanatomical relationship between GnRH neurons and a glycoprotein implicated in neuroplasticity, the polysialylated form of neural cell adhesion molecule (PSA-NCAM). U...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.142.3.8000
更新日期:2001-03-01 00:00:00
abstract::An estrogen-responsive uterine proenzyme of a proteinase in the immature rat uterus has been known for some time. Its mol wt is 77,000, its N-terminal amino acid sequence is the same as prothrombin's for 15 residues, it contains gamma-carboxyl glutamate residues, its biosynthesis is prevented by warfarin, it cross-rea...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-126-1-167
更新日期:1990-01-01 00:00:00
abstract::We previously reported that TNF-alpha-induced apoptosis of lactotropes is estrogen dependent and predominant at proestrus. Here we observed that TNF-alpha (50 ng/ml) failed to induce apoptosis of anterior pituitary cells from ovariectomized rats cultured in the presence of progesterone (10(-6) m). However, progesteron...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2004-1276
更新日期:2005-02-01 00:00:00
abstract::The importance of monoaminergic mechanisms for the regulation of GH-releasing factor (GRF)-stimulated GH secretion was studied in perifused rat anterior pituitaries. Dopamine (greater than 1 microL) reduced GRF-stimulated GH release, but 5-hydroxytryptamine (5-HT; 1 mL) had no effect. The substrates for L-aromatic ami...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-120-2-780
更新日期:1987-02-01 00:00:00
abstract::We have studied the long-term effects of nicotinamide (NIC) on the synthesis of NO by insulin producing cells. NIC delays the formation of nitrite by interleukin (IL)-1 beta-(IL-1, 25 U/ml)-stimulated RINm5F cells, and previous exposure of cells to IL-1 for 15 h prevents this effect. The delay is associated with a lac...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.11.8895350
更新日期:1996-11-01 00:00:00
abstract::The secretion of neurohypophyseal hormone and ACTH in the rat has been shown to exhibit circadian rhythms, with high values during the day and low values throughout the night. The neurohypophyseal hormone daily rhythm is altered by exposure to constant light and by pinealectomy. It was, thus, proposed that the observe...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.132.3.8440190
更新日期:1993-03-01 00:00:00
abstract::Five studies are reported which were designed to define the effects of an estrogen and a progestogen, alone and in combination, on tissue concentrations (heart, kidney, and liver) of two trace metals (zinc, copper) and four bulk cations (sodium, potassium, calcium, magnesium). Male rats received Premarin (0.08 mg) and...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-5-1263
更新日期:1975-11-01 00:00:00
abstract::The disappearance of 125-I-ACTH from the circulation of 4 pregnant and fetal sheep has been followed after a single injection to the ewe or fetus. The mean metabolic clearance rate for the fetus and the ewe was 55 and 34 ml/min/kg respectively, giving a half-life in each case of about 1 min. The higher fetal than mate...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-1-231
更新日期:1975-01-01 00:00:00
abstract::From the MtTF4 tumor of rat pituitary origin we established the F4Z2 cell line whose growth is stimulated by 17 beta-estradiol (E2). Taking E2 actions as references we investigated actions of other effectors on the proliferation, protein, and insulin growth factor-I (IGF-I) secretions of F4F2 cells. Dexamethasone (Dex...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-128-6-2761
更新日期:1991-06-01 00:00:00
abstract::Insulin and epidermal growth factor (EGF) share a number of metabolic actions, including stimulation of protein synthesis and growth in certain tissues, and activation of apparent receptor tyrosine kinase activities. We have shown that insulin and EGF promote the phosphorylation of a number of intracellular proteins i...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-114-1-141
更新日期:1984-01-01 00:00:00
abstract::Estrogens have been implicated in the regulation of prolactin gene expression in man, although previous studies have not defined the molecular mechanism whereby estradiol activates the human prolactin gene promoter (hPrl). We found that estradiol induced a reproducible 1.8-fold activation of the hPrl gene promoter, us...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-1066
更新日期:2008-02-01 00:00:00
abstract::This study examined the effect of two thirds hepatectomy on rat liver insulin-like growth factor-II (IGF-II) receptors and IGF-II receptor messenger RNA (mRNA) levels. IGF-II receptor levels were determined in liver plasma membrane and Golgi/endosome fractions from sham-operated and hepatectomized rats by ligand bindi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-127-5-2210
更新日期:1990-11-01 00:00:00
abstract::To assess the possible source of progesterone in the fetal fluids of pregnant sheep, we measured the changes in progesterone concentrations in amniotic fluid (AF) and allantoic fluid (ALF) during pregnancy and compared these values with those in the maternal and fetal circulations. In acute experiments, the concentrat...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-110-2-481
更新日期:1982-02-01 00:00:00
abstract::Decidual/trophoblast PRL-related protein (d/tPRP) is a member of the PRL gene family and is dually expressed in uterine and placental tissues in a highly coordinated pattern during pregnancy. In the present study, we describe the isolation and characterization of the d/tPRP gene. A lambda DASH II Wistar-Kyoto rat geno...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.6.5155
更新日期:1997-06-01 00:00:00
abstract::We have found that microwave (MW) stabilization greatly improves detection of the estrogen receptor (ER) in frozen sections of rhesus monkey oviduct by immunocytochemistry (ICC). Fresh samples of fimbriae were MW-irradiated, frozen, and then cryosectioned. The frozen sections were also MW-treated and then fixed in a p...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.136.9.7649110
更新日期:1995-09-01 00:00:00
abstract::The effect of an i.v. administration of different doses (250, 500, and 1000 pmol) of ovine CRF (oCRF) on plasma glucose and insulin levels in lean and genetically obese fa/fa rats was investigated. In both phenotypes, i.v. CRF promoted a rapid (peak at 1 min) transient doubling of basal insulin levels without a concom...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.130.4.1312430
更新日期:1992-04-01 00:00:00
abstract::The atrophy and hypofunction of the adrenal cortex following long-term pharmacologic glucocorticoid therapy is a major health problem necessitating chronic glucocorticoid replacement that often prolongs the ultimate return of endogenous adrenocortical function. Underlying this functional recovery is anatomic regenerat...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-03061
更新日期:2018-02-01 00:00:00
abstract::Ca2+/calmodulin-dependent processes are altered by manipulations of the hypothalamic-pituitary-adrenal axis. In particular, adrenalectomy (ADX) attenuates hippocampal, but not cortical, calmodulin-dependent adenylate cyclase activity measured during the active (waking) phase of rats. The involvement of calmodulin- and...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.134.2.8299580
更新日期:1994-02-01 00:00:00
abstract::PRL receptor (PRL-R) expression has been analyzed in human hematopoietic tissues using flow cytofluorometric analysis with a series of biotinylated monoclonal antibodies (mAbs) directed against the extracellular domain of the rat liver PRL-R. In the thymus, more than 75% of cells were labeled by the anti-PRL-R mAb. Re...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.134.5.8156910
更新日期:1994-05-01 00:00:00
abstract::Testicular tissue of normal and hCG-stimulated European eels was incubated in vitro with tritiated progesterone or androstenedione as substrates. The following compounds were isolated and identified: 5 beta-androstane-3,17-dione; 17 beta-hydroxy-5 beta-androstan-3-one; androst-4-ene-3,11,17-trione (adrenosterone); 11 ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-110-3-916
更新日期:1982-03-01 00:00:00
abstract::Vasoactive intestinal polypeptide (VIP) was measured by RIA in the hypophysial portal blood of rats after total hypophysectomy. The mean (+/- SE) VIP concentrations were 1332 +/- 171 pg/ml (range, 300-3868 pg/ml) under urethane anesthesia and 1735 +/- 707 pg/ml under pentobarbital anesthesia. The concentrations of VIP...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-108-2-395
更新日期:1981-02-01 00:00:00
abstract::Gamma-aminobutyric acid (GABA) is one of the most important neurotransmitters that regulate the excitability of GnRH neurons. Numerous studies have shown that GABA activates Cl(-) currents in GnRH neurons, and these effects are antagonized by GABA(A) receptor antagonists. The GABA(B) receptor is a heterodimer composed...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-1313
更新日期:2009-05-01 00:00:00
abstract::Estrogens play a central role in regulating female reproduction throughout the reproductive axis, and the pituitary is one of the major targets of estrogen action. We hypothesized that estrogen receptor alpha (ERalpha) mediates estrogen action in the pituitary gonadotroph. To test this hypothesis, we generated a mouse...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-1084
更新日期:2008-01-01 00:00:00
abstract::Periodontitis, an inflammatory disease of periodontal tissues, is characterized by excessive alveolar bone resorption. An increase in the receptor activator of nuclear factor-κB ligand (RANKL) to osteoprotegerin (OPG) ratio is thought to reflect the severity of periodontitis. Here, we examined alveolar bone loss in OP...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1928
更新日期:2013-02-01 00:00:00
abstract::The most significant increase in metabolic syndrome over the previous decade occurred in women of reproductive age, which is alarming given that metabolic syndrome is associated with reproductive problems including subfertility and early pregnancy loss. Individuals with metabolic syndrome often consume excess fructose...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1618
更新日期:2016-02-01 00:00:00
abstract::Hyperaldosteronism is linked to the development and progression of several different cardiovascular diseases. Angiotensin (Ang) II increases aldosterone secretion and adrenal blood flow. Ang II peptide fragments are produced by various peptidases, and these Angs have diverse and vital physiologic roles. Due to the unc...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1160
更新日期:2013-12-01 00:00:00
abstract::As a model of the changes in peripheral iodothyronine metabolism that occur during ontogeny, we have studied the metabolism of 125I-labeled T4 and several of its partially deiodinated derivatives by the liver of the chick embryo. Homogenates of livers obtained from chicks varying in embryonic age from 8 days to the ti...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-107-6-1751
更新日期:1980-12-01 00:00:00